Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIA5_LEIBR

TriTrypDb:

LbrM.30.1660 , LBRM2903_300022300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.622
CLV_NRD_NRD_1	123	125	PF00675	0.506
CLV_NRD_NRD_1	287	289	PF00675	0.538
CLV_NRD_NRD_1	375	377	PF00675	0.587
CLV_PCSK_FUR_1	373	377	PF00082	0.634
CLV_PCSK_KEX2_1	123	125	PF00082	0.506
CLV_PCSK_KEX2_1	287	289	PF00082	0.513
CLV_PCSK_KEX2_1	361	363	PF00082	0.554
CLV_PCSK_KEX2_1	375	377	PF00082	0.496
CLV_PCSK_KEX2_1	379	381	PF00082	0.458
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.560
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.379
CLV_PCSK_PC7_1	375	381	PF00082	0.609
CLV_PCSK_SKI1_1	245	249	PF00082	0.408
CLV_PCSK_SKI1_1	380	384	PF00082	0.625
CLV_PCSK_SKI1_1	93	97	PF00082	0.469
CLV_Separin_Metazoa	38	42	PF03568	0.513
DEG_APCC_DBOX_1	82	90	PF00400	0.433
DEG_APCC_DBOX_1	92	100	PF00400	0.436
DEG_COP1_1	198	208	PF00400	0.504
DEG_SCF_FBW7_2	480	487	PF00400	0.432
DEG_SPOP_SBC_1	100	104	PF00917	0.471
DEG_SPOP_SBC_1	59	63	PF00917	0.718
DOC_CKS1_1	481	486	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.517
DOC_MAPK_gen_1	471	480	PF00069	0.418
DOC_MAPK_MEF2A_6	93	101	PF00069	0.404
DOC_MIT_MIM_1	118	128	PF04212	0.297
DOC_PP1_RVXF_1	190	196	PF00149	0.369
DOC_PP2B_LxvP_1	347	350	PF13499	0.503
DOC_PP2B_LxvP_1	97	100	PF13499	0.465
DOC_USP7_MATH_1	100	104	PF00917	0.493
DOC_USP7_MATH_1	160	164	PF00917	0.359
DOC_USP7_MATH_1	199	203	PF00917	0.654
DOC_USP7_MATH_1	391	395	PF00917	0.547
DOC_USP7_MATH_1	53	57	PF00917	0.753
DOC_USP7_MATH_1	59	63	PF00917	0.762
DOC_USP7_UBL2_3	280	284	PF12436	0.743
DOC_WW_Pin1_4	238	243	PF00397	0.525
DOC_WW_Pin1_4	324	329	PF00397	0.753
DOC_WW_Pin1_4	480	485	PF00397	0.561
LIG_14-3-3_CanoR_1	165	174	PF00244	0.471
LIG_14-3-3_CanoR_1	288	298	PF00244	0.521
LIG_14-3-3_CanoR_1	378	383	PF00244	0.682
LIG_14-3-3_CanoR_1	48	53	PF00244	0.613
LIG_14-3-3_CanoR_1	502	508	PF00244	0.641
LIG_14-3-3_CanoR_1	71	75	PF00244	0.361
LIG_BH_BH3_1	117	133	PF00452	0.289
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_CSL_BTD_1	490	493	PF09270	0.576
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.478
LIG_deltaCOP1_diTrp_1	188	195	PF00928	0.353
LIG_FHA_1	192	198	PF00498	0.517
LIG_FHA_1	215	221	PF00498	0.533
LIG_FHA_1	26	32	PF00498	0.534
LIG_FHA_1	34	40	PF00498	0.458
LIG_FHA_1	382	388	PF00498	0.465
LIG_FHA_1	464	470	PF00498	0.517
LIG_FHA_1	5	11	PF00498	0.319
LIG_FHA_2	196	202	PF00498	0.622
