Pyridoxal kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyridoxal kinase

Gene product:

pyridoxal kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI77_LEIBR

TriTrypDb:

LbrM.30.1370 , LBRM2903_300019200

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI77

PDB structure(s): 6k8z_A , 6k8z_B , 6k90_A , 6k90_B , 6k91_A , 6k91_B , 6k92_A , 6k92_B

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006766	vitamin metabolic process	3	12
GO:0006767	water-soluble vitamin metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009110	vitamin biosynthetic process	4	12
GO:0009443	pyridoxal 5'-phosphate salvage	4	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042364	water-soluble vitamin biosynthetic process	5	12
GO:0042816	vitamin B6 metabolic process	5	12
GO:0042819	vitamin B6 biosynthetic process	6	12
GO:0042822	pyridoxal phosphate metabolic process	4	12
GO:0042823	pyridoxal phosphate biosynthetic process	5	12
GO:0043094	cellular metabolic compound salvage	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046184	aldehyde biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	12
GO:0072525	pyridine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008478	pyridoxal kinase activity	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.449
CLV_PCSK_FUR_1	103	107	PF00082	0.226
CLV_PCSK_KEX2_1	105	107	PF00082	0.252
CLV_PCSK_KEX2_1	213	215	PF00082	0.342
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.226
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.388
CLV_PCSK_SKI1_1	187	191	PF00082	0.359
CLV_PCSK_SKI1_1	199	203	PF00082	0.373
CLV_PCSK_SKI1_1	22	26	PF00082	0.414
CLV_PCSK_SKI1_1	5	9	PF00082	0.420
DOC_CKS1_1	147	152	PF01111	0.502
DOC_CKS1_1	179	184	PF01111	0.579
DOC_CYCLIN_RxL_1	196	206	PF00134	0.588
DOC_MAPK_gen_1	111	117	PF00069	0.534
DOC_PP1_RVXF_1	110	117	PF00149	0.503
DOC_PP4_FxxP_1	117	120	PF00568	0.588
DOC_PP4_FxxP_1	189	192	PF00568	0.523
DOC_WW_Pin1_4	146	151	PF00397	0.502
DOC_WW_Pin1_4	178	183	PF00397	0.607
DOC_WW_Pin1_4	296	301	PF00397	0.585
LIG_14-3-3_CanoR_1	199	208	PF00244	0.565
LIG_14-3-3_CanoR_1	281	286	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_CaM_IQ_9	254	269	PF13499	0.607
LIG_CtBP_PxDLS_1	245	249	PF00389	0.588
LIG_FHA_1	158	164	PF00498	0.601
LIG_FHA_1	179	185	PF00498	0.537
LIG_FHA_1	214	220	PF00498	0.528
LIG_FHA_1	227	233	PF00498	0.502
LIG_FHA_1	23	29	PF00498	0.404
LIG_FHA_1	38	44	PF00498	0.365
LIG_FHA_1	61	67	PF00498	0.494
LIG_FHA_1	81	87	PF00498	0.329
LIG_FHA_2	188	194	PF00498	0.442
LIG_FHA_2	62	68	PF00498	0.428
LIG_FHA_2	96	102	PF00498	0.513
LIG_LIR_Apic_2	188	192	PF02991	0.426
LIG_LIR_Gen_1	60	69	PF02991	0.434
LIG_LIR_Gen_1	76	86	PF02991	0.370
LIG_LIR_Nem_3	212	218	PF02991	0.607
LIG_LIR_Nem_3	47	52	PF02991	0.473
LIG_LIR_Nem_3	60	65	PF02991	0.439
LIG_LIR_Nem_3	76	81	PF02991	0.375
LIG_LYPXL_yS_3	49	52	PF13949	0.471
LIG_NRBOX	197	203	PF00104	0.588
LIG_Rb_LxCxE_1	124	140	PF01857	0.588
LIG_SH2_CRK	215	219	PF00017	0.607
LIG_SH2_CRK	78	82	PF00017	0.365
LIG_SH2_GRB2like	85	88	PF00017	0.513
LIG_SH2_SRC	78	81	PF00017	0.514
LIG_SH2_STAP1	78	82	PF00017	0.428
LIG_SH2_STAT5	129	132	PF00017	0.517
LIG_SH2_STAT5	152	155	PF00017	0.588
LIG_SH2_STAT5	18	21	PF00017	0.389
LIG_SH2_STAT5	215	218	PF00017	0.576
LIG_SH2_STAT5	226	229	PF00017	0.512
LIG_SH2_STAT5	80	83	PF00017	0.368
LIG_SH2_STAT5	85	88	PF00017	0.498
LIG_SH3_3	189	195	PF00018	0.509
LIG_SUMO_SIM_par_1	159	165	PF11976	0.601
LIG_SUMO_SIM_par_1	181	188	PF11976	0.538
LIG_SUMO_SIM_par_1	293	299	PF11976	0.350
LIG_SUMO_SIM_par_1	39	44	PF11976	0.438
LIG_SUMO_SIM_par_1	6	12	PF11976	0.397
