Putative GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI87_LEIBR

TriTrypDb:

LbrM.30.1470 , LBRM2903_300020300

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI87

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0098772	molecular function regulator activity	1	5
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.700
CLV_C14_Caspase3-7	576	580	PF00656	0.388
CLV_C14_Caspase3-7	69	73	PF00656	0.577
CLV_NRD_NRD_1	178	180	PF00675	0.318
CLV_NRD_NRD_1	232	234	PF00675	0.485
CLV_NRD_NRD_1	392	394	PF00675	0.565
CLV_NRD_NRD_1	468	470	PF00675	0.312
CLV_NRD_NRD_1	652	654	PF00675	0.388
CLV_PCSK_KEX2_1	178	180	PF00082	0.399
CLV_PCSK_KEX2_1	231	233	PF00082	0.603
CLV_PCSK_KEX2_1	392	394	PF00082	0.565
CLV_PCSK_KEX2_1	652	654	PF00082	0.388
CLV_PCSK_SKI1_1	419	423	PF00082	0.534
CLV_PCSK_SKI1_1	46	50	PF00082	0.553
CLV_PCSK_SKI1_1	493	497	PF00082	0.312
CLV_PCSK_SKI1_1	531	535	PF00082	0.225
CLV_PCSK_SKI1_1	632	636	PF00082	0.312
CLV_Separin_Metazoa	423	427	PF03568	0.532
DEG_APCC_DBOX_1	265	273	PF00400	0.667
DEG_APCC_DBOX_1	418	426	PF00400	0.532
DEG_APCC_DBOX_1	96	104	PF00400	0.502
DEG_COP1_1	288	300	PF00400	0.527
DEG_MDM2_SWIB_1	621	629	PF02201	0.312
DEG_SCF_FBW7_1	155	162	PF00400	0.622
DEG_SCF_FBW7_1	281	288	PF00400	0.549
DEG_SCF_FBW7_1	384	390	PF00400	0.544
DEG_SPOP_SBC_1	39	43	PF00917	0.594
DOC_AGCK_PIF_1	618	623	PF00069	0.312
DOC_CKS1_1	151	156	PF01111	0.648
DOC_CKS1_1	384	389	PF01111	0.542
DOC_CYCLIN_RxL_1	490	499	PF00134	0.312
DOC_MAPK_gen_1	94	103	PF00069	0.531
DOC_PP1_RVXF_1	193	200	PF00149	0.364
DOC_PP1_RVXF_1	491	497	PF00149	0.312
DOC_PP2B_LxvP_1	134	137	PF13499	0.668
DOC_PP2B_LxvP_1	349	352	PF13499	0.556
DOC_PP2B_LxvP_1	425	428	PF13499	0.597
DOC_PP2B_LxvP_1	514	517	PF13499	0.312
DOC_PP2B_LxvP_1	687	690	PF13499	0.280
DOC_PP4_FxxP_1	139	142	PF00568	0.496
DOC_PP4_FxxP_1	414	417	PF00568	0.604
DOC_USP7_MATH_1	166	170	PF00917	0.569
DOC_USP7_MATH_1	227	231	PF00917	0.340
DOC_USP7_MATH_1	295	299	PF00917	0.513
DOC_USP7_MATH_1	31	35	PF00917	0.619
DOC_USP7_MATH_1	368	372	PF00917	0.675
DOC_USP7_MATH_1	377	381	PF00917	0.616
DOC_USP7_MATH_1	388	392	PF00917	0.572
DOC_USP7_MATH_1	39	43	PF00917	0.554
DOC_USP7_MATH_1	394	398	PF00917	0.560
DOC_USP7_MATH_1	404	408	PF00917	0.550
DOC_USP7_MATH_1	434	438	PF00917	0.605
DOC_USP7_MATH_1	473	477	PF00917	0.312
DOC_USP7_MATH_2	691	697	PF00917	0.472
