Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIA4_LEIBR

TriTrypDb:

LbrM.30.1650 , LBRM2903_300022200

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HIA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.714
CLV_NRD_NRD_1	312	314	PF00675	0.615
CLV_NRD_NRD_1	347	349	PF00675	0.407
CLV_PCSK_KEX2_1	346	348	PF00082	0.378
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.385
CLV_PCSK_SKI1_1	269	273	PF00082	0.608
CLV_PCSK_SKI1_1	308	312	PF00082	0.657
CLV_PCSK_SKI1_1	8	12	PF00082	0.558
DEG_APCC_DBOX_1	153	161	PF00400	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DEG_SPOP_SBC_1	288	292	PF00917	0.335
DOC_CKS1_1	24	29	PF01111	0.496
DOC_CKS1_1	303	308	PF01111	0.360
DOC_MAPK_gen_1	152	160	PF00069	0.329
DOC_MAPK_JIP1_4	154	160	PF00069	0.345
DOC_MAPK_MEF2A_6	152	159	PF00069	0.402
DOC_PP4_FxxP_1	177	180	PF00568	0.236
DOC_PP4_FxxP_1	2	5	PF00568	0.419
DOC_PP4_FxxP_1	41	44	PF00568	0.300
DOC_PP4_FxxP_1	50	53	PF00568	0.215
DOC_USP7_MATH_1	138	142	PF00917	0.408
DOC_USP7_MATH_1	227	231	PF00917	0.427
DOC_USP7_MATH_1	242	246	PF00917	0.504
DOC_USP7_MATH_1	25	29	PF00917	0.426
DOC_USP7_MATH_1	306	310	PF00917	0.462
DOC_USP7_UBL2_3	131	135	PF12436	0.403
DOC_WW_Pin1_4	129	134	PF00397	0.520
DOC_WW_Pin1_4	23	28	PF00397	0.396
DOC_WW_Pin1_4	302	307	PF00397	0.342
DOC_WW_Pin1_4	8	13	PF00397	0.613
LIG_14-3-3_CanoR_1	269	276	PF00244	0.329
LIG_14-3-3_CanoR_1	71	77	PF00244	0.380
LIG_14-3-3_CanoR_1	98	102	PF00244	0.378
LIG_BRCT_BRCA1_1	142	146	PF00533	0.525
LIG_BRCT_BRCA1_1	74	78	PF00533	0.286
LIG_Clathr_ClatBox_1	157	161	PF01394	0.315
LIG_eIF4E_1	178	184	PF01652	0.398
LIG_FHA_1	171	177	PF00498	0.345
LIG_FHA_2	270	276	PF00498	0.381
LIG_LIR_Apic_2	175	180	PF02991	0.328
LIG_LIR_Apic_2	40	44	PF02991	0.396
LIG_LIR_Apic_2	47	53	PF02991	0.331
LIG_LIR_Gen_1	323	332	PF02991	0.268
LIG_LIR_Nem_3	323	327	PF02991	0.268
LIG_LIR_Nem_3	60	66	PF02991	0.275
LIG_Pex14_1	299	303	PF04695	0.302
LIG_Pex14_1	320	324	PF04695	0.348
LIG_Pex14_2	46	50	PF04695	0.400
LIG_PTB_Apo_2	35	42	PF02174	0.342
LIG_SH2_CRK	303	307	PF00017	0.322
LIG_SH2_CRK	324	328	PF00017	0.402
LIG_SH2_NCK_1	303	307	PF00017	0.351
LIG_SH2_SRC	178	181	PF00017	0.388
LIG_SH2_STAT5	178	181	PF00017	0.388
LIG_SH2_STAT5	303	306	PF00017	0.271
LIG_SH3_1	313	319	PF00018	0.389
LIG_SH3_3	313	319	PF00018	0.416
LIG_SUMO_SIM_par_1	156	161	PF11976	0.347
LIG_UBA3_1	86	93	PF00899	0.359
