Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HI85_LEIBR

TriTrypDb:

LbrM.30.1450 , LBRM2903_300020100

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.410
CLV_NRD_NRD_1	27	29	PF00675	0.379
CLV_NRD_NRD_1	337	339	PF00675	0.336
CLV_NRD_NRD_1	53	55	PF00675	0.321
CLV_PCSK_KEX2_1	148	150	PF00082	0.656
CLV_PCSK_KEX2_1	204	206	PF00082	0.486
CLV_PCSK_KEX2_1	273	275	PF00082	0.391
CLV_PCSK_KEX2_1	337	339	PF00082	0.268
CLV_PCSK_KEX2_1	52	54	PF00082	0.339
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.652
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.391
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.349
CLV_PCSK_SKI1_1	168	172	PF00082	0.454
CLV_PCSK_SKI1_1	222	226	PF00082	0.332
CLV_PCSK_SKI1_1	237	241	PF00082	0.246
CLV_PCSK_SKI1_1	258	262	PF00082	0.261
CLV_PCSK_SKI1_1	303	307	PF00082	0.351
CLV_PCSK_SKI1_1	317	321	PF00082	0.124
CLV_PCSK_SKI1_1	380	384	PF00082	0.368
CLV_Separin_Metazoa	87	91	PF03568	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DEG_SPOP_SBC_1	174	178	PF00917	0.554
DOC_CKS1_1	442	447	PF01111	0.440
DOC_MAPK_gen_1	273	281	PF00069	0.391
DOC_MAPK_gen_1	337	345	PF00069	0.306
DOC_MAPK_gen_1	416	425	PF00069	0.292
DOC_MAPK_HePTP_8	126	138	PF00069	0.410
DOC_MAPK_MEF2A_6	129	138	PF00069	0.410
DOC_MAPK_MEF2A_6	317	324	PF00069	0.283
DOC_MAPK_MEF2A_6	337	345	PF00069	0.334
DOC_MAPK_NFAT4_5	338	346	PF00069	0.280
DOC_PP1_RVXF_1	122	129	PF00149	0.496
DOC_PP1_RVXF_1	436	443	PF00149	0.334
DOC_USP7_MATH_1	157	161	PF00917	0.679
DOC_USP7_MATH_1	174	178	PF00917	0.674
DOC_USP7_MATH_1	180	184	PF00917	0.727
DOC_USP7_MATH_1	191	195	PF00917	0.432
DOC_WW_Pin1_4	170	175	PF00397	0.532
DOC_WW_Pin1_4	18	23	PF00397	0.508
DOC_WW_Pin1_4	205	210	PF00397	0.459
DOC_WW_Pin1_4	441	446	PF00397	0.435
LIG_14-3-3_CanoR_1	28	33	PF00244	0.468
LIG_14-3-3_CanoR_1	37	47	PF00244	0.439
LIG_14-3-3_CanoR_1	380	385	PF00244	0.284
LIG_14-3-3_CanoR_1	82	86	PF00244	0.342
LIG_Clathr_ClatBox_1	117	121	PF01394	0.476
LIG_CSL_BTD_1	5	8	PF09270	0.459
LIG_deltaCOP1_diTrp_1	439	446	PF00928	0.395
LIG_DLG_GKlike_1	28	36	PF00625	0.279
LIG_EH1_1	82	90	PF00400	0.286
LIG_FHA_1	102	108	PF00498	0.329
LIG_FHA_1	113	119	PF00498	0.332
LIG_FHA_1	133	139	PF00498	0.205
LIG_FHA_1	190	196	PF00498	0.485
LIG_FHA_1	356	362	PF00498	0.257
LIG_FHA_2	446	452	PF00498	0.428
LIG_FHA_2	73	79	PF00498	0.333
LIG_FHA_2	82	88	PF00498	0.330
LIG_GBD_Chelix_1	32	40	PF00786	0.336
LIG_HP1_1	350	354	PF01393	0.280
LIG_LIR_Apic_2	439	445	PF02991	0.387
LIG_LIR_Gen_1	229	238	PF02991	0.340
LIG_LIR_Gen_1	290	300	PF02991	0.365
