PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIA3_LEIBR

TriTrypDb:

LbrM.30.1640 , LBRM2903_300022100

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.516
CLV_C14_Caspase3-7	234	238	PF00656	0.312
CLV_NRD_NRD_1	152	154	PF00675	0.765
CLV_NRD_NRD_1	301	303	PF00675	0.617
CLV_NRD_NRD_1	366	368	PF00675	0.359
CLV_NRD_NRD_1	442	444	PF00675	0.469
CLV_NRD_NRD_1	47	49	PF00675	0.339
CLV_NRD_NRD_1	635	637	PF00675	0.663
CLV_NRD_NRD_1	677	679	PF00675	0.674
CLV_PCSK_KEX2_1	301	303	PF00082	0.617
CLV_PCSK_KEX2_1	366	368	PF00082	0.359
CLV_PCSK_KEX2_1	635	637	PF00082	0.676
CLV_PCSK_KEX2_1	677	679	PF00082	0.632
CLV_PCSK_SKI1_1	301	305	PF00082	0.546
CLV_PCSK_SKI1_1	327	331	PF00082	0.647
CLV_PCSK_SKI1_1	370	374	PF00082	0.520
CLV_PCSK_SKI1_1	378	382	PF00082	0.578
CLV_PCSK_SKI1_1	454	458	PF00082	0.445
CLV_PCSK_SKI1_1	580	584	PF00082	0.591
CLV_PCSK_SKI1_1	8	12	PF00082	0.502
CLV_PCSK_SKI1_1	86	90	PF00082	0.504
DEG_SIAH_1	415	423	PF03145	0.530
DEG_SPOP_SBC_1	202	206	PF00917	0.561
DOC_CKS1_1	673	678	PF01111	0.541
DOC_CYCLIN_RxL_1	295	307	PF00134	0.500
DOC_CYCLIN_RxL_1	319	330	PF00134	0.742
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.532
DOC_MAPK_gen_1	227	235	PF00069	0.559
DOC_MAPK_gen_1	48	56	PF00069	0.623
DOC_SPAK_OSR1_1	282	286	PF12202	0.488
DOC_USP7_MATH_1	106	110	PF00917	0.685
DOC_USP7_MATH_1	161	165	PF00917	0.774
DOC_USP7_MATH_1	265	269	PF00917	0.570
DOC_USP7_MATH_1	306	310	PF00917	0.676
DOC_USP7_MATH_1	320	324	PF00917	0.545
DOC_USP7_MATH_1	513	517	PF00917	0.479
DOC_USP7_MATH_1	566	570	PF00917	0.612
DOC_USP7_MATH_1	620	624	PF00917	0.560
DOC_WW_Pin1_4	1	6	PF00397	0.735
DOC_WW_Pin1_4	180	185	PF00397	0.766
DOC_WW_Pin1_4	261	266	PF00397	0.542
DOC_WW_Pin1_4	412	417	PF00397	0.434
DOC_WW_Pin1_4	476	481	PF00397	0.458
DOC_WW_Pin1_4	651	656	PF00397	0.510
DOC_WW_Pin1_4	668	673	PF00397	0.521
LIG_14-3-3_CanoR_1	295	300	PF00244	0.492
LIG_14-3-3_CanoR_1	327	334	PF00244	0.616
LIG_14-3-3_CanoR_1	36	40	PF00244	0.444
LIG_14-3-3_CanoR_1	425	431	PF00244	0.468
LIG_14-3-3_CanoR_1	443	447	PF00244	0.659
LIG_14-3-3_CanoR_1	86	93	PF00244	0.407
LIG_Actin_WH2_2	70	88	PF00022	0.508
LIG_AP2alpha_2	57	59	PF02296	0.660
LIG_APCC_ABBA_1	380	385	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.526
LIG_BIR_II_1	1	5	PF00653	0.459
LIG_BRCT_BRCA1_1	67	71	PF00533	0.392
LIG_CSL_BTD_1	445	448	PF09270	0.444
LIG_deltaCOP1_diTrp_1	20	23	PF00928	0.577
LIG_deltaCOP1_diTrp_1	307	312	PF00928	0.577
LIG_deltaCOP1_diTrp_1	352	362	PF00928	0.420
LIG_deltaCOP1_diTrp_1	472	477	PF00928	0.474
LIG_deltaCOP1_diTrp_1	632	641	PF00928	0.538
LIG_FHA_1	108	114	PF00498	0.695
LIG_FHA_1	124	130	PF00498	0.573
LIG_FHA_1	190	196	PF00498	0.691
LIG_FHA_1	209	215	PF00498	0.538
LIG_FHA_1	388	394	PF00498	0.602
LIG_FHA_1	448	454	PF00498	0.361
LIG_FHA_1	468	474	PF00498	0.349
LIG_FHA_1	537	543	PF00498	0.448
LIG_FHA_1	606	612	PF00498	0.517
LIG_FHA_1	72	78	PF00498	0.494
LIG_FHA_1	87	93	PF00498	0.504
