Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI80_LEIBR

TriTrypDb:

LbrM.30.1400 , LBRM2903_300019500

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.510
CLV_C14_Caspase3-7	323	327	PF00656	0.617
CLV_C14_Caspase3-7	57	61	PF00656	0.491
CLV_C14_Caspase3-7	585	589	PF00656	0.662
CLV_NRD_NRD_1	268	270	PF00675	0.435
CLV_NRD_NRD_1	343	345	PF00675	0.501
CLV_NRD_NRD_1	385	387	PF00675	0.428
CLV_NRD_NRD_1	401	403	PF00675	0.532
CLV_NRD_NRD_1	603	605	PF00675	0.496
CLV_NRD_NRD_1	658	660	PF00675	0.610
CLV_NRD_NRD_1	680	682	PF00675	0.566
CLV_NRD_NRD_1	83	85	PF00675	0.393
CLV_PCSK_KEX2_1	268	270	PF00082	0.435
CLV_PCSK_KEX2_1	343	345	PF00082	0.501
CLV_PCSK_KEX2_1	384	386	PF00082	0.427
CLV_PCSK_KEX2_1	401	403	PF00082	0.286
CLV_PCSK_KEX2_1	603	605	PF00082	0.640
CLV_PCSK_KEX2_1	657	659	PF00082	0.602
CLV_PCSK_KEX2_1	680	682	PF00082	0.566
CLV_PCSK_KEX2_1	82	84	PF00082	0.464
CLV_PCSK_SKI1_1	16	20	PF00082	0.459
CLV_PCSK_SKI1_1	261	265	PF00082	0.613
CLV_PCSK_SKI1_1	300	304	PF00082	0.463
CLV_PCSK_SKI1_1	385	389	PF00082	0.419
CLV_PCSK_SKI1_1	635	639	PF00082	0.493
CLV_Separin_Metazoa	666	670	PF03568	0.583
DEG_APCC_DBOX_1	267	275	PF00400	0.522
DEG_APCC_DBOX_1	515	523	PF00400	0.581
DOC_CYCLIN_RxL_1	297	305	PF00134	0.450
DOC_CYCLIN_RxL_1	432	442	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.438
DOC_MAPK_gen_1	82	90	PF00069	0.294
DOC_MAPK_MEF2A_6	6	14	PF00069	0.355
DOC_MAPK_MEF2A_6	82	90	PF00069	0.480
DOC_MAPK_NFAT4_5	83	91	PF00069	0.299
DOC_MAPK_RevD_3	68	83	PF00069	0.466
DOC_PP2B_LxvP_1	48	51	PF13499	0.447
DOC_USP7_MATH_1	322	326	PF00917	0.499
DOC_USP7_MATH_1	506	510	PF00917	0.564
DOC_USP7_MATH_1	551	555	PF00917	0.583
DOC_USP7_MATH_1	576	580	PF00917	0.582
DOC_USP7_MATH_1	584	588	PF00917	0.722
DOC_USP7_MATH_1	589	593	PF00917	0.541
DOC_WW_Pin1_4	222	227	PF00397	0.681
DOC_WW_Pin1_4	235	240	PF00397	0.801
DOC_WW_Pin1_4	307	312	PF00397	0.494
DOC_WW_Pin1_4	609	614	PF00397	0.522
DOC_WW_Pin1_4	668	673	PF00397	0.670
LIG_14-3-3_CanoR_1	102	109	PF00244	0.384
LIG_14-3-3_CanoR_1	209	213	PF00244	0.576
LIG_14-3-3_CanoR_1	261	266	PF00244	0.596
LIG_14-3-3_CanoR_1	300	309	PF00244	0.356
LIG_14-3-3_CanoR_1	32	40	PF00244	0.494
LIG_14-3-3_CanoR_1	385	395	PF00244	0.538
LIG_Actin_WH2_2	33	49	PF00022	0.473
LIG_BIR_III_4	24	28	PF00653	0.446
LIG_BRCT_BRCA1_1	457	461	PF00533	0.460
LIG_Clathr_ClatBox_1	11	15	PF01394	0.359
LIG_Clathr_ClatBox_1	470	474	PF01394	0.360
LIG_EH1_1	42	50	PF00400	0.421
LIG_eIF4E_1	632	638	PF01652	0.523
LIG_FHA_1	108	114	PF00498	0.469
LIG_FHA_1	139	145	PF00498	0.423
LIG_FHA_1	262	268	PF00498	0.545
