Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-tubulin complex component 4

Species:

Leishmania braziliensis

UniProt:

A4HI49_LEIBR

TriTrypDb:

LbrM.30.1060 , LBRM2903_300016200

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	11
GO:0005737	cytoplasm	2	11
GO:0005815	microtubule organizing center	2	11
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0000923	equatorial microtubule organizing center	3	1
GO:0000930	gamma-tubulin complex	2	1
GO:0005813	centrosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HI49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI49

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0007017	microtubule-based process	2	11
GO:0007020	microtubule nucleation	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0007051	spindle organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051321	meiotic cell cycle	2	1
GO:0070925	organelle assembly	5	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0043015	gamma-tubulin binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.405
CLV_C14_Caspase3-7	432	436	PF00656	0.492
CLV_MEL_PAP_1	537	543	PF00089	0.296
CLV_NRD_NRD_1	168	170	PF00675	0.504
CLV_NRD_NRD_1	196	198	PF00675	0.325
CLV_NRD_NRD_1	257	259	PF00675	0.399
CLV_NRD_NRD_1	481	483	PF00675	0.279
CLV_NRD_NRD_1	50	52	PF00675	0.610
CLV_NRD_NRD_1	568	570	PF00675	0.296
CLV_NRD_NRD_1	748	750	PF00675	0.801
CLV_NRD_NRD_1	776	778	PF00675	0.773
CLV_PCSK_KEX2_1	168	170	PF00082	0.504
CLV_PCSK_KEX2_1	196	198	PF00082	0.435
CLV_PCSK_KEX2_1	257	259	PF00082	0.399
CLV_PCSK_KEX2_1	481	483	PF00082	0.279
CLV_PCSK_KEX2_1	50	52	PF00082	0.612
CLV_PCSK_KEX2_1	568	570	PF00082	0.296
CLV_PCSK_KEX2_1	748	750	PF00082	0.801
CLV_PCSK_KEX2_1	776	778	PF00082	0.777
CLV_PCSK_SKI1_1	104	108	PF00082	0.500
CLV_PCSK_SKI1_1	168	172	PF00082	0.449
CLV_PCSK_SKI1_1	257	261	PF00082	0.405
CLV_PCSK_SKI1_1	341	345	PF00082	0.273
CLV_PCSK_SKI1_1	498	502	PF00082	0.282
CLV_PCSK_SKI1_1	550	554	PF00082	0.213
CLV_PCSK_SKI1_1	568	572	PF00082	0.232
CLV_PCSK_SKI1_1	63	67	PF00082	0.312
DEG_APCC_DBOX_1	497	505	PF00400	0.496
DEG_APCC_DBOX_1	539	547	PF00400	0.458
DEG_APCC_DBOX_1	677	685	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.438
DEG_SPOP_SBC_1	217	221	PF00917	0.706
DOC_CKS1_1	772	777	PF01111	0.566
DOC_CYCLIN_RxL_1	165	174	PF00134	0.490
DOC_CYCLIN_RxL_1	547	555	PF00134	0.567
DOC_CYCLIN_RxL_1	59	68	PF00134	0.547
DOC_MAPK_gen_1	196	203	PF00069	0.321
DOC_MAPK_gen_1	50	58	PF00069	0.595
DOC_MAPK_gen_1	725	734	PF00069	0.604
DOC_MAPK_HePTP_8	323	335	PF00069	0.578
DOC_MAPK_MEF2A_6	326	335	PF00069	0.582
DOC_MAPK_MEF2A_6	725	734	PF00069	0.691
DOC_PP1_RVXF_1	712	718	PF00149	0.482
DOC_PP4_FxxP_1	744	747	PF00568	0.724
DOC_USP7_MATH_1	216	220	PF00917	0.705
DOC_USP7_MATH_1	277	281	PF00917	0.614
DOC_USP7_MATH_1	41	45	PF00917	0.648
DOC_USP7_MATH_1	416	420	PF00917	0.565
DOC_USP7_MATH_1	421	425	PF00917	0.567
