DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania braziliensis

UniProt:

A4HI58_LEIBR

TriTrypDb:

LbrM.30.1150 , LBRM2903_300017100

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI58

PDB structure(s): 7am2_BS

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0044183	protein folding chaperone	1	1
GO:0051082	unfolded protein binding	3	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.594
CLV_MEL_PAP_1	2	8	PF00089	0.472
CLV_NRD_NRD_1	128	130	PF00675	0.483
CLV_NRD_NRD_1	19	21	PF00675	0.476
CLV_NRD_NRD_1	4	6	PF00675	0.517
CLV_NRD_NRD_1	72	74	PF00675	0.725
CLV_NRD_NRD_1	93	95	PF00675	0.529
CLV_PCSK_FUR_1	126	130	PF00082	0.489
CLV_PCSK_KEX2_1	126	128	PF00082	0.480
CLV_PCSK_KEX2_1	18	20	PF00082	0.433
CLV_PCSK_KEX2_1	4	6	PF00082	0.494
CLV_PCSK_KEX2_1	71	73	PF00082	0.725
CLV_PCSK_KEX2_1	93	95	PF00082	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.376
DEG_SPOP_SBC_1	77	81	PF00917	0.774
DOC_ANK_TNKS_1	140	147	PF00023	0.512
DOC_CKS1_1	238	243	PF01111	0.480
DOC_PP1_SILK_1	199	204	PF00149	0.616
DOC_WW_Pin1_4	158	163	PF00397	0.715
DOC_WW_Pin1_4	207	212	PF00397	0.543
DOC_WW_Pin1_4	237	242	PF00397	0.474
DOC_WW_Pin1_4	282	287	PF00397	0.664
DOC_WW_Pin1_4	55	60	PF00397	0.740
LIG_14-3-3_CanoR_1	158	162	PF00244	0.512
LIG_14-3-3_CanoR_1	206	211	PF00244	0.593
LIG_14-3-3_CanoR_1	289	294	PF00244	0.580
LIG_14-3-3_CanoR_1	4	13	PF00244	0.402
LIG_AP2alpha_1	108	112	PF02296	0.488
LIG_CaM_IQ_9	121	136	PF13499	0.501
LIG_DLG_GKlike_1	289	297	PF00625	0.572
LIG_FHA_1	295	301	PF00498	0.575
LIG_FHA_2	114	120	PF00498	0.502
LIG_FHA_2	182	188	PF00498	0.494
LIG_FHA_2	238	244	PF00498	0.459
LIG_FHA_2	278	284	PF00498	0.648
LIG_FHA_2	28	34	PF00498	0.507
LIG_Integrin_RGD_1	101	103	PF01839	0.416
LIG_LIR_Apic_2	267	273	PF02991	0.521
LIG_LIR_Apic_2	312	316	PF02991	0.425
LIG_LIR_Gen_1	7	17	PF02991	0.405
LIG_LIR_Nem_3	221	226	PF02991	0.426
LIG_LIR_Nem_3	267	272	PF02991	0.671
LIG_LIR_Nem_3	7	13	PF02991	0.406
LIG_Pex14_2	108	112	PF04695	0.394
LIG_SH2_CRK	313	317	PF00017	0.434
LIG_SH2_CRK	95	99	PF00017	0.598
LIG_SH2_SRC	270	273	PF00017	0.656
LIG_SH2_SRC	281	284	PF00017	0.549
LIG_SH2_STAT3	88	91	PF00017	0.488
LIG_SH2_STAT5	299	302	PF00017	0.591
LIG_SH3_3	159	165	PF00018	0.562
LIG_SH3_3	210	216	PF00018	0.516
LIG_SH3_3	222	228	PF00018	0.401
LIG_SH3_3	230	236	PF00018	0.405
