Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI47_LEIBR

TriTrypDb:

LbrM.30.1040 , LBRM2903_300016000

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.510
CLV_MEL_PAP_1	533	539	PF00089	0.506
CLV_NRD_NRD_1	742	744	PF00675	0.690
CLV_NRD_NRD_1	870	872	PF00675	0.546
CLV_PCSK_KEX2_1	48	50	PF00082	0.626
CLV_PCSK_KEX2_1	742	744	PF00082	0.645
CLV_PCSK_KEX2_1	921	923	PF00082	0.525
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.553
CLV_PCSK_PC1ET2_1	921	923	PF00082	0.525
CLV_PCSK_SKI1_1	332	336	PF00082	0.554
CLV_PCSK_SKI1_1	614	618	PF00082	0.513
CLV_PCSK_SKI1_1	694	698	PF00082	0.476
CLV_PCSK_SKI1_1	855	859	PF00082	0.500
CLV_PCSK_SKI1_1	871	875	PF00082	0.559
CLV_PCSK_SKI1_1	904	908	PF00082	0.457
DEG_APCC_DBOX_1	854	862	PF00400	0.507
DEG_MDM2_SWIB_1	822	830	PF02201	0.431
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DOC_CYCLIN_RxL_1	852	862	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	762	768	PF00134	0.561
DOC_PP1_RVXF_1	858	864	PF00149	0.423
DOC_PP2B_LxvP_1	172	175	PF13499	0.579
DOC_PP4_FxxP_1	499	502	PF00568	0.523
DOC_USP7_MATH_1	239	243	PF00917	0.743
DOC_USP7_MATH_1	372	376	PF00917	0.709
DOC_USP7_MATH_1	401	405	PF00917	0.324
DOC_USP7_MATH_1	500	504	PF00917	0.697
DOC_USP7_MATH_1	54	58	PF00917	0.765
DOC_USP7_MATH_1	573	577	PF00917	0.525
DOC_USP7_MATH_1	626	630	PF00917	0.623
DOC_USP7_MATH_1	686	690	PF00917	0.518
DOC_USP7_MATH_1	727	731	PF00917	0.643
DOC_USP7_MATH_2	564	570	PF00917	0.544
DOC_USP7_UBL2_3	369	373	PF12436	0.779
DOC_USP7_UBL2_3	904	908	PF12436	0.438
DOC_WW_Pin1_4	121	126	PF00397	0.474
DOC_WW_Pin1_4	170	175	PF00397	0.360
DOC_WW_Pin1_4	571	576	PF00397	0.754
DOC_WW_Pin1_4	584	589	PF00397	0.474
DOC_WW_Pin1_4	656	661	PF00397	0.588
DOC_WW_Pin1_4	725	730	PF00397	0.695
DOC_WW_Pin1_4	791	796	PF00397	0.687
DOC_WW_Pin1_4	81	86	PF00397	0.590
LIG_14-3-3_CanoR_1	267	271	PF00244	0.522
LIG_14-3-3_CanoR_1	3	7	PF00244	0.596
LIG_14-3-3_CanoR_1	321	327	PF00244	0.495
LIG_14-3-3_CanoR_1	38	46	PF00244	0.585
LIG_14-3-3_CanoR_1	471	475	PF00244	0.559
LIG_14-3-3_CanoR_1	49	54	PF00244	0.691
LIG_14-3-3_CanoR_1	495	500	PF00244	0.674
LIG_14-3-3_CanoR_1	536	545	PF00244	0.469
LIG_14-3-3_CanoR_1	632	642	PF00244	0.506
LIG_14-3-3_CanoR_1	743	749	PF00244	0.629
LIG_14-3-3_CanoR_1	871	879	PF00244	0.564
