RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4HI75_LEIBR

TriTrypDb:

LbrM.30.1350 , LBRM2903_300019000

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI75

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072344	rescue of stalled ribosome	6	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0005488	binding	1	4
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0044877	protein-containing complex binding	2	1
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.565
CLV_NRD_NRD_1	4	6	PF00675	0.605
CLV_NRD_NRD_1	446	448	PF00675	0.440
CLV_NRD_NRD_1	546	548	PF00675	0.552
CLV_NRD_NRD_1	591	593	PF00675	0.755
CLV_NRD_NRD_1	706	708	PF00675	0.609
CLV_NRD_NRD_1	72	74	PF00675	0.417
CLV_PCSK_KEX2_1	102	104	PF00082	0.565
CLV_PCSK_KEX2_1	212	214	PF00082	0.566
CLV_PCSK_KEX2_1	4	6	PF00082	0.605
CLV_PCSK_KEX2_1	706	708	PF00082	0.608
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.566
CLV_PCSK_SKI1_1	103	107	PF00082	0.479
CLV_PCSK_SKI1_1	172	176	PF00082	0.328
CLV_PCSK_SKI1_1	593	597	PF00082	0.640
CLV_PCSK_SKI1_1	74	78	PF00082	0.350
DEG_APCC_KENBOX_2	350	354	PF00400	0.646
DEG_SPOP_SBC_1	181	185	PF00917	0.273
DOC_ANK_TNKS_1	6	13	PF00023	0.461
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.434
DOC_MAPK_gen_1	73	81	PF00069	0.368
DOC_PP1_RVXF_1	296	302	PF00149	0.509
DOC_PP4_FxxP_1	497	500	PF00568	0.537
DOC_USP7_MATH_1	133	137	PF00917	0.418
DOC_USP7_MATH_1	181	185	PF00917	0.413
DOC_USP7_MATH_1	313	317	PF00917	0.615
DOC_USP7_MATH_1	324	328	PF00917	0.656
DOC_USP7_MATH_1	397	401	PF00917	0.582
DOC_USP7_MATH_1	555	559	PF00917	0.571
DOC_USP7_MATH_1	643	647	PF00917	0.593
DOC_USP7_MATH_1	657	661	PF00917	0.640
DOC_USP7_MATH_1	674	678	PF00917	0.599
DOC_WW_Pin1_4	114	119	PF00397	0.482
DOC_WW_Pin1_4	299	304	PF00397	0.570
DOC_WW_Pin1_4	461	466	PF00397	0.559
DOC_WW_Pin1_4	585	590	PF00397	0.683
DOC_WW_Pin1_4	632	637	PF00397	0.673
DOC_WW_Pin1_4	669	674	PF00397	0.736
LIG_14-3-3_CanoR_1	102	111	PF00244	0.486
LIG_14-3-3_CanoR_1	199	203	PF00244	0.575
LIG_14-3-3_CanoR_1	239	245	PF00244	0.480
LIG_14-3-3_CanoR_1	60	65	PF00244	0.417
LIG_Actin_WH2_2	97	114	PF00022	0.448
LIG_AP2alpha_2	144	146	PF02296	0.499
LIG_AP2alpha_2	626	628	PF02296	0.503
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_eIF4E_1	218	224	PF01652	0.376
LIG_EVH1_2	206	210	PF00568	0.424
LIG_FHA_1	129	135	PF00498	0.474
LIG_FHA_1	231	237	PF00498	0.404
LIG_FHA_1	388	394	PF00498	0.547
LIG_FHA_1	402	408	PF00498	0.748
LIG_FHA_1	511	517	PF00498	0.417
LIG_FHA_1	81	87	PF00498	0.398
LIG_FHA_2	417	423	PF00498	0.658
LIG_LIR_Apic_2	129	133	PF02991	0.322
LIG_LIR_Apic_2	495	500	PF02991	0.534
LIG_LIR_Gen_1	144	152	PF02991	0.391
LIG_LIR_Gen_1	161	169	PF02991	0.357
LIG_LIR_Gen_1	335	342	PF02991	0.547
LIG_LIR_Gen_1	422	431	PF02991	0.472
LIG_LIR_Gen_1	486	497	PF02991	0.304
LIG_LIR_Nem_3	144	149	PF02991	0.421
LIG_LIR_Nem_3	161	167	PF02991	0.419
LIG_LIR_Nem_3	243	247	PF02991	0.402
LIG_LIR_Nem_3	335	339	PF02991	0.553
LIG_LIR_Nem_3	422	428	PF02991	0.486
LIG_LIR_Nem_3	485	491	PF02991	0.355
LIG_LIR_Nem_3	694	700	PF02991	0.578
LIG_LRP6_Inhibitor_1	700	706	PF00058	0.598
LIG_NRP_CendR_1	723	724	PF00754	0.664
LIG_Pex14_1	138	142	PF04695	0.420
LIG_Pex14_2	242	246	PF04695	0.523
LIG_Pex14_2	336	340	PF04695	0.650
LIG_Pex14_2	503	507	PF04695	0.415
LIG_SH2_CRK	130	134	PF00017	0.354
LIG_SH2_CRK	489	493	PF00017	0.400
LIG_SH2_SRC	142	145	PF00017	0.413
LIG_SH2_SRC	385	388	PF00017	0.325
LIG_SH2_STAP1	182	186	PF00017	0.447
LIG_SH2_STAP1	232	236	PF00017	0.499
LIG_SH2_STAP1	474	478	PF00017	0.509
LIG_SH2_STAP1	489	493	PF00017	0.538
LIG_SH2_STAT5	110	113	PF00017	0.438
