Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI54_LEIBR

TriTrypDb:

LbrM.30.1110 , LBRM2903_300016700

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.440
CLV_C14_Caspase3-7	395	399	PF00656	0.492
CLV_C14_Caspase3-7	513	517	PF00656	0.463
CLV_C14_Caspase3-7	89	93	PF00656	0.603
CLV_NRD_NRD_1	239	241	PF00675	0.620
CLV_NRD_NRD_1	288	290	PF00675	0.658
CLV_NRD_NRD_1	329	331	PF00675	0.567
CLV_NRD_NRD_1	475	477	PF00675	0.373
CLV_NRD_NRD_1	55	57	PF00675	0.638
CLV_PCSK_FUR_1	289	293	PF00082	0.662
CLV_PCSK_KEX2_1	239	241	PF00082	0.620
CLV_PCSK_KEX2_1	272	274	PF00082	0.523
CLV_PCSK_KEX2_1	288	290	PF00082	0.607
CLV_PCSK_KEX2_1	291	293	PF00082	0.614
CLV_PCSK_KEX2_1	329	331	PF00082	0.567
CLV_PCSK_KEX2_1	475	477	PF00082	0.373
CLV_PCSK_KEX2_1	55	57	PF00082	0.638
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.523
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.614
CLV_PCSK_SKI1_1	174	178	PF00082	0.598
CLV_PCSK_SKI1_1	219	223	PF00082	0.430
CLV_PCSK_SKI1_1	262	266	PF00082	0.504
CLV_PCSK_SKI1_1	352	356	PF00082	0.636
CLV_PCSK_SKI1_1	367	371	PF00082	0.557
CLV_PCSK_SKI1_1	372	376	PF00082	0.528
CLV_PCSK_SKI1_1	41	45	PF00082	0.500
CLV_PCSK_SKI1_1	475	479	PF00082	0.361
CLV_PCSK_SKI1_1	515	519	PF00082	0.320
DEG_APCC_DBOX_1	291	299	PF00400	0.532
DEG_SCF_FBW7_1	184	189	PF00400	0.508
DEG_SPOP_SBC_1	316	320	PF00917	0.643
DOC_CKS1_1	298	303	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.525
DOC_MAPK_gen_1	329	336	PF00069	0.551
DOC_MAPK_MEF2A_6	329	338	PF00069	0.550
DOC_PP1_RVXF_1	370	377	PF00149	0.549
DOC_PP1_RVXF_1	39	46	PF00149	0.494
DOC_PP2B_LxvP_1	313	316	PF13499	0.527
DOC_PP2B_LxvP_1	357	360	PF13499	0.458
DOC_PP2B_LxvP_1	375	378	PF13499	0.563
DOC_PP2B_LxvP_1	390	393	PF13499	0.396
DOC_PP4_FxxP_1	415	418	PF00568	0.416
DOC_USP7_MATH_1	303	307	PF00917	0.717
DOC_USP7_MATH_1	316	320	PF00917	0.548
DOC_USP7_MATH_1	344	348	PF00917	0.705
DOC_USP7_MATH_1	440	444	PF00917	0.354
DOC_USP7_MATH_1	549	553	PF00917	0.588
DOC_USP7_MATH_1	64	68	PF00917	0.528
DOC_USP7_MATH_1	7	11	PF00917	0.630
DOC_USP7_MATH_1	88	92	PF00917	0.693
DOC_USP7_MATH_1	96	100	PF00917	0.689
DOC_WW_Pin1_4	16	21	PF00397	0.592
DOC_WW_Pin1_4	182	187	PF00397	0.618
DOC_WW_Pin1_4	198	203	PF00397	0.750
DOC_WW_Pin1_4	233	238	PF00397	0.565
DOC_WW_Pin1_4	297	302	PF00397	0.645
DOC_WW_Pin1_4	33	38	PF00397	0.614
DOC_WW_Pin1_4	340	345	PF00397	0.570
