Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI45_LEIBR

TriTrypDb:

LbrM.30.1020 , LBRM2903_300015800

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.560
CLV_C14_Caspase3-7	32	36	PF00656	0.573
CLV_NRD_NRD_1	165	167	PF00675	0.688
CLV_NRD_NRD_1	179	181	PF00675	0.615
CLV_NRD_NRD_1	187	189	PF00675	0.633
CLV_NRD_NRD_1	280	282	PF00675	0.343
CLV_NRD_NRD_1	377	379	PF00675	0.614
CLV_NRD_NRD_1	484	486	PF00675	0.632
CLV_NRD_NRD_1	539	541	PF00675	0.737
CLV_PCSK_KEX2_1	165	167	PF00082	0.678
CLV_PCSK_KEX2_1	179	181	PF00082	0.615
CLV_PCSK_KEX2_1	245	247	PF00082	0.446
CLV_PCSK_KEX2_1	279	281	PF00082	0.365
CLV_PCSK_KEX2_1	484	486	PF00082	0.632
CLV_PCSK_KEX2_1	539	541	PF00082	0.647
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.446
CLV_PCSK_SKI1_1	235	239	PF00082	0.326
CLV_PCSK_SKI1_1	272	276	PF00082	0.486
CLV_PCSK_SKI1_1	293	297	PF00082	0.409
CLV_PCSK_SKI1_1	344	348	PF00082	0.338
CLV_PCSK_SKI1_1	382	386	PF00082	0.728
CLV_PCSK_SKI1_1	50	54	PF00082	0.564
CLV_PCSK_SKI1_1	567	571	PF00082	0.532
CLV_PCSK_SKI1_1	618	622	PF00082	0.390
DEG_APCC_DBOX_1	105	113	PF00400	0.670
DEG_APCC_DBOX_1	271	279	PF00400	0.429
DEG_APCC_DBOX_1	49	57	PF00400	0.563
DEG_APCC_DBOX_1	617	625	PF00400	0.519
DEG_APCC_DBOX_1	635	643	PF00400	0.314
DEG_COP1_1	572	581	PF00400	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DEG_SPOP_SBC_1	359	363	PF00917	0.494
DOC_CYCLIN_RxL_1	502	514	PF00134	0.523
DOC_CYCLIN_RxL_1	615	625	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.568
DOC_MAPK_gen_1	165	171	PF00069	0.731
DOC_MAPK_gen_1	339	348	PF00069	0.507
DOC_MAPK_gen_1	616	623	PF00069	0.349
DOC_MAPK_MEF2A_6	226	233	PF00069	0.347
DOC_PP2B_LxvP_1	4	7	PF13499	0.517
DOC_PP2B_LxvP_1	421	424	PF13499	0.537
DOC_PP2B_LxvP_1	576	579	PF13499	0.518
DOC_PP4_FxxP_1	205	208	PF00568	0.597
DOC_SPAK_OSR1_1	339	343	PF12202	0.325
DOC_USP7_MATH_1	102	106	PF00917	0.658
DOC_USP7_MATH_1	135	139	PF00917	0.597
DOC_USP7_MATH_1	154	158	PF00917	0.662
DOC_USP7_MATH_1	183	187	PF00917	0.647
DOC_USP7_MATH_1	305	309	PF00917	0.633
DOC_USP7_MATH_1	369	373	PF00917	0.685
DOC_USP7_MATH_1	380	384	PF00917	0.629
DOC_USP7_MATH_1	401	405	PF00917	0.566
DOC_USP7_MATH_1	416	420	PF00917	0.673
DOC_USP7_MATH_1	475	479	PF00917	0.595
DOC_USP7_MATH_1	490	494	PF00917	0.594
DOC_USP7_MATH_1	569	573	PF00917	0.621
DOC_USP7_MATH_1	577	581	PF00917	0.651
DOC_WW_Pin1_4	131	136	PF00397	0.696
