Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI68_LEIBR

TriTrypDb:

LbrM.30.1260 , LBRM2903_300018100

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HI68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.488
CLV_NRD_NRD_1	173	175	PF00675	0.726
CLV_PCSK_KEX2_1	133	135	PF00082	0.490
CLV_PCSK_KEX2_1	173	175	PF00082	0.706
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.490
CLV_PCSK_SKI1_1	126	130	PF00082	0.504
CLV_PCSK_SKI1_1	137	141	PF00082	0.338
DEG_Nend_UBRbox_3	1	3	PF02207	0.754
DOC_CYCLIN_RxL_1	123	130	PF00134	0.580
DOC_CYCLIN_RxL_1	149	158	PF00134	0.513
DOC_MAPK_gen_1	133	141	PF00069	0.670
DOC_PP1_RVXF_1	135	142	PF00149	0.678
DOC_PP1_RVXF_1	150	157	PF00149	0.353
DOC_USP7_MATH_1	51	55	PF00917	0.490
DOC_USP7_MATH_1	56	60	PF00917	0.482
DOC_WW_Pin1_4	127	132	PF00397	0.584
DOC_WW_Pin1_4	63	68	PF00397	0.568
DOC_WW_Pin1_4	98	103	PF00397	0.760
LIG_14-3-3_CanoR_1	173	177	PF00244	0.376
LIG_FHA_1	103	109	PF00498	0.671
LIG_FHA_1	122	128	PF00498	0.578
LIG_FHA_1	32	38	PF00498	0.411
LIG_FHA_1	39	45	PF00498	0.411
LIG_FHA_1	64	70	PF00498	0.507
LIG_FHA_1	72	78	PF00498	0.448
LIG_FHA_1	81	87	PF00498	0.353
LIG_LIR_Gen_1	71	81	PF02991	0.411
LIG_LIR_LC3C_4	41	44	PF02991	0.418
LIG_LIR_LC3C_4	8	11	PF02991	0.667
LIG_LIR_Nem_3	155	159	PF02991	0.524
LIG_LIR_Nem_3	71	76	PF02991	0.411
LIG_LIR_Nem_3	88	94	PF02991	0.609
LIG_Rb_pABgroove_1	7	15	PF01858	0.669
LIG_SH2_CRK	91	95	PF00017	0.767
LIG_SH2_STAT3	177	180	PF00017	0.379
LIG_SH2_STAT5	107	110	PF00017	0.678
LIG_SH2_STAT5	24	27	PF00017	0.763
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.513
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.667
LIG_SUMO_SIM_par_1	34	41	PF11976	0.469
LIG_SUMO_SIM_par_1	8	15	PF11976	0.687
LIG_SUMO_SIM_par_1	82	88	PF11976	0.506
LIG_TRAF2_1	120	123	PF00917	0.577
LIG_TYR_ITIM	89	94	PF00017	0.714
LIG_WRC_WIRS_1	153	158	PF05994	0.411
LIG_WRC_WIRS_1	70	75	PF05994	0.411
MOD_CDC14_SPxK_1	130	133	PF00782	0.575
MOD_CDK_SPK_2	98	103	PF00069	0.760
MOD_CDK_SPxK_1	127	133	PF00069	0.581
MOD_CDK_SPxxK_3	127	134	PF00069	0.582
MOD_CK1_1	155	161	PF00069	0.513
MOD_CK1_1	38	44	PF00069	0.513
MOD_CK1_1	72	78	PF00069	0.306
MOD_CK1_1	80	86	PF00069	0.418
MOD_CK2_1	2	8	PF00069	0.692
MOD_CK2_1	98	104	PF00069	0.755
MOD_CMANNOS	167	170	PF00535	0.678
MOD_GlcNHglycan	53	56	PF01048	0.692
MOD_GlcNHglycan	58	61	PF01048	0.691
MOD_GSK3_1	168	175	PF00069	0.370
MOD_GSK3_1	31	38	PF00069	0.448
MOD_GSK3_1	51	58	PF00069	0.322
MOD_GSK3_1	68	75	PF00069	0.225
MOD_GSK3_1	94	101	PF00069	0.693
MOD_NEK2_1	12	17	PF00069	0.706
MOD_NEK2_1	121	126	PF00069	0.635
MOD_NEK2_1	20	25	PF00069	0.746
MOD_NEK2_1	32	37	PF00069	0.183
MOD_NEK2_1	50	55	PF00069	0.417
MOD_NEK2_1	68	73	PF00069	0.379
MOD_NEK2_1	85	90	PF00069	0.388
MOD_NEK2_2	168	173	PF00069	0.550
MOD_PIKK_1	12	18	PF00454	0.759
MOD_PIKK_1	61	67	PF00454	0.387
MOD_PKA_2	102	108	PF00069	0.716
MOD_PKA_2	172	178	PF00069	0.375
MOD_Plk_1	121	127	PF00069	0.759
MOD_Plk_4	152	158	PF00069	0.397
MOD_Plk_4	161	167	PF00069	0.411
MOD_Plk_4	20	26	PF00069	0.721
MOD_Plk_4	32	38	PF00069	0.298
MOD_Plk_4	72	78	PF00069	0.467
MOD_Plk_4	80	86	PF00069	0.416
MOD_Plk_4	94	100	PF00069	0.625
MOD_ProDKin_1	127	133	PF00069	0.581
MOD_ProDKin_1	63	69	PF00069	0.567
MOD_ProDKin_1	98	104	PF00069	0.755
TRG_DiLeu_BaEn_1	123	128	PF01217	0.582
TRG_DiLeu_BaEn_1	149	154	PF01217	0.261
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.497
TRG_DiLeu_LyEn_5	123	128	PF01217	0.582
TRG_ENDOCYTIC_2	91	94	PF00928	0.765
TRG_ER_diArg_1	172	174	PF00400	0.527
TRG_NES_CRM1_1	2	14	PF08389	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z6	Leptomonas seymouri	52%	100%
A0A3S7X3F8	Leishmania donovani	76%	100%
A4I5E5	Leishmania infantum	76%	100%
E9B0P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q7I9	Leishmania major	76%	100%