Putative surface protein amastin

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface protein amastin, putative

Species:

Leishmania braziliensis

UniProt:

A4HI41_LEIBR

TriTrypDb:

LbrM.30.0980 , LBRM2903_300015400

Length:

198

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 87
NetGPI	no	yes: 0, no: 90

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	77
GO:0110165	cellular anatomical entity	1	77

Expansion

Sequence features

A4HI41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.266
CLV_PCSK_SKI1_1	169	173	PF00082	0.404
CLV_PCSK_SKI1_1	81	85	PF00082	0.550
DOC_MAPK_gen_1	113	121	PF00069	0.517
DOC_MAPK_MEF2A_6	113	120	PF00069	0.546
DOC_MAPK_MEF2A_6	9	16	PF00069	0.533
DOC_USP7_MATH_1	163	167	PF00917	0.207
DOC_USP7_MATH_1	42	46	PF00917	0.197
LIG_EH1_1	90	98	PF00400	0.349
LIG_FHA_1	147	153	PF00498	0.332
LIG_FHA_1	191	197	PF00498	0.331
LIG_GBD_Chelix_1	96	104	PF00786	0.338
LIG_LIR_Gen_1	21	31	PF02991	0.369
LIG_LIR_Nem_3	21	26	PF02991	0.389
LIG_NRBOX	191	197	PF00104	0.208
LIG_NRBOX	99	105	PF00104	0.326
LIG_OCRL_FandH_1	2	14	PF00620	0.518
LIG_PDZ_Class_2	193	198	PF00595	0.227
LIG_Pex14_1	140	144	PF04695	0.317
LIG_SH2_CRK	164	168	PF00017	0.195
LIG_SH2_SRC	91	94	PF00017	0.233
LIG_SH2_STAT3	144	147	PF00017	0.189
LIG_SH2_STAT5	108	111	PF00017	0.329
LIG_SH2_STAT5	144	147	PF00017	0.285
LIG_SH2_STAT5	91	94	PF00017	0.395
LIG_SUMO_SIM_par_1	192	197	PF11976	0.329
LIG_TYR_ITIM	162	167	PF00017	0.191
LIG_WRC_WIRS_1	96	101	PF05994	0.367
MOD_CK1_1	98	104	PF00069	0.324
MOD_GlcNHglycan	104	107	PF01048	0.380
MOD_GlcNHglycan	155	158	PF01048	0.567
MOD_GlcNHglycan	174	177	PF01048	0.514
MOD_GlcNHglycan	28	31	PF01048	0.380
MOD_GlcNHglycan	37	40	PF01048	0.536
MOD_GlcNHglycan	43	47	PF01048	0.566
MOD_GSK3_1	163	170	PF00069	0.200
MOD_GSK3_1	190	197	PF00069	0.409
MOD_GSK3_1	26	33	PF00069	0.335
MOD_GSK3_1	42	49	PF00069	0.299
MOD_GSK3_1	69	76	PF00069	0.312
MOD_GSK3_1	95	102	PF00069	0.305
MOD_N-GLC_1	152	157	PF02516	0.495
MOD_N-GLC_2	61	63	PF02516	0.511
MOD_NEK2_1	16	21	PF00069	0.419
MOD_NEK2_1	172	177	PF00069	0.277
MOD_NEK2_1	180	185	PF00069	0.307
MOD_NEK2_1	25	30	PF00069	0.348
MOD_NEK2_1	35	40	PF00069	0.267
MOD_NEK2_1	99	104	PF00069	0.291
MOD_NEK2_2	18	23	PF00069	0.189
MOD_PIKK_1	30	36	PF00454	0.398
MOD_PK_1	71	77	PF00069	0.207
MOD_PKA_2	35	41	PF00069	0.297
MOD_PKA_2	70	76	PF00069	0.386
MOD_Plk_4	146	152	PF00069	0.322
MOD_Plk_4	163	169	PF00069	0.209
MOD_Plk_4	18	24	PF00069	0.342
MOD_Plk_4	190	196	PF00069	0.277
MOD_Plk_4	95	101	PF00069	0.347
TRG_ENDOCYTIC_2	164	167	PF00928	0.195
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	27%	100%
A0A0N0P547	Leptomonas seymouri	27%	100%
A0A0N0P6P9	Leptomonas seymouri	26%	86%
A0A0N0P993	Leptomonas seymouri	26%	88%
A0A0N1I0E5	Leptomonas seymouri	26%	100%
A0A0N1PAD5	Leptomonas seymouri	26%	79%
