Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI57_LEIBR

TriTrypDb:

LbrM.30.1140 , LBRM2903_300017000

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.711
CLV_NRD_NRD_1	138	140	PF00675	0.609
CLV_NRD_NRD_1	207	209	PF00675	0.561
CLV_NRD_NRD_1	246	248	PF00675	0.687
CLV_NRD_NRD_1	36	38	PF00675	0.624
CLV_NRD_NRD_1	388	390	PF00675	0.627
CLV_NRD_NRD_1	392	394	PF00675	0.617
CLV_NRD_NRD_1	437	439	PF00675	0.514
CLV_NRD_NRD_1	452	454	PF00675	0.554
CLV_NRD_NRD_1	54	56	PF00675	0.625
CLV_PCSK_FUR_1	21	25	PF00082	0.673
CLV_PCSK_FUR_1	39	43	PF00082	0.639
CLV_PCSK_KEX2_1	138	140	PF00082	0.609
CLV_PCSK_KEX2_1	23	25	PF00082	0.681
CLV_PCSK_KEX2_1	246	248	PF00082	0.683
CLV_PCSK_KEX2_1	36	38	PF00082	0.661
CLV_PCSK_KEX2_1	41	43	PF00082	0.636
CLV_PCSK_KEX2_1	437	439	PF00082	0.489
CLV_PCSK_KEX2_1	54	56	PF00082	0.625
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.681
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.645
CLV_PCSK_PC7_1	19	25	PF00082	0.668
CLV_PCSK_PC7_1	37	43	PF00082	0.610
CLV_PCSK_SKI1_1	15	19	PF00082	0.595
CLV_PCSK_SKI1_1	159	163	PF00082	0.514
CLV_PCSK_SKI1_1	335	339	PF00082	0.377
CLV_PCSK_SKI1_1	389	393	PF00082	0.620
CLV_Separin_Metazoa	414	418	PF03568	0.595
DEG_APCC_DBOX_1	436	444	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DEG_SPOP_SBC_1	279	283	PF00917	0.706
DEG_SPOP_SBC_1	362	366	PF00917	0.527
DOC_CYCLIN_RxL_1	472	483	PF00134	0.549
DOC_MAPK_DCC_7	437	445	PF00069	0.527
DOC_MAPK_gen_1	246	254	PF00069	0.525
DOC_MAPK_gen_1	333	341	PF00069	0.491
DOC_MAPK_gen_1	389	398	PF00069	0.744
DOC_MAPK_gen_1	437	445	PF00069	0.479
DOC_MAPK_gen_1	86	96	PF00069	0.429
DOC_MAPK_MEF2A_6	247	256	PF00069	0.604
DOC_MAPK_MEF2A_6	437	446	PF00069	0.474
DOC_PP2B_LxvP_1	148	151	PF13499	0.588
DOC_PP2B_LxvP_1	256	259	PF13499	0.686
DOC_PP2B_LxvP_1	76	79	PF13499	0.555
DOC_USP7_MATH_1	137	141	PF00917	0.407
DOC_USP7_MATH_1	279	283	PF00917	0.639
DOC_USP7_MATH_1	293	297	PF00917	0.767
DOC_USP7_MATH_1	314	318	PF00917	0.711
DOC_USP7_MATH_1	362	366	PF00917	0.792
DOC_USP7_MATH_1	408	412	PF00917	0.527
DOC_USP7_MATH_1	463	467	PF00917	0.724
DOC_USP7_MATH_1	490	494	PF00917	0.518
DOC_USP7_UBL2_3	390	394	PF12436	0.664
DOC_WW_Pin1_4	192	197	PF00397	0.588
DOC_WW_Pin1_4	275	280	PF00397	0.610
LIG_14-3-3_CanoR_1	11	18	PF00244	0.656
LIG_14-3-3_CanoR_1	138	142	PF00244	0.571
LIG_14-3-3_CanoR_1	223	231	PF00244	0.534
LIG_14-3-3_CanoR_1	3	7	PF00244	0.674
