Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HI43_LEIBR

TriTrypDb:

LbrM.30.1000 , LBRM2903_300015600

Length:

212

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 108
NetGPI	no	yes: 0, no: 115

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	101
GO:0110165	cellular anatomical entity	1	101

Expansion

Sequence features

A4HI43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.563
CLV_NRD_NRD_1	11	13	PF00675	0.370
CLV_NRD_NRD_1	78	80	PF00675	0.517
CLV_PCSK_KEX2_1	78	80	PF00082	0.505
CLV_PCSK_SKI1_1	78	82	PF00082	0.539
DOC_CKS1_1	151	156	PF01111	0.198
DOC_MAPK_MEF2A_6	126	134	PF00069	0.554
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_WW_Pin1_4	150	155	PF00397	0.265
DOC_WW_Pin1_4	32	37	PF00397	0.369
LIG_14-3-3_CanoR_1	78	83	PF00244	0.282
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BIR_III_4	207	211	PF00653	0.588
LIG_FHA_2	91	97	PF00498	0.396
LIG_LIR_Apic_2	148	154	PF02991	0.241
LIG_LIR_Gen_1	136	147	PF02991	0.339
LIG_LIR_Gen_1	24	30	PF02991	0.314
LIG_LIR_Gen_1	99	109	PF02991	0.250
LIG_LIR_Nem_3	108	113	PF02991	0.310
LIG_LIR_Nem_3	116	120	PF02991	0.394
LIG_LIR_Nem_3	136	142	PF02991	0.340
LIG_LIR_Nem_3	24	28	PF02991	0.324
LIG_LIR_Nem_3	99	104	PF02991	0.254
LIG_Pex14_2	135	139	PF04695	0.336
LIG_PTB_Apo_2	56	63	PF02174	0.423
LIG_PTB_Phospho_1	56	62	PF10480	0.194
LIG_SH2_CRK	172	176	PF00017	0.204
LIG_SH2_STAP1	172	176	PF00017	0.324
LIG_SH2_STAP1	7	11	PF00017	0.541
LIG_SH2_STAT5	152	155	PF00017	0.284
LIG_SH2_STAT5	62	65	PF00017	0.293
LIG_SH2_STAT5	75	78	PF00017	0.365
LIG_SH3_3	54	60	PF00018	0.260
LIG_SUMO_SIM_anti_2	24	32	PF11976	0.305
LIG_SUMO_SIM_par_1	102	108	PF11976	0.395
LIG_SUMO_SIM_par_1	130	136	PF11976	0.294
LIG_SUMO_SIM_par_1	38	44	PF11976	0.304
LIG_TRAF2_1	44	47	PF00917	0.249
LIG_WRC_WIRS_1	176	181	PF05994	0.295
LIG_WRC_WIRS_1	22	27	PF05994	0.266
MOD_CK1_1	133	139	PF00069	0.274
MOD_CK1_1	49	55	PF00069	0.349
MOD_CK2_1	41	47	PF00069	0.293
MOD_CK2_1	90	96	PF00069	0.284
MOD_GlcNHglycan	14	17	PF01048	0.239
MOD_GlcNHglycan	51	54	PF01048	0.506
MOD_GSK3_1	120	127	PF00069	0.294
MOD_GSK3_1	133	140	PF00069	0.283
MOD_GSK3_1	159	166	PF00069	0.224
MOD_GSK3_1	28	35	PF00069	0.320
MOD_GSK3_1	47	54	PF00069	0.268
MOD_GSK3_1	86	93	PF00069	0.247
MOD_N-GLC_1	47	52	PF02516	0.420
MOD_N-GLC_1	86	91	PF02516	0.515
MOD_N-GLC_2	69	71	PF02516	0.466
MOD_NEK2_1	113	118	PF00069	0.323
MOD_NEK2_1	130	135	PF00069	0.322
MOD_NEK2_1	175	180	PF00069	0.308
MOD_NEK2_1	21	26	PF00069	0.385
MOD_NEK2_1	28	33	PF00069	0.355
MOD_NEK2_2	105	110	PF00069	0.503
MOD_NEK2_2	2	7	PF00069	0.545
MOD_PKA_1	12	18	PF00069	0.390
MOD_PKA_1	78	84	PF00069	0.273
MOD_PKA_2	78	84	PF00069	0.339
MOD_Plk_4	113	119	PF00069	0.311
MOD_Plk_4	125	131	PF00069	0.496
MOD_Plk_4	2	8	PF00069	0.553
MOD_Plk_4	21	27	PF00069	0.276
MOD_Plk_4	60	66	PF00069	0.303
MOD_ProDKin_1	150	156	PF00069	0.265
MOD_ProDKin_1	32	38	PF00069	0.369
TRG_ENDOCYTIC_2	152	155	PF00928	0.276
TRG_ENDOCYTIC_2	172	175	PF00928	0.427
TRG_ER_diArg_1	78	80	PF00400	0.319
TRG_NES_CRM1_1	182	193	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	27%	100%
A0A0N0P547	Leptomonas seymouri	30%	100%
A0A0N0P993	Leptomonas seymouri	54%	95%