LIG_LIR_Gen_1	395	404	PF02991	0.269
LIG_LIR_Nem_3	127	131	PF02991	0.375
LIG_LIR_Nem_3	165	169	PF02991	0.516
LIG_LIR_Nem_3	220	224	PF02991	0.368
LIG_LIR_Nem_3	229	233	PF02991	0.284
LIG_LIR_Nem_3	290	295	PF02991	0.419
LIG_LIR_Nem_3	388	394	PF02991	0.316
LIG_LIR_Nem_3	395	400	PF02991	0.310
LIG_LYPXL_S_1	62	66	PF13949	0.272
LIG_LYPXL_yS_3	63	66	PF13949	0.285
LIG_NRBOX	341	347	PF00104	0.305
LIG_OCRL_FandH_1	260	272	PF00620	0.285
LIG_Pex14_1	442	446	PF04695	0.425
LIG_PTB_Apo_2	224	231	PF02174	0.340
LIG_REV1ctd_RIR_1	258	268	PF16727	0.305
LIG_SH2_CRK	221	225	PF00017	0.282
LIG_SH2_SRC	374	377	PF00017	0.384
LIG_SH2_STAP1	102	106	PF00017	0.314
LIG_SH2_STAP1	141	145	PF00017	0.468
LIG_SH2_STAP1	374	378	PF00017	0.315
LIG_SH2_STAP1	386	390	PF00017	0.256
LIG_SH2_STAT3	141	144	PF00017	0.460
LIG_SH3_3	156	162	PF00018	0.615
LIG_SH3_3	16	22	PF00018	0.485
LIG_SH3_3	190	196	PF00018	0.595
LIG_SH3_3	2	8	PF00018	0.486
LIG_SH3_5	137	141	PF00018	0.376
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.337
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.262
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.360
LIG_SUMO_SIM_par_1	318	323	PF11976	0.340
LIG_SUMO_SIM_par_1	347	356	PF11976	0.246
LIG_SUMO_SIM_par_1	399	405	PF11976	0.351
LIG_TYR_ITIM	219	224	PF00017	0.341
LIG_UBA3_1	106	111	PF00899	0.431
LIG_UBA3_1	251	258	PF00899	0.261
LIG_UBA3_1	341	349	PF00899	0.261
MOD_CK1_1	147	153	PF00069	0.642
MOD_CK1_1	173	179	PF00069	0.628
MOD_CK1_1	183	189	PF00069	0.590
MOD_CK1_1	246	252	PF00069	0.205
MOD_CK1_1	283	289	PF00069	0.261
MOD_CK1_1	441	447	PF00069	0.423
MOD_CK2_1	11	17	PF00069	0.325
MOD_CK2_1	205	211	PF00069	0.510
MOD_CK2_1	28	34	PF00069	0.286
MOD_CK2_1	308	314	PF00069	0.312
MOD_CK2_1	329	335	PF00069	0.246
MOD_CK2_1	45	51	PF00069	0.370
MOD_CK2_1	81	87	PF00069	0.496
MOD_Cter_Amidation	271	274	PF01082	0.391
MOD_DYRK1A_RPxSP_1	18	22	PF00069	0.556
MOD_GlcNHglycan	149	152	PF01048	0.567
MOD_GlcNHglycan	159	162	PF01048	0.510
MOD_GlcNHglycan	182	185	PF01048	0.699
MOD_GlcNHglycan	189	192	PF01048	0.706
MOD_GlcNHglycan	245	248	PF01048	0.240
MOD_GlcNHglycan	332	335	PF01048	0.248
MOD_GlcNHglycan	48	51	PF01048	0.356
MOD_GSK3_1	170	177	PF00069	0.599
MOD_GSK3_1	179	186	PF00069	0.585
MOD_GSK3_1	187	194	PF00069	0.546
MOD_GSK3_1	243	250	PF00069	0.305
MOD_GSK3_1	380	387	PF00069	0.361
MOD_GSK3_1	415	422	PF00069	0.442
MOD_GSK3_1	441	448	PF00069	0.437
MOD_GSK3_1	7	14	PF00069	0.544
MOD_N-GLC_1	226	231	PF02516	0.379
MOD_N-GLC_1	243	248	PF02516	0.169
MOD_NEK2_1	280	285	PF00069	0.349