LIG_WRC_WIRS_1	186	191	PF05994	0.502
MOD_CK1_1	156	162	PF00069	0.513
MOD_CK1_1	44	50	PF00069	0.453
MOD_CK1_1	9	15	PF00069	0.402
MOD_CK2_1	156	162	PF00069	0.564
MOD_CK2_1	165	171	PF00069	0.509
MOD_CK2_1	95	101	PF00069	0.513
MOD_Cter_Amidation	109	112	PF01082	0.362
MOD_GlcNHglycan	167	170	PF01048	0.357
MOD_GlcNHglycan	269	272	PF01048	0.554
MOD_GlcNHglycan	46	49	PF01048	0.449
MOD_GSK3_1	153	160	PF00069	0.542
MOD_GSK3_1	209	216	PF00069	0.575
MOD_GSK3_1	267	274	PF00069	0.623
MOD_GSK3_1	290	297	PF00069	0.354
MOD_GSK3_1	37	44	PF00069	0.420
MOD_GSK3_1	57	64	PF00069	0.445
MOD_N-GLC_1	44	49	PF02516	0.439
MOD_NEK2_1	153	158	PF00069	0.562
MOD_NEK2_1	200	205	PF00069	0.523
MOD_NEK2_1	233	238	PF00069	0.530
MOD_PKA_1	213	219	PF00069	0.542
MOD_PKA_2	213	219	PF00069	0.513
MOD_PKA_2	224	230	PF00069	0.513
MOD_PKA_2	280	286	PF00069	0.490
MOD_Plk_1	153	159	PF00069	0.513
MOD_Plk_1	60	66	PF00069	0.466
MOD_Plk_2-3	61	67	PF00069	0.448
MOD_Plk_4	153	159	PF00069	0.504
MOD_Plk_4	180	186	PF00069	0.562
MOD_Plk_4	233	239	PF00069	0.542
MOD_Plk_4	291	297	PF00069	0.376
MOD_Plk_4	61	67	PF00069	0.448
MOD_ProDKin_1	146	152	PF00069	0.502
MOD_ProDKin_1	178	184	PF00069	0.607
MOD_ProDKin_1	296	302	PF00069	0.599
MOD_SUMO_rev_2	156	166	PF00179	0.592
TRG_DiLeu_BaEn_1	162	167	PF01217	0.426
TRG_DiLeu_BaEn_1	61	66	PF01217	0.325
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.351
TRG_ENDOCYTIC_2	138	141	PF00928	0.510
TRG_ENDOCYTIC_2	215	218	PF00928	0.607
TRG_ENDOCYTIC_2	49	52	PF00928	0.455
TRG_ENDOCYTIC_2	78	81	PF00928	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ2	Leptomonas seymouri	75%	100%
A0A0S4IJ51	Bodo saltans	41%	90%
A0A1X0P263	Trypanosomatidae	61%	98%
A0A3S7X3C0	Leishmania donovani	88%	100%
A0A422P4Z2	Trypanosoma rangeli	63%	100%
A1ADT5	Escherichia coli O1:K1 / APEC	31%	100%
A4I5F6	Leishmania infantum	88%	100%
A5UA83	Haemophilus influenzae (strain PittEE)	27%	100%
A7ZPL9	Escherichia coli O139:H28 (strain E24377A / ETEC)	31%	100%
A8A2R4	Escherichia coli O9:H4 (strain HS)	30%	100%
B0UUD2	Histophilus somni (strain 2336)	30%	100%
B1IX53	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	30%	100%
B1LML3	Escherichia coli (strain SMS-3-5 / SECEC)	31%	100%
B1XA89	Escherichia coli (strain K12 / DH10B)	30%	100%
B2TX08	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	31%	100%
B5YZW5	Escherichia coli O157:H7 (strain EC4115 / EHEC)	31%	100%
B6I4Z5	Escherichia coli (strain SE11)	31%	100%
B7LCG3	Escherichia coli (strain 55989 / EAEC)	31%	100%
B7LL66	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	31%	100%
B7M6S8	Escherichia coli O8 (strain IAI1)	31%	100%
B7MHS2	Escherichia coli O45:K1 (strain S88 / ExPEC)	31%	100%
B7MY71	Escherichia coli O81 (strain ED1a)	31%	100%
B7N609	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
B7NPV5	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	31%	100%
B7UGB9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	31%	100%
C3K4G7	Pseudomonas fluorescens (strain SBW25)	26%	100%
C4ZVU9	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	100%
C9ZQU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B0Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O00764	Homo sapiens	36%	97%
O01824	Caenorhabditis elegans	37%	94%
O14242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	98%
O31620	Bacillus subtilis (strain 168)	30%	100%
O35331	Rattus norvegicus	37%	97%
O46560	Sus scrofa	38%	94%
O74860	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	89%
P39988	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P40191	Escherichia coli (strain K12)	30%	100%
P40192	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
