Autophagy protein 5 (ATG5)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 5

Species:

Leishmania braziliensis

UniProt:

A4HI53_LEIBR

TriTrypDb:

LbrM.30.1100 , LBRM2903_300016600

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI53

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0061919	process utilizing autophagic mechanism	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	422	424	PF00675	0.685
CLV_PCSK_KEX2_1	422	424	PF00082	0.685
CLV_PCSK_SKI1_1	225	229	PF00082	0.733
CLV_PCSK_SKI1_1	357	361	PF00082	0.751
CLV_PCSK_SKI1_1	451	455	PF00082	0.660
CLV_PCSK_SKI1_1	7	11	PF00082	0.545
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DOC_CDC14_PxL_1	300	308	PF14671	0.641
DOC_CKS1_1	227	232	PF01111	0.665
DOC_CKS1_1	435	440	PF01111	0.772
DOC_CYCLIN_RxL_1	222	229	PF00134	0.728
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.664
DOC_MAPK_MEF2A_6	264	273	PF00069	0.762
DOC_MAPK_MEF2A_6	401	408	PF00069	0.716
DOC_MAPK_MEF2A_6	451	459	PF00069	0.659
DOC_MAPK_NFAT4_5	401	409	PF00069	0.679
DOC_PP1_RVXF_1	176	183	PF00149	0.499
DOC_PP1_RVXF_1	237	243	PF00149	0.663
DOC_PP1_RVXF_1	420	427	PF00149	0.732
DOC_PP2B_LxvP_1	375	378	PF13499	0.510
DOC_PP2B_LxvP_1	431	434	PF13499	0.534
DOC_PP4_FxxP_1	211	214	PF00568	0.731
DOC_PP4_FxxP_1	301	304	PF00568	0.628
DOC_SPAK_OSR1_1	425	429	PF12202	0.798
DOC_USP7_MATH_1	412	416	PF00917	0.798
DOC_USP7_UBL2_3	127	131	PF12436	0.497
DOC_WW_Pin1_4	210	215	PF00397	0.706
DOC_WW_Pin1_4	226	231	PF00397	0.531
DOC_WW_Pin1_4	31	36	PF00397	0.568
DOC_WW_Pin1_4	370	375	PF00397	0.677
DOC_WW_Pin1_4	414	419	PF00397	0.672
DOC_WW_Pin1_4	434	439	PF00397	0.736
DOC_WW_Pin1_4	65	70	PF00397	0.627
LIG_14-3-3_CanoR_1	183	190	PF00244	0.514
LIG_14-3-3_CanoR_1	264	271	PF00244	0.763
LIG_APCC_ABBA_1	18	23	PF00400	0.417
LIG_EVH1_2	207	211	PF00568	0.504
LIG_FHA_1	22	28	PF00498	0.618
LIG_FHA_1	327	333	PF00498	0.505
LIG_FHA_1	358	364	PF00498	0.722
LIG_FHA_2	371	377	PF00498	0.709
LIG_HCF-1_HBM_1	338	341	PF13415	0.473
LIG_LIR_Apic_2	37	41	PF02991	0.568
LIG_LIR_Gen_1	218	228	PF02991	0.624
LIG_LIR_Gen_1	338	349	PF02991	0.662
LIG_LIR_Nem_3	135	141	PF02991	0.548
LIG_LIR_Nem_3	218	223	PF02991	0.615
LIG_LIR_Nem_3	25	31	PF02991	0.494
LIG_LIR_Nem_3	254	260	PF02991	0.695
LIG_LIR_Nem_3	338	344	PF02991	0.613
LIG_NRBOX	223	229	PF00104	0.728
LIG_PDZ_Class_2	454	459	PF00595	0.732
LIG_SH2_CRK	134	138	PF00017	0.544
LIG_SH2_CRK	220	224	PF00017	0.577
LIG_SH2_GRB2like	112	115	PF00017	0.577
LIG_SH2_GRB2like	48	51	PF00017	0.574
LIG_SH2_NCK_1	352	356	PF00017	0.767
LIG_SH2_SRC	352	355	PF00017	0.692
LIG_SH2_STAP1	134	138	PF00017	0.588
LIG_SH2_STAP1	16	20	PF00017	0.605
LIG_SH2_STAT5	112	115	PF00017	0.577
LIG_SH2_STAT5	134	137	PF00017	0.583
LIG_SH2_STAT5	141	144	PF00017	0.578
LIG_SH2_STAT5	215	218	PF00017	0.707
LIG_SH2_STAT5	236	239	PF00017	0.652
LIG_SH2_STAT5	257	260	PF00017	0.693
LIG_SH2_STAT5	48	51	PF00017	0.574
LIG_SH3_3	371	377	PF00018	0.709