LIG_Actin_WH2_2	376	394	PF00022	0.550
LIG_Actin_WH2_2	527	545	PF00022	0.561
LIG_Actin_WH2_2	603	620	PF00022	0.564
LIG_BIR_III_2	79	83	PF00653	0.492
LIG_BIR_III_4	811	815	PF00653	0.475
LIG_BRCT_BRCA1_1	403	407	PF00533	0.568
LIG_BRCT_BRCA1_1	635	639	PF00533	0.619
LIG_BRCT_BRCA1_1	818	822	PF00533	0.469
LIG_CaM_IQ_9	456	472	PF13499	0.539
LIG_eIF4E_1	126	132	PF01652	0.541
LIG_eIF4E_1	436	442	PF01652	0.452
LIG_eIF4E_1	90	96	PF01652	0.569
LIG_FHA_1	103	109	PF00498	0.577
LIG_FHA_1	154	160	PF00498	0.530
LIG_FHA_1	321	327	PF00498	0.505
LIG_FHA_1	375	381	PF00498	0.648
LIG_FHA_1	454	460	PF00498	0.473
LIG_FHA_1	585	591	PF00498	0.678
LIG_FHA_1	602	608	PF00498	0.322
LIG_FHA_1	802	808	PF00498	0.648
LIG_FHA_1	831	837	PF00498	0.551
LIG_FHA_2	155	161	PF00498	0.602
LIG_FHA_2	221	227	PF00498	0.478
LIG_FHA_2	286	292	PF00498	0.487
LIG_FHA_2	299	305	PF00498	0.460
LIG_FHA_2	344	350	PF00498	0.678
LIG_FHA_2	539	545	PF00498	0.578
LIG_FHA_2	607	613	PF00498	0.570
LIG_FHA_2	795	801	PF00498	0.517
LIG_FHA_2	826	832	PF00498	0.326
LIG_FHA_2	918	924	PF00498	0.629
LIG_IBAR_NPY_1	769	771	PF08397	0.540
LIG_LIR_Apic_2	497	502	PF02991	0.522
LIG_LIR_Gen_1	160	169	PF02991	0.446
LIG_LIR_Gen_1	288	296	PF02991	0.392
LIG_LIR_Gen_1	636	647	PF02991	0.586
LIG_LIR_Gen_1	715	724	PF02991	0.633
LIG_LIR_Gen_1	819	830	PF02991	0.436
LIG_LIR_Gen_1	847	858	PF02991	0.404
LIG_LIR_Nem_3	288	293	PF02991	0.283
LIG_LIR_Nem_3	303	309	PF02991	0.550
LIG_LIR_Nem_3	576	582	PF02991	0.623
LIG_LIR_Nem_3	667	672	PF02991	0.563
LIG_LIR_Nem_3	68	72	PF02991	0.528
LIG_LIR_Nem_3	715	719	PF02991	0.589
LIG_LIR_Nem_3	8	12	PF02991	0.553
LIG_LIR_Nem_3	819	825	PF02991	0.403
LIG_LIR_Nem_3	847	853	PF02991	0.391
LIG_LIR_Nem_3	888	894	PF02991	0.401
LIG_MLH1_MIPbox_1	818	822	PF16413	0.469
LIG_MYND_1	656	660	PF01753	0.692
LIG_NRBOX	253	259	PF00104	0.396
LIG_NRBOX	853	859	PF00104	0.273
LIG_PCNA_yPIPBox_3	16	28	PF02747	0.616
LIG_PCNA_yPIPBox_3	321	334	PF02747	0.290
LIG_Pex14_1	279	283	PF04695	0.487
LIG_Pex14_2	309	313	PF04695	0.541
LIG_Pex14_2	822	826	PF04695	0.404
LIG_SH2_CRK	879	883	PF00017	0.585
LIG_SH2_GRB2like	435	438	PF00017	0.321
LIG_SH2_SRC	672	675	PF00017	0.473
LIG_SH2_STAP1	162	166	PF00017	0.442
LIG_SH2_STAP1	520	524	PF00017	0.326
LIG_SH2_STAP1	879	883	PF00017	0.483
LIG_SH2_STAT5	114	117	PF00017	0.527
