Adenosine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenosine kinase

Gene product:

adenosine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI44_LEIBR

TriTrypDb:

LbrM.30.1010 , LBRM2903_300015700

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI44

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006163	purine nucleotide metabolic process	5	13
GO:0006164	purine nucleotide biosynthetic process	6	13
GO:0006166	purine ribonucleoside salvage	5	13
GO:0006167	AMP biosynthetic process	8	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006753	nucleoside phosphate metabolic process	4	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009116	nucleoside metabolic process	4	13
GO:0009117	nucleotide metabolic process	5	13
GO:0009119	ribonucleoside metabolic process	5	13
GO:0009123	nucleoside monophosphate metabolic process	5	13
GO:0009124	nucleoside monophosphate biosynthetic process	6	13
GO:0009126	purine nucleoside monophosphate metabolic process	6	13
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	13
GO:0009150	purine ribonucleotide metabolic process	6	13
GO:0009152	purine ribonucleotide biosynthetic process	7	13
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	13
GO:0009161	ribonucleoside monophosphate metabolic process	6	13
GO:0009163	nucleoside biosynthetic process	5	13
GO:0009165	nucleotide biosynthetic process	6	13
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	13
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	13
GO:0009259	ribonucleotide metabolic process	5	13
GO:0009260	ribonucleotide biosynthetic process	6	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0018130	heterocycle biosynthetic process	4	13
GO:0019438	aromatic compound biosynthetic process	4	13
GO:0019637	organophosphate metabolic process	3	13
GO:0019693	ribose phosphate metabolic process	4	13
GO:0032261	purine nucleotide salvage	5	13
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034654	nucleobase-containing compound biosynthetic process	4	13
GO:0042278	purine nucleoside metabolic process	5	13
GO:0042451	purine nucleoside biosynthetic process	6	13
GO:0042455	ribonucleoside biosynthetic process	6	13
GO:0043094	cellular metabolic compound salvage	3	13
GO:0043101	purine-containing compound salvage	4	13
GO:0043173	nucleotide salvage	4	13
GO:0043174	nucleoside salvage	4	13
GO:0044209	AMP salvage	7	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0044281	small molecule metabolic process	2	13
GO:0044283	small molecule biosynthetic process	3	13
GO:0046033	AMP metabolic process	7	13
GO:0046128	purine ribonucleoside metabolic process	6	13
GO:0046129	purine ribonucleoside biosynthetic process	7	13
GO:0046390	ribose phosphate biosynthetic process	5	13
GO:0046483	heterocycle metabolic process	3	13
GO:0055086	nucleobase-containing small molecule metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:0072521	purine-containing compound metabolic process	4	13
GO:0072522	purine-containing compound biosynthetic process	5	13
GO:0090407	organophosphate biosynthetic process	4	13
GO:0106380	purine ribonucleotide salvage	6	13
GO:1901135	carbohydrate derivative metabolic process	3	13