DOC_WW_Pin1_4	402	407	PF00397	0.674
LIG_14-3-3_CanoR_1	174	180	PF00244	0.656
LIG_14-3-3_CanoR_1	367	376	PF00244	0.485
LIG_14-3-3_CanoR_1	65	73	PF00244	0.653
LIG_BIR_III_4	114	118	PF00653	0.587
LIG_Clathr_ClatBox_1	193	197	PF01394	0.522
LIG_eIF4E_1	556	562	PF01652	0.483
LIG_FHA_1	186	192	PF00498	0.508
LIG_FHA_1	213	219	PF00498	0.594
LIG_FHA_1	255	261	PF00498	0.548
LIG_FHA_1	308	314	PF00498	0.683
LIG_FHA_1	351	357	PF00498	0.487
LIG_FHA_1	505	511	PF00498	0.497
LIG_FHA_1	517	523	PF00498	0.335
LIG_FHA_1	81	87	PF00498	0.648
LIG_FHA_2	246	252	PF00498	0.529
LIG_LIR_Gen_1	127	136	PF02991	0.553
LIG_LIR_Gen_1	480	489	PF02991	0.456
LIG_LIR_LC3C_4	542	545	PF02991	0.492
LIG_LIR_Nem_3	127	132	PF02991	0.487
LIG_LIR_Nem_3	349	354	PF02991	0.485
LIG_LIR_Nem_3	480	484	PF02991	0.411
LIG_MYND_1	410	414	PF01753	0.608
LIG_NRBOX	260	266	PF00104	0.502
LIG_NRBOX	353	359	PF00104	0.544
LIG_NRBOX	39	45	PF00104	0.488
LIG_SH2_STAT5	481	484	PF00017	0.362
LIG_SH3_2	50	55	PF14604	0.600
LIG_SH3_3	14	20	PF00018	0.550
LIG_SH3_3	295	301	PF00018	0.637
LIG_SH3_3	375	381	PF00018	0.474
LIG_SH3_3	408	414	PF00018	0.607
LIG_SH3_3	47	53	PF00018	0.537
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.413
LIG_SUMO_SIM_par_1	192	199	PF11976	0.516
LIG_SUMO_SIM_par_1	224	231	PF11976	0.546
LIG_SUMO_SIM_par_1	355	362	PF11976	0.453
MOD_CDC14_SPxK_1	236	239	PF00782	0.512
MOD_CDK_SPK_2	402	407	PF00069	0.539
MOD_CDK_SPxK_1	233	239	PF00069	0.496
MOD_CDK_SPxxK_3	233	240	PF00069	0.545
MOD_CK1_1	166	172	PF00069	0.545
MOD_CK1_1	19	25	PF00069	0.636
MOD_CK1_1	195	201	PF00069	0.710
MOD_CK1_1	204	210	PF00069	0.688
MOD_CK1_1	279	285	PF00069	0.691
MOD_CK1_1	306	312	PF00069	0.730
MOD_CK1_1	347	353	PF00069	0.542
MOD_CK1_1	361	367	PF00069	0.498
MOD_CK1_1	501	507	PF00069	0.513
MOD_CK1_1	54	60	PF00069	0.640
MOD_CK1_1	67	73	PF00069	0.536
MOD_CK1_1	84	90	PF00069	0.703
MOD_CK2_1	245	251	PF00069	0.535
MOD_GlcNHglycan	103	106	PF01048	0.651
MOD_GlcNHglycan	14	17	PF01048	0.638
MOD_GlcNHglycan	197	201	PF01048	0.776
MOD_GlcNHglycan	207	210	PF01048	0.730
MOD_GlcNHglycan	230	233	PF01048	0.578
MOD_GlcNHglycan	278	281	PF01048	0.658
MOD_GlcNHglycan	305	308	PF01048	0.596
MOD_GlcNHglycan	323	326	PF01048	0.455
MOD_GlcNHglycan	346	349	PF01048	0.592
MOD_GlcNHglycan	361	364	PF01048	0.486
MOD_GlcNHglycan	367	370	PF01048	0.583
MOD_GlcNHglycan	402	405	PF01048	0.691
MOD_GlcNHglycan	484	487	PF01048	0.381