DOC_USP7_MATH_1	460	464	PF00917	0.590
DOC_USP7_MATH_1	489	493	PF00917	0.550
DOC_USP7_MATH_1	642	646	PF00917	0.527
DOC_WW_Pin1_4	116	121	PF00397	0.478
DOC_WW_Pin1_4	240	245	PF00397	0.473
DOC_WW_Pin1_4	377	382	PF00397	0.570
DOC_WW_Pin1_4	388	393	PF00397	0.596
DOC_WW_Pin1_4	559	564	PF00397	0.456
DOC_WW_Pin1_4	670	675	PF00397	0.559
DOC_WW_Pin1_4	764	769	PF00397	0.628
DOC_WW_Pin1_4	771	776	PF00397	0.657
LIG_14-3-3_CanoR_1	358	366	PF00244	0.513
LIG_14-3-3_CanoR_1	531	536	PF00244	0.456
LIG_14-3-3_CanoR_1	540	544	PF00244	0.512
LIG_14-3-3_CanoR_1	550	558	PF00244	0.574
LIG_14-3-3_CanoR_1	568	574	PF00244	0.425
LIG_14-3-3_CanoR_1	641	647	PF00244	0.572
LIG_14-3-3_CanoR_1	659	665	PF00244	0.366
LIG_14-3-3_CanoR_1	678	688	PF00244	0.560
LIG_14-3-3_CanoR_1	735	744	PF00244	0.726
LIG_14-3-3_CanoR_1	74	80	PF00244	0.450
LIG_14-3-3_CanoR_1	751	758	PF00244	0.793
LIG_14-3-3_CanoR_1	764	768	PF00244	0.486
LIG_14-3-3_CanoR_1	81	88	PF00244	0.423
LIG_Actin_WH2_2	554	570	PF00022	0.405
LIG_AP2alpha_1	618	622	PF02296	0.586
LIG_BRCT_BRCA1_1	220	224	PF00533	0.743
LIG_deltaCOP1_diTrp_1	350	355	PF00928	0.482
LIG_DLG_GKlike_1	531	539	PF00625	0.430
LIG_DLG_GKlike_1	569	576	PF00625	0.502
LIG_FHA_1	127	133	PF00498	0.438
LIG_FHA_1	233	239	PF00498	0.465
LIG_FHA_1	454	460	PF00498	0.535
LIG_FHA_1	547	553	PF00498	0.562
LIG_FHA_1	59	65	PF00498	0.422
LIG_FHA_1	595	601	PF00498	0.509
LIG_FHA_1	89	95	PF00498	0.323
LIG_FHA_2	133	139	PF00498	0.522
LIG_FHA_2	29	35	PF00498	0.578
LIG_FHA_2	430	436	PF00498	0.492
LIG_FHA_2	608	614	PF00498	0.567
LIG_FHA_2	671	677	PF00498	0.546
LIG_Integrin_RGD_1	348	350	PF01839	0.282
LIG_LIR_Apic_2	743	747	PF02991	0.731
LIG_LIR_Gen_1	133	141	PF02991	0.448
LIG_LIR_Gen_1	173	184	PF02991	0.428
LIG_LIR_Gen_1	198	207	PF02991	0.515
LIG_LIR_Gen_1	350	360	PF02991	0.482
LIG_LIR_Gen_1	572	580	PF02991	0.517
LIG_LIR_Gen_1	75	82	PF02991	0.560
LIG_LIR_Nem_3	133	137	PF02991	0.420
LIG_LIR_Nem_3	173	179	PF02991	0.370
LIG_LIR_Nem_3	198	203	PF02991	0.395
LIG_LIR_Nem_3	329	333	PF02991	0.397
LIG_LIR_Nem_3	350	356	PF02991	0.482
LIG_LIR_Nem_3	449	455	PF02991	0.483
LIG_LIR_Nem_3	572	577	PF02991	0.562
LIG_LIR_Nem_3	663	667	PF02991	0.536
LIG_LIR_Nem_3	716	720	PF02991	0.460
LIG_LIR_Nem_3	75	79	PF02991	0.503
LIG_MYND_1	388	392	PF01753	0.516
LIG_NRBOX	572	578	PF00104	0.487
LIG_PCNA_yPIPBox_3	687	696	PF02747	0.562
LIG_Pex14_2	289	293	PF04695	0.505
LIG_Pex14_2	618	622	PF04695	0.586
LIG_Pex14_2	717	721	PF04695	0.562
LIG_SH2_CRK	529	533	PF00017	0.482
LIG_SH2_CRK	76	80	PF00017	0.514
LIG_SH2_PTP2	511	514	PF00017	0.482
LIG_SH2_SRC	110	113	PF00017	0.412
LIG_SH2_SRC	511	514	PF00017	0.513
LIG_SH2_STAP1	110	114	PF00017	0.359
LIG_SH2_STAP1	234	238	PF00017	0.567
LIG_SH2_STAP1	596	600	PF00017	0.405
LIG_SH2_STAT3	272	275	PF00017	0.494
LIG_SH2_STAT3	586	589	PF00017	0.482
LIG_SH2_STAT3	596	599	PF00017	0.482
LIG_SH2_STAT3	720	723	PF00017	0.645
