Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI71_LEIBR

TriTrypDb:

LbrM.30.1290 , LBRM2903_300018400

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HI71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI71

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.775
CLV_C14_Caspase3-7	24	28	PF00656	0.680
CLV_NRD_NRD_1	157	159	PF00675	0.469
CLV_NRD_NRD_1	309	311	PF00675	0.538
CLV_NRD_NRD_1	328	330	PF00675	0.388
CLV_NRD_NRD_1	399	401	PF00675	0.495
CLV_NRD_NRD_1	478	480	PF00675	0.461
CLV_NRD_NRD_1	716	718	PF00675	0.445
CLV_PCSK_KEX2_1	157	159	PF00082	0.469
CLV_PCSK_KEX2_1	309	311	PF00082	0.466
CLV_PCSK_KEX2_1	398	400	PF00082	0.484
CLV_PCSK_KEX2_1	478	480	PF00082	0.466
CLV_PCSK_KEX2_1	674	676	PF00082	0.339
CLV_PCSK_KEX2_1	749	751	PF00082	0.470
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.339
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.470
CLV_PCSK_SKI1_1	399	403	PF00082	0.499
CLV_PCSK_SKI1_1	671	675	PF00082	0.335
CLV_PCSK_SKI1_1	83	87	PF00082	0.479
CLV_Separin_Metazoa	741	745	PF03568	0.727
DEG_APCC_DBOX_1	397	405	PF00400	0.687
DEG_APCC_DBOX_1	478	486	PF00400	0.590
DEG_APCC_KENBOX_2	253	257	PF00400	0.803
DEG_COP1_1	504	513	PF00400	0.694
DOC_ANK_TNKS_1	204	211	PF00023	0.658
DOC_CKS1_1	168	173	PF01111	0.669
DOC_CYCLIN_RxL_1	133	143	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	513	519	PF00134	0.640
DOC_MAPK_FxFP_2	10	13	PF00069	0.674
DOC_MAPK_FxFP_2	621	624	PF00069	0.411
DOC_MAPK_gen_1	599	609	PF00069	0.414
DOC_MAPK_MEF2A_6	407	415	PF00069	0.736
DOC_MAPK_MEF2A_6	602	611	PF00069	0.346
DOC_PP1_RVXF_1	703	709	PF00149	0.641
DOC_PP2B_LxvP_1	11	14	PF13499	0.668
DOC_PP2B_LxvP_1	508	511	PF13499	0.675
DOC_PP4_FxxP_1	10	13	PF00568	0.674
DOC_PP4_FxxP_1	390	393	PF00568	0.593
DOC_PP4_FxxP_1	621	624	PF00568	0.411
DOC_USP7_MATH_1	142	146	PF00917	0.669
DOC_USP7_MATH_1	181	185	PF00917	0.704
DOC_USP7_MATH_1	245	249	PF00917	0.730
DOC_USP7_MATH_1	25	29	PF00917	0.710
DOC_USP7_MATH_1	40	44	PF00917	0.745
DOC_USP7_MATH_1	439	443	PF00917	0.730
DOC_USP7_MATH_1	451	455	PF00917	0.734
DOC_USP7_MATH_1	46	50	PF00917	0.842
DOC_USP7_MATH_1	460	464	PF00917	0.650
DOC_USP7_MATH_1	53	57	PF00917	0.740
DOC_USP7_MATH_1	78	82	PF00917	0.711
DOC_USP7_UBL2_3	644	648	PF12436	0.546
DOC_WW_Pin1_4	138	143	PF00397	0.673
DOC_WW_Pin1_4	167	172	PF00397	0.669
DOC_WW_Pin1_4	241	246	PF00397	0.737