LIG_SH2_STAT5	130	133	PF00017	0.348
LIG_SH2_STAT5	164	167	PF00017	0.320
LIG_SH2_STAT5	232	235	PF00017	0.508
LIG_SH2_STAT5	385	388	PF00017	0.482
LIG_SH2_STAT5	474	477	PF00017	0.528
LIG_SH2_STAT5	52	55	PF00017	0.338
LIG_SH3_3	370	376	PF00018	0.519
LIG_SH3_3	695	701	PF00018	0.525
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.570
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.502
LIG_SUMO_SIM_par_1	507	513	PF11976	0.356
LIG_TRAF2_1	375	378	PF00917	0.520
LIG_TRAF2_1	522	525	PF00917	0.530
LIG_TRAF2_1	541	544	PF00917	0.344
LIG_TRAF2_1	558	561	PF00917	0.379
LIG_TRAF2_1	87	90	PF00917	0.550
LIG_TRAF2_1	94	97	PF00917	0.515
LIG_TRAF2_2	621	626	PF00917	0.724
LIG_TYR_ITIM	162	167	PF00017	0.318
MOD_CDK_SPxxK_3	585	592	PF00069	0.728
MOD_CK1_1	200	206	PF00069	0.516
MOD_CK1_1	316	322	PF00069	0.695
MOD_CK1_1	369	375	PF00069	0.384
MOD_CK1_1	408	414	PF00069	0.692
MOD_CK1_1	421	427	PF00069	0.650
MOD_CK1_1	635	641	PF00069	0.609
MOD_CK1_1	646	652	PF00069	0.602
MOD_CK1_1	669	675	PF00069	0.680
MOD_CK2_1	555	561	PF00069	0.480
MOD_CK2_1	84	90	PF00069	0.575
MOD_CK2_1	91	97	PF00069	0.562
MOD_Cter_Amidation	2	5	PF01082	0.545
MOD_Cter_Amidation	590	593	PF01082	0.573
MOD_GlcNHglycan	1	4	PF01048	0.610
MOD_GlcNHglycan	310	313	PF01048	0.654
MOD_GlcNHglycan	315	318	PF01048	0.670
MOD_GlcNHglycan	407	410	PF01048	0.718
MOD_GlcNHglycan	425	428	PF01048	0.627
MOD_GlcNHglycan	480	483	PF01048	0.427
MOD_GlcNHglycan	557	560	PF01048	0.580
MOD_GlcNHglycan	580	583	PF01048	0.607
MOD_GlcNHglycan	617	620	PF01048	0.776
MOD_GlcNHglycan	641	644	PF01048	0.633
MOD_GlcNHglycan	652	655	PF01048	0.582
MOD_GlcNHglycan	659	662	PF01048	0.613
MOD_GlcNHglycan	676	679	PF01048	0.622
MOD_GlcNHglycan	93	96	PF01048	0.486
MOD_GSK3_1	242	249	PF00069	0.480
MOD_GSK3_1	318	325	PF00069	0.683
MOD_GSK3_1	397	404	PF00069	0.469
MOD_GSK3_1	478	485	PF00069	0.500
MOD_GSK3_1	551	558	PF00069	0.487
MOD_GSK3_1	605	612	PF00069	0.669
MOD_GSK3_1	635	642	PF00069	0.621
MOD_GSK3_1	646	653	PF00069	0.522
MOD_GSK3_1	657	664	PF00069	0.641
MOD_GSK3_1	674	681	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.439
MOD_N-GLC_1	416	421	PF02516	0.722
MOD_N-GLC_1	569	574	PF02516	0.690
MOD_NEK2_1	242	247	PF00069	0.413
MOD_NEK2_1	478	483	PF00069	0.482
MOD_NEK2_1	614	619	PF00069	0.777
MOD_NEK2_2	50	55	PF00069	0.423
MOD_NEK2_2	643	648	PF00069	0.738
MOD_OFUCOSY	132	137	PF10250	0.410
MOD_OFUCOSY	49	54	PF10250	0.406
MOD_PIKK_1	80	86	PF00454	0.460
MOD_PK_1	60	66	PF00069	0.193
MOD_PKA_2	198	204	PF00069	0.558
MOD_Plk_1	197	203	PF00069	0.507
MOD_Plk_1	693	699	PF00069	0.646
MOD_Plk_2-3	268	274	PF00069	0.383
MOD_Plk_4	219	225	PF00069	0.458
MOD_ProDKin_1	114	120	PF00069	0.477
MOD_ProDKin_1	299	305	PF00069	0.572
MOD_ProDKin_1	461	467	PF00069	0.553
MOD_ProDKin_1	585	591	PF00069	0.684
MOD_ProDKin_1	632	638	PF00069	0.671
MOD_ProDKin_1	669	675	PF00069	0.738
MOD_SUMO_for_1	595	598	PF00179	0.510
MOD_SUMO_rev_2	24	30	PF00179	0.368
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.345
TRG_ENDOCYTIC_2	164	167	PF00928	0.320
TRG_ENDOCYTIC_2	468	471	PF00928	0.456
TRG_ENDOCYTIC_2	488	491	PF00928	0.308
TRG_ER_diArg_1	101	103	PF00400	0.486
TRG_ER_diArg_1	4	7	PF00400	0.487
TRG_ER_diArg_1	705	707	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA72	Leptomonas seymouri	62%	100%
A0A0S4KKN7	Bodo saltans	38%	100%
A0A1X0P1Y0	Trypanosomatidae	43%	100%
A0A3S7X380	Leishmania donovani	81%	100%
A0A422P542	Trypanosoma rangeli	43%	100%
A4I5F4	Leishmania infantum	81%	100%
C9ZQU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7I1	Leishmania major	80%	100%
V5BYZ6	Trypanosoma cruzi	37%	100%