LIG_FHA_2	49	55	PF00498	0.757
LIG_FHA_2	502	508	PF00498	0.613
LIG_FHA_2	512	518	PF00498	0.526
LIG_LIR_Apic_2	487	493	PF02991	0.482
LIG_LIR_Gen_1	109	116	PF02991	0.538
LIG_LIR_Gen_1	365	374	PF02991	0.542
LIG_LIR_Gen_1	475	485	PF02991	0.569
LIG_LIR_LC3C_4	7	10	PF02991	0.284
LIG_LIR_Nem_3	109	114	PF02991	0.540
LIG_LIR_Nem_3	187	193	PF02991	0.584
LIG_LIR_Nem_3	28	32	PF02991	0.490
LIG_LIR_Nem_3	365	371	PF02991	0.533
LIG_LIR_Nem_3	475	480	PF02991	0.536
LIG_LYPXL_yS_3	29	32	PF13949	0.525
LIG_MYND_1	206	210	PF01753	0.688
LIG_NRBOX	312	318	PF00104	0.516
LIG_SH2_CRK	257	261	PF00017	0.287
LIG_SH2_SRC	351	354	PF00017	0.521
LIG_SH2_STAP1	257	261	PF00017	0.285
LIG_SH2_STAP1	353	357	PF00017	0.391
LIG_SH2_STAT3	11	14	PF00017	0.536
LIG_SH2_STAT5	18	21	PF00017	0.419
LIG_SH2_STAT5	351	354	PF00017	0.503
LIG_SH2_STAT5	358	361	PF00017	0.498
LIG_SH3_3	24	30	PF00018	0.566
LIG_SH3_3	483	489	PF00018	0.633
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.579
LIG_SUMO_SIM_par_1	124	131	PF11976	0.394
LIG_SUMO_SIM_par_1	235	241	PF11976	0.478
LIG_TRAF2_1	514	517	PF00917	0.571
MOD_CDK_SPK_2	238	243	PF00069	0.330
MOD_CDK_SPxxK_3	238	245	PF00069	0.457
MOD_CK1_1	103	109	PF00069	0.451
MOD_CK1_1	149	155	PF00069	0.413
MOD_CK1_1	381	387	PF00069	0.711
MOD_CK1_1	408	414	PF00069	0.814
MOD_CK1_1	431	437	PF00069	0.734
MOD_CK1_1	453	459	PF00069	0.696
MOD_CK1_1	460	466	PF00069	0.636
MOD_CK1_1	498	504	PF00069	0.477
MOD_CK1_1	58	64	PF00069	0.711
MOD_CK2_1	103	109	PF00069	0.492
MOD_CK2_1	201	207	PF00069	0.546
MOD_CK2_1	261	267	PF00069	0.477
MOD_CK2_1	31	37	PF00069	0.513
MOD_CK2_1	391	397	PF00069	0.631
MOD_CK2_1	441	447	PF00069	0.809
MOD_CK2_1	511	517	PF00069	0.509
MOD_Cter_Amidation	285	288	PF01082	0.522
MOD_GlcNHglycan	1	4	PF01048	0.622
MOD_GlcNHglycan	117	121	PF01048	0.535
MOD_GlcNHglycan	133	136	PF01048	0.497
MOD_GlcNHglycan	230	233	PF01048	0.647
MOD_GlcNHglycan	257	260	PF01048	0.398
MOD_GlcNHglycan	329	332	PF01048	0.772
MOD_GlcNHglycan	407	410	PF01048	0.816
MOD_GlcNHglycan	412	415	PF01048	0.726
MOD_GlcNHglycan	438	441	PF01048	0.780
MOD_GlcNHglycan	57	60	PF01048	0.745
MOD_GlcNHglycan	67	70	PF01048	0.537
MOD_GSK3_1	160	167	PF00069	0.534
MOD_GSK3_1	180	187	PF00069	0.249
MOD_GSK3_1	191	198	PF00069	0.556
MOD_GSK3_1	271	278	PF00069	0.648
MOD_GSK3_1	323	330	PF00069	0.694
MOD_GSK3_1	378	385	PF00069	0.604
MOD_GSK3_1	428	435	PF00069	0.728
MOD_GSK3_1	451	458	PF00069	0.702
MOD_GSK3_1	459	466	PF00069	0.616
