Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone-binding protein RBBP4 or subunit C of CAF1 complex/WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HI50_LEIBR

TriTrypDb:

LbrM.30.1070 , LBRM2903_300016300

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A4HI50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI50

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.424
CLV_C14_Caspase3-7	496	500	PF00656	0.500
CLV_NRD_NRD_1	125	127	PF00675	0.505
CLV_NRD_NRD_1	153	155	PF00675	0.659
CLV_NRD_NRD_1	220	222	PF00675	0.580
CLV_NRD_NRD_1	414	416	PF00675	0.515
CLV_NRD_NRD_1	552	554	PF00675	0.435
CLV_NRD_NRD_1	77	79	PF00675	0.642
CLV_NRD_NRD_1	92	94	PF00675	0.566
CLV_PCSK_FUR_1	151	155	PF00082	0.656
CLV_PCSK_KEX2_1	124	126	PF00082	0.497
CLV_PCSK_KEX2_1	151	153	PF00082	0.672
CLV_PCSK_KEX2_1	219	221	PF00082	0.591
CLV_PCSK_KEX2_1	344	346	PF00082	0.583
CLV_PCSK_KEX2_1	414	416	PF00082	0.515
CLV_PCSK_KEX2_1	552	554	PF00082	0.403
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.565
CLV_PCSK_PC7_1	121	127	PF00082	0.479
CLV_PCSK_SKI1_1	126	130	PF00082	0.517
CLV_PCSK_SKI1_1	381	385	PF00082	0.308
CLV_PCSK_SKI1_1	589	593	PF00082	0.389
DEG_APCC_DBOX_1	588	596	PF00400	0.582
DEG_MDM2_SWIB_1	418	425	PF02201	0.408
DEG_Nend_UBRbox_3	1	3	PF02207	0.542
DOC_ANK_TNKS_1	197	204	PF00023	0.528
DOC_CDC14_PxL_1	26	34	PF14671	0.534
DOC_CYCLIN_RxL_1	231	241	PF00134	0.633
DOC_MAPK_MEF2A_6	302	310	PF00069	0.445
DOC_PP1_RVXF_1	587	594	PF00149	0.493
DOC_PP2B_LxvP_1	32	35	PF13499	0.531
DOC_PP2B_LxvP_1	609	612	PF13499	0.469
DOC_PP4_FxxP_1	17	20	PF00568	0.620
DOC_PP4_FxxP_1	273	276	PF00568	0.493
DOC_USP7_MATH_1	22	26	PF00917	0.570
DOC_USP7_MATH_1	494	498	PF00917	0.526
DOC_USP7_MATH_1	519	523	PF00917	0.455
DOC_USP7_MATH_1	596	600	PF00917	0.326
DOC_USP7_MATH_1	612	616	PF00917	0.414
DOC_USP7_MATH_1	654	658	PF00917	0.381
DOC_USP7_UBL2_3	94	98	PF12436	0.559
DOC_WW_Pin1_4	128	133	PF00397	0.675
DOC_WW_Pin1_4	571	576	PF00397	0.493
LIG_14-3-3_CanoR_1	125	131	PF00244	0.517
LIG_14-3-3_CanoR_1	39	49	PF00244	0.643
LIG_14-3-3_CanoR_1	508	516	PF00244	0.509
LIG_14-3-3_CanoR_1	552	557	PF00244	0.484
LIG_14-3-3_CanoR_1	624	632	PF00244	0.410
LIG_14-3-3_CanoR_1	653	659	PF00244	0.288
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.517
LIG_EVH1_1	17	21	PF00568	0.524
LIG_FHA_1	253	259	PF00498	0.493
LIG_FHA_1	260	266	PF00498	0.493
LIG_FHA_1	298	304	PF00498	0.447
LIG_FHA_1	311	317	PF00498	0.587
LIG_FHA_1	373	379	PF00498	0.415
LIG_FHA_1	382	388	PF00498	0.391
LIG_FHA_1	553	559	PF00498	0.518
LIG_FHA_1	577	583	PF00498	0.558
