PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI97_LEIBR

TriTrypDb:

LbrM.30.1570 , LBRM2903_300021500

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI97

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	331	333	PF00675	0.346
CLV_NRD_NRD_1	377	379	PF00675	0.609
CLV_NRD_NRD_1	409	411	PF00675	0.608
CLV_NRD_NRD_1	47	49	PF00675	0.358
CLV_NRD_NRD_1	89	91	PF00675	0.335
CLV_PCSK_KEX2_1	288	290	PF00082	0.418
CLV_PCSK_KEX2_1	331	333	PF00082	0.346
CLV_PCSK_KEX2_1	377	379	PF00082	0.508
CLV_PCSK_KEX2_1	407	409	PF00082	0.542
CLV_PCSK_KEX2_1	49	51	PF00082	0.346
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.418
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.542
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.346
CLV_PCSK_SKI1_1	174	178	PF00082	0.418
CLV_PCSK_SKI1_1	200	204	PF00082	0.247
CLV_PCSK_SKI1_1	278	282	PF00082	0.418
CLV_PCSK_SKI1_1	34	38	PF00082	0.411
CLV_PCSK_SKI1_1	385	389	PF00082	0.428
CLV_PCSK_SKI1_1	401	405	PF00082	0.539
CLV_PCSK_SKI1_1	52	56	PF00082	0.346
DEG_COP1_1	210	218	PF00400	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DEG_ODPH_VHL_1	325	337	PF01847	0.618
DEG_SPOP_SBC_1	152	156	PF00917	0.442
DOC_CYCLIN_RxL_1	382	391	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.442
DOC_MAPK_gen_1	278	287	PF00069	0.589
DOC_MAPK_gen_1	331	337	PF00069	0.546
DOC_MAPK_gen_1	405	415	PF00069	0.613
DOC_MAPK_gen_1	48	56	PF00069	0.600
DOC_MAPK_gen_1	87	96	PF00069	0.531
DOC_MAPK_MEF2A_6	317	324	PF00069	0.463
DOC_PP1_RVXF_1	338	345	PF00149	0.585
DOC_PP1_RVXF_1	50	57	PF00149	0.546
DOC_PP2B_LxvP_1	292	295	PF13499	0.545
DOC_PP2B_LxvP_1	324	327	PF13499	0.618
DOC_PP2B_LxvP_1	386	389	PF13499	0.471
DOC_USP7_MATH_1	161	165	PF00917	0.527
DOC_USP7_MATH_1	247	251	PF00917	0.545
DOC_USP7_MATH_1	274	278	PF00917	0.565
DOC_USP7_MATH_1	280	284	PF00917	0.525
DOC_USP7_MATH_1	297	301	PF00917	0.546
DOC_USP7_MATH_1	366	370	PF00917	0.630
DOC_USP7_MATH_1	421	425	PF00917	0.552
DOC_USP7_MATH_1	435	439	PF00917	0.375
DOC_USP7_UBL2_3	194	198	PF12436	0.442
DOC_USP7_UBL2_3	51	55	PF12436	0.463
DOC_WW_Pin1_4	127	132	PF00397	0.442
LIG_14-3-3_CanoR_1	200	205	PF00244	0.488
LIG_14-3-3_CanoR_1	207	216	PF00244	0.566
LIG_14-3-3_CanoR_1	278	287	PF00244	0.498
LIG_14-3-3_CanoR_1	317	323	PF00244	0.442
LIG_BRCT_BRCA1_1	435	439	PF00533	0.592
LIG_deltaCOP1_diTrp_1	428	433	PF00928	0.509
LIG_FHA_1	218	224	PF00498	0.589
LIG_FHA_1	280	286	PF00498	0.546
LIG_FHA_1	319	325	PF00498	0.544
LIG_FHA_1	397	403	PF00498	0.618
LIG_FHA_1	410	416	PF00498	0.413
LIG_FHA_1	429	435	PF00498	0.593
LIG_FHA_1	62	68	PF00498	0.546
LIG_FHA_2	219	225	PF00498	0.483
LIG_FHA_2	239	245	PF00498	0.582
LIG_FHA_2	261	267	PF00498	0.546
LIG_FHA_2	370	376	PF00498	0.483
LIG_LIR_Gen_1	25	36	PF02991	0.442
LIG_LIR_Gen_1	369	379	PF02991	0.452
LIG_LIR_Gen_1	428	437	PF02991	0.495
LIG_LIR_Nem_3	236	242	PF02991	0.549
LIG_LIR_Nem_3	369	374	PF02991	0.500
LIG_LIR_Nem_3	428	433	PF02991	0.509
LIG_LIR_Nem_3	436	442	PF02991	0.509
LIG_NRBOX	172	178	PF00104	0.442
