PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HI42_LEIBR

TriTrypDb:

LbrM.30.0990 , LBRM2903_320025000

Length:

102

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI42

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004722	protein serine/threonine phosphatase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.549
CLV_PCSK_KEX2_1	29	31	PF00082	0.549
DOC_USP7_UBL2_3	74	78	PF12436	0.549
LIG_14-3-3_CanoR_1	29	33	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_Clathr_ClatBox_1	38	42	PF01394	0.549
LIG_FHA_1	35	41	PF00498	0.549
LIG_FHA_2	29	35	PF00498	0.549
LIG_LIR_Gen_1	64	75	PF02991	0.549
LIG_LIR_Gen_1	87	96	PF02991	0.549
LIG_LIR_Nem_3	14	20	PF02991	0.657
LIG_LIR_Nem_3	64	70	PF02991	0.549
LIG_LIR_Nem_3	87	92	PF02991	0.549
LIG_SH2_STAP1	86	90	PF00017	0.549
LIG_SH2_STAT3	65	68	PF00017	0.549
LIG_SH2_STAT5	61	64	PF00017	0.549
LIG_SH2_STAT5	95	98	PF00017	0.620
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.549
LIG_SUMO_SIM_par_1	36	42	PF11976	0.549
LIG_UBA3_1	38	43	PF00899	0.549
LIG_WRC_WIRS_1	86	91	PF05994	0.549
MOD_GlcNHglycan	11	14	PF01048	0.664
MOD_GlcNHglycan	53	56	PF01048	0.549
MOD_GSK3_1	51	58	PF00069	0.549
MOD_NEK2_1	85	90	PF00069	0.549
MOD_PKA_2	28	34	PF00069	0.549
MOD_Plk_4	34	40	PF00069	0.549
MOD_Plk_4	85	91	PF00069	0.549
MOD_SUMO_for_1	77	80	PF00179	0.549
TRG_ENDOCYTIC_2	86	89	PF00928	0.549
TRG_ER_diArg_1	28	30	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0BLX0	PARTE	34%	34%
A0BQL0	PARTE	36%	34%
A0CUB5	PARTE	35%	35%
A0DSB3	PARTE	38%	35%
A0DTY1	PARTE	37%	34%
P35182	YEAST	37%	36%
P49444	PARTE	33%	34%