GO:1901137	carbohydrate derivative biosynthetic process	4	13
GO:1901293	nucleoside phosphate biosynthetic process	5	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:1901362	organic cyclic compound biosynthetic process	4	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13
GO:1901657	glycosyl compound metabolic process	4	13
GO:1901659	glycosyl compound biosynthetic process	5	13
GO:0006144	purine nucleobase metabolic process	5	1
GO:0009112	nucleobase metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004001	adenosine kinase activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0019205	nucleobase-containing compound kinase activity	5	13
GO:0019206	nucleoside kinase activity	6	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	244	246	PF00675	0.225
CLV_PCSK_KEX2_1	244	246	PF00082	0.205
CLV_PCSK_SKI1_1	245	249	PF00082	0.280
CLV_PCSK_SKI1_1	44	48	PF00082	0.307
DOC_CDC14_PxL_1	1	9	PF14671	0.515
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.464
DOC_MAPK_MEF2A_6	210	219	PF00069	0.524
DOC_PP1_RVXF_1	256	263	PF00149	0.464
DOC_PP2B_LxvP_1	195	198	PF13499	0.464
DOC_USP7_MATH_1	118	122	PF00917	0.475
DOC_USP7_MATH_1	184	188	PF00917	0.501
DOC_USP7_MATH_1	272	276	PF00917	0.543
DOC_USP7_MATH_1	60	64	PF00917	0.465
DOC_USP7_MATH_1	78	82	PF00917	0.568
DOC_USP7_MATH_2	285	291	PF00917	0.400
DOC_USP7_UBL2_3	28	32	PF12436	0.280
LIG_14-3-3_CanoR_1	149	157	PF00244	0.400
LIG_14-3-3_CanoR_1	244	252	PF00244	0.423
LIG_APCC_ABBA_1	107	112	PF00400	0.565
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_BRCT_BRCA1_1	195	199	PF00533	0.455
LIG_eIF4E_1	337	343	PF01652	0.479
LIG_FHA_1	167	173	PF00498	0.455
LIG_FHA_1	65	71	PF00498	0.488
LIG_FHA_2	334	340	PF00498	0.476
LIG_LIR_LC3C_4	257	261	PF02991	0.501
LIG_LIR_Nem_3	23	29	PF02991	0.272
LIG_LIR_Nem_3	80	85	PF02991	0.481
LIG_LIR_Nem_3	91	97	PF02991	0.439
LIG_Pex14_2	204	208	PF04695	0.477
LIG_Pex14_2	301	305	PF04695	0.464
LIG_REV1ctd_RIR_1	23	32	PF16727	0.278
LIG_SH2_CRK	94	98	PF00017	0.455
LIG_SH2_SRC	214	217	PF00017	0.467
LIG_SH2_SRC	58	61	PF00017	0.489
LIG_SH2_STAP1	113	117	PF00017	0.565
LIG_SH2_STAT3	176	179	PF00017	0.565
LIG_SH2_STAT5	113	116	PF00017	0.489
LIG_SH2_STAT5	164	167	PF00017	0.455
LIG_SH2_STAT5	176	179	PF00017	0.455
LIG_SH2_STAT5	203	206	PF00017	0.504
LIG_SH2_STAT5	214	217	PF00017	0.416
LIG_SH2_STAT5	58	61	PF00017	0.489
LIG_SH2_STAT5	8	11	PF00017	0.303
LIG_SH2_STAT5	85	88	PF00017	0.479
LIG_SH3_3	279	285	PF00018	0.407
LIG_SH3_3	335	341	PF00018	0.455
LIG_SUMO_SIM_par_1	13	18	PF11976	0.326
LIG_SUMO_SIM_par_1	168	173	PF11976	0.464
LIG_TYR_ITIM	212	217	PF00017	0.432
MOD_CK1_1	266	272	PF00069	0.539
MOD_CK1_1	275	281	PF00069	0.531
MOD_CK2_1	124	130	PF00069	0.402
MOD_CK2_1	333	339	PF00069	0.476
MOD_GlcNHglycan	1	4	PF01048	0.484
MOD_GlcNHglycan	126	129	PF01048	0.338
MOD_GlcNHglycan	137	140	PF01048	0.266
MOD_GlcNHglycan	16	20	PF01048	0.276
MOD_GlcNHglycan	186	189	PF01048	0.291
MOD_GlcNHglycan	195	198	PF01048	0.225
MOD_GlcNHglycan	274	277	PF01048	0.329
MOD_GlcNHglycan	62	65	PF01048	0.265
MOD_GSK3_1	112	119	PF00069	0.455
MOD_GSK3_1	168	175	PF00069	0.400
MOD_GSK3_1	266	273	PF00069	0.475
MOD_GSK3_1	60	67	PF00069	0.478