DOC_USP7_UBL2_3	466	470	PF12436	0.388
DOC_WW_Pin1_4	138	143	PF00397	0.623
DOC_WW_Pin1_4	150	155	PF00397	0.562
DOC_WW_Pin1_4	18	23	PF00397	0.529
DOC_WW_Pin1_4	281	286	PF00397	0.686
DOC_WW_Pin1_4	322	327	PF00397	0.545
DOC_WW_Pin1_4	383	388	PF00397	0.587
DOC_WW_Pin1_4	405	410	PF00397	0.594
LIG_14-3-3_CanoR_1	266	270	PF00244	0.568
LIG_14-3-3_CanoR_1	305	310	PF00244	0.533
LIG_14-3-3_CanoR_1	392	400	PF00244	0.702
LIG_14-3-3_CanoR_1	526	533	PF00244	0.237
LIG_14-3-3_CanoR_1	53	61	PF00244	0.696
LIG_14-3-3_CanoR_1	652	657	PF00244	0.388
LIG_14-3-3_CanoR_1	97	101	PF00244	0.663
LIG_Actin_WH2_2	289	307	PF00022	0.524
LIG_BIR_III_2	359	363	PF00653	0.636
LIG_BRCT_BRCA1_1	704	708	PF00533	0.357
LIG_deltaCOP1_diTrp_1	209	218	PF00928	0.341
LIG_eIF4E_1	660	666	PF01652	0.312
LIG_EVH1_1	384	388	PF00568	0.539
LIG_FHA_1	313	319	PF00498	0.542
LIG_FHA_1	528	534	PF00498	0.312
LIG_FHA_1	538	544	PF00498	0.312
LIG_FHA_1	554	560	PF00498	0.312
LIG_FHA_1	568	574	PF00498	0.235
LIG_FHA_1	635	641	PF00498	0.312
LIG_FHA_1	690	696	PF00498	0.462
LIG_FHA_2	287	293	PF00498	0.541
LIG_FHA_2	574	580	PF00498	0.388
LIG_LIR_Apic_2	138	142	PF02991	0.499
LIG_LIR_Gen_1	248	256	PF02991	0.405
LIG_LIR_LC3C_4	513	516	PF02991	0.312
LIG_LIR_Nem_3	209	214	PF02991	0.364
LIG_LIR_Nem_3	235	239	PF02991	0.383
LIG_LIR_Nem_3	242	247	PF02991	0.410
LIG_LIR_Nem_3	248	252	PF02991	0.407
LIG_LIR_Nem_3	42	48	PF02991	0.658
LIG_LYPXL_yS_3	12	15	PF13949	0.502
LIG_MYND_1	327	331	PF01753	0.531
LIG_MYND_1	59	63	PF01753	0.541
LIG_Pex14_1	568	572	PF04695	0.312
LIG_Pex14_2	621	625	PF04695	0.312
LIG_PTB_Apo_2	238	245	PF02174	0.314
LIG_PTB_Phospho_1	238	244	PF10480	0.313
LIG_SH2_CRK	45	49	PF00017	0.568
LIG_SH2_CRK	607	611	PF00017	0.312
LIG_SH2_GRB2like	239	242	PF00017	0.309
LIG_SH2_SRC	239	242	PF00017	0.390
LIG_SH2_STAP1	208	212	PF00017	0.363
LIG_SH2_STAP1	236	240	PF00017	0.364
LIG_SH2_STAP1	539	543	PF00017	0.388
LIG_SH2_STAP1	714	718	PF00017	0.385
LIG_SH2_STAT3	148	151	PF00017	0.528
LIG_SH2_STAT5	148	151	PF00017	0.528
LIG_SH2_STAT5	239	242	PF00017	0.389
LIG_SH2_STAT5	481	484	PF00017	0.312
LIG_SH2_STAT5	507	510	PF00017	0.312
LIG_SH2_STAT5	539	542	PF00017	0.312
LIG_SH2_STAT5	572	575	PF00017	0.312
LIG_SH2_STAT5	581	584	PF00017	0.312
LIG_SH2_STAT5	646	649	PF00017	0.312
LIG_SH2_STAT5	660	663	PF00017	0.312
LIG_SH2_STAT5	680	683	PF00017	0.234
LIG_SH3_2	328	333	PF14604	0.538
LIG_SH3_3	325	331	PF00018	0.534
