Autophagy protein 5 (ATG5)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 5

Species:

Leishmania braziliensis

UniProt:

A4HI53_LEIBR

TriTrypDb:

LbrM.30.1100 , LBRM2903_300016600

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HI53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI53

Function

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Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0061919	process utilizing autophagic mechanism	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	422	424	PF00675	0.685
CLV_PCSK_KEX2_1	422	424	PF00082	0.685
CLV_PCSK_SKI1_1	225	229	PF00082	0.733
CLV_PCSK_SKI1_1	357	361	PF00082	0.751
CLV_PCSK_SKI1_1	451	455	PF00082	0.660
CLV_PCSK_SKI1_1	7	11	PF00082	0.545
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DOC_CDC14_PxL_1	300	308	PF14671	0.641
DOC_CKS1_1	227	232	PF01111	0.665
DOC_CKS1_1	435	440	PF01111	0.772

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W7	Leptomonas seymouri	55%	86%
A0A3S7X356	Leishmania donovani	84%	100%
A4I5C9	Leishmania infantum	84%	100%
E9B0M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7K5	Leishmania major	82%	100%
V5BPN6	Trypanosoma cruzi	22%	100%

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