Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI86_LEIBR

TriTrypDb:

LbrM.30.1460 , LBRM2903_300020200

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.729
CLV_NRD_NRD_1	169	171	PF00675	0.658
CLV_PCSK_KEX2_1	104	106	PF00082	0.509
CLV_PCSK_KEX2_1	168	170	PF00082	0.656
CLV_PCSK_KEX2_1	223	225	PF00082	0.570
CLV_PCSK_KEX2_1	314	316	PF00082	0.635
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.650
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.668
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.582
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.613
CLV_PCSK_PC7_1	164	170	PF00082	0.644
CLV_PCSK_SKI1_1	117	121	PF00082	0.585
CLV_PCSK_SKI1_1	224	228	PF00082	0.661
DEG_SPOP_SBC_1	252	256	PF00917	0.542
DEG_SPOP_SBC_1	288	292	PF00917	0.536
DOC_CYCLIN_RxL_1	218	228	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.514
DOC_PP2B_LxvP_1	281	284	PF13499	0.550
DOC_USP7_MATH_1	119	123	PF00917	0.672
DOC_USP7_MATH_1	19	23	PF00917	0.552
DOC_USP7_MATH_1	198	202	PF00917	0.551
DOC_USP7_MATH_1	250	254	PF00917	0.586
DOC_WW_Pin1_4	225	230	PF00397	0.631
DOC_WW_Pin1_4	231	236	PF00397	0.589
DOC_WW_Pin1_4	263	268	PF00397	0.683
DOC_WW_Pin1_4	282	287	PF00397	0.772
DOC_WW_Pin1_4	289	294	PF00397	0.766
DOC_WW_Pin1_4	32	37	PF00397	0.510
LIG_FHA_1	128	134	PF00498	0.727
LIG_FHA_1	237	243	PF00498	0.678
LIG_LIR_Gen_1	35	46	PF02991	0.588
LIG_LIR_Nem_3	35	41	PF02991	0.625
LIG_NRP_CendR_1	315	318	PF00754	0.696
LIG_PCNA_yPIPBox_3	150	159	PF02747	0.422
LIG_SH2_STAP1	38	42	PF00017	0.630
LIG_SH2_STAT5	27	30	PF00017	0.526
LIG_SH3_3	290	296	PF00018	0.730
LIG_SUMO_SIM_par_1	130	137	PF11976	0.515
MOD_CDK_SPK_2	231	236	PF00069	0.544
MOD_CDK_SPK_2	263	268	PF00069	0.683
MOD_CDK_SPK_2	289	294	PF00069	0.718
MOD_CK1_1	134	140	PF00069	0.646
MOD_CK1_1	240	246	PF00069	0.790
MOD_CK1_1	253	259	PF00069	0.714
MOD_CK1_1	266	272	PF00069	0.778
MOD_CK1_1	68	74	PF00069	0.667
MOD_CK1_1	97	103	PF00069	0.413
MOD_CK2_1	34	40	PF00069	0.545
MOD_CK2_1	97	103	PF00069	0.524
MOD_Cter_Amidation	312	315	PF01082	0.572
MOD_GlcNHglycan	136	139	PF01048	0.560
MOD_GlcNHglycan	244	247	PF01048	0.742
MOD_GlcNHglycan	259	262	PF01048	0.775
MOD_GlcNHglycan	268	271	PF01048	0.663
MOD_GlcNHglycan	308	311	PF01048	0.643
MOD_GlcNHglycan	99	102	PF01048	0.535
MOD_GSK3_1	127	134	PF00069	0.653
MOD_GSK3_1	210	217	PF00069	0.691
MOD_GSK3_1	236	243	PF00069	0.761
MOD_GSK3_1	253	260	PF00069	0.749
MOD_N-GLC_1	236	241	PF02516	0.554
MOD_N-GLC_1	32	37	PF02516	0.631
MOD_NEK2_1	242	247	PF00069	0.606
MOD_NEK2_1	306	311	PF00069	0.687
MOD_NEK2_1	65	70	PF00069	0.728
MOD_PKA_2	240	246	PF00069	0.655
MOD_PKA_2	306	312	PF00069	0.675
MOD_PKA_2	97	103	PF00069	0.639
MOD_Plk_1	237	243	PF00069	0.668
MOD_ProDKin_1	225	231	PF00069	0.632
MOD_ProDKin_1	263	269	PF00069	0.683
MOD_ProDKin_1	282	288	PF00069	0.773
MOD_ProDKin_1	289	295	PF00069	0.759
MOD_ProDKin_1	32	38	PF00069	0.511
MOD_SUMO_for_1	175	178	PF00179	0.744
TRG_DiLeu_BaEn_1	109	114	PF01217	0.533
TRG_ENDOCYTIC_2	38	41	PF00928	0.629
TRG_ER_diArg_1	315	318	PF00400	0.660
TRG_ER_diArg_1	44	47	PF00400	0.641
TRG_NLS_MonoCore_2	167	172	PF00514	0.693
TRG_NLS_MonoCore_2	313	318	PF00514	0.606
TRG_NLS_MonoExtC_3	167	173	PF00514	0.691
TRG_NLS_MonoExtC_3	313	318	PF00514	0.752
TRG_NLS_MonoExtN_4	166	172	PF00514	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P252	Trypanosomatidae	28%	100%
A0A3S7X3H3	Leishmania donovani	71%	100%
A0A422N7B9	Trypanosoma rangeli	31%	100%
A4I5G5	Leishmania infantum	70%	100%
C9ZQV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q7H0	Leishmania major	70%	100%
V5BYY3	Trypanosoma cruzi	30%	79%