LIG_GBD_Chelix_1	11	19	PF00786	0.564
LIG_GSK3_LRP6_1	672	677	PF00069	0.543
LIG_LIR_Apic_2	475	480	PF02991	0.447
LIG_LIR_Apic_2	667	672	PF02991	0.562
LIG_LIR_Gen_1	307	316	PF02991	0.612
LIG_LIR_Gen_1	331	341	PF02991	0.595
LIG_LIR_Gen_1	551	560	PF02991	0.537
LIG_LIR_Nem_3	20	24	PF02991	0.558
LIG_LIR_Nem_3	26	32	PF02991	0.465
LIG_LIR_Nem_3	281	287	PF02991	0.493
LIG_LIR_Nem_3	307	313	PF02991	0.620
LIG_LIR_Nem_3	331	337	PF02991	0.566
LIG_LIR_Nem_3	47	53	PF02991	0.612
LIG_LIR_Nem_3	551	556	PF02991	0.465
LIG_NRBOX	96	102	PF00104	0.555
LIG_PAM2_1	371	383	PF00658	0.502
LIG_Pex14_1	21	25	PF04695	0.552
LIG_Pex14_1	228	232	PF04695	0.516
LIG_Pex14_2	10	14	PF04695	0.478
LIG_SH2_CRK	466	470	PF00017	0.542
LIG_SH2_SRC	412	415	PF00017	0.631
LIG_SH2_SRC	466	469	PF00017	0.545
LIG_SH2_STAP1	25	29	PF00017	0.473
LIG_SH2_STAP1	553	557	PF00017	0.455
LIG_SH2_STAP1	93	97	PF00017	0.580
LIG_SH2_STAT5	256	259	PF00017	0.519
LIG_SH2_STAT5	29	32	PF00017	0.436
LIG_SH2_STAT5	360	363	PF00017	0.496
LIG_SH2_STAT5	392	395	PF00017	0.301
LIG_SH3_2	673	678	PF14604	0.541
LIG_SH3_3	100	106	PF00018	0.538
LIG_SH3_3	432	438	PF00018	0.522
LIG_SH3_3	507	513	PF00018	0.427
LIG_SH3_3	619	625	PF00018	0.611
LIG_SH3_3	670	676	PF00018	0.550
LIG_SH3_CIN85_PxpxPR_1	672	677	PF14604	0.543
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.511
LIG_SUMO_SIM_par_1	209	216	PF11976	0.581
LIG_SUMO_SIM_par_1	394	399	PF11976	0.602
LIG_TRAF2_1	185	188	PF00917	0.503
LIG_TRAF2_1	289	292	PF00917	0.505
LIG_TRAF2_1	349	352	PF00917	0.355
LIG_TRAF2_1	411	414	PF00917	0.628
LIG_TRAF2_1	88	91	PF00917	0.347
LIG_TYR_ITIM	285	290	PF00017	0.586
LIG_UBA3_1	213	220	PF00899	0.498
LIG_WRC_WIRS_1	347	352	PF05994	0.523
LIG_WRC_WIRS_1	53	58	PF05994	0.538
MOD_CDK_SPK_2	672	677	PF00069	0.543
MOD_CDK_SPxK_1	672	678	PF00069	0.543
MOD_CDK_SPxxK_3	1	8	PF00069	0.723
MOD_CDK_SPxxK_3	651	658	PF00069	0.518
MOD_CDK_SPxxK_3	672	679	PF00069	0.543
MOD_CK1_1	107	113	PF00069	0.765
MOD_CK1_1	123	129	PF00069	0.581
MOD_CK1_1	204	210	PF00069	0.488
MOD_CK1_1	245	251	PF00069	0.559
MOD_CK1_1	62	68	PF00069	0.452
MOD_CK2_1	10	16	PF00069	0.572
MOD_CK2_1	213	219	PF00069	0.502
MOD_CK2_1	246	252	PF00069	0.555
MOD_CK2_1	286	292	PF00069	0.499
MOD_CK2_1	346	352	PF00069	0.338
MOD_CK2_1	566	572	PF00069	0.620
MOD_CMANNOS	474	477	PF00535	0.465
MOD_GlcNHglycan	1	4	PF01048	0.499
MOD_GlcNHglycan	110	113	PF01048	0.690
MOD_GlcNHglycan	116	119	PF01048	0.718
MOD_GlcNHglycan	140	143	PF01048	0.719
MOD_GlcNHglycan	163	166	PF01048	0.790
MOD_GlcNHglycan	206	209	PF01048	0.516
MOD_GlcNHglycan	245	248	PF01048	0.553
MOD_GlcNHglycan	278	281	PF01048	0.438
MOD_GlcNHglycan	330	333	PF01048	0.575
MOD_GlcNHglycan	342	345	PF01048	0.409
MOD_GlcNHglycan	461	464	PF01048	0.624
MOD_GlcNHglycan	515	518	PF01048	0.523
MOD_GlcNHglycan	521	524	PF01048	0.613
MOD_GlcNHglycan	568	571	PF01048	0.649
MOD_GSK3_1	104	111	PF00069	0.634
MOD_GSK3_1	119	126	PF00069	0.714
MOD_GSK3_1	133	140	PF00069	0.704
MOD_GSK3_1	175	182	PF00069	0.773