LIG_SH2_STAT5	130	133	PF00017	0.272
LIG_SH2_STAT5	181	184	PF00017	0.355
LIG_SH2_STAT5	186	189	PF00017	0.342
LIG_SH2_STAT5	199	202	PF00017	0.309
LIG_SH2_STAT5	234	237	PF00017	0.542
LIG_SH2_STAT5	272	275	PF00017	0.493
LIG_SH2_STAT5	428	431	PF00017	0.577
LIG_SH2_STAT5	511	514	PF00017	0.474
LIG_SH2_STAT5	52	55	PF00017	0.518
LIG_SH2_STAT5	596	599	PF00017	0.526
LIG_SH2_STAT5	654	657	PF00017	0.482
LIG_SH2_STAT5	720	723	PF00017	0.673
LIG_SH3_1	725	731	PF00018	0.598
LIG_SH3_3	146	152	PF00018	0.488
LIG_SH3_3	382	388	PF00018	0.502
LIG_SH3_3	54	60	PF00018	0.560
LIG_SH3_3	725	731	PF00018	0.722
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.298
LIG_SUMO_SIM_par_1	516	522	PF11976	0.564
LIG_SUMO_SIM_par_1	591	597	PF11976	0.496
LIG_SUMO_SIM_par_1	730	736	PF11976	0.513
LIG_TRAF2_1	304	307	PF00917	0.435
LIG_TRAF2_1	402	405	PF00917	0.405
LIG_TRAF2_1	82	85	PF00917	0.564
LIG_TYR_ITIM	351	356	PF00017	0.562
LIG_TYR_ITIM	662	667	PF00017	0.562
LIG_UBA3_1	136	142	PF00899	0.359
LIG_UBA3_1	248	255	PF00899	0.382
LIG_UBA3_1	517	524	PF00899	0.586
LIG_WRC_WIRS_1	131	136	PF05994	0.277
LIG_WRC_WIRS_1	532	537	PF05994	0.402
MOD_CDC14_SPxK_1	380	383	PF00782	0.405
MOD_CDK_SPK_2	764	769	PF00069	0.650
MOD_CDK_SPK_2	771	776	PF00069	0.667
MOD_CDK_SPxK_1	377	383	PF00069	0.405
MOD_CDK_SPxK_1	771	777	PF00069	0.567
MOD_CK1_1	219	225	PF00069	0.692
MOD_CK1_1	36	42	PF00069	0.621
MOD_CK1_1	522	528	PF00069	0.508
MOD_CK1_1	551	557	PF00069	0.554
MOD_CK1_1	594	600	PF00069	0.562
MOD_CK1_1	645	651	PF00069	0.505
MOD_CK1_1	740	746	PF00069	0.755
MOD_CK1_1	75	81	PF00069	0.489
MOD_CK1_1	763	769	PF00069	0.725
MOD_CK2_1	132	138	PF00069	0.521
MOD_CK2_1	277	283	PF00069	0.563
MOD_CK2_1	28	34	PF00069	0.666
MOD_CK2_1	670	676	PF00069	0.546
MOD_CK2_1	679	685	PF00069	0.516
MOD_Cter_Amidation	479	482	PF01082	0.292
MOD_DYRK1A_RPxSP_1	764	768	PF00069	0.686
MOD_GlcNHglycan	12	15	PF01048	0.537
MOD_GlcNHglycan	120	123	PF01048	0.496
MOD_GlcNHglycan	24	27	PF01048	0.677
MOD_GlcNHglycan	34	38	PF01048	0.631
MOD_GlcNHglycan	360	363	PF01048	0.272
MOD_GlcNHglycan	44	47	PF01048	0.534
MOD_GlcNHglycan	563	566	PF01048	0.313
MOD_GlcNHglycan	67	70	PF01048	0.294
MOD_GlcNHglycan	681	684	PF01048	0.276
MOD_GlcNHglycan	737	740	PF01048	0.672
MOD_GlcNHglycan	753	756	PF01048	0.696
MOD_GlcNHglycan	778	781	PF01048	0.753
MOD_GSK3_1	126	133	PF00069	0.538
MOD_GSK3_1	22	29	PF00069	0.563
MOD_GSK3_1	388	395	PF00069	0.542
MOD_GSK3_1	603	610	PF00069	0.564
MOD_GSK3_1	645	652	PF00069	0.529
MOD_GSK3_1	719	726	PF00069	0.586
MOD_GSK3_1	733	740	PF00069	0.662
MOD_GSK3_1	747	754	PF00069	0.651
MOD_GSK3_1	756	763	PF00069	0.701
MOD_GSK3_1	771	778	PF00069	0.793
MOD_N-GLC_1	559	564	PF02516	0.205
MOD_N-GLC_1	670	675	PF02516	0.321
MOD_N-GLC_2	647	649	PF02516	0.362
MOD_NEK2_1	132	137	PF00069	0.487
MOD_NEK2_1	171	176	PF00069	0.360
MOD_NEK2_1	179	184	PF00069	0.333
MOD_NEK2_1	429	434	PF00069	0.491
