TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI51_LEIBR

TriTrypDb:

LbrM.30.1080 , LBRM2903_300016400

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.574
CLV_NRD_NRD_1	190	192	PF00675	0.806
CLV_NRD_NRD_1	30	32	PF00675	0.814
CLV_NRD_NRD_1	54	56	PF00675	0.762
CLV_PCSK_KEX2_1	32	34	PF00082	0.851
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.852
CLV_PCSK_SKI1_1	299	303	PF00082	0.562
CLV_PCSK_SKI1_1	351	355	PF00082	0.605
CLV_PCSK_SKI1_1	396	400	PF00082	0.687
CLV_PCSK_SKI1_1	446	450	PF00082	0.728
DOC_CDC14_PxL_1	266	274	PF14671	0.770
DOC_CKS1_1	116	121	PF01111	0.562
DOC_CKS1_1	300	305	PF01111	0.540
DOC_CKS1_1	64	69	PF01111	0.809
DOC_CYCLIN_yClb1_LxF_4	399	405	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.743
DOC_CYCLIN_yCln2_LP_2	238	241	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.537
DOC_MAPK_DCC_7	60	70	PF00069	0.586
DOC_MAPK_gen_1	296	306	PF00069	0.559
DOC_MAPK_MEF2A_6	299	308	PF00069	0.559
DOC_PP2B_LxvP_1	128	131	PF13499	0.549
DOC_PP2B_LxvP_1	150	153	PF13499	0.768
DOC_PP2B_LxvP_1	238	241	PF13499	0.589
DOC_PP2B_LxvP_1	68	71	PF13499	0.673
DOC_PP2B_LxvP_1	87	90	PF13499	0.546
DOC_PP4_FxxP_1	404	407	PF00568	0.702
DOC_PP4_FxxP_1	410	413	PF00568	0.628
DOC_USP7_MATH_1	13	17	PF00917	0.580
DOC_USP7_MATH_1	156	160	PF00917	0.697
DOC_USP7_MATH_1	184	188	PF00917	0.635
DOC_USP7_MATH_1	72	76	PF00917	0.588
DOC_USP7_MATH_2	156	162	PF00917	0.571
DOC_WW_Pin1_4	106	111	PF00397	0.594
DOC_WW_Pin1_4	115	120	PF00397	0.611
DOC_WW_Pin1_4	152	157	PF00397	0.756
DOC_WW_Pin1_4	273	278	PF00397	0.741
DOC_WW_Pin1_4	299	304	PF00397	0.541
DOC_WW_Pin1_4	326	331	PF00397	0.845
DOC_WW_Pin1_4	359	364	PF00397	0.646
DOC_WW_Pin1_4	38	43	PF00397	0.738
DOC_WW_Pin1_4	63	68	PF00397	0.803
LIG_14-3-3_CanoR_1	160	166	PF00244	0.835
LIG_14-3-3_CanoR_1	197	201	PF00244	0.640
LIG_14-3-3_CanoR_1	69	78	PF00244	0.701
LIG_Clathr_ClatBox_1	402	406	PF01394	0.696
LIG_CtBP_PxDLS_1	130	134	PF00389	0.544
LIG_EVH1_1	113	117	PF00568	0.564
LIG_FHA_1	12	18	PF00498	0.605
LIG_FHA_1	234	240	PF00498	0.588
LIG_FHA_1	397	403	PF00498	0.685
LIG_FHA_1	93	99	PF00498	0.552
LIG_FHA_2	24	30	PF00498	0.573
LIG_FHA_2	259	265	PF00498	0.749
LIG_FHA_2	424	430	PF00498	0.695
LIG_HCF-1_HBM_1	420	423	PF13415	0.709
LIG_LIR_Apic_2	61	67	PF02991	0.797
LIG_LIR_Gen_1	254	265	PF02991	0.616
LIG_LIR_Nem_3	118	124	PF02991	0.573
LIG_LIR_Nem_3	254	260	PF02991	0.630
LIG_LIR_Nem_3	261	266	PF02991	0.616
LIG_PDZ_Class_1	446	451	PF00595	0.738
LIG_Pex14_2	394	398	PF04695	0.659
LIG_SH2_NCK_1	151	155	PF00017	0.534
LIG_SH2_SRC	151	154	PF00017	0.529
LIG_SH2_STAP1	253	257	PF00017	0.566
LIG_SH3_1	274	280	PF00018	0.805
LIG_SH3_3	111	117	PF00018	0.697
LIG_SH3_3	150	156	PF00018	0.743
LIG_SH3_3	208	214	PF00018	0.566
LIG_SH3_3	237	243	PF00018	0.819
LIG_SH3_3	265	271	PF00018	0.693
LIG_SH3_3	274	280	PF00018	0.617
LIG_SH3_3	349	355	PF00018	0.825
