Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI55_LEIBR

TriTrypDb:

LbrM.30.1120 , LBRM2903_300016800

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI55

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.674
CLV_C14_Caspase3-7	467	471	PF00656	0.581
CLV_C14_Caspase3-7	474	478	PF00656	0.730
CLV_NRD_NRD_1	130	132	PF00675	0.256
CLV_NRD_NRD_1	290	292	PF00675	0.576
CLV_NRD_NRD_1	301	303	PF00675	0.246
CLV_NRD_NRD_1	391	393	PF00675	0.422
CLV_NRD_NRD_1	450	452	PF00675	0.672
CLV_PCSK_FUR_1	299	303	PF00082	0.218
CLV_PCSK_FUR_1	448	452	PF00082	0.563
CLV_PCSK_KEX2_1	172	174	PF00082	0.322
CLV_PCSK_KEX2_1	289	291	PF00082	0.562
CLV_PCSK_KEX2_1	301	303	PF00082	0.328
CLV_PCSK_KEX2_1	391	393	PF00082	0.419
CLV_PCSK_KEX2_1	410	412	PF00082	0.178
CLV_PCSK_KEX2_1	450	452	PF00082	0.672
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.268
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.402
CLV_PCSK_SKI1_1	214	218	PF00082	0.223
CLV_PCSK_SKI1_1	290	294	PF00082	0.560
CLV_PCSK_SKI1_1	344	348	PF00082	0.359
CLV_PCSK_SKI1_1	76	80	PF00082	0.154
DEG_COP1_1	135	144	PF00400	0.362
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DEG_SPOP_SBC_1	178	182	PF00917	0.492
DOC_CKS1_1	563	568	PF01111	0.689
DOC_CYCLIN_RxL_1	182	191	PF00134	0.492
DOC_CYCLIN_RxL_1	341	351	PF00134	0.190
DOC_MAPK_gen_1	214	223	PF00069	0.436
DOC_MAPK_gen_1	226	234	PF00069	0.423
DOC_MAPK_JIP1_4	18	24	PF00069	0.510
DOC_MAPK_MEF2A_6	367	376	PF00069	0.356
DOC_MAPK_MEF2A_6	44	53	PF00069	0.458
DOC_PP1_RVXF_1	183	190	PF00149	0.465
DOC_PP1_RVXF_1	371	377	PF00149	0.398
DOC_PP4_FxxP_1	510	513	PF00568	0.595
DOC_USP7_MATH_1	10	14	PF00917	0.554
DOC_USP7_MATH_1	157	161	PF00917	0.570
DOC_USP7_MATH_1	162	166	PF00917	0.545
DOC_USP7_MATH_1	167	171	PF00917	0.507
DOC_USP7_MATH_1	260	264	PF00917	0.662
DOC_USP7_MATH_1	277	281	PF00917	0.640
DOC_USP7_MATH_1	283	287	PF00917	0.685
DOC_USP7_MATH_1	29	33	PF00917	0.352
DOC_USP7_MATH_1	384	388	PF00917	0.258
DOC_USP7_MATH_1	425	429	PF00917	0.239
DOC_USP7_MATH_1	47	51	PF00917	0.504
DOC_USP7_MATH_1	472	476	PF00917	0.709
DOC_USP7_MATH_1	486	490	PF00917	0.695
DOC_USP7_MATH_1	497	501	PF00917	0.434
DOC_USP7_MATH_1	545	549	PF00917	0.691
DOC_USP7_MATH_1	551	555	PF00917	0.646
DOC_USP7_UBL2_3	56	60	PF12436	0.423
DOC_USP7_UBL2_3	601	605	PF12436	0.489
DOC_WW_Pin1_4	140	145	PF00397	0.481
DOC_WW_Pin1_4	312	317	PF00397	0.292
DOC_WW_Pin1_4	4	9	PF00397	0.576
DOC_WW_Pin1_4	562	567	PF00397	0.624
