ER membrane protein complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

Protein of unknown function (DUF1077), putative

Species:

Leishmania braziliensis

UniProt:

A4HIA9_LEIBR

TriTrypDb:

LbrM.30.1700 , LBRM2903_300022800

Length:

149


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

A4HIA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA9


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.286
CLV_PCSK_SKI1_1	101	105	PF00082	0.307
CLV_PCSK_SKI1_1	13	17	PF00082	0.737
DOC_PP1_RVXF_1	116	122	PF00149	0.310
DOC_USP7_MATH_1	126	130	PF00917	0.364
DOC_USP7_MATH_1	69	73	PF00917	0.456
DOC_WW_Pin1_4	133	138	PF00397	0.270
LIG_14-3-3_CanoR_1	28	36	PF00244	0.294
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	144	148	PF00533	0.490
LIG_BRCT_BRCA1_1	57	61	PF00533	0.329
LIG_FHA_1	32	38	PF00498	0.350
LIG_FHA_2	137	143	PF00498	0.447
LIG_FHA_2	14	20	PF00498	0.512
LIG_LIR_Gen_1	139	148	PF02991	0.468
LIG_LIR_Gen_1	55	65	PF02991	0.329
LIG_LIR_Nem_3	139	143	PF02991	0.472
LIG_PCNA_yPIPBox_3	33	46	PF02747	0.227
LIG_Pex14_2	57	61	PF04695	0.310
LIG_SH3_3	63	69	PF00018	0.294
LIG_TRAF2_1	139	142	PF00917	0.504
LIG_TRAF2_1	16	19	PF00917	0.400
LIG_UBA3_1	109	118	PF00899	0.330
LIG_WW_1	137	140	PF00397	0.407
MOD_CK1_1	3	9	PF00069	0.416
MOD_CK1_1	55	61	PF00069	0.329
MOD_CK2_1	13	19	PF00069	0.494
MOD_CK2_1	136	142	PF00069	0.445
MOD_GlcNHglycan	144	147	PF01048	0.684
MOD_GlcNHglycan	8	11	PF01048	0.707
MOD_GlcNHglycan	94	97	PF01048	0.270
MOD_GSK3_1	27	34	PF00069	0.314
MOD_N-GLC_1	6	11	PF02516	0.744
MOD_PIKK_1	31	37	PF00454	0.364
MOD_PKA_2	27	33	PF00069	0.335
MOD_Plk_1	52	58	PF00069	0.329
MOD_Plk_4	52	58	PF00069	0.284
MOD_Plk_4	69	75	PF00069	0.376
MOD_ProDKin_1	133	139	PF00069	0.270
MOD_SUMO_rev_2	82	89	PF00179	0.538
TRG_ENDOCYTIC_2	140	143	PF00928	0.475
TRG_ER_diArg_1	22	25	PF00400	0.277


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL3	Leptomonas seymouri	80%	100%
A0A0S4J2Y6	Bodo saltans	51%	100%
A0A1X0P234	Trypanosomatidae	64%	100%
A0A3Q8IJD4	Leishmania donovani	89%	99%
A0A3R7RTR5	Trypanosoma rangeli	55%	100%
A4I5J3	Leishmania infantum	89%	99%
B5XB24	Salmo salar	32%	79%
C9ZQS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B0T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
O94520	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	77%
P53073	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	78%
Q3T0K8	Bos taurus	33%	81%
Q4Q7D8	Leishmania major	87%	100%
Q5J8M3	Homo sapiens	33%	81%
Q5RC35	Pongo abelii	33%	81%
Q6GR43	Xenopus laevis	31%	83%
Q6P011	Danio rerio	32%	79%
Q6PBF7	Xenopus tropicalis	31%	83%
Q9CZX9	Mus musculus	33%	81%