MOD_GSK3_1	197	204	PF00069	0.704
MOD_GSK3_1	208	215	PF00069	0.544
MOD_GSK3_1	242	249	PF00069	0.522
MOD_GSK3_1	261	268	PF00069	0.564
MOD_GSK3_1	328	335	PF00069	0.587
MOD_GSK3_1	392	399	PF00069	0.473
MOD_GSK3_1	468	475	PF00069	0.601
MOD_GSK3_1	564	571	PF00069	0.706
MOD_GSK3_1	649	656	PF00069	0.585
MOD_GSK3_1	65	72	PF00069	0.598
MOD_GSK3_1	668	675	PF00069	0.824
MOD_N-GLC_1	107	112	PF02516	0.489
MOD_N-GLC_2	668	670	PF02516	0.752
MOD_N-GLC_2	682	684	PF02516	0.732
MOD_NEK2_1	10	15	PF00069	0.470
MOD_NEK2_1	114	119	PF00069	0.530
MOD_NEK2_1	212	217	PF00069	0.473
MOD_NEK2_1	273	278	PF00069	0.481
MOD_NEK2_1	32	37	PF00069	0.473
MOD_NEK2_1	362	367	PF00069	0.410
MOD_NEK2_1	396	401	PF00069	0.640
MOD_NEK2_1	536	541	PF00069	0.450
MOD_NEK2_1	71	76	PF00069	0.301
MOD_NEK2_2	320	325	PF00069	0.749
MOD_NEK2_2	59	64	PF00069	0.590
MOD_PIKK_1	163	169	PF00454	0.820
MOD_PIKK_1	265	271	PF00454	0.376
MOD_PIKK_1	620	626	PF00454	0.503
MOD_PIKK_1	86	92	PF00454	0.323
MOD_PK_1	286	292	PF00069	0.499
MOD_PK_1	295	301	PF00069	0.493
MOD_PKA_1	635	641	PF00069	0.671
MOD_PKA_1	678	684	PF00069	0.627
MOD_PKA_2	243	249	PF00069	0.517
MOD_PKA_2	35	41	PF00069	0.458
MOD_PKA_2	442	448	PF00069	0.570
MOD_PKA_2	528	534	PF00069	0.537
MOD_PKA_2	59	65	PF00069	0.583
MOD_PKA_2	635	641	PF00069	0.671
MOD_PKB_1	325	333	PF00069	0.644
MOD_Plk_1	124	130	PF00069	0.815
MOD_Plk_1	186	192	PF00069	0.535
MOD_Plk_1	306	312	PF00069	0.573
MOD_Plk_2-3	79	85	PF00069	0.619
MOD_Plk_4	10	16	PF00069	0.472
MOD_Plk_4	124	130	PF00069	0.579
MOD_Plk_4	208	214	PF00069	0.557
MOD_Plk_4	355	361	PF00069	0.513
MOD_Plk_4	49	55	PF00069	0.624
MOD_Plk_4	605	611	PF00069	0.523
MOD_Plk_4	92	98	PF00069	0.558
MOD_Plk_4	99	105	PF00069	0.501
MOD_ProDKin_1	1	7	PF00069	0.731
MOD_ProDKin_1	180	186	PF00069	0.762
MOD_ProDKin_1	261	267	PF00069	0.549
MOD_ProDKin_1	412	418	PF00069	0.430
MOD_ProDKin_1	476	482	PF00069	0.458
MOD_ProDKin_1	651	657	PF00069	0.514
MOD_ProDKin_1	668	674	PF00069	0.520
MOD_SUMO_rev_2	13	19	PF00179	0.466
MOD_SUMO_rev_2	42	50	PF00179	0.633
TRG_DiLeu_BaEn_2	25	31	PF01217	0.461
TRG_DiLeu_BaEn_4	576	582	PF01217	0.645
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.499
TRG_ENDOCYTIC_2	232	235	PF00928	0.464
TRG_ENDOCYTIC_2	287	290	PF00928	0.595
TRG_ENDOCYTIC_2	29	32	PF00928	0.436
TRG_ENDOCYTIC_2	334	337	PF00928	0.596
TRG_ENDOCYTIC_2	553	556	PF00928	0.451
TRG_ER_diArg_1	224	227	PF00400	0.664
TRG_ER_diArg_1	228	231	PF00400	0.523
TRG_ER_diArg_1	301	303	PF00400	0.554
TRG_ER_diArg_1	324	327	PF00400	0.659
TRG_ER_diArg_1	366	368	PF00400	0.359
TRG_ER_diArg_1	546	549	PF00400	0.475
TRG_ER_diArg_1	578	581	PF00400	0.652
TRG_ER_diArg_1	634	636	PF00400	0.620
TRG_ER_diArg_1	676	678	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V2	Leptomonas seymouri	57%	78%
A0A3S7X3F2	Leishmania donovani	79%	81%
A4I5I7	Leishmania infantum	79%	81%
E9B0T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	81%
Q4Q7E6	Leishmania major	78%	100%