Putative ferric reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIA6_LEIBR

TriTrypDb:

LbrM.30.1670 , LBRM2903_300022500

Length:

1085

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

A4HIA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000293	ferric-chelate reductase activity	4	2
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016722	oxidoreductase activity, acting on metal ions	3	2
GO:0016723	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	4	2
GO:0140618	ferric-chelate reductase (NADH) activity	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1003	1007	PF00656	0.726
CLV_C14_Caspase3-7	197	201	PF00656	0.582
CLV_C14_Caspase3-7	883	887	PF00656	0.578
CLV_C14_Caspase3-7	974	978	PF00656	0.616
CLV_NRD_NRD_1	189	191	PF00675	0.368
CLV_NRD_NRD_1	279	281	PF00675	0.606
CLV_NRD_NRD_1	298	300	PF00675	0.671
CLV_NRD_NRD_1	361	363	PF00675	0.345
CLV_NRD_NRD_1	48	50	PF00675	0.593
CLV_NRD_NRD_1	531	533	PF00675	0.263

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3B5	Leishmania donovani	73%	100%
A0A422N2V3	Trypanosoma rangeli	33%	100%
A4I5J0	Leishmania infantum	72%	100%
D0A6T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B0T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q7E3	Leishmania major	72%	100%

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