DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI48_LEIBR

TriTrypDb:

LbrM.30.1050 , LBRM2903_300016100

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016829	lyase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.380
CLV_NRD_NRD_1	166	168	PF00675	0.414
CLV_NRD_NRD_1	319	321	PF00675	0.392
CLV_NRD_NRD_1	462	464	PF00675	0.322
CLV_PCSK_KEX2_1	166	168	PF00082	0.433
CLV_PCSK_KEX2_1	319	321	PF00082	0.461
CLV_PCSK_KEX2_1	462	464	PF00082	0.305
CLV_PCSK_KEX2_1	558	560	PF00082	0.409
CLV_PCSK_KEX2_1	98	100	PF00082	0.560
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.409
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.559
CLV_PCSK_PC7_1	458	464	PF00082	0.318
CLV_PCSK_SKI1_1	166	170	PF00082	0.417
CLV_PCSK_SKI1_1	209	213	PF00082	0.518
CLV_PCSK_SKI1_1	308	312	PF00082	0.380
CLV_PCSK_SKI1_1	531	535	PF00082	0.255
DEG_APCC_DBOX_1	177	185	PF00400	0.538
DOC_CKS1_1	571	576	PF01111	0.614
DOC_CYCLIN_yClb1_LxF_4	387	392	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.207
DOC_MAPK_gen_1	383	392	PF00069	0.362
DOC_MAPK_gen_1	531	540	PF00069	0.460
DOC_MAPK_gen_1	555	565	PF00069	0.431
DOC_MAPK_gen_1	7	15	PF00069	0.288
DOC_MAPK_MEF2A_6	371	379	PF00069	0.311
DOC_MAPK_MEF2A_6	397	404	PF00069	0.417
DOC_PP1_RVXF_1	387	393	PF00149	0.417
DOC_PP2B_LxvP_1	150	153	PF13499	0.342
DOC_PP2B_LxvP_1	337	340	PF13499	0.350
DOC_PP4_FxxP_1	24	27	PF00568	0.524
DOC_PP4_MxPP_1	301	304	PF00568	0.316
DOC_USP7_MATH_1	158	162	PF00917	0.563
DOC_USP7_MATH_1	32	36	PF00917	0.512
DOC_USP7_UBL2_3	568	572	PF12436	0.233
DOC_USP7_UBL2_3	94	98	PF12436	0.497
DOC_WW_Pin1_4	239	244	PF00397	0.337
DOC_WW_Pin1_4	280	285	PF00397	0.302
DOC_WW_Pin1_4	286	291	PF00397	0.301
DOC_WW_Pin1_4	436	441	PF00397	0.447
DOC_WW_Pin1_4	570	575	PF00397	0.594
DOC_WW_Pin1_4	73	78	PF00397	0.558
LIG_14-3-3_CanoR_1	123	128	PF00244	0.354
LIG_14-3-3_CanoR_1	166	174	PF00244	0.461
LIG_14-3-3_CanoR_1	19	25	PF00244	0.279
LIG_14-3-3_CanoR_1	265	271	PF00244	0.299
LIG_14-3-3_CanoR_1	276	284	PF00244	0.378
LIG_14-3-3_CanoR_1	296	302	PF00244	0.119
LIG_14-3-3_CanoR_1	3	7	PF00244	0.520
LIG_APCC_ABBA_1	13	18	PF00400	0.409
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	332	336	PF00533	0.246
LIG_deltaCOP1_diTrp_1	44	51	PF00928	0.557
LIG_deltaCOP1_diTrp_1	546	551	PF00928	0.391
LIG_FHA_1	213	219	PF00498	0.476
LIG_FHA_1	224	230	PF00498	0.517
LIG_FHA_1	325	331	PF00498	0.320
LIG_FHA_1	336	342	PF00498	0.347
LIG_FHA_1	35	41	PF00498	0.352
LIG_FHA_1	451	457	PF00498	0.336
LIG_FHA_1	497	503	PF00498	0.338
LIG_FHA_1	51	57	PF00498	0.458
LIG_FHA_1	535	541	PF00498	0.419
LIG_FHA_1	542	548	PF00498	0.428
LIG_FHA_2	266	272	PF00498	0.302