LIG_FHA_1	644	650	PF00498	0.425
LIG_FHA_2	129	135	PF00498	0.651
LIG_FHA_2	310	316	PF00498	0.490
LIG_FHA_2	395	401	PF00498	0.565
LIG_FHA_2	402	408	PF00498	0.451
LIG_FHA_2	461	467	PF00498	0.536
LIG_FHA_2	84	90	PF00498	0.613
LIG_LIR_Apic_2	15	20	PF02991	0.599
LIG_LIR_Apic_2	270	276	PF02991	0.502
LIG_LIR_Gen_1	281	291	PF02991	0.453
LIG_LIR_Gen_1	421	430	PF02991	0.410
LIG_LIR_Gen_1	613	622	PF02991	0.419
LIG_LIR_Nem_3	23	29	PF02991	0.539
LIG_LIR_Nem_3	259	263	PF02991	0.459
LIG_LIR_Nem_3	281	287	PF02991	0.453
LIG_LIR_Nem_3	315	321	PF02991	0.543
LIG_LIR_Nem_3	384	389	PF02991	0.339
LIG_LIR_Nem_3	421	425	PF02991	0.412
LIG_LIR_Nem_3	435	441	PF02991	0.311
LIG_LIR_Nem_3	613	619	PF02991	0.425
LIG_Pex14_1	559	563	PF04695	0.451
LIG_Pex14_2	418	422	PF04695	0.397
LIG_SH2_CRK	26	30	PF00017	0.536
LIG_SH2_CRK	390	394	PF00017	0.421
LIG_SH2_CRK	652	656	PF00017	0.525
LIG_SH2_GRB2like	438	441	PF00017	0.380
LIG_SH2_NCK_1	390	394	PF00017	0.375
LIG_SH2_STAP1	280	284	PF00017	0.493
LIG_SH2_STAT3	280	283	PF00017	0.493
LIG_SH2_STAT3	333	336	PF00017	0.513
LIG_SH2_STAT5	112	115	PF00017	0.446
LIG_SH2_STAT5	248	251	PF00017	0.577
LIG_SH2_STAT5	252	255	PF00017	0.549
LIG_SH2_STAT5	280	283	PF00017	0.507
LIG_SH2_STAT5	284	287	PF00017	0.498
LIG_SH2_STAT5	438	441	PF00017	0.354
LIG_SH3_3	15	21	PF00018	0.615
LIG_SH3_3	255	261	PF00018	0.493
LIG_SH3_3	30	36	PF00018	0.552
LIG_SH3_3	303	309	PF00018	0.481
LIG_SH3_3	648	654	PF00018	0.394
LIG_SH3_5	276	280	PF00018	0.493
LIG_SUMO_SIM_par_1	261	266	PF11976	0.499
LIG_SUMO_SIM_par_1	374	382	PF11976	0.442
LIG_SUMO_SIM_par_1	577	583	PF11976	0.494
LIG_TRAF2_1	334	337	PF00917	0.476
LIG_TYR_ITIM	282	287	PF00017	0.493
LIG_TYR_ITIM	439	444	PF00017	0.381
MOD_CDK_SPxxK_3	128	135	PF00069	0.583
MOD_CK1_1	173	179	PF00069	0.777
MOD_CK1_1	210	216	PF00069	0.643
MOD_CK1_1	38	44	PF00069	0.586
MOD_CK1_1	4	10	PF00069	0.614
MOD_CK1_1	421	427	PF00069	0.409
MOD_CK1_1	512	518	PF00069	0.461
MOD_CK1_1	522	528	PF00069	0.362
MOD_CK1_1	574	580	PF00069	0.403
MOD_CK1_1	61	67	PF00069	0.708
MOD_CK1_1	642	648	PF00069	0.437
MOD_CK1_1	96	102	PF00069	0.633
MOD_CK2_1	394	400	PF00069	0.515
MOD_CK2_1	460	466	PF00069	0.530
MOD_CK2_1	52	58	PF00069	0.771
MOD_CK2_1	630	636	PF00069	0.550
MOD_Cter_Amidation	342	345	PF01082	0.599
MOD_GlcNHglycan	173	176	PF01048	0.769
MOD_GlcNHglycan	209	212	PF01048	0.581
MOD_GlcNHglycan	294	297	PF01048	0.382
MOD_GlcNHglycan	431	434	PF01048	0.386
MOD_GlcNHglycan	454	458	PF01048	0.566
MOD_GlcNHglycan	517	520	PF01048	0.419
MOD_GlcNHglycan	521	524	PF01048	0.437
MOD_GlcNHglycan	6	9	PF01048	0.553
