Putative U3 small nuclear ribonucleoprotein (SnRNP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nuclear ribonucleoprotein (snRNP), putative

Species:

Leishmania braziliensis

UniProt:

A4HI82_LEIBR

TriTrypDb:

LbrM.30.1420 , LBRM2903_300019800

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0034457	Mpp10 complex	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HI82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI82

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0042134	rRNA primary transcript binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0030515	snoRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.209
CLV_NRD_NRD_1	14	16	PF00675	0.368
CLV_NRD_NRD_1	2	4	PF00675	0.414
CLV_NRD_NRD_1	27	29	PF00675	0.374
CLV_NRD_NRD_1	285	287	PF00675	0.426
CLV_NRD_NRD_1	8	10	PF00675	0.387
CLV_PCSK_KEX2_1	2	4	PF00082	0.454
CLV_PCSK_KEX2_1	240	242	PF00082	0.161
CLV_PCSK_KEX2_1	284	286	PF00082	0.443
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.161
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.443
CLV_PCSK_SKI1_1	10	14	PF00082	0.408
CLV_PCSK_SKI1_1	200	204	PF00082	0.232
CLV_PCSK_SKI1_1	216	220	PF00082	0.225
CLV_PCSK_SKI1_1	258	262	PF00082	0.363
CLV_PCSK_SKI1_1	33	37	PF00082	0.429
CLV_PCSK_SKI1_1	48	52	PF00082	0.412
CLV_PCSK_SKI1_1	54	58	PF00082	0.342
DEG_APCC_DBOX_1	257	265	PF00400	0.453
DEG_APCC_KENBOX_2	129	133	PF00400	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.464
DOC_CYCLIN_RxL_1	211	223	PF00134	0.424
DOC_MAPK_gen_1	113	121	PF00069	0.431
DOC_MAPK_gen_1	235	245	PF00069	0.409
DOC_MAPK_gen_1	47	53	PF00069	0.384
DOC_PP1_RVXF_1	214	221	PF00149	0.415
DOC_PP1_RVXF_1	94	101	PF00149	0.406
DOC_PP2B_LxvP_1	106	109	PF13499	0.417
DOC_PP4_FxxP_1	207	210	PF00568	0.408
DOC_USP7_MATH_1	212	216	PF00917	0.461
DOC_USP7_UBL2_3	236	240	PF12436	0.468
DOC_WW_Pin1_4	252	257	PF00397	0.417
DOC_WW_Pin1_4	37	42	PF00397	0.431
LIG_14-3-3_CanoR_1	116	122	PF00244	0.429
LIG_14-3-3_CanoR_1	2	6	PF00244	0.416
LIG_14-3-3_CanoR_1	216	221	PF00244	0.406
LIG_14-3-3_CanoR_1	230	235	PF00244	0.406
LIG_14-3-3_CanoR_1	65	75	PF00244	0.464
LIG_14-3-3_CanoR_1	91	100	PF00244	0.470
LIG_EH1_1	161	169	PF00400	0.417
LIG_FHA_1	132	138	PF00498	0.509
LIG_FHA_1	159	165	PF00498	0.514
LIG_FHA_1	269	275	PF00498	0.341
LIG_FHA_1	37	43	PF00498	0.329
LIG_FHA_1	62	68	PF00498	0.456
LIG_FHA_2	176	182	PF00498	0.406
LIG_FHA_2	55	61	PF00498	0.447
LIG_FHA_2	6	12	PF00498	0.462
LIG_FHA_2	67	73	PF00498	0.399
LIG_LIR_Gen_1	131	139	PF02991	0.476
LIG_LIR_Gen_1	223	234	PF02991	0.410
LIG_LIR_Nem_3	131	136	PF02991	0.476
LIG_LIR_Nem_3	180	186	PF02991	0.423
LIG_LIR_Nem_3	223	229	PF02991	0.410
LIG_LIR_Nem_3	255	260	PF02991	0.490
LIG_LYPXL_SIV_4	256	264	PF13949	0.553
LIG_LYPXL_yS_3	183	186	PF13949	0.446
LIG_RPA_C_Fungi	86	98	PF08784	0.386
LIG_SH2_CRK	257	261	PF00017	0.430
LIG_SH2_GRB2like	278	281	PF00017	0.375
LIG_SH2_NCK_1	75	79	PF00017	0.423
LIG_SH2_STAP1	133	137	PF00017	0.277
LIG_SH2_STAT5	133	136	PF00017	0.440
LIG_SH2_STAT5	205	208	PF00017	0.303
LIG_SH3_3	152	158	PF00018	0.277
LIG_SH3_3	271	277	PF00018	0.385
LIG_SUMO_SIM_anti_2	134	142	PF11976	0.266
LIG_SUMO_SIM_par_1	134	142	PF11976	0.243
LIG_TRAF2_1	78	81	PF00917	0.497
LIG_TRFH_1	252	256	PF08558	0.386
LIG_TYR_ITSM	253	260	PF00017	0.337