DOC_WW_Pin1_4	204	209	PF00397	0.644
DOC_WW_Pin1_4	23	28	PF00397	0.621
DOC_WW_Pin1_4	30	35	PF00397	0.685
DOC_WW_Pin1_4	429	434	PF00397	0.575
DOC_WW_Pin1_4	479	484	PF00397	0.730
DOC_WW_Pin1_4	486	491	PF00397	0.573
DOC_WW_Pin1_4	527	532	PF00397	0.621
DOC_WW_Pin1_4	533	538	PF00397	0.592
DOC_WW_Pin1_4	546	551	PF00397	0.623
DOC_WW_Pin1_4	567	572	PF00397	0.614
DOC_WW_Pin1_4	57	62	PF00397	0.697
DOC_WW_Pin1_4	593	598	PF00397	0.760
DOC_WW_Pin1_4	603	608	PF00397	0.756
DOC_WW_Pin1_4	98	103	PF00397	0.606
LIG_14-3-3_CanoR_1	106	116	PF00244	0.618
LIG_14-3-3_CanoR_1	235	240	PF00244	0.424
LIG_14-3-3_CanoR_1	246	250	PF00244	0.393
LIG_14-3-3_CanoR_1	436	444	PF00244	0.553
LIG_14-3-3_CanoR_1	484	492	PF00244	0.635
LIG_14-3-3_CanoR_1	506	511	PF00244	0.661
LIG_14-3-3_CanoR_1	539	545	PF00244	0.649
LIG_14-3-3_CanoR_1	55	61	PF00244	0.557
LIG_14-3-3_CanoR_1	573	577	PF00244	0.661
LIG_14-3-3_CanoR_1	592	597	PF00244	0.529
LIG_14-3-3_CanoR_1	598	607	PF00244	0.495
LIG_Actin_WH2_2	553	569	PF00022	0.533
LIG_APCC_ABBA_1	508	513	PF00400	0.640
LIG_APCC_ABBA_1	68	73	PF00400	0.567
LIG_BIR_III_4	158	162	PF00653	0.557
LIG_EH1_1	339	347	PF00400	0.327
LIG_EVH1_1	4	8	PF00568	0.515
LIG_FHA_1	352	358	PF00498	0.472
LIG_FHA_1	457	463	PF00498	0.529
LIG_FHA_1	539	545	PF00498	0.571
LIG_FHA_1	573	579	PF00498	0.523
LIG_FHA_1	58	64	PF00498	0.590
LIG_FHA_1	600	606	PF00498	0.564
LIG_FHA_1	629	635	PF00498	0.387
LIG_FHA_2	219	225	PF00498	0.519
LIG_FHA_2	330	336	PF00498	0.415
LIG_FHA_2	412	418	PF00498	0.536
LIG_HP1_1	553	557	PF01393	0.537
LIG_Integrin_RGD_1	636	638	PF01839	0.362
LIG_LIR_Apic_2	202	208	PF02991	0.593
LIG_LIR_Apic_2	593	597	PF02991	0.613
LIG_LIR_Gen_1	322	333	PF02991	0.321
LIG_LIR_Nem_3	15	19	PF02991	0.533
LIG_LIR_Nem_3	322	328	PF02991	0.474
LIG_LIR_Nem_3	530	535	PF02991	0.631
LIG_PCNA_TLS_4	279	286	PF02747	0.341
LIG_SH2_CRK	325	329	PF00017	0.310
LIG_SH2_CRK	532	536	PF00017	0.721
LIG_SH2_CRK	594	598	PF00017	0.612
LIG_SH2_STAT3	285	288	PF00017	0.497
LIG_SH2_STAT3	526	529	PF00017	0.740
LIG_SH2_STAT3	650	653	PF00017	0.362
LIG_SH2_STAT5	285	288	PF00017	0.497
LIG_SH2_STAT5	434	437	PF00017	0.519
LIG_SH2_STAT5	659	662	PF00017	0.382
LIG_SH3_1	263	269	PF00018	0.576
LIG_SH3_2	534	539	PF14604	0.549
LIG_SH3_3	2	8	PF00018	0.695
LIG_SH3_3	205	211	PF00018	0.629
LIG_SH3_3	263	269	PF00018	0.576
LIG_SH3_3	528	534	PF00018	0.550
LIG_SH3_3	544	550	PF00018	0.509