P44690	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
P44697	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	30%	100%
P53727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	95%
P77150	Escherichia coli (strain K12)	29%	100%
P82197	Ovis aries	39%	97%
Q0BSF0	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)	31%	100%
Q0I3D2	Haemophilus somnus (strain 129Pt)	30%	100%
Q0II59	Bos taurus	39%	97%
Q0TF48	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	31%	100%
Q0THJ1	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	29%	100%
Q141E8	Paraburkholderia xenovorans (strain LB400)	29%	100%
Q1BXQ7	Burkholderia cenocepacia (strain AU 1054)	30%	100%
Q1C792	Yersinia pestis bv. Antiqua (strain Antiqua)	29%	100%
Q1CIM6	Yersinia pestis bv. Antiqua (strain Nepal516)	29%	100%
Q1J237	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	33%	100%
Q1LFU5	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	28%	100%
Q1PCB1	Bombyx mori	38%	100%
Q1R8V2	Escherichia coli (strain UTI89 / UPEC)	31%	100%
Q1RBF9	Escherichia coli (strain UTI89 / UPEC)	29%	100%
Q2L1P5	Bordetella avium (strain 197N)	35%	100%
Q2SXQ4	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	32%	100%
Q320Z3	Shigella boydii serotype 4 (strain Sb227)	29%	100%
Q32DD5	Shigella dysenteriae serotype 1 (strain Sd197)	31%	100%
Q32FD7	Shigella dysenteriae serotype 1 (strain Sd197)	28%	100%
Q39I40	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	31%	100%
Q3JQA6	Burkholderia pseudomallei (strain 1710b)	31%	100%
Q3K4B8	Pseudomonas fluorescens (strain Pf0-1)	24%	100%
Q3YZC3	Shigella sonnei (strain Ss046)	31%	100%
Q3Z1Z2	Shigella sonnei (strain Ss046)	30%	100%
Q4K3F6	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	26%	100%
Q4Q7H9	Leishmania major	86%	100%
Q51892	Proteus mirabilis	28%	100%
Q55EK9	Dictyostelium discoideum	34%	100%
Q57LS3	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q57PI7	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q5E345	Aliivibrio fischeri (strain ATCC 700601 / ES114)	29%	100%
Q5PIK8	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q5PNC8	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q62LP6	Burkholderia mallei (strain ATCC 23344)	31%	100%
Q63SC2	Burkholderia pseudomallei (strain K96243)	31%	100%
Q65UE8	Mannheimia succiniciproducens (strain MBEL55E)	32%	100%
Q66A50	Yersinia pseudotuberculosis serotype I (strain IP32953)	29%	100%
Q6AFC1	Leifsonia xyli subsp. xyli (strain CTCB07)	29%	100%
Q6LP62	Photobacterium profundum (strain SS9)	28%	100%
Q6NG19	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	30%	100%
Q7CIR8	Yersinia pestis	29%	100%
Q7N3W7	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	28%	100%
Q7VYK4	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	31%	100%
Q7W6K7	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	31%	100%
Q7WII1	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	31%	100%
Q83K78	Shigella flexneri	30%	100%
Q83KY1	Shigella flexneri	29%	100%
Q88C26	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	29%	100%
Q8FFB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
Q8FH89	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
Q8K183	Mus musculus	38%	97%
Q8W1X2	Arabidopsis thaliana	37%	98%
Q8X649	Escherichia coli O157:H7	29%	100%
Q8XBL0	Escherichia coli O157:H7	31%	100%
Q8Z4W1	Salmonella typhi	28%	100%
Q8ZPM8	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
Q9CNY1	Pasteurella multocida (strain Pm70)	28%	100%
Q9RYX0	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	35%	100%
V5BPL8	Trypanosoma cruzi	61%	100%