LIG_FHA_2	410	416	PF00498	0.406
LIG_FHA_2	510	516	PF00498	0.320
LIG_FHA_2	537	543	PF00498	0.420
LIG_FHA_2	552	558	PF00498	0.445
LIG_Integrin_RGD_1	133	135	PF01839	0.610
LIG_LIR_Apic_2	23	27	PF02991	0.520
LIG_LIR_Apic_2	360	365	PF02991	0.423
LIG_LIR_Gen_1	269	279	PF02991	0.306
LIG_LIR_Gen_1	412	421	PF02991	0.346
LIG_LIR_Gen_1	546	553	PF02991	0.385
LIG_LIR_Gen_1	560	569	PF02991	0.254
LIG_LIR_LC3C_4	213	218	PF02991	0.500
LIG_LIR_Nem_3	269	275	PF02991	0.306
LIG_LIR_Nem_3	412	417	PF02991	0.349
LIG_LIR_Nem_3	44	49	PF02991	0.448
LIG_LIR_Nem_3	50	54	PF02991	0.461
LIG_LIR_Nem_3	546	552	PF02991	0.311
LIG_LIR_Nem_3	560	564	PF02991	0.222
LIG_MYND_1	291	295	PF01753	0.423
LIG_Pex14_1	241	245	PF04695	0.302
LIG_Pex14_2	561	565	PF04695	0.311
LIG_REV1ctd_RIR_1	160	171	PF16727	0.522
LIG_RPA_C_Plants	167	178	PF08784	0.494
LIG_SH2_CRK	362	366	PF00017	0.423
LIG_SH2_NCK_1	362	366	PF00017	0.423
LIG_SH2_SRC	251	254	PF00017	0.424
LIG_SH2_SRC	362	365	PF00017	0.423
LIG_SH2_STAP1	16	20	PF00017	0.384
LIG_SH2_STAP1	207	211	PF00017	0.319
LIG_SH2_STAP1	245	249	PF00017	0.318
LIG_SH2_STAP1	251	255	PF00017	0.318
LIG_SH2_STAP1	260	264	PF00017	0.447
LIG_SH2_STAP1	483	487	PF00017	0.318
LIG_SH2_STAT5	149	152	PF00017	0.421
LIG_SH2_STAT5	207	210	PF00017	0.330
LIG_SH2_STAT5	485	488	PF00017	0.373
LIG_SH3_3	26	32	PF00018	0.483
LIG_SH3_3	289	295	PF00018	0.384
LIG_SH3_3	337	343	PF00018	0.411
LIG_SH3_3	390	396	PF00018	0.447
LIG_SH3_3	568	574	PF00018	0.504
LIG_SUMO_SIM_anti_2	108	117	PF11976	0.423
LIG_SUMO_SIM_anti_2	253	261	PF11976	0.442
LIG_SUMO_SIM_anti_2	509	519	PF11976	0.399
LIG_SUMO_SIM_par_1	228	233	PF11976	0.447
LIG_SUMO_SIM_par_1	25	31	PF11976	0.459
LIG_SUMO_SIM_par_1	450	457	PF11976	0.207
LIG_SUMO_SIM_par_1	498	504	PF11976	0.341
LIG_SUMO_SIM_par_1	536	544	PF11976	0.409
LIG_TRAF2_1	106	109	PF00917	0.533
LIG_TRAF2_1	440	443	PF00917	0.388
LIG_TYR_ITSM	410	417	PF00017	0.447
LIG_UBA3_1	255	263	PF00899	0.207
LIG_WRC_WIRS_1	124	129	PF05994	0.356
LIG_WRC_WIRS_1	159	164	PF05994	0.531
MOD_CDC14_SPxK_1	76	79	PF00782	0.586
MOD_CDK_SPxK_1	73	79	PF00069	0.587
MOD_CK1_1	2	8	PF00069	0.512
MOD_CK1_1	280	286	PF00069	0.323
MOD_CK1_1	352	358	PF00069	0.277
MOD_CK1_1	447	453	PF00069	0.336
MOD_CK1_1	474	480	PF00069	0.377
MOD_CK1_1	509	515	PF00069	0.314
MOD_CK2_1	251	257	PF00069	0.447
MOD_CK2_1	409	415	PF00069	0.423
MOD_CK2_1	436	442	PF00069	0.363
MOD_CK2_1	536	542	PF00069	0.410
MOD_CK2_1	551	557	PF00069	0.445
MOD_CMANNOS	294	297	PF00535	0.423
MOD_GlcNHglycan	201	204	PF01048	0.596
MOD_GlcNHglycan	223	226	PF01048	0.470
MOD_GlcNHglycan	236	239	PF01048	0.423
MOD_GlcNHglycan	24	27	PF01048	0.528