LIG_PCNA_PIPBox_1	86	95	PF02747	0.618
LIG_SH2_CRK	239	243	PF00017	0.546
LIG_SH2_PTP2	93	96	PF00017	0.546
LIG_SH2_SRC	380	383	PF00017	0.443
LIG_SH2_STAT5	291	294	PF00017	0.618
LIG_SH2_STAT5	352	355	PF00017	0.492
LIG_SH2_STAT5	380	383	PF00017	0.418
LIG_SH2_STAT5	93	96	PF00017	0.528
LIG_SH3_3	1	7	PF00018	0.380
LIG_SH3_3	177	183	PF00018	0.442
LIG_SH3_3	251	257	PF00018	0.546
LIG_SH3_3	360	366	PF00018	0.525
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.549
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.555
LIG_TYR_ITIM	237	242	PF00017	0.618
LIG_UBA3_1	284	288	PF00899	0.546
MOD_CK1_1	117	123	PF00069	0.585
MOD_CK1_1	164	170	PF00069	0.514
MOD_CK1_1	210	216	PF00069	0.618
MOD_CK1_1	217	223	PF00069	0.536
MOD_CK1_1	304	310	PF00069	0.515
MOD_CK1_1	367	373	PF00069	0.695
MOD_CK2_1	152	158	PF00069	0.508
MOD_CK2_1	218	224	PF00069	0.515
MOD_CK2_1	238	244	PF00069	0.456
MOD_CK2_1	260	266	PF00069	0.546
MOD_CK2_1	369	375	PF00069	0.493
MOD_CK2_1	423	429	PF00069	0.731
MOD_Cter_Amidation	329	332	PF01082	0.346
MOD_GlcNHglycan	115	119	PF01048	0.346
MOD_GlcNHglycan	163	166	PF01048	0.355
MOD_GlcNHglycan	313	316	PF01048	0.242
MOD_GlcNHglycan	366	369	PF01048	0.542
MOD_GlcNHglycan	423	426	PF01048	0.721
MOD_GlcNHglycan	439	442	PF01048	0.352
MOD_GlcNHglycan	64	67	PF01048	0.346
MOD_GSK3_1	207	214	PF00069	0.592
MOD_GSK3_1	297	304	PF00069	0.510
MOD_GSK3_1	347	354	PF00069	0.420
MOD_GSK3_1	366	373	PF00069	0.754
MOD_GSK3_1	409	416	PF00069	0.595
MOD_GSK3_1	419	426	PF00069	0.710
MOD_GSK3_1	433	440	PF00069	0.358
MOD_N-GLC_1	419	424	PF02516	0.588
MOD_N-GLC_2	137	139	PF02516	0.418
MOD_NEK2_1	218	223	PF00069	0.515
MOD_NEK2_1	287	292	PF00069	0.571
MOD_NEK2_1	433	438	PF00069	0.389
MOD_NEK2_1	62	67	PF00069	0.552
MOD_OFUCOSY	114	121	PF10250	0.242
MOD_PIKK_1	306	312	PF00454	0.442
MOD_PKA_1	409	415	PF00069	0.503
MOD_PKA_2	208	214	PF00069	0.565
MOD_PKA_2	409	415	PF00069	0.503
MOD_Plk_1	419	425	PF00069	0.629
MOD_Plk_4	200	206	PF00069	0.576
MOD_Plk_4	247	253	PF00069	0.592
MOD_Plk_4	280	286	PF00069	0.546
MOD_Plk_4	318	324	PF00069	0.546
MOD_Plk_4	347	353	PF00069	0.367
MOD_ProDKin_1	127	133	PF00069	0.442
TRG_DiLeu_BaEn_1	186	191	PF01217	0.535
TRG_DiLeu_BaEn_2	428	434	PF01217	0.501
TRG_DiLeu_BaEn_4	168	174	PF01217	0.442
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.449
TRG_ENDOCYTIC_2	239	242	PF00928	0.546
TRG_ENDOCYTIC_2	28	31	PF00928	0.442
TRG_ENDOCYTIC_2	93	96	PF00928	0.504
TRG_ER_diArg_1	377	379	PF00400	0.607
TRG_ER_diArg_1	408	410	PF00400	0.563
TRG_NLS_MonoCore_2	404	409	PF00514	0.601
TRG_NLS_MonoCore_2	47	52	PF00514	0.547
TRG_NLS_MonoExtC_3	404	409	PF00514	0.601
TRG_NLS_MonoExtC_3	47	52	PF00514	0.442
TRG_NLS_MonoExtN_4	405	410	PF00514	0.605
TRG_NLS_MonoExtN_4	48	54	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P976	Leptomonas seymouri	50%	100%
A0A3S7X3F6	Leishmania donovani	72%	100%
A4I5I1	Leishmania infantum	72%	100%
E9B0S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q7F2	Leishmania major	71%	100%