Putative calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI76_LEIBR

TriTrypDb:

LbrM.30.1360 , LBRM2903_300019100

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HI76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI76

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.578
CLV_NRD_NRD_1	225	227	PF00675	0.370
CLV_NRD_NRD_1	307	309	PF00675	0.426
CLV_PCSK_KEX2_1	130	132	PF00082	0.455
CLV_PCSK_KEX2_1	225	227	PF00082	0.475
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.468
CLV_PCSK_SKI1_1	130	134	PF00082	0.553
CLV_PCSK_SKI1_1	184	188	PF00082	0.544
CLV_PCSK_SKI1_1	226	230	PF00082	0.511
CLV_PCSK_SKI1_1	310	314	PF00082	0.531
CLV_PCSK_SKI1_1	357	361	PF00082	0.440
CLV_PCSK_SKI1_1	38	42	PF00082	0.446
DEG_APCC_DBOX_1	183	191	PF00400	0.530
DEG_SPOP_SBC_1	100	104	PF00917	0.388
DOC_MAPK_gen_1	130	139	PF00069	0.557
DOC_MAPK_gen_1	15	24	PF00069	0.471
DOC_MAPK_gen_1	181	189	PF00069	0.564
DOC_MAPK_gen_1	308	315	PF00069	0.527
DOC_MAPK_gen_1	354	362	PF00069	0.452
DOC_MAPK_MEF2A_6	130	139	PF00069	0.521
DOC_PP2B_LxvP_1	118	121	PF13499	0.571
DOC_PP2B_LxvP_1	170	173	PF13499	0.752
DOC_PP2B_PxIxI_1	205	211	PF00149	0.538
DOC_SPAK_OSR1_1	131	135	PF12202	0.558
DOC_USP7_MATH_1	88	92	PF00917	0.702
DOC_USP7_UBL2_3	400	404	PF12436	0.520
LIG_14-3-3_CanoR_1	218	227	PF00244	0.572
LIG_Actin_WH2_2	179	196	PF00022	0.546
LIG_APCC_ABBA_1	372	377	PF00400	0.438
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	239	243	PF00533	0.466
LIG_BRCT_BRCA1_1	72	76	PF00533	0.370
LIG_EH1_1	109	117	PF00400	0.585
LIG_FHA_1	144	150	PF00498	0.658
LIG_FHA_1	262	268	PF00498	0.479
LIG_FHA_1	275	281	PF00498	0.601
LIG_FHA_1	374	380	PF00498	0.430
LIG_FHA_1	391	397	PF00498	0.534
LIG_FHA_1	400	406	PF00498	0.551
LIG_FHA_2	104	110	PF00498	0.564
LIG_FHA_2	257	263	PF00498	0.506
LIG_FHA_2	326	332	PF00498	0.562
LIG_Integrin_isoDGR_2	32	34	PF01839	0.426
LIG_Integrin_RGD_1	18	20	PF01839	0.533
LIG_LIR_Apic_2	401	406	PF02991	0.526
LIG_LIR_Gen_1	20	29	PF02991	0.426
LIG_LIR_Gen_1	265	276	PF02991	0.508
LIG_LIR_Gen_1	292	300	PF02991	0.436
LIG_LIR_Gen_1	314	321	PF02991	0.444
LIG_LIR_Gen_1	392	399	PF02991	0.372
LIG_LIR_Gen_1	8	16	PF02991	0.570
LIG_LIR_Nem_3	20	24	PF02991	0.412
LIG_LIR_Nem_3	265	271	PF02991	0.505
LIG_LIR_Nem_3	292	296	PF02991	0.450
LIG_LIR_Nem_3	314	319	PF02991	0.436
LIG_LIR_Nem_3	376	381	PF02991	0.411
LIG_LIR_Nem_3	392	398	PF02991	0.421
LIG_LIR_Nem_3	73	79	PF02991	0.519
LIG_LIR_Nem_3	8	13	PF02991	0.581
LIG_LYPXL_yS_3	65	68	PF13949	0.378
LIG_Pex14_1	408	412	PF04695	0.580
LIG_Pex14_1	48	52	PF04695	0.422
LIG_Pex14_2	359	363	PF04695	0.420
LIG_PTB_Apo_2	59	66	PF02174	0.590
LIG_PTB_Phospho_1	59	65	PF10480	0.588
LIG_SH2_CRK	382	386	PF00017	0.404
LIG_SH2_GRB2like	381	384	PF00017	0.415
LIG_SH2_NCK_1	10	14	PF00017	0.529
LIG_SH2_SRC	197	200	PF00017	0.577
LIG_SH2_STAP1	10	14	PF00017	0.663
LIG_SH2_STAP1	293	297	PF00017	0.429
LIG_SH2_STAP1	375	379	PF00017	0.410
LIG_SH2_STAT5	105	108	PF00017	0.548
LIG_SH2_STAT5	197	200	PF00017	0.459
LIG_SH2_STAT5	21	24	PF00017	0.543