LIG_SH3_3	66	72	PF00018	0.558
LIG_TYR_ITIM	113	118	PF00017	0.563
LIG_UBA3_1	92	101	PF00899	0.385
LIG_WRPW_2	13	16	PF00400	0.678
LIG_WRPW_2	161	164	PF00400	0.624
LIG_WW_3	354	358	PF00397	0.784
MOD_CK1_1	194	200	PF00069	0.756
MOD_CK1_1	317	323	PF00069	0.745
MOD_CK1_1	64	70	PF00069	0.662
MOD_CK1_1	73	79	PF00069	0.570
MOD_CK1_1	84	90	PF00069	0.660
MOD_CK2_1	332	338	PF00069	0.732
MOD_CK2_1	370	376	PF00069	0.787
MOD_CK2_1	437	443	PF00069	0.677
MOD_CMANNOS	380	383	PF00535	0.670
MOD_Cter_Amidation	420	423	PF01082	0.667
MOD_GlcNHglycan	149	152	PF01048	0.664
MOD_GlcNHglycan	185	188	PF01048	0.698
MOD_GlcNHglycan	197	200	PF01048	0.731
MOD_GlcNHglycan	201	204	PF01048	0.733
MOD_GlcNHglycan	265	268	PF01048	0.613
MOD_GlcNHglycan	273	276	PF01048	0.580
MOD_GlcNHglycan	329	332	PF01048	0.716
MOD_GlcNHglycan	61	64	PF01048	0.704
MOD_GlcNHglycan	72	75	PF01048	0.639
MOD_GSK3_1	190	197	PF00069	0.754
MOD_GSK3_1	259	266	PF00069	0.633
MOD_GSK3_1	27	34	PF00069	0.538
MOD_GSK3_1	271	278	PF00069	0.678
MOD_GSK3_1	314	321	PF00069	0.724
MOD_GSK3_1	433	440	PF00069	0.757
MOD_GSK3_1	61	68	PF00069	0.595
MOD_GSK3_1	73	80	PF00069	0.655
MOD_GSK3_1	97	104	PF00069	0.415
MOD_N-GLC_1	139	144	PF02516	0.567
MOD_N-GLC_1	444	449	PF02516	0.484
MOD_N-GLC_2	50	52	PF02516	0.576
MOD_NEK2_1	105	110	PF00069	0.601
MOD_NEK2_1	271	276	PF00069	0.724
MOD_NEK2_1	344	349	PF00069	0.599
MOD_NEK2_1	369	374	PF00069	0.774
MOD_NEK2_1	61	66	PF00069	0.714
MOD_NEK2_1	77	82	PF00069	0.609
MOD_NEK2_2	139	144	PF00069	0.567
MOD_PIKK_1	22	28	PF00454	0.546
MOD_PKA_2	263	269	PF00069	0.684
MOD_Plk_1	139	145	PF00069	0.568
MOD_Plk_1	22	28	PF00069	0.546
MOD_Plk_1	318	324	PF00069	0.564
MOD_Plk_1	337	343	PF00069	0.654
MOD_Plk_1	383	389	PF00069	0.483
MOD_Plk_4	132	138	PF00069	0.655
MOD_Plk_4	139	145	PF00069	0.604
MOD_Plk_4	34	40	PF00069	0.619
MOD_Plk_4	383	389	PF00069	0.611
MOD_Plk_4	437	443	PF00069	0.677
MOD_Plk_4	61	67	PF00069	0.575
MOD_Plk_4	73	79	PF00069	0.580
MOD_Plk_4	81	87	PF00069	0.662
MOD_ProDKin_1	210	216	PF00069	0.703
MOD_ProDKin_1	226	232	PF00069	0.531
MOD_ProDKin_1	31	37	PF00069	0.566
MOD_ProDKin_1	370	376	PF00069	0.675
MOD_ProDKin_1	414	420	PF00069	0.672
MOD_ProDKin_1	434	440	PF00069	0.737
MOD_ProDKin_1	65	71	PF00069	0.623
MOD_SUMO_rev_2	119	129	PF00179	0.647
TRG_DiLeu_BaEn_1	219	224	PF01217	0.713
TRG_DiLeu_BaEn_1	88	93	PF01217	0.397
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.711
TRG_ENDOCYTIC_2	115	118	PF00928	0.560
TRG_ENDOCYTIC_2	134	137	PF00928	0.538
TRG_ENDOCYTIC_2	161	164	PF00928	0.624
TRG_ENDOCYTIC_2	177	180	PF00928	0.680
TRG_ENDOCYTIC_2	220	223	PF00928	0.641
TRG_ENDOCYTIC_2	341	344	PF00928	0.617
TRG_ER_diArg_1	422	425	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W7	Leptomonas seymouri	55%	86%
A0A3S7X356	Leishmania donovani	84%	100%
A4I5C9	Leishmania infantum	84%	100%
E9B0M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7K5	Leishmania major	82%	100%
V5BPN6	Trypanosoma cruzi	22%	100%