LIG_SUMO_SIM_par_1	553	558	PF11976	0.539
LIG_SUMO_SIM_par_1	574	580	PF11976	0.523
LIG_SUMO_SIM_par_1	619	625	PF11976	0.340
LIG_TRAF2_1	299	302	PF00917	0.389
LIG_TRAF2_1	332	335	PF00917	0.496
LIG_TYR_ITIM	170	175	PF00017	0.663
LIG_UBA3_1	620	629	PF00899	0.526
LIG_WW_3	40	44	PF00397	0.717
MOD_CDC14_SPxK_1	536	539	PF00782	0.639
MOD_CDK_SPK_2	479	484	PF00069	0.553
MOD_CDK_SPK_2	593	598	PF00069	0.760
MOD_CDK_SPxK_1	479	485	PF00069	0.556
MOD_CDK_SPxK_1	533	539	PF00069	0.636
MOD_CDK_SPxK_1	567	573	PF00069	0.535
MOD_CDK_SPxxK_3	429	436	PF00069	0.551
MOD_CDK_SPxxK_3	533	540	PF00069	0.672
MOD_CK1_1	105	111	PF00069	0.672
MOD_CK1_1	140	146	PF00069	0.567
MOD_CK1_1	191	197	PF00069	0.622
MOD_CK1_1	319	325	PF00069	0.425
MOD_CK1_1	329	335	PF00069	0.409
MOD_CK1_1	358	364	PF00069	0.650
MOD_CK1_1	372	378	PF00069	0.609
MOD_CK1_1	383	389	PF00069	0.544
MOD_CK1_1	404	410	PF00069	0.681
MOD_CK1_1	520	526	PF00069	0.560
MOD_CK1_1	572	578	PF00069	0.668
MOD_CK2_1	105	111	PF00069	0.524
MOD_CK2_1	181	187	PF00069	0.558
MOD_CK2_1	245	251	PF00069	0.386
MOD_CK2_1	270	276	PF00069	0.358
MOD_CK2_1	329	335	PF00069	0.440
MOD_CK2_1	411	417	PF00069	0.533
MOD_Cter_Amidation	163	166	PF01082	0.614
MOD_DYRK1A_RPxSP_1	567	571	PF00069	0.532
MOD_GlcNHglycan	137	140	PF01048	0.607
MOD_GlcNHglycan	190	193	PF01048	0.583
MOD_GlcNHglycan	307	310	PF01048	0.581
MOD_GlcNHglycan	357	360	PF01048	0.512
MOD_GlcNHglycan	367	370	PF01048	0.647
MOD_GlcNHglycan	382	385	PF01048	0.721
MOD_GlcNHglycan	406	409	PF01048	0.711
MOD_GlcNHglycan	440	443	PF01048	0.709
MOD_GlcNHglycan	45	48	PF01048	0.584
MOD_GlcNHglycan	477	480	PF01048	0.789
MOD_GlcNHglycan	493	496	PF01048	0.559
MOD_GlcNHglycan	557	560	PF01048	0.631
MOD_GlcNHglycan	567	570	PF01048	0.655
MOD_GlcNHglycan	579	582	PF01048	0.481
MOD_GlcNHglycan	91	94	PF01048	0.660
MOD_GSK3_1	112	119	PF00069	0.549
MOD_GSK3_1	131	138	PF00069	0.580
MOD_GSK3_1	188	195	PF00069	0.665
MOD_GSK3_1	30	37	PF00069	0.706
MOD_GSK3_1	329	336	PF00069	0.381
MOD_GSK3_1	351	358	PF00069	0.576
MOD_GSK3_1	360	367	PF00069	0.572
MOD_GSK3_1	370	377	PF00069	0.579
MOD_GSK3_1	378	385	PF00069	0.588
MOD_GSK3_1	407	414	PF00069	0.761
MOD_GSK3_1	461	468	PF00069	0.632
MOD_GSK3_1	475	482	PF00069	0.612
MOD_GSK3_1	484	491	PF00069	0.717
MOD_GSK3_1	513	520	PF00069	0.775
MOD_GSK3_1	565	572	PF00069	0.591
MOD_GSK3_1	593	600	PF00069	0.633
MOD_GSK3_1	85	92	PF00069	0.649
MOD_GSK3_1	98	105	PF00069	0.564