LIG_FHA_1	273	279	PF00498	0.472
LIG_FHA_1	362	368	PF00498	0.475
LIG_FHA_1	452	458	PF00498	0.461
LIG_FHA_1	532	538	PF00498	0.569
LIG_FHA_1	688	694	PF00498	0.508
LIG_FHA_2	19	25	PF00498	0.653
LIG_FHA_2	425	431	PF00498	0.481
LIG_FHA_2	508	514	PF00498	0.589
LIG_FHA_2	533	539	PF00498	0.594
LIG_FHA_2	55	61	PF00498	0.578
LIG_LIR_Nem_3	296	302	PF02991	0.418
LIG_NRBOX	542	548	PF00104	0.375
LIG_NRBOX	624	630	PF00104	0.526
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.502
LIG_PCNA_yPIPBox_3	615	629	PF02747	0.555
LIG_PCNA_yPIPBox_3	678	692	PF02747	0.549
LIG_PTB_Apo_2	210	217	PF02174	0.499
LIG_PTB_Apo_2	259	266	PF02174	0.551
LIG_PTB_Phospho_1	259	265	PF10480	0.554
LIG_SH2_CRK	299	303	PF00017	0.453
LIG_SH2_CRK	634	638	PF00017	0.447
LIG_SH2_STAP1	96	100	PF00017	0.449
LIG_SH2_STAT5	92	95	PF00017	0.377
LIG_SH3_2	610	615	PF14604	0.451
LIG_SH3_3	223	229	PF00018	0.641
LIG_SH3_3	234	240	PF00018	0.478
LIG_SH3_3	563	569	PF00018	0.509
LIG_SH3_3	607	613	PF00018	0.480
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.432
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.586
LIG_SUMO_SIM_par_1	149	154	PF11976	0.334
LIG_SUMO_SIM_par_1	363	371	PF11976	0.357
LIG_SUMO_SIM_par_1	434	440	PF11976	0.523
LIG_SUMO_SIM_par_1	468	474	PF11976	0.566
LIG_SUMO_SIM_par_1	554	560	PF11976	0.452
LIG_SUMO_SIM_par_1	9	15	PF11976	0.274
LIG_TRAF2_1	167	170	PF00917	0.487
LIG_TRAF2_1	2	5	PF00917	0.504
LIG_TRAF2_1	252	255	PF00917	0.616
LIG_TRAF2_1	389	392	PF00917	0.416
LIG_TRAF2_1	61	64	PF00917	0.551
LIG_TRFH_1	185	189	PF08558	0.480
MOD_CDC14_SPxK_1	612	615	PF00782	0.444
MOD_CDK_SPxK_1	609	615	PF00069	0.456
MOD_CK1_1	105	111	PF00069	0.379
MOD_CK1_1	201	207	PF00069	0.622
MOD_CK1_1	238	244	PF00069	0.662
MOD_CK1_1	460	466	PF00069	0.553
MOD_CK1_1	53	59	PF00069	0.551
MOD_CK1_1	579	585	PF00069	0.710
MOD_CK1_1	611	617	PF00069	0.607
MOD_CK2_1	386	392	PF00069	0.420
MOD_CK2_1	424	430	PF00069	0.593
MOD_CK2_1	532	538	PF00069	0.545
MOD_CK2_1	579	585	PF00069	0.750
MOD_CK2_1	58	64	PF00069	0.609
MOD_CK2_1	660	666	PF00069	0.657
MOD_GlcNHglycan	126	131	PF01048	0.621
MOD_GlcNHglycan	153	156	PF01048	0.375
MOD_GlcNHglycan	243	246	PF01048	0.589
MOD_GlcNHglycan	388	391	PF01048	0.531
MOD_GlcNHglycan	549	552	PF01048	0.543
MOD_GlcNHglycan	553	556	PF01048	0.544
MOD_GlcNHglycan	558	562	PF01048	0.598
MOD_GlcNHglycan	570	573	PF01048	0.725
MOD_GlcNHglycan	93	96	PF01048	0.279
MOD_GSK3_1	100	107	PF00069	0.532
MOD_GSK3_1	194	201	PF00069	0.608
MOD_GSK3_1	203	210	PF00069	0.583
MOD_GSK3_1	332	339	PF00069	0.614
MOD_GSK3_1	451	458	PF00069	0.676
