Flavoprotein domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenoylcysteine decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI99_LEIBR

TriTrypDb:

LbrM.30.1590 , LBRM2903_300021700

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0071513	phosphopantothenoylcysteine decarboxylase complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HI99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI99

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0000166	nucleotide binding	3	1
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	5	3
GO:0005488	binding	1	1
GO:0010181	FMN binding	4	1
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	298	300	PF00675	0.572
CLV_NRD_NRD_1	307	309	PF00675	0.611
CLV_NRD_NRD_1	62	64	PF00675	0.381
CLV_NRD_NRD_1	99	101	PF00675	0.346
CLV_PCSK_FUR_1	305	309	PF00082	0.406
CLV_PCSK_KEX2_1	297	299	PF00082	0.576
CLV_PCSK_KEX2_1	307	309	PF00082	0.663
CLV_PCSK_KEX2_1	62	64	PF00082	0.425
CLV_PCSK_KEX2_1	99	101	PF00082	0.346
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.576
CLV_PCSK_PC7_1	294	300	PF00082	0.549
CLV_PCSK_SKI1_1	117	121	PF00082	0.434
CLV_PCSK_SKI1_1	55	59	PF00082	0.334
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DOC_CDC14_PxL_1	333	341	PF14671	0.507
DOC_CKS1_1	339	344	PF01111	0.511
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.509
DOC_MAPK_gen_1	99	107	PF00069	0.341
DOC_MAPK_MEF2A_6	252	259	PF00069	0.397
DOC_MAPK_NFAT4_5	252	260	PF00069	0.295
DOC_PP2B_LxvP_1	243	246	PF13499	0.432
DOC_PP4_FxxP_1	193	196	PF00568	0.490
DOC_USP7_MATH_1	10	14	PF00917	0.563
DOC_USP7_MATH_1	222	226	PF00917	0.711
DOC_USP7_MATH_1	64	68	PF00917	0.355
DOC_USP7_MATH_1	72	76	PF00917	0.409
DOC_USP7_MATH_2	369	375	PF00917	0.537
DOC_WW_Pin1_4	214	219	PF00397	0.649
DOC_WW_Pin1_4	338	343	PF00397	0.672
LIG_14-3-3_CanoR_1	174	179	PF00244	0.544
LIG_14-3-3_CanoR_1	287	291	PF00244	0.410
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.310
LIG_eIF4E_1	17	23	PF01652	0.469
LIG_FHA_1	196	202	PF00498	0.509
LIG_FHA_1	229	235	PF00498	0.769
LIG_FHA_1	25	31	PF00498	0.321
LIG_FHA_1	287	293	PF00498	0.404
LIG_FHA_1	33	39	PF00498	0.330
LIG_FHA_2	10	16	PF00498	0.388
LIG_FHA_2	198	204	PF00498	0.647
LIG_FHA_2	248	254	PF00498	0.467
LIG_GBD_Chelix_1	118	126	PF00786	0.369
LIG_GBD_Chelix_1	282	290	PF00786	0.486
LIG_LIR_Apic_2	149	155	PF02991	0.310
LIG_LIR_Apic_2	166	171	PF02991	0.310
LIG_LIR_Apic_2	190	196	PF02991	0.476
LIG_LIR_Gen_1	253	262	PF02991	0.357
LIG_LIR_Gen_1	84	94	PF02991	0.420
LIG_LIR_LC3C_4	103	106	PF02991	0.369
LIG_LIR_LC3C_4	254	259	PF02991	0.280
LIG_LIR_Nem_3	14	20	PF02991	0.515
LIG_LIR_Nem_3	253	259	PF02991	0.399
LIG_LYPXL_yS_3	17	20	PF13949	0.480
LIG_PDZ_Class_1	370	375	PF00595	0.539
LIG_SH2_STAT5	168	171	PF00017	0.472
LIG_SH2_STAT5	256	259	PF00017	0.278
LIG_SH2_STAT5	285	288	PF00017	0.380
LIG_SH3_1	331	337	PF00018	0.514
LIG_SH3_3	103	109	PF00018	0.310
LIG_SH3_3	242	248	PF00018	0.656
LIG_SH3_3	255	261	PF00018	0.326
LIG_SH3_3	331	337	PF00018	0.762
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.334
LIG_SUMO_SIM_par_1	21	27	PF11976	0.310
LIG_SUMO_SIM_par_1	247	254	PF11976	0.491
LIG_SUMO_SIM_par_1	336	341	PF11976	0.731
LIG_SxIP_EBH_1	63	77	PF03271	0.425
LIG_TRAF2_1	12	15	PF00917	0.578
LIG_TRAF2_1	278	281	PF00917	0.451
LIG_WW_2	245	248	PF00397	0.522
MOD_CK1_1	3	9	PF00069	0.786
MOD_CK1_1	314	320	PF00069	0.681
MOD_CK2_1	197	203	PF00069	0.519
MOD_CK2_1	247	253	PF00069	0.526
MOD_CK2_1	275	281	PF00069	0.521
MOD_CK2_1	9	15	PF00069	0.495
MOD_CMANNOS	83	86	PF00535	0.310
MOD_GlcNHglycan	213	217	PF01048	0.767
MOD_GlcNHglycan	313	316	PF01048	0.602
MOD_GlcNHglycan	8	11	PF01048	0.651
MOD_GSK3_1	197	204	PF00069	0.767
MOD_GSK3_1	212	219	PF00069	0.714
MOD_GSK3_1	247	254	PF00069	0.536
MOD_GSK3_1	6	13	PF00069	0.659
MOD_N-GLC_1	220	225	PF02516	0.776
MOD_NEK2_1	24	29	PF00069	0.350
MOD_NEK2_1	251	256	PF00069	0.465
MOD_NEK2_2	197	202	PF00069	0.520
MOD_PIKK_1	348	354	PF00454	0.545
MOD_PIKK_1	4	10	PF00454	0.507
MOD_PKA_2	251	257	PF00069	0.451
MOD_PKA_2	286	292	PF00069	0.403
MOD_Plk_4	251	257	PF00069	0.417
MOD_Plk_4	341	347	PF00069	0.585
MOD_Plk_4	72	78	PF00069	0.453
MOD_ProDKin_1	214	220	PF00069	0.646
MOD_ProDKin_1	338	344	PF00069	0.675
MOD_SUMO_rev_2	351	358	PF00179	0.550
TRG_DiLeu_BaEn_1	253	258	PF01217	0.287
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.529
TRG_ENDOCYTIC_2	17	20	PF00928	0.480
TRG_ENDOCYTIC_2	256	259	PF00928	0.491
TRG_ER_diArg_1	305	308	PF00400	0.477
TRG_ER_diArg_1	61	63	PF00400	0.425
TRG_ER_diArg_1	98	100	PF00400	0.310
TRG_NES_CRM1_1	280	296	PF08389	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH1	Leptomonas seymouri	64%	100%
A0A1X0P262	Trypanosomatidae	49%	100%
A0A3Q8IBY6	Leishmania donovani	79%	100%
A0A3R7KRR4	Trypanosoma rangeli	49%	100%
A4I5I3	Leishmania infantum	79%	100%
C9ZQW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B0S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O35033	Bacillus subtilis (strain 168)	27%	92%
Q4Q7F0	Leishmania major	80%	99%