Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HI91_LEIBR

TriTrypDb:

LbrM.30.1510 , LBRM2903_300020900

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005730	nucleolus	5	4

Expansion

Sequence features

A4HI91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI91

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.550
CLV_C14_Caspase3-7	183	187	PF00656	0.490
CLV_C14_Caspase3-7	416	420	PF00656	0.368
CLV_NRD_NRD_1	269	271	PF00675	0.326
CLV_NRD_NRD_1	471	473	PF00675	0.367
CLV_NRD_NRD_1	71	73	PF00675	0.590
CLV_PCSK_FUR_1	69	73	PF00082	0.516
CLV_PCSK_KEX2_1	269	271	PF00082	0.326
CLV_PCSK_KEX2_1	387	389	PF00082	0.405
CLV_PCSK_KEX2_1	471	473	PF00082	0.496
CLV_PCSK_KEX2_1	71	73	PF00082	0.534
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.405
CLV_PCSK_SKI1_1	244	248	PF00082	0.474
CLV_PCSK_SKI1_1	427	431	PF00082	0.399
CLV_PCSK_SKI1_1	528	532	PF00082	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SCF_FBW7_1	443	449	PF00400	0.247
DOC_CKS1_1	443	448	PF01111	0.309
DOC_CKS1_1	82	87	PF01111	0.494
DOC_CYCLIN_yCln2_LP_2	195	198	PF00134	0.303
DOC_MAPK_gen_1	471	479	PF00069	0.248
DOC_PP2B_LxvP_1	195	198	PF13499	0.303
DOC_PP4_FxxP_1	531	534	PF00568	0.373
DOC_USP7_MATH_1	101	105	PF00917	0.779
DOC_USP7_MATH_1	174	178	PF00917	0.470
DOC_USP7_MATH_1	184	188	PF00917	0.434
DOC_USP7_MATH_1	219	223	PF00917	0.637
DOC_USP7_MATH_1	49	53	PF00917	0.613
DOC_USP7_MATH_1	532	536	PF00917	0.383
DOC_WW_Pin1_4	145	150	PF00397	0.669
DOC_WW_Pin1_4	220	225	PF00397	0.501
DOC_WW_Pin1_4	442	447	PF00397	0.316
DOC_WW_Pin1_4	530	535	PF00397	0.351
DOC_WW_Pin1_4	57	62	PF00397	0.566
DOC_WW_Pin1_4	81	86	PF00397	0.691
LIG_14-3-3_CanoR_1	264	272	PF00244	0.526
LIG_14-3-3_CanoR_1	421	430	PF00244	0.559
LIG_14-3-3_CanoR_1	471	480	PF00244	0.286
LIG_14-3-3_CanoR_1	50	54	PF00244	0.787
LIG_14-3-3_CanoR_1	521	530	PF00244	0.477
LIG_14-3-3_CanoR_1	55	61	PF00244	0.802
LIG_APCC_ABBA_1	405	410	PF00400	0.426
LIG_BIR_III_4	419	423	PF00653	0.417
LIG_BRCT_BRCA1_1	210	214	PF00533	0.454
LIG_Clathr_ClatBox_1	189	193	PF01394	0.311
LIG_deltaCOP1_diTrp_1	258	265	PF00928	0.432
LIG_FHA_1	176	182	PF00498	0.282
LIG_FHA_1	255	261	PF00498	0.473
LIG_FHA_1	299	305	PF00498	0.459
LIG_FHA_1	324	330	PF00498	0.432
LIG_FHA_1	357	363	PF00498	0.511
LIG_FHA_1	367	373	PF00498	0.496
LIG_FHA_1	443	449	PF00498	0.271
LIG_FHA_1	511	517	PF00498	0.508
LIG_FHA_1	522	528	PF00498	0.389
LIG_FHA_1	62	68	PF00498	0.643
LIG_FHA_2	103	109	PF00498	0.622
LIG_FHA_2	142	148	PF00498	0.596
LIG_FHA_2	240	246	PF00498	0.404
LIG_FHA_2	414	420	PF00498	0.327
LIG_FHA_2	537	543	PF00498	0.283
LIG_Integrin_isoDGR_2	503	505	PF01839	0.447
LIG_LIR_Apic_2	168	174	PF02991	0.498
LIG_LIR_Apic_2	529	534	PF02991	0.370
LIG_LIR_Gen_1	352	362	PF02991	0.461
LIG_LIR_Nem_3	352	357	PF02991	0.461
LIG_LIR_Nem_3	81	86	PF02991	0.497
LIG_PCNA_yPIPBox_3	411	421	PF02747	0.262
LIG_SH2_STAP1	323	327	PF00017	0.432
LIG_SH2_STAP1	488	492	PF00017	0.487
LIG_SH2_STAP1	518	522	PF00017	0.369
LIG_SH2_STAT5	250	253	PF00017	0.418
LIG_SH3_2	25	30	PF14604	0.507
LIG_SH3_3	134	140	PF00018	0.674
LIG_SH3_3	191	197	PF00018	0.239
LIG_SH3_3	203	209	PF00018	0.410
LIG_SH3_3	22	28	PF00018	0.526
LIG_SH3_3	448	454	PF00018	0.387
LIG_SH3_4	427	434	PF00018	0.408
LIG_SUMO_SIM_par_1	413	419	PF11976	0.244
LIG_SUMO_SIM_par_1	452	458	PF11976	0.381
LIG_WRC_WIRS_1	439	444	PF05994	0.447