MOD_NEK2_1	308	313	PF00069	0.312
MOD_NEK2_1	404	409	PF00069	0.346
MOD_NEK2_1	449	454	PF00069	0.478
MOD_PK_1	419	425	PF00069	0.416
MOD_PKA_1	28	34	PF00069	0.490
MOD_PKA_2	27	33	PF00069	0.319
MOD_PKA_2	308	314	PF00069	0.285
MOD_PKA_2	38	44	PF00069	0.495
MOD_PKA_2	415	421	PF00069	0.496
MOD_PKA_2	81	87	PF00069	0.342
MOD_PKB_1	436	444	PF00069	0.345
MOD_Plk_1	132	138	PF00069	0.392
MOD_Plk_1	226	232	PF00069	0.324
MOD_Plk_1	374	380	PF00069	0.375
MOD_Plk_1	404	410	PF00069	0.385
MOD_Plk_1	438	444	PF00069	0.368
MOD_Plk_1	449	455	PF00069	0.389
MOD_Plk_2-3	72	78	PF00069	0.342
MOD_Plk_2-3	81	87	PF00069	0.327
MOD_Plk_4	195	201	PF00069	0.648
MOD_Plk_4	247	253	PF00069	0.246
MOD_Plk_4	266	272	PF00069	0.267
MOD_Plk_4	280	286	PF00069	0.266
MOD_Plk_4	380	386	PF00069	0.288
MOD_Plk_4	7	13	PF00069	0.484
MOD_Plk_4	81	87	PF00069	0.396
MOD_ProDKin_1	170	176	PF00069	0.531
MOD_ProDKin_1	18	24	PF00069	0.513
MOD_ProDKin_1	205	211	PF00069	0.449
MOD_ProDKin_1	441	447	PF00069	0.436
MOD_SUMO_rev_2	121	131	PF00179	0.412
MOD_SUMO_rev_2	21	31	PF00179	0.553
TRG_ENDOCYTIC_2	166	169	PF00928	0.557
TRG_ENDOCYTIC_2	221	224	PF00928	0.349
TRG_ENDOCYTIC_2	276	279	PF00928	0.272
TRG_ENDOCYTIC_2	63	66	PF00928	0.349
TRG_ER_diArg_1	337	339	PF00400	0.421
TRG_ER_diArg_1	36	39	PF00400	0.391
TRG_ER_diArg_1	435	438	PF00400	0.266
TRG_ER_diArg_1	53	55	PF00400	0.324
TRG_NES_CRM1_1	314	327	PF08389	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R4	Leptomonas seymouri	70%	90%
A0A0S4J6G0	Bodo saltans	50%	91%
A0A1X0P1Z8	Trypanosomatidae	55%	93%
A0A3R7K7R6	Trypanosoma rangeli	54%	95%
A0A3S7X391	Leishmania donovani	79%	100%
A4I5G4	Leishmania infantum	79%	100%
C9ZQV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	91%
E9B0R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P33916	Escherichia coli (strain K12)	23%	90%
Q4Q7H1	Leishmania major	79%	100%
Q5HCL3	Staphylococcus aureus (strain COL)	23%	83%
Q6G5Z1	Staphylococcus aureus (strain MSSA476)	23%	83%
Q6GDC0	Staphylococcus aureus (strain MRSA252)	23%	83%
Q7A342	Staphylococcus aureus (strain N315)	23%	83%
Q87G35	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	24%	82%
Q897I2	Clostridium tetani (strain Massachusetts / E88)	21%	100%
Q8NUH8	Staphylococcus aureus (strain MW2)	23%	83%
Q8PSR0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	21%	80%
Q8TQ05	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	23%	77%
Q8XK20	Clostridium perfringens (strain 13 / Type A)	24%	83%
Q99QV7	Staphylococcus aureus (strain Mu50 / ATCC 700699)	23%	83%
V5BPK8	Trypanosoma cruzi	56%	100%