RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4HI75_LEIBR

TriTrypDb:

LbrM.30.1350 , LBRM2903_300019000

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Expansion

Sequence features

A4HI75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI75

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0044877	protein-containing complex binding	2	1

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.565
CLV_NRD_NRD_1	4	6	PF00675	0.605
CLV_NRD_NRD_1	446	448	PF00675	0.440
CLV_NRD_NRD_1	546	548	PF00675	0.552
CLV_NRD_NRD_1	591	593	PF00675	0.755
CLV_NRD_NRD_1	706	708	PF00675	0.609
CLV_NRD_NRD_1	72	74	PF00675	0.417
CLV_PCSK_KEX2_1	102	104	PF00082	0.565
CLV_PCSK_KEX2_1	212	214	PF00082	0.566
CLV_PCSK_KEX2_1	4	6	PF00082	0.605

Previous1 2 3 4 5…18Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA72	Leptomonas seymouri	62%	100%
A0A0S4KKN7	Bodo saltans	38%	100%
A0A1X0P1Y0	Trypanosomatidae	43%	100%
A0A3S7X380	Leishmania donovani	81%	100%
A0A422P542	Trypanosoma rangeli	43%	100%
A4I5F4	Leishmania infantum	81%	100%
C9ZQU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7I1	Leishmania major	80%	100%
V5BYZ6	Trypanosoma cruzi	37%	100%

Previous1Next