LIG_SH3_3	238	244	PF00018	0.444
LIG_TRAF2_1	165	168	PF00917	0.655
LIG_TRAF2_1	251	254	PF00917	0.645
LIG_WRPW_2	226	229	PF00400	0.423
MOD_CDK_SPxxK_3	282	289	PF00069	0.530
MOD_CK1_1	264	270	PF00069	0.588
MOD_CK1_1	288	294	PF00069	0.430
MOD_CK1_1	75	81	PF00069	0.725
MOD_CK1_1	82	88	PF00069	0.610
MOD_CK2_1	113	119	PF00069	0.574
MOD_CK2_1	181	187	PF00069	0.642
MOD_CK2_1	237	243	PF00069	0.450
MOD_CK2_1	248	254	PF00069	0.488
MOD_CK2_1	257	263	PF00069	0.366
MOD_DYRK1A_RPxSP_1	158	162	PF00069	0.509
MOD_DYRK1A_RPxSP_1	55	59	PF00069	0.711
MOD_GlcNHglycan	134	137	PF01048	0.463
MOD_GlcNHglycan	258	262	PF01048	0.533
MOD_GlcNHglycan	36	39	PF01048	0.764
MOD_GlcNHglycan	66	69	PF01048	0.756
MOD_GSK3_1	150	157	PF00069	0.754
MOD_GSK3_1	249	256	PF00069	0.583
MOD_GSK3_1	257	264	PF00069	0.536
MOD_GSK3_1	285	292	PF00069	0.516
MOD_GSK3_1	39	46	PF00069	0.571
MOD_GSK3_1	51	58	PF00069	0.770
MOD_GSK3_1	62	69	PF00069	0.773
MOD_GSK3_1	72	79	PF00069	0.732
MOD_LATS_1	204	210	PF00433	0.441
MOD_NEK2_1	66	71	PF00069	0.527
MOD_PIKK_1	249	255	PF00454	0.638
MOD_PKA_1	4	10	PF00069	0.540
MOD_PKA_1	72	78	PF00069	0.650
MOD_PKA_2	157	163	PF00069	0.507
MOD_PKA_2	288	294	PF00069	0.378
MOD_PKA_2	4	10	PF00069	0.540
MOD_PKA_2	72	78	PF00069	0.691
MOD_PKB_1	71	79	PF00069	0.526
MOD_Plk_1	253	259	PF00069	0.627
MOD_Plk_2-3	113	119	PF00069	0.509
MOD_ProDKin_1	158	164	PF00069	0.712
MOD_ProDKin_1	207	213	PF00069	0.542
MOD_ProDKin_1	237	243	PF00069	0.479
MOD_ProDKin_1	282	288	PF00069	0.663
MOD_ProDKin_1	55	61	PF00069	0.742
MOD_SUMO_rev_2	110	117	PF00179	0.518
TRG_DiLeu_BaEn_1	167	172	PF01217	0.466
TRG_DiLeu_BaEn_4	167	173	PF01217	0.466
TRG_ENDOCYTIC_2	10	13	PF00928	0.398
TRG_ENDOCYTIC_2	223	226	PF00928	0.428
TRG_ER_diArg_1	126	129	PF00400	0.488
TRG_ER_diArg_1	17	20	PF00400	0.625
TRG_ER_diArg_1	3	5	PF00400	0.546
TRG_ER_diArg_1	71	73	PF00400	0.648
TRG_ER_diArg_1	93	95	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S6	Leptomonas seymouri	59%	77%
A0A0S4JEE6	Bodo saltans	30%	99%
A0A1X0P2B2	Trypanosomatidae	35%	87%
A0A3Q8IFJ9	Leishmania donovani	79%	75%
A0A3R7P4U9	Trypanosoma rangeli	36%	94%
A4I5D4	Leishmania infantum	79%	100%
C9ZQR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	82%
E9B0N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	74%
Q4Q7K0	Leishmania major	78%	100%
V5BPN3	Trypanosoma cruzi	33%	95%