Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania braziliensis

UniProt:

A4HIA2_LEIBR

TriTrypDb:

LbrM.30.1630 , LBRM2903_300022000

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.546
CLV_NRD_NRD_1	146	148	PF00675	0.329
CLV_NRD_NRD_1	242	244	PF00675	0.441
CLV_NRD_NRD_1	309	311	PF00675	0.617
CLV_PCSK_FUR_1	397	401	PF00082	0.368
CLV_PCSK_KEX2_1	145	147	PF00082	0.373
CLV_PCSK_KEX2_1	242	244	PF00082	0.589
CLV_PCSK_KEX2_1	309	311	PF00082	0.598
CLV_PCSK_KEX2_1	399	401	PF00082	0.460
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.419
CLV_PCSK_SKI1_1	207	211	PF00082	0.450
CLV_PCSK_SKI1_1	410	414	PF00082	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.322
DEG_SCF_FBW7_1	246	251	PF00400	0.472
DEG_SCF_FBW7_2	311	318	PF00400	0.417
DEG_SPOP_SBC_1	103	107	PF00917	0.165
DEG_SPOP_SBC_1	91	95	PF00917	0.188
DOC_CDC14_PxL_1	265	273	PF14671	0.362
DOC_CKS1_1	312	317	PF01111	0.416
DOC_CYCLIN_RxL_1	407	415	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.188
DOC_MAPK_gen_1	197	206	PF00069	0.396
DOC_PP2B_LxvP_1	53	56	PF13499	0.188
DOC_USP7_MATH_1	104	108	PF00917	0.191
DOC_USP7_MATH_1	226	230	PF00917	0.528
DOC_USP7_MATH_1	25	29	PF00917	0.391
DOC_USP7_MATH_1	89	93	PF00917	0.489
DOC_WW_Pin1_4	231	236	PF00397	0.514
DOC_WW_Pin1_4	244	249	PF00397	0.614
DOC_WW_Pin1_4	311	316	PF00397	0.551
DOC_WW_Pin1_4	72	77	PF00397	0.195
LIG_14-3-3_CanoR_1	3	8	PF00244	0.335
LIG_14-3-3_CanoR_1	35	39	PF00244	0.337
LIG_14-3-3_CterR_2	410	415	PF00244	0.544
LIG_APCC_ABBA_1	313	318	PF00400	0.422
LIG_BRCT_BRCA1_1	108	112	PF00533	0.188
LIG_BRCT_BRCA1_1	27	31	PF00533	0.315
LIG_FHA_1	206	212	PF00498	0.347
LIG_FHA_1	217	223	PF00498	0.462
LIG_FHA_1	232	238	PF00498	0.386
LIG_FHA_1	245	251	PF00498	0.433
LIG_FHA_1	260	266	PF00498	0.495
LIG_FHA_1	92	98	PF00498	0.188
LIG_FHA_2	129	135	PF00498	0.366
LIG_LIR_Apic_2	75	80	PF02991	0.188
LIG_LIR_Gen_1	277	286	PF02991	0.446
LIG_LIR_Gen_1	28	38	PF02991	0.472
LIG_LIR_Gen_1	314	322	PF02991	0.506
LIG_LIR_Gen_1	404	413	PF02991	0.519
LIG_LIR_LC3C_4	208	212	PF02991	0.450
LIG_LIR_Nem_3	277	282	PF02991	0.434
LIG_LIR_Nem_3	28	34	PF02991	0.414
LIG_LIR_Nem_3	290	295	PF02991	0.441
LIG_LIR_Nem_3	314	319	PF02991	0.514
LIG_LIR_Nem_3	37	41	PF02991	0.355
LIG_LIR_Nem_3	404	409	PF02991	0.489
LIG_NRBOX	408	414	PF00104	0.534
LIG_Pex14_2	335	339	PF04695	0.405
LIG_SH2_CRK	279	283	PF00017	0.473
LIG_SH2_CRK	77	81	PF00017	0.188
LIG_SH2_STAP1	302	306	PF00017	0.527
LIG_SH2_STAT3	87	90	PF00017	0.246
LIG_SH2_STAT5	305	308	PF00017	0.594
LIG_SH2_STAT5	316	319	PF00017	0.544
LIG_SH2_STAT5	87	90	PF00017	0.315
