Helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNF2 family N-terminal domain/Helicase conserved C-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI83_LEIBR

TriTrypDb:

LbrM.30.1430 , LBRM2903_300019900

Length:

1235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HI83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI83

Function

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Biological processes
Term	Name	Level	Count
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0044030	regulation of DNA methylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	1
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016491	oxidoreductase activity	2	6
GO:0017076	purine nucleotide binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1190	1194	PF00656	0.454
CLV_C14_Caspase3-7	215	219	PF00656	0.543
CLV_C14_Caspase3-7	26	30	PF00656	0.566
CLV_C14_Caspase3-7	459	463	PF00656	0.546
CLV_NRD_NRD_1	1082	1084	PF00675	0.566
CLV_NRD_NRD_1	1172	1174	PF00675	0.651
CLV_NRD_NRD_1	1175	1177	PF00675	0.593
CLV_NRD_NRD_1	1178	1180	PF00675	0.581
CLV_NRD_NRD_1	1226	1228	PF00675	0.644
CLV_NRD_NRD_1	1230	1232	PF00675	0.675

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z0	Leptomonas seymouri	51%	94%
A0A3S5H7M8	Leishmania donovani	76%	100%
A4I5G2	Leishmania infantum	76%	100%
E9B0R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q7H3	Leishmania major	75%	100%

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