LIG_WRC_WIRS_1	217	222	PF05994	0.243
MOD_CDK_SPxK_1	252	258	PF00069	0.258
MOD_CK2_1	175	181	PF00069	0.251
MOD_CK2_1	5	11	PF00069	0.463
MOD_Cter_Amidation	238	241	PF01082	0.386
MOD_GlcNHglycan	76	79	PF01048	0.452
MOD_GSK3_1	1	8	PF00069	0.576
MOD_GSK3_1	145	152	PF00069	0.249
MOD_GSK3_1	156	163	PF00069	0.244
MOD_GSK3_1	212	219	PF00069	0.243
MOD_GSK3_1	87	94	PF00069	0.276
MOD_N-GLC_1	131	136	PF02516	0.310
MOD_N-GLC_1	189	194	PF02516	0.243
MOD_N-GLC_1	91	96	PF02516	0.386
MOD_NEK2_1	1	6	PF00069	0.426
MOD_NEK2_1	139	144	PF00069	0.289
MOD_NEK2_1	149	154	PF00069	0.200
MOD_NEK2_1	36	41	PF00069	0.341
MOD_NEK2_1	86	91	PF00069	0.347
MOD_NEK2_2	117	122	PF00069	0.277
MOD_PIKK_1	139	145	PF00454	0.258
MOD_PIKK_1	91	97	PF00454	0.253
MOD_PKA_1	54	60	PF00069	0.396
MOD_PKA_2	1	7	PF00069	0.424
MOD_PKA_2	115	121	PF00069	0.426
MOD_Plk_1	212	218	PF00069	0.261
MOD_Plk_4	145	151	PF00069	0.258
MOD_ProDKin_1	252	258	PF00069	0.258
MOD_ProDKin_1	37	43	PF00069	0.427
MOD_SUMO_for_1	234	237	PF00179	0.386
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.303
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.419
TRG_ENDOCYTIC_2	133	136	PF00928	0.318
TRG_ENDOCYTIC_2	183	186	PF00928	0.284
TRG_ENDOCYTIC_2	257	260	PF00928	0.434
TRG_ER_diArg_1	1	3	PF00400	0.439
TRG_ER_diArg_1	285	287	PF00400	0.392
TRG_ER_diArg_1	6	9	PF00400	0.388
TRG_NLS_MonoCore_2	282	287	PF00514	0.388
TRG_NLS_MonoExtN_4	283	288	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI1	Leptomonas seymouri	90%	100%
A0A0N1PE93	Leptomonas seymouri	34%	87%
A0A0S4IS82	Bodo saltans	77%	99%
A0A0S4JV56	Bodo saltans	35%	87%
A0A1X0P1W8	Trypanosomatidae	81%	100%
A0A1X0P3X9	Trypanosomatidae	35%	87%
A0A3S7X0F1	Leishmania donovani	35%	87%
A0A3S7X394	Leishmania donovani	95%	100%
A0A422NTE1	Trypanosoma rangeli	35%	87%
A0A422P551	Trypanosoma rangeli	80%	100%
A4HFG9	Leishmania braziliensis	35%	87%
A4I2N1	Leishmania infantum	35%	87%
A4I5G1	Leishmania infantum	95%	100%
C9ZQU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0A5P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	87%
E9AD22	Leishmania major	35%	87%
E9AYU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B0Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13823	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
O14180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	94%
O62518	Caenorhabditis elegans	48%	99%
P38805	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	98%
P53941	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	99%
P54073	Caenorhabditis elegans	33%	75%
Q0VD01	Bos taurus	51%	99%
Q4Q7H4	Leishmania major	95%	100%
Q5PQR5	Rattus norvegicus	51%	99%
Q5R631	Pongo abelii	33%	83%
Q5R947	Pongo abelii	52%	99%
Q5RJS9	Rattus norvegicus	33%	83%
Q6BYD9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6C804	Yarrowia lipolytica (strain CLIB 122 / E 150)	44%	100%
Q6FNN7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q6IQU6	Danio rerio	31%	87%
Q755T8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	44%	100%
Q7TND5	Mus musculus	33%	83%
Q8AVP1	Xenopus laevis	32%	84%
Q8VHZ7	Mus musculus	51%	99%
Q96G21	Homo sapiens	52%	99%
Q9H9Y2	Homo sapiens	33%	83%
Q9VKB4	Drosophila melanogaster	33%	73%
V5B7H7	Trypanosoma cruzi	35%	87%
V5BYY7	Trypanosoma cruzi	81%	100%