DOC_WW_Pin1_4	319	324	PF00397	0.624
DOC_WW_Pin1_4	33	38	PF00397	0.762
DOC_WW_Pin1_4	42	47	PF00397	0.797
LIG_14-3-3_CanoR_1	172	177	PF00244	0.666
LIG_14-3-3_CanoR_1	22	30	PF00244	0.834
LIG_14-3-3_CanoR_1	247	253	PF00244	0.735
LIG_14-3-3_CanoR_1	259	264	PF00244	0.735
LIG_14-3-3_CanoR_1	340	345	PF00244	0.515
LIG_14-3-3_CanoR_1	478	483	PF00244	0.691
LIG_14-3-3_CanoR_1	502	510	PF00244	0.707
LIG_14-3-3_CanoR_1	744	748	PF00244	0.548
LIG_14-3-3_CanoR_1	83	88	PF00244	0.808
LIG_BIR_II_1	1	5	PF00653	0.817
LIG_BRCT_BRCA1_1	313	317	PF00533	0.772
LIG_BRCT_BRCA1_1	48	52	PF00533	0.752
LIG_BRCT_BRCA1_1	565	569	PF00533	0.512
LIG_BRCT_BRCA1_1	649	653	PF00533	0.674
LIG_CtBP_PxDLS_1	191	195	PF00389	0.655
LIG_deltaCOP1_diTrp_1	365	375	PF00928	0.418
LIG_eIF4E_1	562	568	PF01652	0.411
LIG_FHA_1	127	133	PF00498	0.655
LIG_FHA_1	248	254	PF00498	0.794
LIG_FHA_1	491	497	PF00498	0.701
LIG_FHA_1	592	598	PF00498	0.402
LIG_FHA_1	738	744	PF00498	0.552
LIG_FHA_2	184	190	PF00498	0.661
LIG_FHA_2	268	274	PF00498	0.635
LIG_FHA_2	636	642	PF00498	0.538
LIG_HCF-1_HBM_1	662	665	PF13415	0.528
LIG_Integrin_RGD_1	407	409	PF01839	0.579
LIG_IRF3_LxIS_1	621	628	PF10401	0.265
LIG_LIR_Apic_2	9	13	PF02991	0.676
LIG_LIR_Gen_1	273	282	PF02991	0.627
LIG_LIR_Gen_1	381	390	PF02991	0.401
LIG_LIR_Gen_1	566	577	PF02991	0.512
LIG_LIR_Gen_1	594	603	PF02991	0.242
LIG_LIR_Gen_1	662	673	PF02991	0.507
LIG_LIR_Nem_3	273	279	PF02991	0.623
LIG_LIR_Nem_3	365	371	PF02991	0.488
LIG_LIR_Nem_3	381	387	PF02991	0.401
LIG_LIR_Nem_3	512	518	PF02991	0.646
LIG_LIR_Nem_3	558	563	PF02991	0.547
LIG_LIR_Nem_3	566	572	PF02991	0.479
LIG_LIR_Nem_3	594	598	PF02991	0.242
LIG_LIR_Nem_3	614	618	PF02991	0.388
LIG_LIR_Nem_3	650	656	PF02991	0.672
LIG_LIR_Nem_3	662	668	PF02991	0.510
LIG_LIR_Nem_3	689	695	PF02991	0.644
LIG_LYPXL_S_1	353	357	PF13949	0.411
LIG_MLH1_MIPbox_1	565	569	PF16413	0.512
LIG_MLH1_MIPbox_1	649	653	PF16413	0.674
LIG_MYND_3	510	514	PF01753	0.641
LIG_Pex14_1	342	346	PF04695	0.411
LIG_Pex14_2	515	519	PF04695	0.631
LIG_Pex14_2	564	568	PF04695	0.512
LIG_SH2_CRK	276	280	PF00017	0.681
LIG_SH2_CRK	348	352	PF00017	0.411
LIG_SH2_CRK	576	580	PF00017	0.411
LIG_SH2_CRK	605	609	PF00017	0.346
LIG_SH2_CRK	665	669	PF00017	0.615
LIG_SH2_GRB2like	665	668	PF00017	0.669
LIG_SH2_NCK_1	276	280	PF00017	0.631
LIG_SH2_SRC	590	593	PF00017	0.394
