Importin subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

importin alpha, putative

Species:

Leishmania braziliensis

UniProt:

A4HI66_LEIBR

TriTrypDb:

LbrM.30.1240 , LBRM2903_300017900

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HI66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI66

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0006607	NLS-bearing protein import into nucleus	6	1

Molecular functions
Term	Name	Level	Count
GO:0061608	nuclear import signal receptor activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140142	nucleocytoplasmic carrier activity	2	12
GO:0005048	signal sequence binding	4	1
GO:0005488	binding	1	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.357
CLV_NRD_NRD_1	22	24	PF00675	0.568
CLV_NRD_NRD_1	355	357	PF00675	0.334
CLV_PCSK_KEX2_1	22	24	PF00082	0.568
CLV_PCSK_KEX2_1	352	354	PF00082	0.307
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.322
CLV_PCSK_SKI1_1	109	113	PF00082	0.320
CLV_PCSK_SKI1_1	232	236	PF00082	0.341
CLV_PCSK_SKI1_1	352	356	PF00082	0.402
CLV_PCSK_SKI1_1	439	443	PF00082	0.363
CLV_PCSK_SKI1_1	8	12	PF00082	0.644
CLV_PCSK_SKI1_1	99	103	PF00082	0.445
CLV_Separin_Metazoa	346	350	PF03568	0.448
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DEG_SPOP_SBC_1	122	126	PF00917	0.448
DOC_CDC14_PxL_1	423	431	PF14671	0.483
DOC_CDC14_PxL_1	82	90	PF14671	0.540
DOC_MAPK_gen_1	22	30	PF00069	0.583
DOC_MAPK_MEF2A_6	138	146	PF00069	0.322
DOC_MAPK_MEF2A_6	418	425	PF00069	0.443
DOC_MAPK_MEF2A_6	491	500	PF00069	0.569
DOC_MAPK_RevD_3	385	399	PF00069	0.341
DOC_PP2B_LxvP_1	306	309	PF13499	0.400
DOC_PP2B_LxvP_1	390	393	PF13499	0.448
DOC_PP2B_PxIxI_1	315	321	PF00149	0.448
DOC_USP7_MATH_1	122	126	PF00917	0.336
DOC_USP7_MATH_1	157	161	PF00917	0.322
DOC_USP7_MATH_1	60	64	PF00917	0.657
DOC_USP7_UBL2_3	7	11	PF12436	0.765
DOC_WW_Pin1_4	178	183	PF00397	0.366
DOC_WW_Pin1_4	73	78	PF00397	0.579
LIG_14-3-3_CanoR_1	109	115	PF00244	0.397
LIG_14-3-3_CanoR_1	232	237	PF00244	0.341
LIG_14-3-3_CanoR_1	25	31	PF00244	0.602
LIG_Actin_WH2_2	216	234	PF00022	0.400
LIG_APCC_ABBAyCdc20_2	31	37	PF00400	0.613
LIG_deltaCOP1_diTrp_1	400	410	PF00928	0.448
LIG_EH1_1	371	379	PF00400	0.448
LIG_eIF4E_1	372	378	PF01652	0.448
LIG_FHA_1	103	109	PF00498	0.382
LIG_FHA_1	161	167	PF00498	0.345
LIG_FHA_1	233	239	PF00498	0.341
LIG_FHA_1	330	336	PF00498	0.411
LIG_FHA_1	440	446	PF00498	0.352
LIG_FHA_2	257	263	PF00498	0.448
LIG_FHA_2	485	491	PF00498	0.582
LIG_FHA_2	504	510	PF00498	0.399
LIG_FHA_2	95	101	PF00498	0.482
LIG_LIR_Gen_1	117	128	PF02991	0.448
LIG_LIR_Nem_3	117	123	PF02991	0.468
LIG_LIR_Nem_3	139	144	PF02991	0.428
LIG_LYPXL_yS_3	141	144	PF13949	0.400
LIG_MAD2	110	118	PF02301	0.498
LIG_MAD2	301	309	PF02301	0.448
LIG_MYND_3	247	251	PF01753	0.508
LIG_NRBOX	131	137	PF00104	0.400
LIG_NRBOX	259	265	PF00104	0.322
LIG_PDZ_Class_2	534	539	PF00595	0.618
LIG_Pex14_1	277	281	PF04695	0.307
LIG_Pex14_2	146	150	PF04695	0.307
LIG_PTB_Apo_2	404	411	PF02174	0.448
LIG_SH2_CRK	120	124	PF00017	0.449
LIG_SH2_NCK_1	120	124	PF00017	0.448
LIG_SH2_STAT5	281	284	PF00017	0.322
LIG_SH2_STAT5	419	422	PF00017	0.352
LIG_SH3_1	243	249	PF00018	0.391
LIG_SH3_3	243	249	PF00018	0.391
LIG_SH3_3	310	316	PF00018	0.408
LIG_SH3_3	379	385	PF00018	0.448
LIG_SH3_3	422	428	PF00018	0.367
LIG_SH3_3	59	65	PF00018	0.573
LIG_SUMO_SIM_anti_2	259	269	PF11976	0.448
LIG_SUMO_SIM_par_1	110	115	PF11976	0.386
LIG_SUMO_SIM_par_1	219	225	PF11976	0.448
LIG_SUMO_SIM_par_1	304	311	PF11976	0.413
LIG_SUMO_SIM_par_1	441	446	PF11976	0.350
LIG_UBA3_1	107	116	PF00899	0.467
LIG_UBA3_1	217	224	PF00899	0.392
LIG_WRC_WIRS_1	501	506	PF05994	0.569
MOD_CK1_1	160	166	PF00069	0.362
MOD_CK1_1	280	286	PF00069	0.307
MOD_CK1_1	307	313	PF00069	0.369
MOD_CK1_1	503	509	PF00069	0.567
MOD_CK2_1	219	225	PF00069	0.448
MOD_CK2_1	388	394	PF00069	0.448
MOD_CK2_1	504	510	PF00069	0.511
MOD_CK2_1	60	66	PF00069	0.650
MOD_CK2_1	94	100	PF00069	0.431
MOD_GlcNHglycan	125	128	PF01048	0.322
MOD_GlcNHglycan	147	150	PF01048	0.413
MOD_GlcNHglycan	188	192	PF01048	0.448
MOD_GlcNHglycan	197	200	PF01048	0.509
MOD_GlcNHglycan	337	340	PF01048	0.351
MOD_GlcNHglycan	390	393	PF01048	0.445
MOD_GlcNHglycan	460	463	PF01048	0.609
MOD_GlcNHglycan	515	518	PF01048	0.536
MOD_GSK3_1	156	163	PF00069	0.328
MOD_GSK3_1	232	239	PF00069	0.341
MOD_GSK3_1	304	311	PF00069	0.339
MOD_GSK3_1	325	332	PF00069	0.379
MOD_GSK3_1	406	413	PF00069	0.495
MOD_GSK3_1	500	507	PF00069	0.490
MOD_GSK3_1	72	79	PF00069	0.554
MOD_N-GLC_1	195	200	PF02516	0.448
MOD_N-GLC_1	232	237	PF02516	0.341
MOD_N-GLC_1	264	269	PF02516	0.392
MOD_N-GLC_1	406	411	PF02516	0.341
MOD_N-GLC_2	240	242	PF02516	0.341
MOD_N-GLC_2	381	383	PF02516	0.437
MOD_N-GLC_2	90	92	PF02516	0.522
MOD_NEK2_1	102	107	PF00069	0.435
MOD_NEK2_1	377	382	PF00069	0.392
MOD_NEK2_1	410	415	PF00069	0.521
MOD_PIKK_1	329	335	PF00454	0.308
MOD_PK_1	110	116	PF00069	0.413
MOD_PKA_1	356	362	PF00069	0.322
MOD_Plk_1	160	166	PF00069	0.370
MOD_Plk_1	187	193	PF00069	0.452
MOD_Plk_1	232	238	PF00069	0.341
MOD_Plk_1	329	335	PF00069	0.448
MOD_Plk_1	406	412	PF00069	0.341
MOD_Plk_2-3	67	73	PF00069	0.535
MOD_Plk_4	102	108	PF00069	0.251
MOD_Plk_4	160	166	PF00069	0.389
MOD_Plk_4	256	262	PF00069	0.376
MOD_Plk_4	500	506	PF00069	0.495
MOD_Plk_4	84	90	PF00069	0.515
