Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase subunit 7

Species:

Leishmania braziliensis

UniProt:

A4HI59_LEIBR

TriTrypDb:

LbrM.30.1160 , LBRM2903_300017200

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	4	1
GO:0032991	protein-containing complex	1	1
GO:0045257	succinate dehydrogenase complex (ubiquinone)	5	1
GO:0045281	succinate dehydrogenase complex	4	1
GO:0045283	fumarate reductase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A4HI59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.519
CLV_NRD_NRD_1	154	156	PF00675	0.463
CLV_NRD_NRD_1	2	4	PF00675	0.573
CLV_NRD_NRD_1	247	249	PF00675	0.579
CLV_PCSK_KEX2_1	2	4	PF00082	0.573
CLV_PCSK_KEX2_1	242	244	PF00082	0.480
CLV_PCSK_KEX2_1	247	249	PF00082	0.506
CLV_PCSK_KEX2_1	56	58	PF00082	0.509
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.480
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.509
CLV_PCSK_PC7_1	243	249	PF00082	0.563
CLV_PCSK_SKI1_1	137	141	PF00082	0.486
CLV_PCSK_SKI1_1	161	165	PF00082	0.445
CLV_PCSK_SKI1_1	243	247	PF00082	0.563
CLV_PCSK_SKI1_1	56	60	PF00082	0.496
CLV_PCSK_SKI1_1	88	92	PF00082	0.452
DEG_APCC_DBOX_1	87	95	PF00400	0.498
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DOC_CYCLIN_RxL_1	82	95	PF00134	0.477
DOC_MAPK_gen_1	217	226	PF00069	0.486
DOC_MAPK_HePTP_8	216	228	PF00069	0.543
DOC_MAPK_MEF2A_6	217	226	PF00069	0.496
DOC_PP1_RVXF_1	159	166	PF00149	0.523
DOC_USP7_MATH_1	11	15	PF00917	0.547
DOC_USP7_MATH_1	204	208	PF00917	0.466
DOC_USP7_MATH_1	227	231	PF00917	0.533
DOC_USP7_UBL2_3	146	150	PF12436	0.443
LIG_14-3-3_CanoR_1	34	44	PF00244	0.615
LIG_14-3-3_CanoR_1	57	64	PF00244	0.547
LIG_BRCT_BRCA1_1	161	165	PF00533	0.396
LIG_BRCT_BRCA1_1	65	69	PF00533	0.551
LIG_CtBP_PxDLS_1	213	217	PF00389	0.538
LIG_deltaCOP1_diTrp_1	46	54	PF00928	0.493
LIG_DLG_GKlike_1	117	124	PF00625	0.496
LIG_eIF4E_1	159	165	PF01652	0.491
LIG_FHA_1	173	179	PF00498	0.357
LIG_FHA_1	244	250	PF00498	0.614
LIG_FHA_1	96	102	PF00498	0.285
LIG_LIR_Apic_2	68	73	PF02991	0.563
LIG_LIR_Gen_1	171	182	PF02991	0.406
LIG_LIR_Nem_3	108	113	PF02991	0.420
LIG_LIR_Nem_3	122	128	PF02991	0.385
LIG_LIR_Nem_3	130	136	PF02991	0.427
LIG_LIR_Nem_3	171	177	PF02991	0.405
LIG_LIR_Nem_3	38	43	PF02991	0.544
LIG_LIR_Nem_3	62	67	PF02991	0.512
LIG_LIR_Nem_3	68	72	PF02991	0.509
LIG_MAD2	126	134	PF02301	0.296
LIG_MYND_3	221	225	PF01753	0.537
LIG_Pex14_1	106	110	PF04695	0.404
LIG_Pex14_2	110	114	PF04695	0.407
LIG_SH2_CRK	125	129	PF00017	0.429
LIG_SH2_CRK	136	140	PF00017	0.455
LIG_SH2_CRK	174	178	PF00017	0.407
LIG_SH2_GRB2like	129	132	PF00017	0.422
LIG_SH2_STAP1	129	133	PF00017	0.406
LIG_SH2_STAP1	174	178	PF00017	0.401
LIG_SH2_STAT3	182	185	PF00017	0.475
LIG_SH2_STAT5	129	132	PF00017	0.451
LIG_SH2_STAT5	138	141	PF00017	0.466
LIG_SH2_STAT5	159	162	PF00017	0.406
LIG_SH2_STAT5	174	177	PF00017	0.406
LIG_SH2_STAT5	183	186	PF00017	0.434
LIG_SH2_STAT5	197	200	PF00017	0.330
LIG_SH2_STAT5	37	40	PF00017	0.600
LIG_SH2_STAT5	89	92	PF00017	0.376
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.497
LIG_UBA3_1	153	161	PF00899	0.531
LIG_WRC_WIRS_1	205	210	PF05994	0.416
LIG_WRC_WIRS_1	64	69	PF05994	0.529
MOD_CK1_1	14	20	PF00069	0.724
MOD_CK2_1	102	108	PF00069	0.387
MOD_CK2_1	89	95	PF00069	0.405
MOD_Cter_Amidation	208	211	PF01082	0.556
MOD_Cter_Amidation	240	243	PF01082	0.578
MOD_GlcNHglycan	24	27	PF01048	0.545
MOD_GlcNHglycan	8	11	PF01048	0.666
MOD_GSK3_1	22	29	PF00069	0.670
MOD_GSK3_1	35	42	PF00069	0.547
MOD_GSK3_1	59	66	PF00069	0.515
MOD_LATS_1	115	121	PF00433	0.409
MOD_N-GLC_1	50	55	PF02516	0.549
MOD_N-GLC_1	95	100	PF02516	0.350
MOD_NEK2_1	102	107	PF00069	0.414
MOD_NEK2_1	35	40	PF00069	0.655
MOD_NEK2_2	227	232	PF00069	0.539
MOD_PIKK_1	57	63	PF00454	0.591
MOD_PKA_1	56	62	PF00069	0.514
MOD_PKA_2	56	62	PF00069	0.494
MOD_Plk_1	50	56	PF00069	0.566
MOD_Plk_2-3	63	69	PF00069	0.640
MOD_Plk_4	159	165	PF00069	0.301
MOD_Plk_4	173	179	PF00069	0.313
MOD_Plk_4	50	56	PF00069	0.555
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.433
TRG_ENDOCYTIC_2	125	128	PF00928	0.419
TRG_ENDOCYTIC_2	136	139	PF00928	0.422
TRG_ENDOCYTIC_2	174	177	PF00928	0.406
TRG_ENDOCYTIC_2	64	67	PF00928	0.510
TRG_ER_diArg_1	1	3	PF00400	0.576
TRG_ER_diArg_1	247	249	PF00400	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB7	Leptomonas seymouri	79%	100%
A0A0S4J0Y6	Bodo saltans	46%	100%
A0A1X0P208	Trypanosomatidae	57%	100%
A0A3R7MXF5	Trypanosoma rangeli	59%	100%
A0A3S7X3E5	Leishmania donovani	84%	100%
A4I5D5	Leishmania infantum	85%	100%
C9ZQR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B0N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7J9	Leishmania major	85%	100%