MOD_NEK2_1	439	444	PF00069	0.480
MOD_NEK2_1	446	451	PF00069	0.462
MOD_NEK2_1	519	524	PF00069	0.513
MOD_NEK2_1	546	551	PF00069	0.581
MOD_NEK2_1	579	584	PF00069	0.499
MOD_NEK2_1	604	609	PF00069	0.433
MOD_NEK2_1	65	70	PF00069	0.490
MOD_NEK2_1	72	77	PF00069	0.467
MOD_NEK2_2	649	654	PF00069	0.514
MOD_OFUCOSY	643	649	PF10250	0.353
MOD_PIKK_1	277	283	PF00454	0.543
MOD_PIKK_1	519	525	PF00454	0.516
MOD_PIKK_1	719	725	PF00454	0.635
MOD_PIKK_1	742	748	PF00454	0.675
MOD_PIKK_1	80	86	PF00454	0.564
MOD_PKA_2	29	35	PF00069	0.586
MOD_PKA_2	416	422	PF00069	0.597
MOD_PKA_2	480	486	PF00069	0.564
MOD_PKA_2	539	545	PF00069	0.496
MOD_PKA_2	660	666	PF00069	0.435
MOD_PKA_2	677	683	PF00069	0.591
MOD_PKA_2	747	753	PF00069	0.753
MOD_PKA_2	756	762	PF00069	0.712
MOD_PKA_2	763	769	PF00069	0.748
MOD_PKA_2	775	781	PF00069	0.780
MOD_PKA_2	80	86	PF00069	0.578
MOD_PKB_1	749	757	PF00069	0.655
MOD_Plk_1	580	586	PF00069	0.586
MOD_Plk_1	627	633	PF00069	0.562
MOD_Plk_4	126	132	PF00069	0.386
MOD_Plk_4	171	177	PF00069	0.385
MOD_Plk_4	288	294	PF00069	0.468
MOD_Plk_4	314	320	PF00069	0.437
MOD_Plk_4	4	10	PF00069	0.412
MOD_Plk_4	627	633	PF00069	0.482
MOD_Plk_4	649	655	PF00069	0.516
MOD_Plk_4	75	81	PF00069	0.518
MOD_ProDKin_1	116	122	PF00069	0.476
MOD_ProDKin_1	240	246	PF00069	0.463
MOD_ProDKin_1	377	383	PF00069	0.570
MOD_ProDKin_1	388	394	PF00069	0.596
MOD_ProDKin_1	559	565	PF00069	0.456
MOD_ProDKin_1	670	676	PF00069	0.559
MOD_ProDKin_1	764	770	PF00069	0.627
MOD_ProDKin_1	771	777	PF00069	0.657
MOD_SUMO_for_1	406	409	PF00179	0.405
MOD_SUMO_rev_2	2	7	PF00179	0.554
TRG_DiLeu_BaEn_1	245	250	PF01217	0.417
TRG_DiLeu_BaEn_1	256	261	PF01217	0.331
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.474
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.497
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.502
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.331
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.518
TRG_ENDOCYTIC_2	353	356	PF00928	0.562
TRG_ENDOCYTIC_2	452	455	PF00928	0.496
TRG_ENDOCYTIC_2	529	532	PF00928	0.471
TRG_ENDOCYTIC_2	587	590	PF00928	0.534
TRG_ENDOCYTIC_2	664	667	PF00928	0.542
TRG_ENDOCYTIC_2	76	79	PF00928	0.511
TRG_ER_diArg_1	167	169	PF00400	0.502
TRG_ER_diArg_1	257	259	PF00400	0.384
TRG_ER_diArg_1	481	484	PF00400	0.554
TRG_ER_diArg_1	49	51	PF00400	0.608
TRG_ER_diArg_1	567	569	PF00400	0.496
TRG_ER_diArg_1	725	728	PF00400	0.669
TRG_ER_diArg_1	747	749	PF00400	0.646
TRG_ER_diArg_1	775	777	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	550	555	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC04	Leptomonas seymouri	63%	97%
A0A1X0P204	Trypanosomatidae	43%	100%
A0A3Q8IEU3	Leishmania donovani	79%	100%
A0A422P4W6	Trypanosoma rangeli	44%	100%
A4I5C5	Leishmania infantum	79%	100%
C9ZQQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q7K9	Leishmania major	82%	100%
V5B937	Trypanosoma cruzi	46%	100%