N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI78_LEIBR

TriTrypDb:

LbrM.30.1380 , LBRM2903_300019300

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI78

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016407	acetyltransferase activity	5	2
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.605
CLV_NRD_NRD_1	104	106	PF00675	0.778
CLV_NRD_NRD_1	184	186	PF00675	0.790
CLV_NRD_NRD_1	226	228	PF00675	0.538
CLV_NRD_NRD_1	272	274	PF00675	0.692
CLV_NRD_NRD_1	331	333	PF00675	0.523
CLV_PCSK_KEX2_1	104	106	PF00082	0.552
CLV_PCSK_KEX2_1	184	186	PF00082	0.790
CLV_PCSK_KEX2_1	225	227	PF00082	0.536
CLV_PCSK_KEX2_1	272	274	PF00082	0.682
CLV_PCSK_KEX2_1	276	278	PF00082	0.695
CLV_PCSK_KEX2_1	331	333	PF00082	0.523
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.712
CLV_PCSK_PC7_1	272	278	PF00082	0.784
CLV_TASPASE1	65	71	PF01112	0.652
DEG_APCC_DBOX_1	261	269	PF00400	0.575
DEG_APCC_DBOX_1	81	89	PF00400	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.707
DEG_SPOP_SBC_1	194	198	PF00917	0.556
DEG_SPOP_SBC_1	43	47	PF00917	0.548
DOC_ANK_TNKS_1	207	214	PF00023	0.507
DOC_CYCLIN_RxL_1	321	330	PF00134	0.481
DOC_CYCLIN_yClb5_NLxxxL_5	50	57	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.678
DOC_MAPK_gen_1	104	111	PF00069	0.557
DOC_MAPK_gen_1	156	166	PF00069	0.339
DOC_MAPK_MEF2A_6	104	111	PF00069	0.557
DOC_MAPK_MEF2A_6	349	358	PF00069	0.452
DOC_MAPK_NFAT4_5	104	112	PF00069	0.558
DOC_PP1_RVXF_1	322	329	PF00149	0.475
DOC_USP7_MATH_1	10	14	PF00917	0.547
DOC_USP7_MATH_1	137	141	PF00917	0.571
DOC_USP7_MATH_1	148	152	PF00917	0.501
DOC_USP7_MATH_1	192	196	PF00917	0.667
DOC_USP7_MATH_1	199	203	PF00917	0.692
DOC_USP7_MATH_1	304	308	PF00917	0.518
DOC_USP7_MATH_1	39	43	PF00917	0.814
DOC_WW_Pin1_4	183	188	PF00397	0.670
DOC_WW_Pin1_4	44	49	PF00397	0.577
DOC_WW_Pin1_4	52	57	PF00397	0.458
LIG_14-3-3_CanoR_1	146	155	PF00244	0.586
LIG_14-3-3_CanoR_1	170	177	PF00244	0.698
LIG_14-3-3_CanoR_1	227	233	PF00244	0.474
LIG_BIR_III_2	301	305	PF00653	0.543
LIG_BRCT_BRCA1_1	351	355	PF00533	0.453
LIG_deltaCOP1_diTrp_1	71	74	PF00928	0.535
LIG_FHA_1	104	110	PF00498	0.521
LIG_FHA_1	125	131	PF00498	0.640
LIG_FHA_1	233	239	PF00498	0.492
LIG_FHA_1	265	271	PF00498	0.591
LIG_FHA_1	88	94	PF00498	0.309
LIG_FHA_1	9	15	PF00498	0.656
LIG_FHA_2	27	33	PF00498	0.498
LIG_LIR_Apic_2	3	8	PF02991	0.504
LIG_LIR_Gen_1	212	222	PF02991	0.485
LIG_LIR_Gen_1	352	363	PF02991	0.504
LIG_LIR_Gen_1	58	66	PF02991	0.602
LIG_LIR_Gen_1	90	99	PF02991	0.384
LIG_LIR_Nem_3	150	155	PF02991	0.579
LIG_LIR_Nem_3	16	21	PF02991	0.387
LIG_LIR_Nem_3	212	217	PF02991	0.422
LIG_LIR_Nem_3	352	358	PF02991	0.494
LIG_LIR_Nem_3	58	62	PF02991	0.505
LIG_LIR_Nem_3	71	77	PF02991	0.445
LIG_LIR_Nem_3	90	95	PF02991	0.458