LIG_SH3_3	382	388	PF00018	0.691
LIG_SH3_3	406	412	PF00018	0.660
LIG_SH3_3	414	420	PF00018	0.687
LIG_SH3_3	45	51	PF00018	0.545
LIG_SH3_3	56	62	PF00018	0.532
LIG_SUMO_SIM_par_1	190	196	PF11976	0.298
LIG_TYR_ITIM	10	15	PF00017	0.483
LIG_TYR_ITSM	41	48	PF00017	0.589
LIG_WRC_WIRS_1	103	108	PF05994	0.513
LIG_WW_1	604	607	PF00397	0.312
LIG_WW_3	416	420	PF00397	0.532
MOD_CDK_SPxxK_3	150	157	PF00069	0.681
MOD_CK1_1	114	120	PF00069	0.567
MOD_CK1_1	122	128	PF00069	0.589
MOD_CK1_1	298	304	PF00069	0.588
MOD_CK1_1	308	314	PF00069	0.566
MOD_CK1_1	380	386	PF00069	0.635
MOD_CK1_1	405	411	PF00069	0.640
MOD_CK1_1	452	458	PF00069	0.702
MOD_CK1_1	529	535	PF00069	0.231
MOD_CK1_1	79	85	PF00069	0.628
MOD_CK1_1	99	105	PF00069	0.630
MOD_CK2_1	286	292	PF00069	0.542
MOD_CK2_1	529	535	PF00069	0.312
MOD_CK2_1	720	726	PF00069	0.549
MOD_GlcNHglycan	125	128	PF01048	0.711
MOD_GlcNHglycan	168	171	PF01048	0.593
MOD_GlcNHglycan	172	175	PF01048	0.537
MOD_GlcNHglycan	221	224	PF01048	0.425
MOD_GlcNHglycan	297	300	PF01048	0.516
MOD_GlcNHglycan	33	36	PF01048	0.636
MOD_GlcNHglycan	340	343	PF01048	0.696
MOD_GlcNHglycan	355	358	PF01048	0.556
MOD_GlcNHglycan	394	397	PF01048	0.637
MOD_GlcNHglycan	404	407	PF01048	0.728
MOD_GlcNHglycan	414	417	PF01048	0.552
MOD_GlcNHglycan	436	439	PF01048	0.656
MOD_GlcNHglycan	451	454	PF01048	0.702
MOD_GlcNHglycan	475	478	PF01048	0.312
MOD_GlcNHglycan	548	551	PF01048	0.372
MOD_GlcNHglycan	68	71	PF01048	0.565
MOD_GlcNHglycan	681	684	PF01048	0.275
MOD_GSK3_1	108	115	PF00069	0.538
MOD_GSK3_1	119	126	PF00069	0.693
MOD_GSK3_1	138	145	PF00069	0.619
MOD_GSK3_1	155	162	PF00069	0.541
MOD_GSK3_1	166	173	PF00069	0.618
MOD_GSK3_1	212	219	PF00069	0.351
MOD_GSK3_1	221	228	PF00069	0.426
MOD_GSK3_1	235	242	PF00069	0.297
MOD_GSK3_1	264	271	PF00069	0.615
MOD_GSK3_1	281	288	PF00069	0.523
MOD_GSK3_1	295	302	PF00069	0.529
MOD_GSK3_1	308	315	PF00069	0.748
MOD_GSK3_1	373	380	PF00069	0.684
MOD_GSK3_1	383	390	PF00069	0.665
MOD_GSK3_1	394	401	PF00069	0.636
MOD_GSK3_1	452	459	PF00069	0.635
MOD_GSK3_1	527	534	PF00069	0.312
MOD_GSK3_1	632	639	PF00069	0.312
MOD_GSK3_1	689	696	PF00069	0.387
MOD_GSK3_1	716	723	PF00069	0.339
MOD_GSK3_1	75	82	PF00069	0.618
MOD_GSK3_1	95	102	PF00069	0.599
MOD_N-GLC_1	240	245	PF02516	0.316
MOD_N-GLC_1	313	318	PF02516	0.538
MOD_N-GLC_1	353	358	PF02516	0.698
MOD_N-GLC_1	579	584	PF02516	0.388
MOD_N-GLC_1	90	95	PF02516	0.549