LIG_SH2_STAT5	12	15	PF00017	0.589
LIG_SH2_STAT5	672	675	PF00017	0.473
LIG_SH2_STAT5	761	764	PF00017	0.653
LIG_SH2_STAT5	843	846	PF00017	0.409
LIG_SH2_STAT5	879	882	PF00017	0.496
LIG_SH3_1	650	656	PF00018	0.654
LIG_SH3_3	400	406	PF00018	0.555
LIG_SH3_3	542	548	PF00018	0.568
LIG_SH3_3	585	591	PF00018	0.643
LIG_SH3_3	650	656	PF00018	0.622
LIG_SH3_3	75	81	PF00018	0.664
LIG_SH3_3	764	770	PF00018	0.581
LIG_SUMO_SIM_anti_2	291	298	PF11976	0.524
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.532
LIG_SUMO_SIM_par_1	291	298	PF11976	0.276
LIG_SUMO_SIM_par_1	331	338	PF11976	0.312
LIG_SUMO_SIM_par_1	595	601	PF11976	0.618
LIG_SUMO_SIM_par_1	84	91	PF11976	0.514
LIG_TRAF2_1	42	45	PF00917	0.615
LIG_WRC_WIRS_1	132	137	PF05994	0.573
LIG_WRC_WIRS_1	313	318	PF05994	0.319
LIG_WRC_WIRS_1	496	501	PF05994	0.526
LIG_WRC_WIRS_1	96	101	PF05994	0.571
LIG_WW_3	651	655	PF00397	0.627
MOD_CK1_1	102	108	PF00069	0.611
MOD_CK1_1	154	160	PF00069	0.613
MOD_CK1_1	233	239	PF00069	0.720
MOD_CK1_1	262	268	PF00069	0.552
MOD_CK1_1	294	300	PF00069	0.528
MOD_CK1_1	342	348	PF00069	0.523
MOD_CK1_1	375	381	PF00069	0.641
MOD_CK1_1	485	491	PF00069	0.705
MOD_CK1_1	5	11	PF00069	0.507
MOD_CK1_1	535	541	PF00069	0.489
MOD_CK1_1	569	575	PF00069	0.785
MOD_CK1_1	578	584	PF00069	0.617
MOD_CK1_1	601	607	PF00069	0.507
MOD_CK1_1	68	74	PF00069	0.694
MOD_CK1_1	689	695	PF00069	0.585
MOD_CK1_1	728	734	PF00069	0.638
MOD_CK1_1	784	790	PF00069	0.586
MOD_CK1_1	794	800	PF00069	0.532
MOD_CK1_1	835	841	PF00069	0.585
MOD_CK2_1	154	160	PF00069	0.613
MOD_CK2_1	343	349	PF00069	0.662
MOD_CK2_1	379	385	PF00069	0.407
MOD_CK2_1	485	491	PF00069	0.627
MOD_CK2_1	495	501	PF00069	0.742
MOD_CK2_1	597	603	PF00069	0.507
MOD_CK2_1	606	612	PF00069	0.424
MOD_CK2_1	730	736	PF00069	0.670
MOD_CK2_1	794	800	PF00069	0.729
MOD_CK2_1	85	91	PF00069	0.530
MOD_CK2_1	917	923	PF00069	0.559
MOD_GlcNHglycan	107	111	PF01048	0.548
MOD_GlcNHglycan	153	156	PF01048	0.575
MOD_GlcNHglycan	213	216	PF01048	0.666
MOD_GlcNHglycan	249	252	PF01048	0.474
MOD_GlcNHglycan	341	344	PF01048	0.672
MOD_GlcNHglycan	374	377	PF01048	0.679
MOD_GlcNHglycan	39	42	PF01048	0.511
MOD_GlcNHglycan	399	402	PF01048	0.360
MOD_GlcNHglycan	491	495	PF01048	0.710
MOD_GlcNHglycan	51	54	PF01048	0.603
MOD_GlcNHglycan	511	514	PF01048	0.659
MOD_GlcNHglycan	537	540	PF01048	0.560