LIG_Rb_LxCxE_1	16	35	PF01857	0.430
LIG_SH2_CRK	323	327	PF00017	0.479
LIG_SH2_PTP2	214	217	PF00017	0.591
LIG_SH2_SRC	59	62	PF00017	0.602
LIG_SH2_STAT3	258	261	PF00017	0.334
LIG_SH2_STAT3	338	341	PF00017	0.392
LIG_SH2_STAT5	21	24	PF00017	0.475
LIG_SH2_STAT5	214	217	PF00017	0.453
LIG_SH2_STAT5	258	261	PF00017	0.397
LIG_SH2_STAT5	333	336	PF00017	0.521
LIG_SH2_STAT5	59	62	PF00017	0.602
LIG_SH3_3	1	7	PF00018	0.528
LIG_SH3_3	152	158	PF00018	0.481
LIG_SH3_3	73	79	PF00018	0.388
LIG_SH3_3	90	96	PF00018	0.307
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.472
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.606
LIG_TRAF2_1	129	132	PF00917	0.706
LIG_TRAF2_1	311	314	PF00917	0.425
LIG_TYR_ITIM	57	62	PF00017	0.506
MOD_CDC14_SPxK_1	47	50	PF00782	0.535
MOD_CDK_SPxK_1	44	50	PF00069	0.541
MOD_CK1_1	124	130	PF00069	0.826
MOD_CK1_1	13	19	PF00069	0.381
MOD_CK1_1	151	157	PF00069	0.687
MOD_CK1_1	172	178	PF00069	0.727
MOD_CK1_1	193	199	PF00069	0.784
MOD_CK1_1	250	256	PF00069	0.474
MOD_CK1_1	42	48	PF00069	0.800
MOD_CK1_1	55	61	PF00069	0.430
MOD_CK1_1	98	104	PF00069	0.523
MOD_CK2_1	126	132	PF00069	0.775
MOD_CK2_1	26	32	PF00069	0.717
MOD_CK2_1	304	310	PF00069	0.763
MOD_GlcNHglycan	123	126	PF01048	0.763
MOD_GlcNHglycan	171	174	PF01048	0.439
MOD_GlcNHglycan	188	191	PF01048	0.523
MOD_GlcNHglycan	192	195	PF01048	0.790
MOD_GlcNHglycan	338	341	PF01048	0.392
MOD_GlcNHglycan	351	354	PF01048	0.389
MOD_GlcNHglycan	41	44	PF01048	0.811
MOD_GlcNHglycan	97	100	PF01048	0.621
MOD_GSK3_1	147	154	PF00069	0.563
MOD_GSK3_1	186	193	PF00069	0.781
MOD_GSK3_1	194	201	PF00069	0.790
MOD_GSK3_1	228	235	PF00069	0.436
MOD_GSK3_1	304	311	PF00069	0.503
MOD_GSK3_1	39	46	PF00069	0.810
MOD_GSK3_1	6	13	PF00069	0.623
MOD_NEK2_1	177	182	PF00069	0.572
MOD_NEK2_2	26	31	PF00069	0.597
MOD_PIKK_1	13	19	PF00454	0.388
MOD_PKA_2	103	109	PF00069	0.682
MOD_PKA_2	137	143	PF00069	0.597
MOD_PKA_2	169	175	PF00069	0.607
MOD_PKA_2	207	213	PF00069	0.582
MOD_PKA_2	308	314	PF00069	0.548
MOD_Plk_1	70	76	PF00069	0.552
MOD_Plk_4	177	183	PF00069	0.768
MOD_Plk_4	228	234	PF00069	0.412
MOD_Plk_4	55	61	PF00069	0.645
MOD_Plk_4	87	93	PF00069	0.359
MOD_ProDKin_1	183	189	PF00069	0.672
MOD_ProDKin_1	44	50	PF00069	0.578
MOD_ProDKin_1	52	58	PF00069	0.445
MOD_SUMO_rev_2	102	111	PF00179	0.550
MOD_SUMO_rev_2	275	285	PF00179	0.549
TRG_ENDOCYTIC_2	214	217	PF00928	0.430
TRG_ENDOCYTIC_2	323	326	PF00928	0.479
TRG_ENDOCYTIC_2	59	62	PF00928	0.500
TRG_ER_diArg_1	224	227	PF00400	0.523
TRG_ER_diArg_1	331	333	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W0	Leptomonas seymouri	40%	100%
A0A3S7X392	Leishmania donovani	69%	100%
A4I5F7	Leishmania infantum	68%	100%
E9B0Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q7H8	Leishmania major	69%	100%