MOD_CDK_SPxxK_3	145	152	PF00069	0.647
MOD_CK1_1	124	130	PF00069	0.621
MOD_CK1_1	145	151	PF00069	0.664
MOD_CK1_1	166	172	PF00069	0.480
MOD_CK1_1	220	226	PF00069	0.560
MOD_CK1_1	302	308	PF00069	0.466
MOD_CK1_1	59	65	PF00069	0.786
MOD_CK1_1	7	13	PF00069	0.506
MOD_CK2_1	166	172	PF00069	0.519
MOD_CK2_1	239	245	PF00069	0.380
MOD_CK2_1	302	308	PF00069	0.445
MOD_GlcNHglycan	123	126	PF01048	0.718
MOD_GlcNHglycan	144	147	PF01048	0.634
MOD_GlcNHglycan	219	222	PF01048	0.473
MOD_GlcNHglycan	229	232	PF01048	0.268
MOD_GlcNHglycan	272	275	PF01048	0.278
MOD_GlcNHglycan	319	322	PF01048	0.268
MOD_GlcNHglycan	344	347	PF01048	0.368
MOD_GlcNHglycan	362	365	PF01048	0.153
MOD_GlcNHglycan	37	40	PF01048	0.498
MOD_GlcNHglycan	424	427	PF01048	0.597
MOD_GlcNHglycan	451	454	PF01048	0.402
MOD_GlcNHglycan	498	501	PF01048	0.353
MOD_GlcNHglycan	6	9	PF01048	0.581
MOD_GSK3_1	141	148	PF00069	0.601
MOD_GSK3_1	15	22	PF00069	0.708
MOD_GSK3_1	160	167	PF00069	0.473
MOD_GSK3_1	250	257	PF00069	0.378
MOD_GSK3_1	26	33	PF00069	0.686
MOD_GSK3_1	298	305	PF00069	0.318
MOD_GSK3_1	313	320	PF00069	0.479
MOD_GSK3_1	352	359	PF00069	0.543
MOD_GSK3_1	438	445	PF00069	0.233
MOD_GSK3_1	532	539	PF00069	0.316
MOD_GSK3_1	55	62	PF00069	0.716
MOD_GSK3_1	81	88	PF00069	0.700
MOD_GSK3_1	97	104	PF00069	0.489
MOD_N-GLC_1	472	477	PF02516	0.320
MOD_NEK2_1	121	126	PF00069	0.586
MOD_NEK2_1	164	169	PF00069	0.500
MOD_NEK2_1	248	253	PF00069	0.379
MOD_NEK2_1	298	303	PF00069	0.273
MOD_NEK2_1	382	387	PF00069	0.436
MOD_NEK2_1	455	460	PF00069	0.424
MOD_NEK2_1	496	501	PF00069	0.324
MOD_NEK2_1	536	541	PF00069	0.484
MOD_NEK2_1	56	61	PF00069	0.647
MOD_NEK2_2	323	328	PF00069	0.432
MOD_PIKK_1	124	130	PF00454	0.638
MOD_PIKK_1	302	308	PF00454	0.461
MOD_PIKK_1	349	355	PF00454	0.513
MOD_PIKK_1	78	84	PF00454	0.550
MOD_PIKK_1	85	91	PF00454	0.769
MOD_PK_1	30	36	PF00069	0.621
MOD_PKA_2	35	41	PF00069	0.747
MOD_PKA_2	49	55	PF00069	0.711
MOD_PKA_2	56	62	PF00069	0.790
MOD_PKA_2	97	103	PF00069	0.549
MOD_Plk_1	323	329	PF00069	0.473
MOD_Plk_2-3	239	245	PF00069	0.368
MOD_Plk_4	166	172	PF00069	0.510
MOD_Plk_4	413	419	PF00069	0.313
MOD_Plk_4	438	444	PF00069	0.447
MOD_Plk_4	532	538	PF00069	0.372
MOD_ProDKin_1	145	151	PF00069	0.665
MOD_ProDKin_1	220	226	PF00069	0.489
MOD_ProDKin_1	442	448	PF00069	0.320
MOD_ProDKin_1	530	536	PF00069	0.350
MOD_ProDKin_1	57	63	PF00069	0.568
MOD_ProDKin_1	81	87	PF00069	0.690
MOD_SUMO_rev_2	239	249	PF00179	0.379
MOD_SUMO_rev_2	273	280	PF00179	0.432
MOD_SUMO_rev_2	542	546	PF00179	0.274
TRG_DiLeu_BaEn_1	512	517	PF01217	0.381
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.357
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.414
TRG_ER_diArg_1	269	271	PF00400	0.526
TRG_ER_diArg_1	71	73	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	21%	100%
A0A0N1IMQ0	Leptomonas seymouri	68%	100%
A0A1X0P1V8	Trypanosomatidae	55%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3Q8IHW0	Leishmania donovani	80%	100%
A0A3R7MF36	Trypanosoma rangeli	49%	100%
A0A3S7WR72	Leishmania donovani	23%	100%
A4H666	Leishmania braziliensis	23%	100%
A4HUJ0	Leishmania infantum	23%	100%
A4I135	Leishmania infantum	24%	100%
A4I5H1	Leishmania infantum	80%	100%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q7G4	Leishmania major	79%	100%
Q4QAA4	Leishmania major	24%	100%
Q4QHD6	Leishmania major	23%	100%
V5BYY0	Trypanosoma cruzi	50%	100%