MOD_GlcNHglycan	641	644	PF01048	0.404
MOD_GSK3_1	142	149	PF00069	0.584
MOD_GSK3_1	189	196	PF00069	0.664
MOD_GSK3_1	203	210	PF00069	0.641
MOD_GSK3_1	40	47	PF00069	0.711
MOD_GSK3_1	442	449	PF00069	0.476
MOD_GSK3_1	508	515	PF00069	0.524
MOD_GSK3_1	54	61	PF00069	0.559
MOD_GSK3_1	576	583	PF00069	0.483
MOD_GSK3_1	626	633	PF00069	0.481
MOD_GSK3_1	639	646	PF00069	0.294
MOD_GSK3_1	83	90	PF00069	0.626
MOD_GSK3_1	93	100	PF00069	0.673
MOD_N-GLC_1	1	6	PF02516	0.672
MOD_N-GLC_1	126	131	PF02516	0.519
MOD_N-GLC_1	146	151	PF02516	0.547
MOD_N-GLC_1	211	216	PF02516	0.508
MOD_N-GLC_1	310	315	PF02516	0.399
MOD_N-GLC_1	509	514	PF02516	0.360
MOD_NEK2_1	222	227	PF00069	0.459
MOD_NEK2_1	294	299	PF00069	0.394
MOD_NEK2_1	418	423	PF00069	0.438
MOD_NEK2_1	429	434	PF00069	0.427
MOD_NEK2_1	492	497	PF00069	0.483
MOD_NEK2_1	509	514	PF00069	0.444
MOD_NEK2_1	576	581	PF00069	0.605
MOD_PIKK_1	20	26	PF00454	0.694
MOD_PIKK_1	286	292	PF00454	0.472
MOD_PIKK_1	40	46	PF00454	0.614
MOD_PIKK_1	485	491	PF00454	0.499
MOD_PIKK_1	87	93	PF00454	0.573
MOD_PKA_1	552	558	PF00069	0.315
MOD_PKA_1	93	99	PF00069	0.586
MOD_PKA_2	115	121	PF00069	0.434
MOD_PKA_2	38	44	PF00069	0.605
MOD_PKA_2	446	452	PF00069	0.499
MOD_PKA_2	551	557	PF00069	0.481
MOD_PKA_2	623	629	PF00069	0.407
MOD_PKB_1	124	132	PF00069	0.515
MOD_PKB_1	219	227	PF00069	0.623
MOD_Plk_1	126	132	PF00069	0.521
MOD_Plk_1	146	152	PF00069	0.519
MOD_Plk_1	278	284	PF00069	0.493
MOD_Plk_1	453	459	PF00069	0.505
MOD_Plk_1	612	618	PF00069	0.412
MOD_Plk_1	626	632	PF00069	0.405
MOD_Plk_2-3	182	188	PF00069	0.538
MOD_Plk_4	108	114	PF00069	0.462
MOD_Plk_4	576	582	PF00069	0.468
MOD_Plk_4	612	618	PF00069	0.412
MOD_ProDKin_1	128	134	PF00069	0.673
MOD_ProDKin_1	571	577	PF00069	0.493
MOD_SUMO_rev_2	241	249	PF00179	0.354
MOD_SUMO_rev_2	54	62	PF00179	0.634
MOD_SUMO_rev_2	68	75	PF00179	0.557
TRG_ENDOCYTIC_2	26	29	PF00928	0.539
TRG_ENDOCYTIC_2	284	287	PF00928	0.493
TRG_ENDOCYTIC_2	390	393	PF00928	0.352
TRG_ENDOCYTIC_2	441	444	PF00928	0.386
TRG_ENDOCYTIC_2	652	655	PF00928	0.403
TRG_ER_diArg_1	124	126	PF00400	0.497
TRG_ER_diArg_1	150	153	PF00400	0.663
TRG_ER_diArg_1	218	221	PF00400	0.594
TRG_ER_diArg_1	551	553	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W9	Leptomonas seymouri	58%	100%
A0A3S7X390	Leishmania donovani	76%	100%
A4HD80	Leishmania braziliensis	23%	100%
A4I5C6	Leishmania infantum	76%	100%
E9AWL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B0M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q7K8	Leishmania major	74%	97%
Q9SU78	Arabidopsis thaliana	23%	100%