LIG_SH2_STAT5	299	302	PF00017	0.448
LIG_SH2_STAT5	375	378	PF00017	0.528
LIG_SH2_STAT5	39	42	PF00017	0.275
LIG_SH2_STAT5	52	55	PF00017	0.400
LIG_SH2_STAT5	79	82	PF00017	0.461
LIG_SH3_1	69	75	PF00018	0.511
LIG_SH3_3	114	120	PF00018	0.547
LIG_SH3_3	276	282	PF00018	0.658
LIG_SH3_3	69	75	PF00018	0.492
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.449
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.431
LIG_SUMO_SIM_par_1	133	138	PF11976	0.563
LIG_SUMO_SIM_par_1	185	191	PF11976	0.515
LIG_SUMO_SIM_par_1	340	347	PF11976	0.498
LIG_TRAF2_1	282	285	PF00917	0.696
LIG_TRAF2_1	286	289	PF00917	0.614
LIG_TRFH_1	147	151	PF08558	0.640
LIG_TRFH_1	370	374	PF08558	0.478
MOD_CK1_1	157	163	PF00069	0.474
MOD_CK1_1	8	14	PF00069	0.647
MOD_CK1_1	91	97	PF00069	0.705
MOD_CK2_1	256	262	PF00069	0.545
MOD_Cter_Amidation	223	226	PF01082	0.530
MOD_GlcNHglycan	250	253	PF01048	0.421
MOD_GlcNHglycan	268	271	PF01048	0.498
MOD_GlcNHglycan	29	32	PF01048	0.593
MOD_GlcNHglycan	385	388	PF01048	0.413
MOD_GlcNHglycan	81	84	PF01048	0.360
MOD_GlcNHglycan	90	93	PF01048	0.642
MOD_GSK3_1	133	140	PF00069	0.502
MOD_GSK3_1	141	148	PF00069	0.505
MOD_GSK3_1	162	169	PF00069	0.637
MOD_GSK3_1	99	106	PF00069	0.556
MOD_LATS_1	141	147	PF00433	0.643
MOD_N-GLC_1	100	105	PF02516	0.602
MOD_N-GLC_1	155	160	PF02516	0.605
MOD_N-GLC_1	304	309	PF02516	0.520
MOD_N-GLC_1	325	330	PF02516	0.575
MOD_N-GLC_1	406	411	PF02516	0.588
MOD_NEK2_1	155	160	PF00069	0.602
MOD_NEK2_1	166	171	PF00069	0.558
MOD_NEK2_1	250	255	PF00069	0.561
MOD_NEK2_1	304	309	PF00069	0.487
MOD_NEK2_1	399	404	PF00069	0.530
MOD_NEK2_1	5	10	PF00069	0.591
MOD_NEK2_2	325	330	PF00069	0.575
MOD_NEK2_2	406	411	PF00069	0.576
MOD_PIKK_1	188	194	PF00454	0.528
MOD_PIKK_1	33	39	PF00454	0.532
MOD_PK_1	133	139	PF00069	0.567
MOD_PKA_1	218	224	PF00069	0.654
MOD_PKA_2	180	186	PF00069	0.402
MOD_PKA_2	33	39	PF00069	0.587
MOD_Plk_1	100	106	PF00069	0.577
MOD_Plk_1	137	143	PF00069	0.482
MOD_Plk_1	325	331	PF00069	0.572
MOD_Plk_1	390	396	PF00069	0.504
MOD_Plk_1	406	412	PF00069	0.577
MOD_Plk_1	5	11	PF00069	0.577
MOD_Plk_4	162	168	PF00069	0.679
MOD_Plk_4	263	269	PF00069	0.570
MOD_Plk_4	390	396	PF00069	0.413
MOD_Plk_4	5	11	PF00069	0.584
MOD_SUMO_rev_2	82	91	PF00179	0.403
TRG_DiLeu_BaEn_3	54	60	PF01217	0.573
TRG_ENDOCYTIC_2	10	13	PF00928	0.593
TRG_ENDOCYTIC_2	21	24	PF00928	0.479
TRG_ENDOCYTIC_2	293	296	PF00928	0.436
TRG_ENDOCYTIC_2	375	378	PF00928	0.450
TRG_ENDOCYTIC_2	382	385	PF00928	0.394
TRG_ENDOCYTIC_2	65	68	PF00928	0.600
TRG_ER_diArg_1	225	227	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW03	Leptomonas seymouri	22%	72%
A0A0N1IBZ1	Leptomonas seymouri	75%	99%
A0A0S4KEH4	Bodo saltans	34%	100%
A0A1X0P2M2	Trypanosomatidae	48%	100%
A0A3Q8IBX6	Leishmania donovani	87%	79%
A0A422P525	Trypanosoma rangeli	50%	100%
A4I676	Leishmania infantum	87%	78%
C9ZQU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B0Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	75%
Q4Q7I0	Leishmania major	88%	100%
V5BU66	Trypanosoma cruzi	49%	100%