LIG_14-3-3_CanoR_1	173	179	PF00244	0.407
LIG_14-3-3_CanoR_1	289	295	PF00244	0.529
LIG_14-3-3_CanoR_1	302	308	PF00244	0.322
LIG_14-3-3_CanoR_1	42	52	PF00244	0.408
LIG_14-3-3_CanoR_1	521	529	PF00244	0.602
LIG_Actin_WH2_2	31	46	PF00022	0.449
LIG_BRCT_BRCA1_1	2	6	PF00533	0.450
LIG_Clathr_ClatBox_1	231	235	PF01394	0.423
LIG_deltaCOP1_diTrp_1	321	331	PF00928	0.322
LIG_EH_1	526	530	PF12763	0.510
LIG_FHA_1	172	178	PF00498	0.486
LIG_FHA_1	234	240	PF00498	0.500
LIG_FHA_1	521	527	PF00498	0.530
LIG_FHA_1	563	569	PF00498	0.676
LIG_FHA_2	291	297	PF00498	0.473
LIG_FHA_2	349	355	PF00498	0.352
LIG_FHA_2	465	471	PF00498	0.532
LIG_FHA_2	472	478	PF00498	0.477
LIG_FHA_2	520	526	PF00498	0.661
LIG_FXI_DFP_1	231	235	PF00024	0.223
LIG_GBD_Chelix_1	195	203	PF00786	0.162
LIG_LIR_Apic_2	310	316	PF02991	0.262
LIG_LIR_Gen_1	188	197	PF02991	0.450
LIG_LIR_Gen_1	351	360	PF02991	0.300
LIG_LIR_Nem_3	188	192	PF02991	0.450
LIG_LIR_Nem_3	351	356	PF02991	0.460
LIG_LIR_Nem_3	99	105	PF02991	0.487
LIG_PCNA_yPIPBox_3	60	73	PF02747	0.523
LIG_Pex14_2	103	107	PF04695	0.487
LIG_Pex14_2	529	533	PF04695	0.662
LIG_PTB_Apo_2	509	516	PF02174	0.423
LIG_PTB_Phospho_1	509	515	PF10480	0.421
LIG_SH2_CRK	505	509	PF00017	0.465
LIG_SH2_NCK_1	338	342	PF00017	0.322
LIG_SH2_PTP2	313	316	PF00017	0.277
LIG_SH2_STAP1	338	342	PF00017	0.334
LIG_SH2_STAP1	515	519	PF00017	0.463
LIG_SH2_STAT3	119	122	PF00017	0.487
LIG_SH2_STAT5	102	105	PF00017	0.363
LIG_SH2_STAT5	313	316	PF00017	0.277
LIG_SH2_STAT5	518	521	PF00017	0.487
LIG_SH2_STAT5	594	597	PF00017	0.613
LIG_SH2_STAT5	87	90	PF00017	0.473
LIG_SH3_3	138	144	PF00018	0.561
LIG_SH3_3	2	8	PF00018	0.596
LIG_SH3_3	249	255	PF00018	0.633
LIG_SH3_3	46	52	PF00018	0.470
LIG_Sin3_3	197	204	PF02671	0.403
LIG_SxIP_EBH_1	172	183	PF03271	0.487
LIG_TRAF2_1	120	123	PF00917	0.462
LIG_TRAF2_1	439	442	PF00917	0.373
LIG_TRFH_1	505	509	PF08558	0.345
LIG_TYR_ITIM	336	341	PF00017	0.297
MOD_CK1_1	137	143	PF00069	0.541
MOD_CK1_1	165	171	PF00069	0.511
MOD_CK1_1	325	331	PF00069	0.262
MOD_CK1_1	348	354	PF00069	0.402
MOD_CK1_1	454	460	PF00069	0.662
MOD_CK2_1	157	163	PF00069	0.362
MOD_CK2_1	290	296	PF00069	0.486
MOD_CK2_1	348	354	PF00069	0.402
MOD_GlcNHglycan	136	139	PF01048	0.276
MOD_GlcNHglycan	151	154	PF01048	0.343
MOD_GlcNHglycan	163	167	PF01048	0.326
MOD_GlcNHglycan	249	252	PF01048	0.640
MOD_GlcNHglycan	279	282	PF01048	0.685
MOD_GlcNHglycan	283	286	PF01048	0.650
MOD_GlcNHglycan	31	34	PF01048	0.251
MOD_GlcNHglycan	347	350	PF01048	0.347