LIG_SH2_SRC	603	606	PF00017	0.282
LIG_SH2_SRC	665	668	PF00017	0.669
LIG_SH2_STAP1	276	280	PF00017	0.631
LIG_SH2_STAP1	456	460	PF00017	0.753
LIG_SH2_STAP1	576	580	PF00017	0.512
LIG_SH2_STAP1	669	673	PF00017	0.606
LIG_SH2_STAT5	252	255	PF00017	0.713
LIG_SH2_STAT5	456	459	PF00017	0.758
LIG_SH2_STAT5	488	491	PF00017	0.683
LIG_SH2_STAT5	562	565	PF00017	0.377
LIG_SH2_STAT5	590	593	PF00017	0.385
LIG_SH2_STAT5	612	615	PF00017	0.425
LIG_SH2_STAT5	652	655	PF00017	0.670
LIG_SH2_STAT5	669	672	PF00017	0.516
LIG_SH3_1	495	501	PF00018	0.643
LIG_SH3_3	165	171	PF00018	0.700
LIG_SH3_3	175	181	PF00018	0.702
LIG_SH3_3	212	218	PF00018	0.770
LIG_SH3_3	300	306	PF00018	0.683
LIG_SH3_3	333	339	PF00018	0.657
LIG_SH3_3	34	40	PF00018	0.810
LIG_SH3_3	410	416	PF00018	0.687
LIG_SH3_3	495	501	PF00018	0.631
LIG_SH3_3	60	66	PF00018	0.739
LIG_SUMO_SIM_anti_2	378	384	PF11976	0.512
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.680
LIG_SUMO_SIM_par_1	188	195	PF11976	0.658
LIG_SUMO_SIM_par_1	235	242	PF11976	0.695
LIG_SUMO_SIM_par_1	623	628	PF11976	0.265
LIG_SxIP_EBH_1	259	272	PF03271	0.737
LIG_TRAF2_1	271	274	PF00917	0.625
LIG_TRAF2_1	713	716	PF00917	0.643
LIG_TYR_ITIM	574	579	PF00017	0.411
LIG_UBA3_1	518	527	PF00899	0.265
LIG_WRC_WIRS_1	612	617	PF05994	0.411
MOD_CDK_SPK_2	167	172	PF00069	0.584
MOD_CDK_SPxK_1	241	247	PF00069	0.579
MOD_CK1_1	128	134	PF00069	0.642
MOD_CK1_1	183	189	PF00069	0.570
MOD_CK1_1	2	8	PF00069	0.630
MOD_CK1_1	246	252	PF00069	0.563
MOD_CK1_1	262	268	PF00069	0.469
MOD_CK1_1	378	384	PF00069	0.411
MOD_CK1_1	42	48	PF00069	0.758
MOD_CK1_1	454	460	PF00069	0.685
MOD_CK1_1	56	62	PF00069	0.692
MOD_CK2_1	142	148	PF00069	0.587
MOD_CK2_1	245	251	PF00069	0.768
MOD_CK2_1	25	31	PF00069	0.626
MOD_CK2_1	267	273	PF00069	0.545
MOD_CK2_1	635	641	PF00069	0.400
MOD_GlcNHglycan	132	135	PF01048	0.652
MOD_GlcNHglycan	143	147	PF01048	0.746
MOD_GlcNHglycan	183	186	PF01048	0.571
MOD_GlcNHglycan	23	26	PF01048	0.804
MOD_GlcNHglycan	377	380	PF01048	0.386
MOD_GlcNHglycan	4	7	PF01048	0.605
MOD_GlcNHglycan	42	45	PF01048	0.629
MOD_GlcNHglycan	441	444	PF01048	0.710
MOD_GlcNHglycan	462	465	PF01048	0.489
MOD_GlcNHglycan	48	51	PF01048	0.820
MOD_GSK3_1	119	126	PF00069	0.653
MOD_GSK3_1	138	145	PF00069	0.510
MOD_GSK3_1	172	179	PF00069	0.683
MOD_GSK3_1	181	188	PF00069	0.567
MOD_GSK3_1	21	28	PF00069	0.847
MOD_GSK3_1	241	248	PF00069	0.812