LIG_14-3-3_CanoR_1	406	416	PF00244	0.598
LIG_14-3-3_CanoR_1	42	50	PF00244	0.627
LIG_14-3-3_CanoR_1	467	473	PF00244	0.518
LIG_14-3-3_CanoR_1	475	480	PF00244	0.398
LIG_14-3-3_CanoR_1	520	530	PF00244	0.756
LIG_Actin_WH2_2	112	130	PF00022	0.609
LIG_BIR_III_2	431	435	PF00653	0.693
LIG_BRCT_BRCA1_1	13	17	PF00533	0.672
LIG_BRCT_BRCA1_1	276	280	PF00533	0.717
LIG_BRCT_BRCA1_1	482	486	PF00533	0.505
LIG_BRCT_BRCA1_1	70	74	PF00533	0.469
LIG_Clathr_ClatBox_1	443	447	PF01394	0.481
LIG_DCNL_PONY_1	1	4	PF03556	0.484
LIG_deltaCOP1_diTrp_1	502	510	PF00928	0.501
LIG_eIF4E_1	225	231	PF01652	0.538
LIG_EVH1_2	267	271	PF00568	0.784
LIG_FHA_1	122	128	PF00498	0.571
LIG_FHA_1	225	231	PF00498	0.557
LIG_FHA_1	279	285	PF00498	0.707
LIG_FHA_1	314	320	PF00498	0.529
LIG_FHA_1	336	342	PF00498	0.347
LIG_FHA_1	386	392	PF00498	0.696
LIG_FHA_1	45	51	PF00498	0.763
LIG_FHA_2	193	199	PF00498	0.605
LIG_FHA_2	3	9	PF00498	0.726
LIG_GBD_Chelix_1	125	133	PF00786	0.398
LIG_GBD_Chelix_1	157	165	PF00786	0.562
LIG_GBD_Chelix_1	497	505	PF00786	0.362
LIG_IBAR_NPY_1	104	106	PF08397	0.576
LIG_LIR_Apic_2	95	100	PF02991	0.584
LIG_LIR_Gen_1	447	455	PF02991	0.626
LIG_LIR_Nem_3	152	157	PF02991	0.528
LIG_LIR_Nem_3	447	451	PF02991	0.566
LIG_LIR_Nem_3	483	489	PF02991	0.469
LIG_LIR_Nem_3	5	9	PF02991	0.472
LIG_LIR_Nem_3	507	513	PF02991	0.372
LIG_SH2_CRK	40	44	PF00017	0.630
LIG_SH2_CRK	448	452	PF00017	0.592
LIG_SH2_NCK_1	448	452	PF00017	0.592
LIG_SH2_STAT3	420	423	PF00017	0.469
LIG_SH2_STAT5	420	423	PF00017	0.499
LIG_SH2_STAT5	513	516	PF00017	0.652
LIG_SH3_3	128	134	PF00018	0.430
LIG_SH3_3	325	331	PF00018	0.513
LIG_SH3_3	355	361	PF00018	0.489
LIG_SUMO_SIM_par_1	441	447	PF11976	0.486
LIG_TRAF2_1	150	153	PF00917	0.565
LIG_TYR_ITIM	4	9	PF00017	0.471
LIG_TYR_ITIM	446	451	PF00017	0.559
LIG_WW_1	260	263	PF00397	0.489
MOD_CK1_1	239	245	PF00069	0.570
MOD_CK1_1	304	310	PF00069	0.682
MOD_CK1_1	317	323	PF00069	0.671
MOD_CK1_1	44	50	PF00069	0.744
MOD_CK1_1	457	463	PF00069	0.599
MOD_CK1_1	85	91	PF00069	0.560
MOD_CK2_1	342	348	PF00069	0.557
MOD_CK2_1	408	414	PF00069	0.584
MOD_CK2_1	85	91	PF00069	0.560
MOD_Cter_Amidation	34	37	PF01082	0.639
MOD_Cter_Amidation	52	55	PF01082	0.627
MOD_GlcNHglycan	165	168	PF01048	0.549
MOD_GlcNHglycan	200	203	PF01048	0.680
MOD_GlcNHglycan	320	323	PF01048	0.689
MOD_GlcNHglycan	343	347	PF01048	0.539
MOD_GlcNHglycan	374	377	PF01048	0.677
MOD_GlcNHglycan	455	459	PF01048	0.603
MOD_GlcNHglycan	482	485	PF01048	0.557