MOD_GlcNHglycan	56	59	PF01048	0.614
MOD_GlcNHglycan	560	563	PF01048	0.638
MOD_GlcNHglycan	570	574	PF01048	0.696
MOD_GlcNHglycan	684	687	PF01048	0.524
MOD_GlcNHglycan	725	728	PF01048	0.676
MOD_GlcNHglycan	753	756	PF01048	0.708
MOD_GSK3_1	102	109	PF00069	0.539
MOD_GSK3_1	127	134	PF00069	0.585
MOD_GSK3_1	151	158	PF00069	0.571
MOD_GSK3_1	200	207	PF00069	0.617
MOD_GSK3_1	225	232	PF00069	0.711
MOD_GSK3_1	234	241	PF00069	0.692
MOD_GSK3_1	261	268	PF00069	0.583
MOD_GSK3_1	291	298	PF00069	0.469
MOD_GSK3_1	339	346	PF00069	0.426
MOD_GSK3_1	355	362	PF00069	0.501
MOD_GSK3_1	372	379	PF00069	0.598
MOD_GSK3_1	397	404	PF00069	0.593
MOD_GSK3_1	443	450	PF00069	0.515
MOD_GSK3_1	482	489	PF00069	0.629
MOD_GSK3_1	49	56	PF00069	0.645
MOD_GSK3_1	490	497	PF00069	0.675
MOD_GSK3_1	502	509	PF00069	0.669
MOD_GSK3_1	558	565	PF00069	0.711
MOD_GSK3_1	569	576	PF00069	0.705
MOD_GSK3_1	578	585	PF00069	0.665
MOD_GSK3_1	597	604	PF00069	0.549
MOD_GSK3_1	608	615	PF00069	0.504
MOD_GSK3_1	67	74	PF00069	0.708
MOD_GSK3_1	682	689	PF00069	0.601
MOD_GSK3_1	723	730	PF00069	0.642
MOD_GSK3_1	737	744	PF00069	0.472
MOD_GSK3_1	777	784	PF00069	0.690
MOD_GSK3_1	785	792	PF00069	0.669
MOD_GSK3_1	81	88	PF00069	0.476
MOD_GSK3_1	831	838	PF00069	0.475
MOD_GSK3_1	867	874	PF00069	0.538
MOD_GSK3_1	94	101	PF00069	0.482
MOD_N-GLC_1	877	882	PF02516	0.509
MOD_N-GLC_2	779	781	PF02516	0.750
MOD_NEK2_1	108	113	PF00069	0.461
MOD_NEK2_1	131	136	PF00069	0.560
MOD_NEK2_1	151	156	PF00069	0.306
MOD_NEK2_1	2	7	PF00069	0.532
MOD_NEK2_1	387	392	PF00069	0.436
MOD_NEK2_1	426	431	PF00069	0.561
MOD_NEK2_1	447	452	PF00069	0.442
MOD_NEK2_1	479	484	PF00069	0.714
MOD_NEK2_1	506	511	PF00069	0.763
MOD_NEK2_1	606	611	PF00069	0.542
MOD_NEK2_1	682	687	PF00069	0.520
MOD_NEK2_1	723	728	PF00069	0.589
MOD_NEK2_1	737	742	PF00069	0.529
MOD_NEK2_1	825	830	PF00069	0.481
MOD_NEK2_1	95	100	PF00069	0.492
MOD_NEK2_2	520	525	PF00069	0.578
MOD_PIKK_1	102	108	PF00454	0.590
MOD_PIKK_1	601	607	PF00454	0.612
MOD_PIKK_1	634	640	PF00454	0.562
MOD_PIKK_1	730	736	PF00454	0.670
MOD_PIKK_1	789	795	PF00454	0.754
MOD_PIKK_1	871	877	PF00454	0.561
MOD_PK_1	832	838	PF00069	0.613
MOD_PKA_1	48	54	PF00069	0.590
MOD_PKA_1	871	877	PF00069	0.561
MOD_PKA_2	2	8	PF00069	0.587
MOD_PKA_2	220	226	PF00069	0.605
MOD_PKA_2	266	272	PF00069	0.543
