RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HI61_LEIBR

TriTrypDb:

LbrM.30.1180 , LBRM2903_300017400

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HI61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI61

Function

Biological processes
Term	Name	Level	Count
GO:0006415	translational termination	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0070126	mitochondrial translational termination	7	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003747	translation release factor activity	5	12
GO:0005488	binding	1	12
GO:0008079	translation termination factor activity	4	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0004045	aminoacyl-tRNA hydrolase activity	5	1
GO:0016150	translation release factor activity, codon nonspecific	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.354
CLV_NRD_NRD_1	150	152	PF00675	0.252
CLV_NRD_NRD_1	185	187	PF00675	0.442
CLV_PCSK_KEX2_1	117	119	PF00082	0.335
CLV_PCSK_KEX2_1	184	186	PF00082	0.454
CLV_PCSK_KEX2_1	64	66	PF00082	0.307
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.307
CLV_PCSK_SKI1_1	140	144	PF00082	0.361
CLV_PCSK_SKI1_1	4	8	PF00082	0.622
DEG_SPOP_SBC_1	88	92	PF00917	0.413
DOC_ANK_TNKS_1	78	85	PF00023	0.431
DOC_CYCLIN_RxL_1	1	9	PF00134	0.443
DOC_USP7_MATH_1	44	48	PF00917	0.613
DOC_USP7_MATH_2	170	176	PF00917	0.518
DOC_WW_Pin1_4	19	24	PF00397	0.605
DOC_WW_Pin1_4	26	31	PF00397	0.562
LIG_14-3-3_CanoR_1	193	203	PF00244	0.474
LIG_14-3-3_CanoR_1	43	52	PF00244	0.429
LIG_BRCT_BRCA1_1	104	108	PF00533	0.442
LIG_FHA_1	128	134	PF00498	0.498
LIG_FHA_1	32	38	PF00498	0.578
LIG_LIR_Apic_2	161	165	PF02991	0.379
LIG_LIR_Nem_3	54	60	PF02991	0.411
LIG_MLH1_MIPbox_1	104	108	PF16413	0.498
LIG_NRBOX	152	158	PF00104	0.535
LIG_PCNA_PIPBox_1	101	110	PF02747	0.498
LIG_RPA_C_Fungi	113	125	PF08784	0.309
LIG_SH3_3	168	174	PF00018	0.539
LIG_SUMO_SIM_par_1	130	135	PF11976	0.285
LIG_WRC_WIRS_1	49	54	PF05994	0.398
MOD_CAAXbox	200	203	PF01239	0.345
MOD_CK1_1	26	32	PF00069	0.503
MOD_CK1_1	36	42	PF00069	0.476
MOD_CK1_1	47	53	PF00069	0.417
MOD_CK2_1	132	138	PF00069	0.295
MOD_CK2_1	36	42	PF00069	0.650
MOD_CK2_1	48	54	PF00069	0.507
MOD_Cter_Amidation	182	185	PF01082	0.343
MOD_GlcNHglycan	140	143	PF01048	0.314
MOD_GlcNHglycan	196	199	PF01048	0.502
MOD_GlcNHglycan	54	57	PF01048	0.340
MOD_GlcNHglycan	80	83	PF01048	0.351
MOD_GSK3_1	123	130	PF00069	0.371
MOD_GSK3_1	172	179	PF00069	0.464
MOD_GSK3_1	19	26	PF00069	0.615
MOD_GSK3_1	31	38	PF00069	0.497
MOD_GSK3_1	44	51	PF00069	0.417
MOD_GSK3_1	74	81	PF00069	0.317
MOD_NEK2_1	194	199	PF00069	0.403
MOD_NEK2_1	33	38	PF00069	0.666
MOD_NEK2_1	52	57	PF00069	0.563
MOD_NEK2_1	6	11	PF00069	0.706
MOD_NEK2_1	78	83	PF00069	0.380
MOD_PK_1	64	70	PF00069	0.295
MOD_PKA_1	186	192	PF00069	0.479
MOD_PKA_1	64	70	PF00069	0.189
MOD_PKA_2	172	178	PF00069	0.524
MOD_PKA_2	44	50	PF00069	0.511
MOD_PKA_2	64	70	PF00069	0.330
MOD_PKA_2	78	84	PF00069	0.341
MOD_PKB_1	184	192	PF00069	0.484
MOD_Plk_4	128	134	PF00069	0.362
MOD_Plk_4	158	164	PF00069	0.345
MOD_Plk_4	172	178	PF00069	0.367
MOD_ProDKin_1	19	25	PF00069	0.606
MOD_ProDKin_1	26	32	PF00069	0.562
TRG_DiLeu_BaEn_2	171	177	PF01217	0.523
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.669
TRG_ENDOCYTIC_2	57	60	PF00928	0.363
TRG_ER_diArg_1	116	118	PF00400	0.408
TRG_ER_diArg_1	184	186	PF00400	0.494
TRG_NLS_MonoExtN_4	184	190	PF00514	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M0	Leptomonas seymouri	79%	100%
A0A0S4IXK6	Bodo saltans	50%	97%
A0A1X0P1Z5	Trypanosomatidae	56%	74%
A0A3S7X372	Leishmania donovani	80%	100%
A0A422P522	Trypanosoma rangeli	51%	79%
A4I5D7	Leishmania infantum	80%	100%
C9ZQR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	89%
E9B0N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q7J7	Leishmania major	85%	99%
V5BZ05	Trypanosoma cruzi	57%	77%