MOD_NEK2_1	180	185	PF00069	0.312
MOD_NEK2_1	212	217	PF00069	0.348
MOD_NEK2_1	337	342	PF00069	0.572
MOD_NEK2_1	344	349	PF00069	0.526
MOD_NEK2_1	353	358	PF00069	0.552
MOD_NEK2_1	375	380	PF00069	0.575
MOD_NEK2_1	451	456	PF00069	0.771
MOD_NEK2_1	496	501	PF00069	0.312
MOD_NEK2_1	527	532	PF00069	0.231
MOD_NEK2_1	573	578	PF00069	0.388
MOD_NEK2_1	634	639	PF00069	0.312
MOD_NEK2_1	80	85	PF00069	0.616
MOD_PIKK_1	119	125	PF00454	0.523
MOD_PIKK_1	361	367	PF00454	0.709
MOD_PIKK_1	40	46	PF00454	0.642
MOD_PIKK_1	52	58	PF00454	0.470
MOD_PIKK_1	553	559	PF00454	0.388
MOD_PIKK_1	634	640	PF00454	0.312
MOD_PK_1	652	658	PF00069	0.388
MOD_PKA_1	392	398	PF00069	0.560
MOD_PKA_1	652	658	PF00069	0.388
MOD_PKA_2	265	271	PF00069	0.567
MOD_PKA_2	392	398	PF00069	0.693
MOD_PKA_2	473	479	PF00069	0.312
MOD_PKA_2	52	58	PF00069	0.667
MOD_PKA_2	652	658	PF00069	0.388
MOD_PKA_2	719	725	PF00069	0.528
MOD_PKA_2	96	102	PF00069	0.670
MOD_Plk_1	195	201	PF00069	0.366
MOD_Plk_1	240	246	PF00069	0.324
MOD_Plk_1	313	319	PF00069	0.599
MOD_Plk_1	344	350	PF00069	0.662
MOD_Plk_1	714	720	PF00069	0.396
MOD_Plk_2-3	693	699	PF00069	0.407
MOD_Plk_4	114	120	PF00069	0.487
MOD_Plk_4	144	150	PF00069	0.516
MOD_Plk_4	235	241	PF00069	0.344
MOD_Plk_4	299	305	PF00069	0.541
MOD_Plk_4	452	458	PF00069	0.553
MOD_Plk_4	568	574	PF00069	0.312
MOD_Plk_4	587	593	PF00069	0.312
MOD_Plk_4	96	102	PF00069	0.525
MOD_ProDKin_1	138	144	PF00069	0.623
MOD_ProDKin_1	150	156	PF00069	0.563
MOD_ProDKin_1	18	24	PF00069	0.531
MOD_ProDKin_1	281	287	PF00069	0.685
MOD_ProDKin_1	322	328	PF00069	0.538
MOD_ProDKin_1	383	389	PF00069	0.590
MOD_ProDKin_1	405	411	PF00069	0.595
TRG_DiLeu_BaEn_2	208	214	PF01217	0.328
TRG_DiLeu_BaEn_2	491	497	PF01217	0.312
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.536
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.312
TRG_ENDOCYTIC_2	12	15	PF00928	0.550
TRG_ENDOCYTIC_2	244	247	PF00928	0.487
TRG_ENDOCYTIC_2	45	48	PF00928	0.585
TRG_ENDOCYTIC_2	607	610	PF00928	0.312
TRG_ER_diArg_1	178	180	PF00400	0.318
TRG_ER_diArg_1	231	233	PF00400	0.410
TRG_ER_diArg_1	652	654	PF00400	0.388
TRG_NES_CRM1_1	699	711	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K2	Leptomonas seymouri	49%	98%
A0A3Q8IE73	Leishmania donovani	78%	100%
A4I5G6	Leishmania infantum	77%	100%
E9B0R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q7G9	Leishmania major	75%	98%