MOD_N-GLC_1	135	140	PF02516	0.365
MOD_N-GLC_1	193	198	PF02516	0.255
MOD_N-GLC_1	252	257	PF02516	0.276
MOD_N-GLC_1	78	83	PF02516	0.200
MOD_N-GLC_2	333	335	PF02516	0.301
MOD_NEK2_1	111	116	PF00069	0.508
MOD_NEK2_1	15	20	PF00069	0.338
MOD_NEK2_1	193	198	PF00069	0.489
MOD_NEK2_1	305	310	PF00069	0.410
MOD_PIKK_1	260	266	PF00454	0.565
MOD_PKA_2	148	154	PF00069	0.400
MOD_PKA_2	184	190	PF00069	0.501
MOD_Plk_1	129	135	PF00069	0.455
MOD_Plk_1	172	178	PF00069	0.527
MOD_Plk_1	266	272	PF00069	0.423
MOD_Plk_1	78	84	PF00069	0.400
MOD_Plk_2-3	287	293	PF00069	0.400
MOD_Plk_4	172	178	PF00069	0.527
MOD_Plk_4	266	272	PF00069	0.482
MOD_Plk_4	278	284	PF00069	0.557
MOD_Plk_4	287	293	PF00069	0.560
MOD_Plk_4	78	84	PF00069	0.467
MOD_SUMO_rev_2	222	228	PF00179	0.562
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.310
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.330
TRG_ENDOCYTIC_2	214	217	PF00928	0.455
TRG_ENDOCYTIC_2	94	97	PF00928	0.455
TRG_NES_CRM1_1	161	173	PF08389	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A6	Leptomonas seymouri	34%	92%
A0A0N0P5S6	Leptomonas seymouri	26%	100%
A0A0N0P8X0	Leptomonas seymouri	73%	100%
A0A0N1PDV7	Leptomonas seymouri	38%	94%
A0A0S4IRE7	Bodo saltans	62%	100%
A0A0S4JPW2	Bodo saltans	40%	97%
A0A0S4JY74	Bodo saltans	27%	100%
A0A1X0P296	Trypanosomatidae	59%	97%
A0A1X0P4P4	Trypanosomatidae	26%	100%
A0A1X0PBE6	Trypanosomatidae	36%	97%
A0A3S5H7M6	Leishmania donovani	84%	100%
A0A3S7X0F5	Leishmania donovani	27%	100%
A0A3S7X8F0	Leishmania donovani	35%	89%
A0A422P4V2	Trypanosoma rangeli	59%	100%
A1A6H3	Arabidopsis thaliana	25%	91%
A4HB78	Leishmania braziliensis	36%	100%
A4HFG6	Leishmania braziliensis	26%	100%
A4I2M8	Leishmania infantum	27%	100%
A4I5C0	Leishmania infantum	85%	100%
A4IAC6	Leishmania infantum	36%	89%
A4IPB3	Geobacillus thermodenitrificans (strain NG80-2)	23%	100%
C9ZQQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AD19	Leishmania major	27%	100%
E9AYU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B0L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B5E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	89%
O29891	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	24%	100%
O49923	Physcomitrium patens	41%	100%
O60116	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O93919	Schizophyllum commune	35%	100%
P25332	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P44331	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
P44482	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P45416	Dickeya dadantii (strain 3937)	25%	100%
P47143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P55262	Cricetulus griseus	43%	96%
P55263	Homo sapiens	42%	95%
P55264	Mus musculus	42%	96%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q4Q2I4	Leishmania major	36%	100%
Q4Q7L4	Leishmania major	32%	100%
Q4Q7L5	Leishmania major	84%	100%
Q54MB5	Dictyostelium discoideum	39%	100%
Q64640	Rattus norvegicus	43%	96%
Q8R1Q9	Mus musculus	27%	100%
Q9H477	Homo sapiens	28%	100%
Q9LZG0	Arabidopsis thaliana	42%	100%
Q9SF85	Arabidopsis thaliana	42%	100%
Q9TVW2	Toxoplasma gondii	33%	95%
V5B941	Trypanosoma cruzi	61%	100%
V5BLW1	Trypanosoma cruzi	37%	85%