MOD_GSK3_1	301	308	PF00069	0.593
MOD_GSK3_1	42	49	PF00069	0.788
MOD_GSK3_1	477	484	PF00069	0.628
MOD_N-GLC_1	402	407	PF02516	0.633
MOD_N-GLC_1	451	456	PF02516	0.633
MOD_N-GLC_2	552	554	PF02516	0.485
MOD_NEK2_1	1	6	PF00069	0.586
MOD_NEK2_1	127	132	PF00069	0.584
MOD_NEK2_1	261	266	PF00069	0.611
MOD_NEK2_1	311	316	PF00069	0.609
MOD_NEK2_1	563	568	PF00069	0.352
MOD_NEK2_1	625	630	PF00069	0.409
MOD_NEK2_2	451	456	PF00069	0.488
MOD_OFUCOSY	548	554	PF10250	0.265
MOD_PIKK_1	432	438	PF00454	0.651
MOD_PIKK_1	657	663	PF00454	0.632
MOD_PK_1	172	178	PF00069	0.574
MOD_PKA_1	478	484	PF00069	0.580
MOD_PKA_2	21	27	PF00069	0.844
MOD_PKA_2	246	252	PF00069	0.563
MOD_PKA_2	328	334	PF00069	0.508
MOD_PKA_2	477	483	PF00069	0.627
MOD_PKA_2	501	507	PF00069	0.749
MOD_PKA_2	743	749	PF00069	0.420
MOD_Plk_1	451	457	PF00069	0.623
MOD_Plk_4	106	112	PF00069	0.573
MOD_Plk_4	232	238	PF00069	0.643
MOD_Plk_4	378	384	PF00069	0.404
MOD_Plk_4	451	457	PF00069	0.721
MOD_Plk_4	470	476	PF00069	0.598
MOD_Plk_4	478	484	PF00069	0.627
MOD_Plk_4	563	569	PF00069	0.411
MOD_ProDKin_1	138	144	PF00069	0.588
MOD_ProDKin_1	167	173	PF00069	0.584
MOD_ProDKin_1	241	247	PF00069	0.677
MOD_ProDKin_1	319	325	PF00069	0.521
MOD_ProDKin_1	33	39	PF00069	0.710
MOD_ProDKin_1	42	48	PF00069	0.763
MOD_SUMO_rev_2	292	300	PF00179	0.605
MOD_SUMO_rev_2	322	331	PF00179	0.502
MOD_SUMO_rev_2	702	706	PF00179	0.540
MOD_SUMO_rev_2	715	720	PF00179	0.552
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.265
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.228
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.199
TRG_ENDOCYTIC_2	276	279	PF00928	0.523
TRG_ENDOCYTIC_2	348	351	PF00928	0.411
TRG_ENDOCYTIC_2	354	357	PF00928	0.183
TRG_ENDOCYTIC_2	560	563	PF00928	0.411
TRG_ENDOCYTIC_2	576	579	PF00928	0.411
TRG_ENDOCYTIC_2	612	615	PF00928	0.411
TRG_ENDOCYTIC_2	665	668	PF00928	0.500
TRG_ENDOCYTIC_2	669	672	PF00928	0.468
TRG_ENDOCYTIC_2	692	695	PF00928	0.541
TRG_ER_diArg_1	309	311	PF00400	0.679
TRG_ER_diArg_1	397	400	PF00400	0.592
TRG_NLS_MonoExtC_3	643	648	PF00514	0.294
TRG_NLS_MonoExtN_4	644	649	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P984	Leptomonas seymouri	63%	100%
A0A3Q8IHU7	Leishmania donovani	72%	100%
A4I5E8	Leishmania infantum	72%	100%
E9B0P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q7I6	Leishmania major	79%	100%