MOD_GlcNHglycan	493	496	PF01048	0.599
MOD_GlcNHglycan	531	534	PF01048	0.479
MOD_GlcNHglycan	56	59	PF01048	0.633
MOD_GlcNHglycan	85	89	PF01048	0.700
MOD_GSK3_1	175	182	PF00069	0.506
MOD_GSK3_1	192	199	PF00069	0.673
MOD_GSK3_1	201	208	PF00069	0.622
MOD_GSK3_1	238	245	PF00069	0.632
MOD_GSK3_1	303	310	PF00069	0.776
MOD_GSK3_1	317	324	PF00069	0.508
MOD_GSK3_1	340	347	PF00069	0.507
MOD_GSK3_1	358	365	PF00069	0.541
MOD_GSK3_1	396	403	PF00069	0.595
MOD_GSK3_1	487	494	PF00069	0.521
MOD_GSK3_1	499	506	PF00069	0.519
MOD_GSK3_1	64	71	PF00069	0.562
MOD_GSK3_1	7	14	PF00069	0.620
MOD_GSK3_1	80	87	PF00069	0.699
MOD_GSK3_1	96	103	PF00069	0.616
MOD_N-GLC_1	396	401	PF02516	0.507
MOD_N-GLC_1	68	73	PF02516	0.527
MOD_NEK2_1	11	16	PF00069	0.642
MOD_NEK2_1	228	233	PF00069	0.715
MOD_NEK2_1	317	322	PF00069	0.654
MOD_NEK2_1	499	504	PF00069	0.521
MOD_NEK2_1	521	526	PF00069	0.496
MOD_NEK2_2	440	445	PF00069	0.471
MOD_PIKK_1	106	112	PF00454	0.646
MOD_PIKK_1	201	207	PF00454	0.526
MOD_PIKK_1	24	30	PF00454	0.569
MOD_PIKK_1	307	313	PF00454	0.548
MOD_PIKK_1	504	510	PF00454	0.416
MOD_PKA_2	282	288	PF00069	0.572
MOD_PKA_2	499	505	PF00069	0.502
MOD_PKA_2	54	60	PF00069	0.640
MOD_PKA_2	64	70	PF00069	0.557
MOD_Plk_1	246	252	PF00069	0.492
MOD_Plk_1	397	403	PF00069	0.529
MOD_Plk_1	68	74	PF00069	0.528
MOD_Plk_4	294	300	PF00069	0.574
MOD_Plk_4	352	358	PF00069	0.586
MOD_Plk_4	440	446	PF00069	0.464
MOD_ProDKin_1	16	22	PF00069	0.594
MOD_ProDKin_1	182	188	PF00069	0.618
MOD_ProDKin_1	198	204	PF00069	0.752
MOD_ProDKin_1	233	239	PF00069	0.571
MOD_ProDKin_1	297	303	PF00069	0.644
MOD_ProDKin_1	33	39	PF00069	0.610
MOD_ProDKin_1	340	346	PF00069	0.566
MOD_ProDKin_1	402	408	PF00069	0.673
MOD_SUMO_rev_2	213	221	PF00179	0.455
MOD_SUMO_rev_2	552	561	PF00179	0.400
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.606
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.377
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.520
TRG_DiLeu_LyEn_5	34	39	PF01217	0.541
TRG_ENDOCYTIC_2	481	484	PF00928	0.413
TRG_ER_diArg_1	121	124	PF00400	0.501
TRG_ER_diArg_1	238	240	PF00400	0.529
TRG_ER_diArg_1	287	289	PF00400	0.655
TRG_ER_diArg_1	474	476	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA3	Leptomonas seymouri	43%	82%
A0A3S7X3A4	Leishmania donovani	71%	99%
A4I5D0	Leishmania infantum	71%	99%
E9B0M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q7K4	Leishmania major	70%	100%