LIG_SH3_3	39	45	PF00018	0.576
LIG_SH3_3	402	408	PF00018	0.699
LIG_SH3_CIN85_PxpxPR_1	110	115	PF14604	0.564
LIG_SUMO_SIM_par_1	412	417	PF11976	0.727
LIG_TRAF2_1	142	145	PF00917	0.721
LIG_TRAF2_1	435	438	PF00917	0.715
LIG_WRC_WIRS_1	391	396	PF05994	0.438
LIG_WW_3	366	370	PF00397	0.546
MOD_CDK_SPK_2	273	278	PF00069	0.795
MOD_CDK_SPxK_1	63	69	PF00069	0.805
MOD_CK1_1	106	112	PF00069	0.549
MOD_CK1_1	159	165	PF00069	0.720
MOD_CK1_1	195	201	PF00069	0.604
MOD_CK1_1	233	239	PF00069	0.639
MOD_CK1_1	252	258	PF00069	0.711
MOD_CK2_1	139	145	PF00069	0.739
MOD_CK2_1	152	158	PF00069	0.584
MOD_CK2_1	182	188	PF00069	0.734
MOD_CK2_1	317	323	PF00069	0.723
MOD_CK2_1	432	438	PF00069	0.721
MOD_DYRK1A_RPxSP_1	115	119	PF00069	0.561
MOD_GlcNHglycan	161	164	PF01048	0.842
MOD_GlcNHglycan	200	203	PF01048	0.651
MOD_GlcNHglycan	7	10	PF01048	0.771
MOD_GlcNHglycan	74	77	PF01048	0.552
MOD_GSK3_1	13	20	PF00069	0.560
MOD_GSK3_1	131	138	PF00069	0.776
MOD_GSK3_1	152	159	PF00069	0.602
MOD_GSK3_1	192	199	PF00069	0.692
MOD_GSK3_1	23	30	PF00069	0.525
MOD_GSK3_1	230	237	PF00069	0.692
MOD_GSK3_1	249	256	PF00069	0.623
MOD_GSK3_1	306	313	PF00069	0.669
MOD_GSK3_1	317	324	PF00069	0.660
MOD_GSK3_1	331	338	PF00069	0.658
MOD_GSK3_1	99	106	PF00069	0.554
MOD_N-GLC_1	317	322	PF02516	0.649
MOD_NEK2_1	103	108	PF00069	0.638
MOD_NEK2_1	17	22	PF00069	0.642
MOD_NEK2_1	272	277	PF00069	0.790
MOD_NEK2_1	317	322	PF00069	0.618
MOD_NEK2_1	325	330	PF00069	0.687
MOD_NEK2_1	5	10	PF00069	0.775
MOD_NEK2_1	58	63	PF00069	0.685
MOD_NEK2_1	83	88	PF00069	0.746
MOD_NEK2_1	94	99	PF00069	0.566
MOD_PIKK_1	202	208	PF00454	0.790
MOD_PIKK_1	317	323	PF00454	0.580
MOD_PIKK_1	335	341	PF00454	0.528
MOD_PKA_2	159	165	PF00069	0.836
MOD_PKA_2	182	188	PF00069	0.717
MOD_PKA_2	196	202	PF00069	0.674
MOD_Plk_1	249	255	PF00069	0.793
MOD_Plk_1	310	316	PF00069	0.727
MOD_Plk_2-3	432	438	PF00069	0.721
MOD_Plk_4	145	151	PF00069	0.528
MOD_Plk_4	234	240	PF00069	0.588
MOD_Plk_4	278	284	PF00069	0.818
MOD_Plk_4	321	327	PF00069	0.599
MOD_Plk_4	423	429	PF00069	0.697
MOD_Plk_4	94	100	PF00069	0.690
MOD_ProDKin_1	106	112	PF00069	0.588
MOD_ProDKin_1	115	121	PF00069	0.615
MOD_ProDKin_1	152	158	PF00069	0.760
MOD_ProDKin_1	273	279	PF00069	0.745
MOD_ProDKin_1	299	305	PF00069	0.542
MOD_ProDKin_1	326	332	PF00069	0.845
MOD_ProDKin_1	359	365	PF00069	0.646
MOD_ProDKin_1	38	44	PF00069	0.733
MOD_ProDKin_1	63	69	PF00069	0.805
MOD_SUMO_rev_2	437	445	PF00179	0.704
MOD_SUMO_rev_2	50	58	PF00179	0.770
TRG_DiLeu_BaEn_1	54	59	PF01217	0.512
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.774
TRG_ER_diArg_1	31	34	PF00400	0.636
TRG_ER_diArg_1	59	62	PF00400	0.670
TRG_NLS_MonoExtC_3	30	35	PF00514	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRU8	Leishmania donovani	64%	77%
A4I5C7	Leishmania infantum	64%	100%
E9B0M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q7K7	Leishmania major	63%	100%