A0A0N1HWY5	Leptomonas seymouri	25%	100%
A0A0N1PAD5	Leptomonas seymouri	24%	84%
A0A0N1PDH0	Leptomonas seymouri	24%	100%
A0A0S4J784	Bodo saltans	26%	95%
A0A1X0NUH1	Trypanosomatidae	25%	93%
A0A1X0P2R3	Trypanosomatidae	39%	100%
A0A1X0P988	Trypanosomatidae	29%	100%
A0A381MTB8	Leishmania infantum	26%	100%
A0A381MVY0	Leishmania infantum	24%	100%
A0A3Q8ID16	Leishmania donovani	23%	100%
A0A3Q8IFI8	Leishmania donovani	25%	100%
A0A3Q8IH65	Leishmania donovani	25%	100%
A0A3Q8IHW7	Leishmania donovani	30%	100%
A0A3Q8IIH1	Leishmania donovani	25%	100%
A0A3Q8IMR4	Leishmania donovani	26%	100%
A0A3Q8IUK8	Leishmania donovani	25%	100%
A0A3S5H666	Leishmania donovani	23%	100%
A0A3S5H7L2	Leishmania donovani	26%	100%
A0A3S5H7V9	Leishmania donovani	26%	100%
A0A3S5H7W2	Leishmania donovani	26%	100%
A0A3S7WQA8	Leishmania donovani	25%	100%
A0A3S7X2E6	Leishmania donovani	26%	100%
A0A3S7X357	Leishmania donovani	68%	95%
A0A3S7X381	Leishmania donovani	25%	100%
A0A3S7X7E5	Leishmania donovani	29%	85%
A0A3S7X7U4	Leishmania donovani	22%	82%
A0A422MVT4	Trypanosoma rangeli	23%	66%
A4H5D1	Leishmania braziliensis	27%	100%
A4H5D2	Leishmania braziliensis	25%	100%
A4H5G0	Leishmania braziliensis	26%	98%
A4H5G9	Leishmania braziliensis	27%	100%
A4H5H0	Leishmania braziliensis	27%	100%
A4H5H1	Leishmania braziliensis	27%	100%
A4H5H3	Leishmania braziliensis	28%	100%
A4H6C8	Leishmania braziliensis	26%	100%
A4H7D7	Leishmania braziliensis	29%	100%
A4HAL2	Leishmania braziliensis	25%	100%
A4HAZ8	Leishmania braziliensis	26%	100%
A4HBJ2	Leishmania braziliensis	26%	100%
A4HDI2	Leishmania braziliensis	27%	100%
A4HI41	Leishmania braziliensis	24%	100%
A4HTM4	Leishmania infantum	25%	100%
A4HTM5	Leishmania infantum	24%	100%
A4I0W3	Leishmania infantum	29%	100%
A4I0W5	Leishmania infantum	23%	100%
A4I0W6	Leishmania infantum	25%	72%
A4I4J2	Leishmania infantum	26%	100%
A4I5B8	Leishmania infantum	25%	100%
A4I5B9	Leishmania infantum	68%	95%
A4I6E5	Leishmania infantum	25%	100%
A4I9R4	Leishmania infantum	26%	100%
A4I9R7	Leishmania infantum	28%	100%
A4I9W8	Leishmania infantum	22%	82%
A4IAL7	Leishmania infantum	30%	100%
C6K3X5	Leptomonas seymouri	28%	100%
C6K3X9	Leptomonas seymouri	27%	100%
E8NHD3	Leishmania infantum	27%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AG83	Leishmania infantum	23%	99%
E9AHI9	Leishmania infantum	27%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	95%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q309	Leishmania major	25%	98%
Q4Q317	Leishmania major	22%	100%
Q4Q325	Leishmania major	24%	99%
Q4Q327	Leishmania major	24%	98%
Q4Q329	Leishmania major	25%	97%
Q4Q341	Leishmania major	25%	96%
Q4Q397	Leishmania major	26%	100%
Q4Q3A9	Leishmania major	26%	100%
Q4Q3F7	Leishmania major	25%	100%
Q4Q7L6	Leishmania major	68%	100%
Q4Q7L7	Leishmania major	28%	100%
Q4Q7L8	Leishmania major	28%	100%
Q4QAK4	Leishmania major	25%	93%
Q4QAK5	Leishmania major	24%	96%
Q4QAK7	Leishmania major	25%	93%
Q4QI84	Leishmania major	27%	99%
Q4QI85	Leishmania major	27%	100%
Q4QI86	Leishmania major	28%	98%
Q4QI87	Leishmania major	25%	100%
Q4QI88	Leishmania major	27%	100%
Q4QI95	Leishmania major	26%	98%