MOD_GSK3_1	50	57	PF00069	0.571
MOD_GSK3_1	507	514	PF00069	0.593
MOD_GSK3_1	547	554	PF00069	0.485
MOD_GSK3_1	59	66	PF00069	0.716
MOD_N-GLC_1	261	266	PF02516	0.506
MOD_N-GLC_1	463	468	PF02516	0.528
MOD_N-GLC_1	511	516	PF02516	0.586
MOD_NEK2_1	101	106	PF00069	0.562
MOD_NEK2_1	18	23	PF00069	0.476
MOD_NEK2_1	208	213	PF00069	0.700
MOD_NEK2_1	457	462	PF00069	0.564
MOD_NEK2_1	547	552	PF00069	0.652
MOD_NEK2_1	687	692	PF00069	0.489
MOD_PIKK_1	138	144	PF00454	0.379
MOD_PIKK_1	273	279	PF00454	0.505
MOD_PIKK_1	31	37	PF00454	0.518
MOD_PIKK_1	361	367	PF00454	0.481
MOD_PIKK_1	424	430	PF00454	0.523
MOD_PKA_2	101	107	PF00069	0.393
MOD_PKA_2	208	214	PF00069	0.670
MOD_PKA_2	229	235	PF00069	0.637
MOD_PKA_2	285	291	PF00069	0.362
MOD_PKA_2	31	37	PF00069	0.352
MOD_PKA_2	483	489	PF00069	0.571
MOD_PKA_2	614	620	PF00069	0.583
MOD_PKB_1	384	392	PF00069	0.534
MOD_Plk_1	261	267	PF00069	0.544
MOD_Plk_1	348	354	PF00069	0.464
MOD_Plk_1	511	517	PF00069	0.584
MOD_Plk_1	576	582	PF00069	0.664
MOD_Plk_1	589	595	PF00069	0.473
MOD_Plk_1	63	69	PF00069	0.706
MOD_Plk_4	336	342	PF00069	0.517
MOD_Plk_4	597	603	PF00069	0.522
MOD_Plk_4	624	630	PF00069	0.416
MOD_Plk_4	641	647	PF00069	0.421
MOD_Plk_4	671	677	PF00069	0.559
MOD_Plk_4	687	693	PF00069	0.541
MOD_ProDKin_1	222	228	PF00069	0.679
MOD_ProDKin_1	235	241	PF00069	0.794
MOD_ProDKin_1	307	313	PF00069	0.497
MOD_ProDKin_1	609	615	PF00069	0.519
MOD_ProDKin_1	668	674	PF00069	0.665
MOD_SUMO_for_1	396	399	PF00179	0.529
MOD_SUMO_rev_2	323	329	PF00179	0.460
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.507
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.542
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.268
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.383
TRG_ENDOCYTIC_2	299	302	PF00928	0.429
TRG_ENDOCYTIC_2	634	637	PF00928	0.449
TRG_ER_diArg_1	267	269	PF00400	0.426
TRG_ER_diArg_1	383	386	PF00400	0.477
TRG_ER_diArg_1	419	422	PF00400	0.335
TRG_ER_diArg_1	602	604	PF00400	0.495
TRG_ER_diArg_1	657	659	PF00400	0.646
TRG_ER_diArg_1	82	84	PF00400	0.457
TRG_NES_CRM1_1	413	426	PF08389	0.566
TRG_NES_CRM1_1	430	444	PF08389	0.321
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	447	452	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P981	Leptomonas seymouri	53%	95%
A0A1X0P283	Trypanosomatidae	28%	100%
A0A3Q8IFR6	Leishmania donovani	79%	100%
A0A3R7NW91	Trypanosoma rangeli	28%	100%
A4I5F9	Leishmania infantum	79%	100%
E9B0Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q7H6	Leishmania major	77%	100%
V5DQP9	Trypanosoma cruzi	31%	100%