MOD_GlcNHglycan	361	364	PF01048	0.294
MOD_GlcNHglycan	453	456	PF01048	0.586
MOD_GlcNHglycan	460	463	PF01048	0.645
MOD_GlcNHglycan	473	477	PF01048	0.659
MOD_GlcNHglycan	496	500	PF01048	0.563
MOD_GlcNHglycan	555	558	PF01048	0.604
MOD_GlcNHglycan	575	578	PF01048	0.603
MOD_GlcNHglycan	8	11	PF01048	0.483
MOD_GSK3_1	132	139	PF00069	0.446
MOD_GSK3_1	167	174	PF00069	0.453
MOD_GSK3_1	277	284	PF00069	0.690
MOD_GSK3_1	29	36	PF00069	0.440
MOD_GSK3_1	303	310	PF00069	0.453
MOD_GSK3_1	43	50	PF00069	0.448
MOD_GSK3_1	454	461	PF00069	0.607
MOD_GSK3_1	472	479	PF00069	0.755
MOD_GSK3_1	531	538	PF00069	0.645
MOD_GSK3_1	551	558	PF00069	0.718
MOD_GSK3_1	6	13	PF00069	0.477
MOD_NEK2_1	136	141	PF00069	0.362
MOD_NEK2_1	171	176	PF00069	0.389
MOD_NEK2_1	239	244	PF00069	0.564
MOD_NEK2_1	307	312	PF00069	0.296
MOD_NEK2_1	43	48	PF00069	0.458
MOD_NEK2_1	592	597	PF00069	0.601
MOD_NEK2_1	91	96	PF00069	0.423
MOD_NEK2_2	167	172	PF00069	0.362
MOD_PIKK_1	33	39	PF00454	0.484
MOD_PIKK_1	348	354	PF00454	0.375
MOD_PK_1	173	179	PF00069	0.362
MOD_PK_1	392	398	PF00069	0.177
MOD_PK_1	68	74	PF00069	0.523
MOD_PKA_1	172	178	PF00069	0.524
MOD_PKA_1	290	296	PF00069	0.539
MOD_PKA_1	301	307	PF00069	0.210
MOD_PKA_2	172	178	PF00069	0.524
MOD_PKA_2	290	296	PF00069	0.530
MOD_PKA_2	301	307	PF00069	0.340
MOD_PKA_2	43	49	PF00069	0.415
MOD_PKA_2	520	526	PF00069	0.595
MOD_PKB_1	299	307	PF00069	0.343
MOD_Plk_1	568	574	PF00069	0.650
MOD_Plk_4	68	74	PF00069	0.523
MOD_ProDKin_1	140	146	PF00069	0.481
MOD_ProDKin_1	312	318	PF00069	0.292
MOD_ProDKin_1	4	10	PF00069	0.574
MOD_ProDKin_1	562	568	PF00069	0.623
MOD_SUMO_for_1	216	219	PF00179	0.423
MOD_SUMO_rev_2	315	325	PF00179	0.402
TRG_ENDOCYTIC_2	102	105	PF00928	0.423
TRG_ENDOCYTIC_2	338	341	PF00928	0.277
TRG_ENDOCYTIC_2	504	507	PF00928	0.478
TRG_ER_diArg_1	288	291	PF00400	0.638
TRG_ER_diArg_1	299	302	PF00400	0.478
TRG_ER_diArg_1	391	393	PF00400	0.406
TRG_ER_diArg_1	447	450	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	56%	98%
A0A0S4IZ51	Bodo saltans	42%	100%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A3S7X363	Leishmania donovani	79%	99%
A0A422P4X7	Trypanosoma rangeli	40%	100%
A4I5D1	Leishmania infantum	79%	99%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
O15530	Homo sapiens	24%	100%
O55173	Rattus norvegicus	24%	100%
P13677	Drosophila melanogaster	21%	86%
Q4Q7K3	Leishmania major	77%	100%
Q9Y1J3	Caenorhabditis elegans	22%	95%
Q9Z2A0	Mus musculus	25%	100%
V5BU83	Trypanosoma cruzi	42%	100%