MOD_GlcNHglycan	523	526	PF01048	0.504
MOD_GlcNHglycan	70	73	PF01048	0.469
MOD_GSK3_1	182	189	PF00069	0.478
MOD_GSK3_1	194	201	PF00069	0.587
MOD_GSK3_1	267	274	PF00069	0.674
MOD_GSK3_1	275	282	PF00069	0.660
MOD_GSK3_1	289	296	PF00069	0.534
MOD_GSK3_1	302	309	PF00069	0.584
MOD_GSK3_1	313	320	PF00069	0.660
MOD_GSK3_1	368	375	PF00069	0.664
MOD_GSK3_1	41	48	PF00069	0.687
MOD_GSK3_1	457	464	PF00069	0.647
MOD_N-GLC_1	100	105	PF02516	0.565
MOD_N-GLC_1	121	126	PF02516	0.517
MOD_N-GLC_1	461	466	PF02516	0.528
MOD_NEK2_1	121	126	PF00069	0.517
MOD_NEK2_1	17	22	PF00069	0.581
MOD_NEK2_1	186	191	PF00069	0.475
MOD_NEK2_1	217	222	PF00069	0.462
MOD_NEK2_1	224	229	PF00069	0.570
MOD_NEK2_1	230	235	PF00069	0.635
MOD_NEK2_1	262	267	PF00069	0.708
MOD_NEK2_1	271	276	PF00069	0.785
MOD_NEK2_1	280	285	PF00069	0.731
MOD_NEK2_1	318	323	PF00069	0.655
MOD_NEK2_1	407	412	PF00069	0.588
MOD_NEK2_1	489	494	PF00069	0.529
MOD_PIKK_1	293	299	PF00454	0.762
MOD_PIKK_1	457	463	PF00454	0.724
MOD_PK_1	42	48	PF00069	0.759
MOD_PKA_1	41	47	PF00069	0.631
MOD_PKA_2	10	16	PF00069	0.595
MOD_PKA_2	137	143	PF00069	0.469
MOD_PKA_2	2	8	PF00069	0.731
MOD_PKA_2	30	36	PF00069	0.646
MOD_PKA_2	356	362	PF00069	0.461
MOD_PKA_2	41	47	PF00069	0.631
MOD_PKA_2	85	91	PF00069	0.664
MOD_Plk_1	121	127	PF00069	0.512
MOD_Plk_1	186	192	PF00069	0.585
MOD_Plk_1	217	223	PF00069	0.336
MOD_Plk_1	446	452	PF00069	0.576
MOD_Plk_1	490	496	PF00069	0.512
MOD_Plk_4	115	121	PF00069	0.505
MOD_Plk_4	280	286	PF00069	0.676
MOD_Plk_4	314	320	PF00069	0.706
MOD_Plk_4	335	341	PF00069	0.483
MOD_Plk_4	468	474	PF00069	0.563
MOD_Plk_4	490	496	PF00069	0.512
MOD_ProDKin_1	192	198	PF00069	0.602
MOD_ProDKin_1	275	281	PF00069	0.537
MOD_SUMO_for_1	235	238	PF00179	0.545
MOD_SUMO_rev_2	111	119	PF00179	0.584
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.569
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.309
TRG_ENDOCYTIC_2	40	43	PF00928	0.637
TRG_ENDOCYTIC_2	448	451	PF00928	0.535
TRG_ENDOCYTIC_2	6	9	PF00928	0.605
TRG_ER_diArg_1	18	21	PF00400	0.627
TRG_ER_diArg_1	246	248	PF00400	0.729
TRG_ER_diArg_1	36	39	PF00400	0.623
TRG_ER_diArg_1	437	439	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGI0	Leptomonas seymouri	49%	93%
A0A1X0P334	Trypanosomatidae	35%	100%
A0A3Q8IFQ7	Leishmania donovani	75%	100%
A4I5D3	Leishmania infantum	74%	100%
C9ZQR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q7K1	Leishmania major	75%	100%