MOD_GlcNHglycan	260	263	PF01048	0.447
MOD_GlcNHglycan	31	35	PF01048	0.584
MOD_GlcNHglycan	404	407	PF01048	0.410
MOD_GlcNHglycan	531	534	PF01048	0.207
MOD_GSK3_1	158	165	PF00069	0.500
MOD_GSK3_1	230	237	PF00069	0.363
MOD_GSK3_1	30	37	PF00069	0.375
MOD_GSK3_1	324	331	PF00069	0.457
MOD_GSK3_1	349	356	PF00069	0.283
MOD_GSK3_1	450	457	PF00069	0.371
MOD_GSK3_1	470	477	PF00069	0.119
MOD_GSK3_1	547	554	PF00069	0.353
MOD_N-GLC_1	409	414	PF02516	0.304
MOD_N-GLC_1	430	435	PF02516	0.396
MOD_N-GLC_1	73	78	PF02516	0.583
MOD_NEK2_1	162	167	PF00069	0.512
MOD_NEK2_1	212	217	PF00069	0.479
MOD_NEK2_1	22	27	PF00069	0.429
MOD_NEK2_1	277	282	PF00069	0.301
MOD_NEK2_1	328	333	PF00069	0.461
MOD_NEK2_1	357	362	PF00069	0.283
MOD_NEK2_1	404	409	PF00069	0.401
MOD_NEK2_1	444	449	PF00069	0.341
MOD_NEK2_1	471	476	PF00069	0.367
MOD_NEK2_1	551	556	PF00069	0.410
MOD_NEK2_2	158	163	PF00069	0.557
MOD_NEK2_2	297	302	PF00069	0.283
MOD_NEK2_2	366	371	PF00069	0.303
MOD_PIKK_1	430	436	PF00454	0.388
MOD_PIKK_1	474	480	PF00454	0.447
MOD_PIKK_1	80	86	PF00454	0.362
MOD_PKA_1	166	172	PF00069	0.386
MOD_PKA_2	166	172	PF00069	0.517
MOD_PKA_2	2	8	PF00069	0.539
MOD_PKA_2	277	283	PF00069	0.375
MOD_PKA_2	295	301	PF00069	0.217
MOD_PKA_2	78	84	PF00069	0.624
MOD_PKB_1	276	284	PF00069	0.423
MOD_Plk_1	212	218	PF00069	0.476
MOD_Plk_1	230	236	PF00069	0.366
MOD_Plk_1	430	436	PF00069	0.373
MOD_Plk_1	444	450	PF00069	0.344
MOD_Plk_2-3	557	563	PF00069	0.398
MOD_Plk_4	11	17	PF00069	0.362
MOD_Plk_4	123	129	PF00069	0.356
MOD_Plk_4	158	164	PF00069	0.456
MOD_Plk_4	212	218	PF00069	0.462
MOD_Plk_4	251	257	PF00069	0.283
MOD_Plk_4	357	363	PF00069	0.410
MOD_Plk_4	425	431	PF00069	0.327
MOD_Plk_4	496	502	PF00069	0.337
MOD_ProDKin_1	239	245	PF00069	0.337
MOD_ProDKin_1	280	286	PF00069	0.302
MOD_ProDKin_1	436	442	PF00069	0.447
MOD_ProDKin_1	570	576	PF00069	0.602
MOD_ProDKin_1	73	79	PF00069	0.563
MOD_SUMO_for_1	8	11	PF00179	0.543
TRG_DiLeu_BaEn_4	109	115	PF01217	0.300
TRG_ENDOCYTIC_2	414	417	PF00928	0.362
TRG_ER_diArg_1	275	278	PF00400	0.391
TRG_ER_diArg_1	319	321	PF00400	0.436
TRG_ER_diArg_1	389	392	PF00400	0.447
TRG_ER_diArg_1	461	463	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA86	Leptomonas seymouri	60%	100%
A0A0S4JNB4	Bodo saltans	31%	100%
A0A1X0P222	Trypanosomatidae	30%	94%
A0A3Q8IHT6	Leishmania donovani	81%	100%
A0A422P4V3	Trypanosoma rangeli	30%	100%
A4HHL0	Leishmania braziliensis	25%	90%
A4I5C4	Leishmania infantum	81%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	90%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O44400	Caenorhabditis elegans	25%	100%
Q4Q7L0	Leishmania major	81%	100%
V5DQS5	Trypanosoma cruzi	33%	100%