Putative DREV methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DREV methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI64_LEIBR

TriTrypDb:

LbrM.30.1220 , LBRM2903_300017700

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0106370	protein-L-histidine N-pros-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.253
CLV_NRD_NRD_1	154	156	PF00675	0.336
CLV_NRD_NRD_1	177	179	PF00675	0.293
CLV_NRD_NRD_1	297	299	PF00675	0.356
CLV_NRD_NRD_1	95	97	PF00675	0.381
CLV_PCSK_FUR_1	151	155	PF00082	0.381
CLV_PCSK_KEX2_1	153	155	PF00082	0.338
CLV_PCSK_KEX2_1	177	179	PF00082	0.293
CLV_PCSK_KEX2_1	299	301	PF00082	0.491
CLV_PCSK_KEX2_1	95	97	PF00082	0.381
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.404
CLV_PCSK_PC7_1	149	155	PF00082	0.381
CLV_PCSK_SKI1_1	18	22	PF00082	0.485
CLV_PCSK_SKI1_1	196	200	PF00082	0.157
CLV_PCSK_SKI1_1	6	10	PF00082	0.403
CLV_PCSK_SKI1_1	61	65	PF00082	0.332
CLV_PCSK_SKI1_1	95	99	PF00082	0.301
DEG_APCC_DBOX_1	195	203	PF00400	0.157
DEG_Nend_UBRbox_3	1	3	PF02207	0.619
DEG_SCF_FBW7_1	100	107	PF00400	0.157
DOC_CKS1_1	101	106	PF01111	0.336
DOC_CYCLIN_RxL_1	191	204	PF00134	0.157
DOC_CYCLIN_RxL_1	55	66	PF00134	0.281
DOC_MAPK_MEF2A_6	207	216	PF00069	0.277
DOC_MAPK_MEF2A_6	256	265	PF00069	0.381
DOC_PP2B_LxvP_1	98	101	PF13499	0.380
DOC_USP7_MATH_1	252	256	PF00917	0.157
DOC_WW_Pin1_4	100	105	PF00397	0.346
DOC_WW_Pin1_4	191	196	PF00397	0.298
DOC_WW_Pin1_4	28	33	PF00397	0.181
LIG_14-3-3_CanoR_1	246	251	PF00244	0.297
LIG_14-3-3_CanoR_1	55	60	PF00244	0.314
LIG_14-3-3_CanoR_1	74	81	PF00244	0.284
LIG_AP2alpha_2	164	166	PF02296	0.292
LIG_APCC_ABBA_1	159	164	PF00400	0.292
LIG_BRCT_BRCA1_1	68	72	PF00533	0.193
LIG_DLG_GKlike_1	246	254	PF00625	0.297
LIG_DLG_GKlike_1	55	62	PF00625	0.336
LIG_FHA_1	104	110	PF00498	0.409
LIG_FHA_1	127	133	PF00498	0.295
LIG_FHA_1	195	201	PF00498	0.145
LIG_FHA_1	46	52	PF00498	0.303
LIG_FHA_1	83	89	PF00498	0.388
LIG_GSK3_LRP6_1	104	109	PF00069	0.157
LIG_Integrin_RGD_1	300	302	PF01839	0.450
LIG_LIR_Gen_1	112	123	PF02991	0.332
LIG_LIR_Gen_1	286	295	PF02991	0.253
LIG_LIR_Nem_3	112	118	PF02991	0.297
LIG_LIR_Nem_3	176	182	PF02991	0.283
LIG_LIR_Nem_3	286	290	PF02991	0.253
LIG_LIR_Nem_3	58	63	PF02991	0.215
LIG_MLH1_MIPbox_1	68	72	PF16413	0.157
LIG_NRBOX	58	64	PF00104	0.157
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.384
LIG_REV1ctd_RIR_1	69	78	PF16727	0.267
LIG_SH2_CRK	287	291	PF00017	0.253
LIG_SH2_CRK	54	58	PF00017	0.157
LIG_SH2_STAP1	140	144	PF00017	0.267
LIG_SH2_STAT5	11	14	PF00017	0.442
LIG_SH2_STAT5	140	143	PF00017	0.397