A0A0N1PDH0	Leptomonas seymouri	24%	98%
A0A1X0NQ58	Trypanosomatidae	31%	100%
A0A1X0NUH1	Trypanosomatidae	24%	87%
A0A1X0NX02	Trypanosomatidae	30%	100%
A0A1X0P2R3	Trypanosomatidae	29%	94%
A0A1X0P988	Trypanosomatidae	26%	100%
A0A381MTB8	Leishmania infantum	26%	100%
A0A381MTC7	Leishmania infantum	26%	97%
A0A3Q8ID16	Leishmania donovani	24%	100%
A0A3Q8IEC2	Leishmania donovani	24%	100%
A0A3Q8IFH7	Leishmania donovani	26%	97%
A0A3Q8IFI8	Leishmania donovani	78%	100%
A0A3Q8IH65	Leishmania donovani	24%	100%
A0A3Q8IHW7	Leishmania donovani	26%	100%
A0A3Q8IIH1	Leishmania donovani	26%	100%
A0A3S5H7D2	Leishmania donovani	26%	100%
A0A3S5H7L2	Leishmania donovani	25%	97%
A0A3S5H7V9	Leishmania donovani	25%	100%
A0A3S7WQA8	Leishmania donovani	26%	100%
A0A3S7WQC1	Leishmania donovani	22%	100%
A0A3S7X2E6	Leishmania donovani	25%	100%
A0A3S7X357	Leishmania donovani	27%	89%
A0A3S7X381	Leishmania donovani	77%	100%
A0A3S7X7E5	Leishmania donovani	29%	79%
A0A3S7X7M4	Leishmania donovani	22%	94%
A0A3S7X7U4	Leishmania donovani	24%	76%
A0A3S7X7W2	Leishmania donovani	24%	94%
A0A3S7X7Y0	Leishmania donovani	25%	100%
A4H5G0	Leishmania braziliensis	24%	100%
A4H5G9	Leishmania braziliensis	25%	100%
A4H5H2	Leishmania braziliensis	24%	100%
A4H6C8	Leishmania braziliensis	25%	100%
A4H7D7	Leishmania braziliensis	28%	100%
A4HAM2	Leishmania braziliensis	26%	100%
A4HAZ8	Leishmania braziliensis	27%	100%
A4HDI3	Leishmania braziliensis	26%	100%
A4HDL3	Leishmania braziliensis	25%	98%
A4HI43	Leishmania braziliensis	24%	93%
A4HTM3	Leishmania infantum	24%	100%
A4HTM4	Leishmania infantum	26%	100%
A4HTM5	Leishmania infantum	25%	100%
A4I0W4	Leishmania infantum	26%	100%
A4I0W5	Leishmania infantum	24%	100%
A4I4J2	Leishmania infantum	29%	97%
A4I5B8	Leishmania infantum	77%	100%
A4I5B9	Leishmania infantum	27%	89%
A4I9Q4	Leishmania infantum	26%	100%
A4I9W8	Leishmania infantum	25%	76%
A4I9X0	Leishmania infantum	24%	94%
A4IAL7	Leishmania infantum	25%	100%
C6K3X5	Leptomonas seymouri	56%	99%
E8NHD3	Leishmania infantum	26%	97%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AHI9	Leishmania infantum	26%	100%
E9AHT2	Leishmania infantum	23%	94%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	95%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	89%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q317	Leishmania major	27%	100%
Q4Q341	Leishmania major	23%	99%
Q4Q3A8	Leishmania major	23%	98%
Q4Q3A9	Leishmania major	24%	100%
Q4Q3F7	Leishmania major	22%	100%
Q4Q7L6	Leishmania major	26%	100%
Q4Q7L7	Leishmania major	76%	99%
Q4Q7L8	Leishmania major	75%	98%
Q4QAK5	Leishmania major	25%	97%
Q4QAK6	Leishmania major	27%	97%
Q4QI84	Leishmania major	25%	90%
Q4QI85	Leishmania major	28%	100%
Q4QI86	Leishmania major	24%	90%
Q4QI87	Leishmania major	24%	100%
Q4QI88	Leishmania major	25%	96%