Succinate dehydrogenase assembly factor 2, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavinator of succinate dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI62_LEIBR

TriTrypDb:

LbrM.30.1190 , LBRM2903_300017500

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HI62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI62

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0018293	protein-FAD linkage	5	7
GO:0019538	protein metabolic process	3	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045333	cellular respiration	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006099	tricarboxylic acid cycle	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0034552	respiratory chain complex II assembly	6	1
GO:0034553	mitochondrial respiratory chain complex II assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.522
CLV_NRD_NRD_1	140	142	PF00675	0.276
CLV_NRD_NRD_1	212	214	PF00675	0.275
CLV_NRD_NRD_1	3	5	PF00675	0.498
CLV_NRD_NRD_1	92	94	PF00675	0.526
CLV_PCSK_KEX2_1	138	140	PF00082	0.422
CLV_PCSK_KEX2_1	212	214	PF00082	0.322
CLV_PCSK_KEX2_1	3	5	PF00082	0.498
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.417
CLV_PCSK_SKI1_1	113	117	PF00082	0.503
CLV_PCSK_SKI1_1	4	8	PF00082	0.738
CLV_PCSK_SKI1_1	66	70	PF00082	0.462
DEG_APCC_DBOX_1	162	170	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_MAPK_gen_1	147	156	PF00069	0.472
DOC_MAPK_MEF2A_6	149	158	PF00069	0.472
DOC_PP2B_LxvP_1	222	225	PF13499	0.398
DOC_USP7_MATH_1	11	15	PF00917	0.533
DOC_USP7_MATH_1	131	135	PF00917	0.465
DOC_USP7_MATH_1	86	90	PF00917	0.741
DOC_USP7_MATH_1	99	103	PF00917	0.578
DOC_WW_Pin1_4	66	71	PF00397	0.492
DOC_WW_Pin1_4	82	87	PF00397	0.616
DOC_WW_Pin1_4	92	97	PF00397	0.657
LIG_14-3-3_CanoR_1	113	118	PF00244	0.500
LIG_14-3-3_CanoR_1	27	33	PF00244	0.621
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.419
LIG_BRCT_BRCA1_1	185	189	PF00533	0.472
LIG_BRCT_BRCA1_1	58	62	PF00533	0.492
LIG_FHA_1	112	118	PF00498	0.502
LIG_FHA_1	44	50	PF00498	0.576
LIG_FHA_2	120	126	PF00498	0.513
LIG_FHA_2	50	56	PF00498	0.508
LIG_FHA_2	67	73	PF00498	0.522
LIG_LIR_Gen_1	176	184	PF02991	0.473
LIG_LIR_Gen_1	186	196	PF02991	0.474
LIG_LIR_Gen_1	59	70	PF02991	0.510
LIG_LIR_Nem_3	155	161	PF02991	0.468
LIG_LIR_Nem_3	176	180	PF02991	0.484
LIG_LIR_Nem_3	186	192	PF02991	0.521
LIG_PCNA_PIPBox_1	154	163	PF02747	0.472
LIG_Pex14_2	58	62	PF04695	0.518
LIG_SH2_CRK	177	181	PF00017	0.472
LIG_SH2_STAP1	177	181	PF00017	0.472
LIG_SH3_3	193	199	PF00018	0.582
LIG_SUMO_SIM_par_1	113	118	PF11976	0.500
LIG_TRAF2_1	198	201	PF00917	0.420
MOD_CDK_SPK_2	66	71	PF00069	0.492
MOD_CK1_1	134	140	PF00069	0.389
MOD_CK1_1	30	36	PF00069	0.537
MOD_CK1_1	95	101	PF00069	0.533
MOD_CK2_1	44	50	PF00069	0.519
MOD_CK2_1	66	72	PF00069	0.587
MOD_CK2_1	99	105	PF00069	0.581
MOD_GlcNHglycan	13	16	PF01048	0.644
MOD_GlcNHglycan	37	40	PF01048	0.524
MOD_GSK3_1	111	118	PF00069	0.594
MOD_GSK3_1	119	126	PF00069	0.498
MOD_GSK3_1	27	34	PF00069	0.491
MOD_GSK3_1	82	89	PF00069	0.583
MOD_GSK3_1	95	102	PF00069	0.605
MOD_N-GLC_1	131	136	PF02516	0.378
MOD_NEK2_1	123	128	PF00069	0.513
MOD_NEK2_1	20	25	PF00069	0.529
MOD_NEK2_1	44	49	PF00069	0.414
MOD_NEK2_1	5	10	PF00069	0.571
MOD_Plk_1	131	137	PF00069	0.409
MOD_Plk_1	49	55	PF00069	0.405
MOD_ProDKin_1	66	72	PF00069	0.489
MOD_ProDKin_1	82	88	PF00069	0.617
MOD_ProDKin_1	92	98	PF00069	0.658
TRG_DiLeu_BaEn_1	176	181	PF01217	0.472
TRG_DiLeu_BaEn_1	218	223	PF01217	0.429
TRG_DiLeu_BaEn_2	209	215	PF01217	0.472
TRG_DiLeu_BaEn_4	200	206	PF01217	0.420
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.308
TRG_ENDOCYTIC_2	148	151	PF00928	0.472
TRG_ENDOCYTIC_2	177	180	PF00928	0.472
TRG_ER_diArg_1	139	141	PF00400	0.312
TRG_ER_diArg_1	2	4	PF00400	0.501
TRG_ER_diArg_1	211	213	PF00400	0.522
TRG_NES_CRM1_1	183	197	PF08389	0.472
TRG_NLS_MonoCore_2	137	142	PF00514	0.407
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P987	Leptomonas seymouri	64%	98%
A0A3S7X377	Leishmania donovani	74%	97%
A4I5D8	Leishmania infantum	74%	97%
E9B0N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
Q4Q7J6	Leishmania major	71%	100%