MOD_N-GLC_1	140	145	PF02516	0.602
MOD_N-GLC_1	527	532	PF02516	0.556
MOD_N-GLC_1	74	79	PF02516	0.794
MOD_NEK2_1	112	117	PF00069	0.557
MOD_NEK2_1	122	127	PF00069	0.479
MOD_NEK2_1	438	443	PF00069	0.517
MOD_NEK2_1	56	61	PF00069	0.588
MOD_NEK2_2	401	406	PF00069	0.518
MOD_PIKK_1	218	224	PF00454	0.511
MOD_PIKK_1	416	422	PF00454	0.543
MOD_PIKK_1	496	502	PF00454	0.523
MOD_PIKK_1	513	519	PF00454	0.633
MOD_PK_1	245	251	PF00069	0.430
MOD_PKA_1	188	194	PF00069	0.563
MOD_PKA_1	245	251	PF00069	0.430
MOD_PKA_1	378	384	PF00069	0.552
MOD_PKA_1	484	490	PF00069	0.573
MOD_PKA_2	105	111	PF00069	0.732
MOD_PKA_2	122	128	PF00069	0.484
MOD_PKA_2	245	251	PF00069	0.386
MOD_PKA_2	355	361	PF00069	0.612
MOD_PKA_2	364	370	PF00069	0.576
MOD_PKA_2	475	481	PF00069	0.541
MOD_PKA_2	483	489	PF00069	0.579
MOD_PKA_2	520	526	PF00069	0.582
MOD_PKA_2	538	544	PF00069	0.628
MOD_PKA_2	56	62	PF00069	0.675
MOD_PKA_2	572	578	PF00069	0.650
MOD_PKA_2	597	603	PF00069	0.512
MOD_PKA_2	88	94	PF00069	0.582
MOD_PKB_1	376	384	PF00069	0.553
MOD_Plk_1	270	276	PF00069	0.466
MOD_Plk_1	329	335	PF00069	0.403
MOD_Plk_1	351	357	PF00069	0.457
MOD_Plk_1	416	422	PF00069	0.543
MOD_Plk_4	235	241	PF00069	0.417
MOD_Plk_4	291	297	PF00069	0.537
MOD_Plk_4	333	339	PF00069	0.451
MOD_ProDKin_1	131	137	PF00069	0.697
MOD_ProDKin_1	204	210	PF00069	0.644
MOD_ProDKin_1	23	29	PF00069	0.619
MOD_ProDKin_1	30	36	PF00069	0.684
MOD_ProDKin_1	429	435	PF00069	0.575
MOD_ProDKin_1	479	485	PF00069	0.733
MOD_ProDKin_1	486	492	PF00069	0.573
MOD_ProDKin_1	527	533	PF00069	0.618
MOD_ProDKin_1	546	552	PF00069	0.509
MOD_ProDKin_1	567	573	PF00069	0.614
MOD_ProDKin_1	57	63	PF00069	0.700
MOD_ProDKin_1	593	599	PF00069	0.757
MOD_ProDKin_1	603	609	PF00069	0.752
MOD_ProDKin_1	98	104	PF00069	0.603
MOD_SUMO_rev_2	184	191	PF00179	0.549
MOD_SUMO_rev_2	290	295	PF00179	0.332
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.651
TRG_ENDOCYTIC_2	172	175	PF00928	0.665
TRG_ENDOCYTIC_2	325	328	PF00928	0.487
TRG_ENDOCYTIC_2	532	535	PF00928	0.633
TRG_ER_diArg_1	165	167	PF00400	0.704
TRG_ER_diArg_1	278	281	PF00400	0.348
TRG_ER_diArg_1	483	485	PF00400	0.616
TRG_ER_diArg_1	615	618	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T3	Leptomonas seymouri	37%	100%
A0A3Q8IE52	Leishmania donovani	54%	98%
A4I5C1	Leishmania infantum	54%	98%
E9B0L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q7L3	Leishmania major	53%	100%