LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HIA8_LEIBR
TriTrypDb:
LbrM.30.1690 , LBRM2903_300022700
Length:
128

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HIA8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 14 18 PF00082 0.478
CLV_PCSK_SKI1_1 7 11 PF00082 0.424
DEG_MDM2_SWIB_1 98 105 PF02201 0.357
DEG_Nend_Nbox_1 1 3 PF02207 0.648
DOC_USP7_MATH_1 22 26 PF00917 0.214
LIG_14-3-3_CanoR_1 14 20 PF00244 0.357
LIG_14-3-3_CanoR_1 33 39 PF00244 0.302
LIG_LIR_Nem_3 37 42 PF02991 0.361
LIG_Pex14_1 58 62 PF04695 0.469
LIG_Pex14_2 98 102 PF04695 0.324
LIG_SH2_CRK 39 43 PF00017 0.445
LIG_SH2_CRK 62 66 PF00017 0.621
LIG_SH2_STAT5 62 65 PF00017 0.613
LIG_SH2_STAT5 91 94 PF00017 0.337
LIG_SH3_3 101 107 PF00018 0.439
LIG_SH3_3 6 12 PF00018 0.533
LIG_SUMO_SIM_par_1 78 85 PF11976 0.629
LIG_WRC_WIRS_1 52 57 PF05994 0.302
MOD_CK1_1 18 24 PF00069 0.412
MOD_CK1_1 54 60 PF00069 0.316
MOD_GlcNHglycan 24 27 PF01048 0.230
MOD_GSK3_1 10 17 PF00069 0.562
MOD_GSK3_1 18 25 PF00069 0.247
MOD_N-GLC_1 5 10 PF02516 0.515
MOD_N-GLC_2 61 63 PF02516 0.363
MOD_NEK2_1 5 10 PF00069 0.731
MOD_PKA_2 10 16 PF00069 0.711
MOD_PKA_2 73 79 PF00069 0.642
MOD_Plk_1 5 11 PF00069 0.533
MOD_Plk_4 34 40 PF00069 0.286
TRG_ENDOCYTIC_2 39 42 PF00928 0.448
TRG_ENDOCYTIC_2 62 65 PF00928 0.613

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Z8 Leptomonas seymouri 90% 100%
A0A0S4JA04 Bodo saltans 50% 100%
A0A1X0P1Y7 Trypanosomatidae 59% 100%
A0A3Q8IE83 Leishmania donovani 93% 100%
A0A422P4W3 Trypanosoma rangeli 58% 96%
A4I5J2 Leishmania infantum 93% 100%
C9ZQS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 98%
E9B0T7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q7D9 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS