Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI65_LEIBR

TriTrypDb:

LbrM.30.1230 , LBRM2903_300017800

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.711
CLV_NRD_NRD_1	144	146	PF00675	0.725
CLV_NRD_NRD_1	355	357	PF00675	0.638
CLV_NRD_NRD_1	422	424	PF00675	0.803
CLV_NRD_NRD_1	50	52	PF00675	0.636
CLV_NRD_NRD_1	612	614	PF00675	0.656
CLV_PCSK_FUR_1	609	613	PF00082	0.698
CLV_PCSK_KEX2_1	112	114	PF00082	0.711
CLV_PCSK_KEX2_1	144	146	PF00082	0.716
CLV_PCSK_KEX2_1	354	356	PF00082	0.647
CLV_PCSK_KEX2_1	424	426	PF00082	0.809
CLV_PCSK_KEX2_1	499	501	PF00082	0.450
CLV_PCSK_KEX2_1	50	52	PF00082	0.636
CLV_PCSK_KEX2_1	510	512	PF00082	0.443
CLV_PCSK_KEX2_1	609	611	PF00082	0.608
CLV_PCSK_KEX2_1	612	614	PF00082	0.648
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.809
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.450
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.443
CLV_PCSK_SKI1_1	150	154	PF00082	0.807
CLV_PCSK_SKI1_1	20	24	PF00082	0.611
CLV_PCSK_SKI1_1	479	483	PF00082	0.585
CLV_PCSK_SKI1_1	510	514	PF00082	0.429
DEG_APCC_DBOX_1	586	594	PF00400	0.503
DEG_Nend_UBRbox_1	1	4	PF02207	0.719
DOC_CKS1_1	292	297	PF01111	0.375
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.511
DOC_MAPK_gen_1	188	196	PF00069	0.611
DOC_MAPK_gen_1	213	222	PF00069	0.611
DOC_MAPK_gen_1	423	432	PF00069	0.509
DOC_MAPK_gen_1	596	605	PF00069	0.605
DOC_MAPK_MEF2A_6	215	224	PF00069	0.719
DOC_MAPK_MEF2A_6	334	342	PF00069	0.544
DOC_MIT_MIM_1	429	439	PF04212	0.424
DOC_PP1_RVXF_1	337	343	PF00149	0.491
DOC_PP1_RVXF_1	556	562	PF00149	0.621
DOC_PP2B_LxvP_1	399	402	PF13499	0.727
DOC_USP7_MATH_1	16	20	PF00917	0.667
DOC_USP7_MATH_1	182	186	PF00917	0.611
DOC_USP7_MATH_1	237	241	PF00917	0.841
DOC_USP7_MATH_1	247	251	PF00917	0.667
DOC_USP7_MATH_1	360	364	PF00917	0.704
DOC_WW_Pin1_4	267	272	PF00397	0.574
DOC_WW_Pin1_4	291	296	PF00397	0.376
DOC_WW_Pin1_4	333	338	PF00397	0.638
DOC_WW_Pin1_4	452	457	PF00397	0.513
DOC_WW_Pin1_4	483	488	PF00397	0.508
LIG_14-3-3_CanoR_1	339	343	PF00244	0.494
LIG_14-3-3_CanoR_1	435	440	PF00244	0.497
LIG_14-3-3_CanoR_1	479	485	PF00244	0.366
LIG_14-3-3_CanoR_1	558	562	PF00244	0.555
LIG_Actin_WH2_2	463	481	PF00022	0.534
LIG_BRCT_BRCA1_1	42	46	PF00533	0.522
LIG_DLG_GKlike_1	435	443	PF00625	0.502
LIG_EH1_1	539	547	PF00400	0.531
LIG_eIF4E_1	394	400	PF01652	0.538
LIG_eIF4E_1	540	546	PF01652	0.509
LIG_FHA_1	204	210	PF00498	0.532
LIG_FHA_1	270	276	PF00498	0.493
LIG_FHA_1	3	9	PF00498	0.494
LIG_FHA_1	305	311	PF00498	0.561
LIG_FHA_1	384	390	PF00498	0.741
LIG_FHA_1	396	402	PF00498	0.638
LIG_FHA_1	517	523	PF00498	0.439
LIG_FHA_1	525	531	PF00498	0.525
LIG_FHA_1	558	564	PF00498	0.531
LIG_FHA_2	240	246	PF00498	0.770
LIG_FHA_2	292	298	PF00498	0.482
LIG_FHA_2	348	354	PF00498	0.567
LIG_FHA_2	80	86	PF00498	0.673
LIG_LIR_Gen_1	174	183	PF02991	0.613
LIG_LIR_Gen_1	43	53	PF02991	0.552
LIG_LIR_Nem_3	174	180	PF02991	0.530
LIG_LIR_Nem_3	290	296	PF02991	0.487
LIG_LIR_Nem_3	43	49	PF02991	0.610
LIG_LIR_Nem_3	483	488	PF02991	0.424
LIG_LIR_Nem_3	526	532	PF02991	0.557
LIG_NRBOX	435	441	PF00104	0.515
LIG_NRBOX	540	546	PF00104	0.538
LIG_Pex14_1	9	13	PF04695	0.610
LIG_SH2_CRK	255	259	PF00017	0.760
LIG_SH2_CRK	44	48	PF00017	0.491
LIG_SH2_CRK	485	489	PF00017	0.502
LIG_SH2_GRB2like	255	258	PF00017	0.582
LIG_SH2_NCK_1	13	17	PF00017	0.664
LIG_SH2_NCK_1	199	203	PF00017	0.611
LIG_SH2_NCK_1	255	259	PF00017	0.581
LIG_SH2_NCK_1	349	353	PF00017	0.651
LIG_SH2_SRC	13	16	PF00017	0.657
LIG_SH2_STAP1	582	586	PF00017	0.589
LIG_SH2_STAT3	582	585	PF00017	0.657
LIG_SH2_STAT5	167	170	PF00017	0.614
LIG_SH2_STAT5	276	279	PF00017	0.507
LIG_SH2_STAT5	349	352	PF00017	0.684
LIG_SH2_STAT5	529	532	PF00017	0.560
LIG_SH2_STAT5	540	543	PF00017	0.428
LIG_SH2_STAT5	81	84	PF00017	0.670
LIG_SH3_1	136	142	PF00018	0.831
LIG_SH3_2	139	144	PF14604	0.811
LIG_SH3_3	136	142	PF00018	0.797
LIG_SH3_3	176	182	PF00018	0.611
LIG_SH3_3	86	92	PF00018	0.693
LIG_SH3_3	97	103	PF00018	0.705
LIG_SUMO_SIM_par_1	542	549	PF11976	0.498
LIG_TRAF2_1	82	85	PF00917	0.681
LIG_TYR_ITIM	197	202	PF00017	0.611
LIG_WRC_WIRS_1	563	568	PF05994	0.623
MOD_CDC14_SPxK_1	486	489	PF00782	0.609
MOD_CDK_SPxK_1	333	339	PF00069	0.642
MOD_CDK_SPxK_1	483	489	PF00069	0.610
MOD_CK1_1	184	190	PF00069	0.594
MOD_CK2_1	239	245	PF00069	0.712
MOD_CK2_1	470	476	PF00069	0.579
MOD_CK2_1	79	85	PF00069	0.597
MOD_GlcNHglycan	239	242	PF01048	0.771
MOD_GlcNHglycan	249	252	PF01048	0.755
MOD_GlcNHglycan	307	310	PF01048	0.400
MOD_GlcNHglycan	472	475	PF01048	0.599
MOD_GlcNHglycan	553	556	PF01048	0.599
MOD_GSK3_1	314	321	PF00069	0.583
MOD_GSK3_1	435	442	PF00069	0.549
MOD_GSK3_1	470	477	PF00069	0.591
MOD_GSK3_1	545	552	PF00069	0.463
MOD_N-GLC_1	253	258	PF02516	0.705
MOD_N-GLC_1	267	272	PF02516	0.556
MOD_N-GLC_1	345	350	PF02516	0.575
MOD_N-GLC_1	73	78	PF02516	0.632
MOD_N-GLC_2	445	447	PF02516	0.520
MOD_NEK2_1	189	194	PF00069	0.571
MOD_NEK2_1	299	304	PF00069	0.464
MOD_NEK2_1	34	39	PF00069	0.629
MOD_NEK2_1	382	387	PF00069	0.720
MOD_NEK2_1	439	444	PF00069	0.496
MOD_NEK2_1	605	610	PF00069	0.640
MOD_NEK2_1	73	78	PF00069	0.632
MOD_NEK2_2	208	213	PF00069	0.611
MOD_NEK2_2	474	479	PF00069	0.614
MOD_PIKK_1	454	460	PF00454	0.596
MOD_PKA_2	338	344	PF00069	0.505
MOD_PKA_2	49	55	PF00069	0.586
MOD_PKA_2	557	563	PF00069	0.579
MOD_PKB_1	500	508	PF00069	0.395
MOD_Plk_1	318	324	PF00069	0.608
MOD_Plk_1	34	40	PF00069	0.558
MOD_Plk_1	345	351	PF00069	0.577
MOD_Plk_1	428	434	PF00069	0.456
MOD_Plk_1	84	90	PF00069	0.502
MOD_Plk_4	395	401	PF00069	0.699
MOD_Plk_4	4	10	PF00069	0.477
MOD_Plk_4	435	441	PF00069	0.586
MOD_Plk_4	480	486	PF00069	0.412
MOD_Plk_4	557	563	PF00069	0.548
MOD_ProDKin_1	267	273	PF00069	0.563
MOD_ProDKin_1	291	297	PF00069	0.380
MOD_ProDKin_1	333	339	PF00069	0.642
MOD_ProDKin_1	452	458	PF00069	0.509
MOD_ProDKin_1	483	489	PF00069	0.505
MOD_SUMO_for_1	597	600	PF00179	0.527
MOD_SUMO_rev_2	149	155	PF00179	0.768
MOD_SUMO_rev_2	283	289	PF00179	0.651
MOD_SUMO_rev_2	35	43	PF00179	0.681
MOD_SUMO_rev_2	53	58	PF00179	0.461
TRG_DiLeu_BaEn_4	83	89	PF01217	0.754
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.625
TRG_ENDOCYTIC_2	199	202	PF00928	0.611
TRG_ENDOCYTIC_2	255	258	PF00928	0.760
TRG_ENDOCYTIC_2	296	299	PF00928	0.598
TRG_ENDOCYTIC_2	44	47	PF00928	0.491
TRG_ENDOCYTIC_2	485	488	PF00928	0.505
TRG_ENDOCYTIC_2	529	532	PF00928	0.551
TRG_ENDOCYTIC_2	540	543	PF00928	0.428
TRG_ENDOCYTIC_2	75	78	PF00928	0.558
TRG_ER_diArg_1	112	115	PF00400	0.711
TRG_ER_diArg_1	144	147	PF00400	0.733
TRG_ER_diArg_1	354	356	PF00400	0.647
TRG_ER_diArg_1	49	51	PF00400	0.621
TRG_ER_diArg_1	609	612	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ3	Leptomonas seymouri	70%	72%
A0A0S4IX72	Bodo saltans	35%	83%
A0A1X0P281	Trypanosomatidae	47%	79%
A0A3R7N4R9	Trypanosoma rangeli	46%	79%
A0A3S7X388	Leishmania donovani	91%	99%
A4I5E2	Leishmania infantum	91%	99%
C9ZQS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	81%
E9B0P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4Q7J2	Leishmania major	91%	100%
V5B929	Trypanosoma cruzi	47%	82%