Putative p22 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p22 protein precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HI52_LEIBR

TriTrypDb:

LbrM.30.1090 , LBRM2903_300016500

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	21
GO:0031974	membrane-enclosed lumen	2	21
GO:0043233	organelle lumen	3	21
GO:0070013	intracellular organelle lumen	4	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A4HI52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI52

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.755
CLV_C14_Caspase3-7	9	13	PF00656	0.568
CLV_NRD_NRD_1	20	22	PF00675	0.686
CLV_NRD_NRD_1	45	47	PF00675	0.653
CLV_PCSK_KEX2_1	129	131	PF00082	0.331
CLV_PCSK_KEX2_1	156	158	PF00082	0.401
CLV_PCSK_KEX2_1	20	22	PF00082	0.683
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.368
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.401
DOC_CKS1_1	35	40	PF01111	0.799
DOC_PP2B_LxvP_1	3	6	PF13499	0.595
DOC_USP7_MATH_1	6	10	PF00917	0.749
DOC_WW_Pin1_4	34	39	PF00397	0.801
LIG_14-3-3_CanoR_1	111	118	PF00244	0.564
LIG_14-3-3_CanoR_1	8	15	PF00244	0.543
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_CtBP_PxDLS_1	61	67	PF00389	0.740
LIG_deltaCOP1_diTrp_1	180	189	PF00928	0.513
LIG_FHA_1	133	139	PF00498	0.597
LIG_FHA_1	35	41	PF00498	0.544
LIG_FHA_1	50	56	PF00498	0.728
LIG_FHA_2	120	126	PF00498	0.510
LIG_FHA_2	150	156	PF00498	0.503
LIG_FHA_2	17	23	PF00498	0.636
LIG_FHA_2	68	74	PF00498	0.728
LIG_GBD_Chelix_1	138	146	PF00786	0.401
LIG_LIR_Apic_2	132	137	PF02991	0.512
LIG_LIR_Gen_1	141	151	PF02991	0.601
LIG_LIR_Gen_1	165	174	PF02991	0.601
LIG_LIR_LC3C_4	62	66	PF02991	0.747
LIG_LIR_Nem_3	141	147	PF02991	0.545
LIG_LIR_Nem_3	165	169	PF02991	0.585
LIG_LIR_Nem_3	81	86	PF02991	0.526
LIG_LRP6_Inhibitor_1	105	111	PF00058	0.401
LIG_PDZ_Class_2	186	191	PF00595	0.523
LIG_PTB_Apo_2	106	113	PF02174	0.559
LIG_SH2_CRK	134	138	PF00017	0.535
LIG_SH2_CRK	144	148	PF00017	0.535
LIG_SH2_NCK_1	113	117	PF00017	0.602
LIG_SH2_STAP1	113	117	PF00017	0.631
LIG_SH2_STAP1	170	174	PF00017	0.526
LIG_SH2_STAP1	179	183	PF00017	0.434
LIG_SH2_STAT3	85	88	PF00017	0.601
LIG_SH2_STAT5	134	137	PF00017	0.601
LIG_SH2_STAT5	153	156	PF00017	0.513
LIG_SH2_STAT5	85	88	PF00017	0.562
LIG_SH3_3	30	36	PF00018	0.687
LIG_TRAF2_1	99	102	PF00917	0.601
LIG_TYR_ITIM	142	147	PF00017	0.581
LIG_WRC_WIRS_1	169	174	PF05994	0.601
MOD_CK2_1	119	125	PF00069	0.536
MOD_CK2_1	149	155	PF00069	0.568
MOD_CK2_1	16	22	PF00069	0.583
MOD_CK2_1	96	102	PF00069	0.588
MOD_GlcNHglycan	121	125	PF01048	0.357
MOD_GlcNHglycan	8	11	PF01048	0.588
MOD_GSK3_1	49	56	PF00069	0.692
MOD_GSK3_1	67	74	PF00069	0.755
MOD_NEK2_1	53	58	PF00069	0.653
MOD_PIKK_1	84	90	PF00454	0.616
MOD_PKA_2	66	72	PF00069	0.734
MOD_Plk_1	96	102	PF00069	0.575
MOD_Plk_4	149	155	PF00069	0.527
MOD_Plk_4	168	174	PF00069	0.540
MOD_ProDKin_1	34	40	PF00069	0.803
MOD_SUMO_rev_2	155	163	PF00179	0.601
TRG_DiLeu_BaEn_1	101	106	PF01217	0.568
TRG_DiLeu_BaEn_1	60	65	PF01217	0.735
TRG_ENDOCYTIC_2	144	147	PF00928	0.581
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	86%	83%
A0A0N1HS24	Leptomonas seymouri	24%	75%
A0A0S4ITN8	Bodo saltans	39%	84%
A0A0S4J7P7	Bodo saltans	30%	100%
A0A1X0NTH7	Trypanosomatidae	26%	73%
A0A1X0P207	Trypanosomatidae	48%	86%
A0A3Q8IBW7	Leishmania donovani	94%	82%
A0A3Q8IFM4	Leishmania donovani	28%	75%
A0A422P4Z7	Trypanosoma rangeli	43%	85%
A4HCI6	Leishmania braziliensis	28%	100%
A4I007	Leishmania infantum	28%	75%
A4I5C8	Leishmania infantum	94%	94%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	84%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	73%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	77%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	82%
Q4Q7K6	Leishmania major	93%	100%
Q4QBJ9	Leishmania major	29%	100%
V5BDB3	Trypanosoma cruzi	26%	73%