LIG_SH3_1	309	315	PF00018	0.432
LIG_SH3_3	309	315	PF00018	0.544
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.347
LIG_SUMO_SIM_par_1	208	214	PF11976	0.402
LIG_SUMO_SIM_par_1	39	45	PF11976	0.460
LIG_TRAF2_1	182	185	PF00917	0.337
LIG_TRAF2_1	24	27	PF00917	0.371
LIG_TRAF2_1	81	84	PF00917	0.315
LIG_UBA3_1	282	291	PF00899	0.404
MOD_CK1_1	287	293	PF00069	0.407
MOD_CK1_1	337	343	PF00069	0.544
MOD_CK1_1	92	98	PF00069	0.293
MOD_GlcNHglycan	106	109	PF01048	0.245
MOD_GlcNHglycan	262	265	PF01048	0.558
MOD_GlcNHglycan	339	342	PF01048	0.575
MOD_GlcNHglycan	60	63	PF01048	0.439
MOD_GSK3_1	11	18	PF00069	0.315
MOD_GSK3_1	169	176	PF00069	0.358
MOD_GSK3_1	244	251	PF00069	0.631
MOD_GSK3_1	256	263	PF00069	0.699
MOD_GSK3_1	287	294	PF00069	0.473
MOD_GSK3_1	301	308	PF00069	0.465
MOD_GSK3_1	330	337	PF00069	0.423
MOD_GSK3_1	89	96	PF00069	0.315
MOD_GSK3_1	98	105	PF00069	0.240
MOD_NEK2_1	122	127	PF00069	0.402
MOD_NEK2_1	15	20	PF00069	0.340
MOD_NEK2_1	173	178	PF00069	0.328
MOD_NEK2_1	295	300	PF00069	0.578
MOD_NEK2_1	335	340	PF00069	0.495
MOD_NEK2_1	49	54	PF00069	0.383
MOD_PIKK_1	122	128	PF00454	0.402
MOD_PKA_2	328	334	PF00069	0.445
MOD_PKA_2	34	40	PF00069	0.320
MOD_Plk_1	25	31	PF00069	0.469
MOD_Plk_1	295	301	PF00069	0.476
MOD_Plk_1	317	323	PF00069	0.505
MOD_Plk_1	391	397	PF00069	0.365
MOD_Plk_2-3	267	273	PF00069	0.520
MOD_Plk_4	11	17	PF00069	0.315
MOD_Plk_4	169	175	PF00069	0.337
MOD_Plk_4	267	273	PF00069	0.551
MOD_Plk_4	278	284	PF00069	0.456
MOD_Plk_4	301	307	PF00069	0.520
MOD_ProDKin_1	231	237	PF00069	0.504
MOD_ProDKin_1	244	250	PF00069	0.626
MOD_ProDKin_1	311	317	PF00069	0.420
MOD_ProDKin_1	72	78	PF00069	0.195
TRG_DiLeu_BaEn_1	267	272	PF01217	0.467
TRG_DiLeu_BaEn_4	184	190	PF01217	0.443
TRG_ENDOCYTIC_2	279	282	PF00928	0.412
TRG_ENDOCYTIC_2	316	319	PF00928	0.472
TRG_ER_diArg_1	144	147	PF00400	0.388
TRG_ER_diArg_1	241	243	PF00400	0.416
TRG_ER_diArg_1	309	311	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	29%	100%
A0A0S4JE30	Bodo saltans	38%	100%
A0A0S4JK16	Bodo saltans	29%	95%
A0A1X0NVQ6	Trypanosomatidae	28%	100%
A0A1X0P1X9	Trypanosomatidae	40%	100%
A0A3Q8IFT0	Leishmania donovani	82%	100%
A0A3R7KWZ0	Trypanosoma rangeli	28%	100%
A0A3R7KYN0	Trypanosoma rangeli	42%	100%
A0A3S7WTN3	Leishmania donovani	27%	100%
A4H8A5	Leishmania braziliensis	28%	87%
A4HWM5	Leishmania infantum	27%	100%
A4I5I6	Leishmania infantum	82%	100%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7E7	Leishmania major	83%	100%
Q4QF43	Leishmania major	29%	89%
V5BPI9	Trypanosoma cruzi	40%	100%
V5BUE5	Trypanosoma cruzi	28%	100%