LIG_SH2_STAT5	179	182	PF00017	0.406
LIG_SH2_STAT5	277	280	PF00017	0.253
LIG_SH3_3	213	219	PF00018	0.238
LIG_SH3_3	258	264	PF00018	0.238
LIG_SH3_3	98	104	PF00018	0.358
LIG_SUMO_SIM_anti_2	292	298	PF11976	0.301
LIG_SUMO_SIM_par_1	196	201	PF11976	0.145
LIG_TYR_ITIM	285	290	PF00017	0.332
LIG_TYR_ITIM	52	57	PF00017	0.157
LIG_UBA3_1	198	207	PF00899	0.332
MOD_CDK_SPK_2	191	196	PF00069	0.157
MOD_CK1_1	73	79	PF00069	0.267
MOD_DYRK1A_RPxSP_1	191	195	PF00069	0.157
MOD_GlcNHglycan	12	15	PF01048	0.415
MOD_GlcNHglycan	143	147	PF01048	0.345
MOD_GSK3_1	100	107	PF00069	0.352
MOD_GSK3_1	135	142	PF00069	0.239
MOD_GSK3_1	246	253	PF00069	0.238
MOD_GSK3_1	66	73	PF00069	0.397
MOD_N-GLC_1	55	60	PF02516	0.321
MOD_NEK2_1	10	15	PF00069	0.436
MOD_NEK2_1	135	140	PF00069	0.296
MOD_NEK2_1	144	149	PF00069	0.401
MOD_NEK2_1	250	255	PF00069	0.297
MOD_NEK2_1	72	77	PF00069	0.335
MOD_NEK2_2	82	87	PF00069	0.157
MOD_PKA_2	202	208	PF00069	0.269
MOD_PKA_2	270	276	PF00069	0.381
MOD_PKA_2	73	79	PF00069	0.272
MOD_PKA_2	82	88	PF00069	0.157
MOD_PKB_1	53	61	PF00069	0.314
MOD_Plk_1	250	256	PF00069	0.258
MOD_Plk_1	301	307	PF00069	0.487
MOD_Plk_1	45	51	PF00069	0.332
MOD_Plk_1	55	61	PF00069	0.216
MOD_Plk_4	114	120	PF00069	0.256
MOD_Plk_4	135	141	PF00069	0.173
MOD_Plk_4	30	36	PF00069	0.358
MOD_Plk_4	66	72	PF00069	0.391
MOD_Plk_4	82	88	PF00069	0.168
MOD_ProDKin_1	100	106	PF00069	0.346
MOD_ProDKin_1	191	197	PF00069	0.298
MOD_ProDKin_1	28	34	PF00069	0.181
MOD_SUMO_rev_2	5	10	PF00179	0.424
TRG_DiLeu_BaEn_2	45	51	PF01217	0.381
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.332
TRG_ENDOCYTIC_2	157	160	PF00928	0.238
TRG_ENDOCYTIC_2	179	182	PF00928	0.240
TRG_ENDOCYTIC_2	287	290	PF00928	0.253
TRG_ENDOCYTIC_2	54	57	PF00928	0.157
TRG_ER_diArg_1	150	153	PF00400	0.328
TRG_ER_diArg_1	16	19	PF00400	0.425
TRG_ER_diArg_1	177	179	PF00400	0.338
TRG_ER_diArg_1	297	300	PF00400	0.395
TRG_ER_diArg_1	94	96	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.157

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ8	Leptomonas seymouri	72%	100%
A0A0S4J0V6	Bodo saltans	46%	100%
A0A1X0P223	Trypanosomatidae	53%	92%
A0A3Q8IJA6	Leishmania donovani	84%	100%
A0A3S5ISQ6	Trypanosoma rangeli	53%	99%
A4I5E1	Leishmania infantum	83%	100%
C9ZQS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B0N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q0VCJ8	Bos taurus	38%	97%
Q4Q7J3	Leishmania major	83%	100%
Q5ZMH6	Gallus gallus	36%	96%
Q9EPL4	Mus musculus	39%	97%
Q9H1A3	Homo sapiens	38%	97%
V5DQR7	Trypanosoma cruzi	55%	98%