MOD_ProDKin_1	178	184	PF00069	0.366
MOD_ProDKin_1	73	79	PF00069	0.573
MOD_SUMO_for_1	397	400	PF00179	0.224
MOD_SUMO_rev_2	431	441	PF00179	0.385
MOD_SUMO_rev_2	456	461	PF00179	0.460
TRG_ENDOCYTIC_2	120	123	PF00928	0.447
TRG_ENDOCYTIC_2	141	144	PF00928	0.437
TRG_ER_diArg_1	22	25	PF00400	0.583
TRG_NES_CRM1_1	373	388	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK7	Leptomonas seymouri	87%	100%
A0A0S4KNG1	Bodo saltans	50%	100%
A0A1X0P216	Trypanosomatidae	57%	100%
A0A3R7LEH1	Trypanosoma rangeli	54%	100%
A0A3S7X3A8	Leishmania donovani	95%	100%
A2VE08	Bos taurus	40%	100%
A4I5E3	Leishmania infantum	95%	100%
A9QM74	Homo sapiens	41%	100%
B6HJ92	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	40%	98%
C0LLJ0	Mus musculus	38%	100%
C1JZ66	Bos taurus	41%	100%
C6K7I2	Sus scrofa	40%	100%
C9ZQT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B0P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F4JL11	Arabidopsis thaliana	41%	100%
F4KF65	Arabidopsis thaliana	28%	100%
G5EB89	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	97%
O00505	Homo sapiens	39%	100%
O00629	Homo sapiens	41%	100%
O04294	Arabidopsis thaliana	41%	100%
O14063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	99%
O15131	Homo sapiens	42%	100%
O22478	Solanum lycopersicum	39%	100%
O35343	Mus musculus	42%	100%
O35344	Mus musculus	39%	100%
O35345	Mus musculus	42%	100%
O60684	Homo sapiens	42%	100%
O80480	Arabidopsis thaliana	40%	100%
O94374	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P52170	Xenopus laevis	39%	100%
P52171	Xenopus laevis	38%	100%
P52292	Homo sapiens	45%	100%
P52293	Mus musculus	45%	100%
P52294	Homo sapiens	40%	100%
P52295	Drosophila melanogaster	35%	100%
P83953	Rattus norvegicus	40%	100%
P91276	Caenorhabditis elegans	33%	100%
Q02821	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	99%
Q0V7M0	Bos taurus	42%	100%
Q19969	Caenorhabditis elegans	40%	100%
Q4Q7J1	Leishmania major	94%	100%
Q4WVW4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	93%
Q503E9	Danio rerio	41%	100%
Q557F4	Dictyostelium discoideum	32%	98%
Q56R16	Rattus norvegicus	42%	100%
Q5R909	Pongo abelii	40%	100%
Q5RBV0	Pongo abelii	42%	100%
Q5ZML1	Gallus gallus	40%	100%
Q60960	Mus musculus	40%	100%
Q71VM4	Oryza sativa subsp. japonica	41%	100%
Q76P29	Dictyostelium discoideum	42%	100%
Q96321	Arabidopsis thaliana	41%	100%
Q9FJ09	Arabidopsis thaliana	41%	100%
Q9FJ92	Arabidopsis thaliana	37%	100%
Q9FWY7	Arabidopsis thaliana	41%	100%
Q9FYP9	Oryza sativa subsp. japonica	28%	100%
Q9M9X7	Arabidopsis thaliana	41%	100%
Q9SLX0	Oryza sativa subsp. japonica	44%	100%
V5B924	Trypanosoma cruzi	54%	100%