MOD_GSK3_1	469	476	PF00069	0.459
MOD_GSK3_1	53	60	PF00069	0.686
MOD_GSK3_1	61	68	PF00069	0.640
MOD_GSK3_1	99	106	PF00069	0.491
MOD_N-GLC_1	429	434	PF02516	0.682
MOD_N-GLC_1	450	455	PF02516	0.708
MOD_N-GLC_1	456	461	PF02516	0.615
MOD_NEK2_1	101	106	PF00069	0.477
MOD_NEK2_1	116	121	PF00069	0.508
MOD_NEK2_1	128	133	PF00069	0.433
MOD_NEK2_1	193	198	PF00069	0.544
MOD_NEK2_1	228	233	PF00069	0.666
MOD_NEK2_1	275	280	PF00069	0.692
MOD_NEK2_1	382	387	PF00069	0.712
MOD_NEK2_1	495	500	PF00069	0.510
MOD_OFUCOSY	138	143	PF10250	0.403
MOD_PIKK_1	109	115	PF00454	0.452
MOD_PIKK_1	261	267	PF00454	0.472
MOD_PKA_1	378	384	PF00069	0.637
MOD_PKA_2	164	170	PF00069	0.568
MOD_PKA_2	289	295	PF00069	0.516
MOD_PKA_2	399	405	PF00069	0.830
MOD_PKA_2	47	53	PF00069	0.600
MOD_PKA_2	501	507	PF00069	0.589
MOD_PKA_2	518	524	PF00069	0.350
MOD_PKA_2	70	76	PF00069	0.461
MOD_PKB_1	288	296	PF00069	0.643
MOD_PKB_1	376	384	PF00069	0.676
MOD_Plk_1	109	115	PF00069	0.531
MOD_Plk_1	116	122	PF00069	0.440
MOD_Plk_2-3	201	207	PF00069	0.517
MOD_Plk_4	14	20	PF00069	0.371
MOD_Plk_4	290	296	PF00069	0.606
MOD_Plk_4	4	10	PF00069	0.449
MOD_Plk_4	464	470	PF00069	0.694
MOD_Plk_4	473	479	PF00069	0.643
MOD_Plk_4	495	501	PF00069	0.532
MOD_Plk_4	521	527	PF00069	0.531
MOD_Plk_4	70	76	PF00069	0.370
MOD_ProDKin_1	238	244	PF00069	0.518
MOD_ProDKin_1	324	330	PF00069	0.758
MOD_ProDKin_1	480	486	PF00069	0.557
TRG_DiLeu_BaEn_1	38	43	PF01217	0.566
TRG_DiLeu_BaEn_4	109	115	PF01217	0.531
TRG_DiLeu_BaEn_4	188	194	PF01217	0.343
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.379
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.579
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.502
TRG_DiLeu_LyEn_5	38	43	PF01217	0.566
TRG_ENDOCYTIC_2	257	260	PF00928	0.390
TRG_ENDOCYTIC_2	29	32	PF00928	0.525
TRG_ENDOCYTIC_2	353	356	PF00928	0.460
TRG_ER_diArg_1	123	125	PF00400	0.506
TRG_ER_diArg_1	287	290	PF00400	0.525
TRG_ER_diArg_1	306	309	PF00400	0.580
TRG_ER_diArg_1	375	378	PF00400	0.609
TRG_ER_diArg_1	82	85	PF00400	0.319
TRG_NLS_Bipartite_1	361	382	PF00514	0.612
TRG_NLS_MonoExtN_4	375	382	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P973	Leptomonas seymouri	44%	100%
A0A3Q8IFL5	Leishmania donovani	75%	100%
A0A3R7NW81	Trypanosoma rangeli	25%	100%
A4I5I9	Leishmania infantum	74%	100%
E9B0T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q7E4	Leishmania major	72%	100%
V5BZ01	Trypanosoma cruzi	26%	100%