MOD_CDC14_SPxK_1	132	135	PF00782	0.404
MOD_CDK_SPK_2	129	134	PF00069	0.396
MOD_CDK_SPxK_1	129	135	PF00069	0.398
MOD_CDK_SPxK_1	302	308	PF00069	0.325
MOD_CK1_1	129	135	PF00069	0.564
MOD_CK1_1	247	253	PF00069	0.605
MOD_CK1_1	257	263	PF00069	0.386
MOD_CK1_1	57	63	PF00069	0.304
MOD_CK2_1	269	275	PF00069	0.308
MOD_Cter_Amidation	344	347	PF01082	0.400
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.377
MOD_GlcNHglycan	128	131	PF01048	0.745
MOD_GlcNHglycan	139	143	PF01048	0.754
MOD_GlcNHglycan	200	203	PF01048	0.598
MOD_GlcNHglycan	246	249	PF01048	0.720
MOD_GlcNHglycan	256	259	PF01048	0.727
MOD_GlcNHglycan	27	30	PF01048	0.653
MOD_GlcNHglycan	275	279	PF01048	0.562
MOD_GlcNHglycan	339	342	PF01048	0.389
MOD_GSK3_1	194	201	PF00069	0.392
MOD_GSK3_1	243	250	PF00069	0.523
MOD_GSK3_1	254	261	PF00069	0.380
MOD_GSK3_1	302	309	PF00069	0.341
MOD_GSK3_1	93	100	PF00069	0.398
MOD_N-GLC_1	66	71	PF02516	0.493
MOD_NEK2_1	146	151	PF00069	0.336
MOD_NEK2_1	170	175	PF00069	0.346
MOD_NEK2_1	54	59	PF00069	0.297
MOD_NEK2_1	66	71	PF00069	0.319
MOD_NEK2_1	72	77	PF00069	0.363
MOD_NEK2_2	172	177	PF00069	0.355
MOD_NEK2_2	289	294	PF00069	0.499
MOD_NEK2_2	306	311	PF00069	0.406
MOD_PIKK_1	57	63	PF00454	0.382
MOD_PIKK_1	93	99	PF00454	0.390
MOD_PKA_2	153	159	PF00069	0.378
MOD_PKA_2	97	103	PF00069	0.377
MOD_Plk_1	39	45	PF00069	0.306
MOD_Plk_1	66	72	PF00069	0.293
MOD_Plk_4	153	159	PF00069	0.293
MOD_Plk_4	172	178	PF00069	0.211
MOD_Plk_4	320	326	PF00069	0.324
MOD_Plk_4	54	60	PF00069	0.298
MOD_Plk_4	97	103	PF00069	0.394
MOD_ProDKin_1	129	135	PF00069	0.522
MOD_ProDKin_1	23	29	PF00069	0.400
MOD_ProDKin_1	302	308	PF00069	0.352
MOD_ProDKin_1	8	14	PF00069	0.610
MOD_SUMO_for_1	353	356	PF00179	0.645
MOD_SUMO_rev_2	110	117	PF00179	0.322
MOD_SUMO_rev_2	307	316	PF00179	0.311
MOD_SUMO_rev_2	85	94	PF00179	0.402
TRG_DiLeu_BaEn_1	153	158	PF01217	0.326
TRG_ENDOCYTIC_2	324	327	PF00928	0.432
TRG_ENDOCYTIC_2	63	66	PF00928	0.268
TRG_NLS_MonoExtC_3	345	351	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH7	Leptomonas seymouri	55%	96%
A0A1X0P321	Trypanosomatidae	30%	100%
A0A3S7X3C2	Leishmania donovani	68%	97%
A0A422P4W9	Trypanosoma rangeli	30%	100%
A4I5I8	Leishmania infantum	68%	97%
C9ZQS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B0T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4Q7E5	Leishmania major	67%	100%
V5BPM9	Trypanosoma cruzi	31%	100%