MOD_PKA_2	320	326	PF00069	0.492
MOD_PKA_2	359	365	PF00069	0.643
MOD_PKA_2	37	43	PF00069	0.536
MOD_PKA_2	470	476	PF00069	0.591
MOD_PKA_2	48	54	PF00069	0.566
MOD_PKA_2	485	491	PF00069	0.681
MOD_PKA_2	494	500	PF00069	0.698
MOD_PKA_2	535	541	PF00069	0.479
MOD_PKA_2	562	568	PF00069	0.687
MOD_PKA_2	601	607	PF00069	0.436
MOD_PKA_2	675	681	PF00069	0.519
MOD_PKA_2	689	695	PF00069	0.381
MOD_PKA_2	741	747	PF00069	0.622
MOD_PKA_2	912	918	PF00069	0.620
MOD_Plk_1	230	236	PF00069	0.668
MOD_Plk_1	676	682	PF00069	0.514
MOD_Plk_1	781	787	PF00069	0.649
MOD_Plk_1	877	883	PF00069	0.461
MOD_Plk_1	885	891	PF00069	0.416
MOD_Plk_2-3	359	365	PF00069	0.781
MOD_Plk_4	127	133	PF00069	0.468
MOD_Plk_4	253	259	PF00069	0.396
MOD_Plk_4	291	297	PF00069	0.496
MOD_Plk_4	379	385	PF00069	0.438
MOD_Plk_4	419	425	PF00069	0.459
MOD_Plk_4	443	449	PF00069	0.480
MOD_Plk_4	529	535	PF00069	0.450
MOD_Plk_4	578	584	PF00069	0.696
MOD_Plk_4	8	14	PF00069	0.524
MOD_Plk_4	825	831	PF00069	0.339
MOD_Plk_4	85	91	PF00069	0.576
MOD_Plk_4	877	883	PF00069	0.457
MOD_Plk_4	886	892	PF00069	0.410
MOD_Plk_4	95	101	PF00069	0.460
MOD_ProDKin_1	121	127	PF00069	0.468
MOD_ProDKin_1	170	176	PF00069	0.358
MOD_ProDKin_1	571	577	PF00069	0.752
MOD_ProDKin_1	584	590	PF00069	0.473
MOD_ProDKin_1	656	662	PF00069	0.582
MOD_ProDKin_1	725	731	PF00069	0.697
MOD_ProDKin_1	791	797	PF00069	0.683
MOD_ProDKin_1	81	87	PF00069	0.573
TRG_DiLeu_BaEn_1	331	336	PF01217	0.558
TRG_DiLeu_BaEn_1	91	96	PF01217	0.465
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.627
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.564
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.306
TRG_ENDOCYTIC_2	162	165	PF00928	0.445
TRG_ENDOCYTIC_2	879	882	PF00928	0.473
TRG_ER_diArg_1	741	743	PF00400	0.605
TRG_ER_diArg_1	75	78	PF00400	0.726
TRG_NES_CRM1_1	702	715	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	760	764	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M8	Leptomonas seymouri	59%	100%
A0A0S4JAN9	Bodo saltans	30%	100%
A0A1X0P2C0	Trypanosomatidae	35%	100%
A0A3Q8IEP4	Leishmania donovani	82%	99%
A0A422P4V0	Trypanosoma rangeli	36%	100%
A4I5C3	Leishmania infantum	82%	99%
E9B0M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q7L1	Leishmania major	82%	100%
V5BU87	Trypanosoma cruzi	37%	100%