G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI40_LEIBR

TriTrypDb:

LbrM.30.0970 , LBRM2903_300015300

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI40

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	5
GO:0016787	hydrolase activity	2	2
GO:0017076	purine nucleotide binding	4	5
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.675
CLV_C14_Caspase3-7	25	29	PF00656	0.519
CLV_C14_Caspase3-7	572	576	PF00656	0.612
CLV_C14_Caspase3-7	65	69	PF00656	0.671
CLV_C14_Caspase3-7	868	872	PF00656	0.682
CLV_NRD_NRD_1	152	154	PF00675	0.577
CLV_NRD_NRD_1	210	212	PF00675	0.691
CLV_NRD_NRD_1	249	251	PF00675	0.602
CLV_NRD_NRD_1	395	397	PF00675	0.577
CLV_NRD_NRD_1	480	482	PF00675	0.403
CLV_NRD_NRD_1	527	529	PF00675	0.580
CLV_NRD_NRD_1	566	568	PF00675	0.516
CLV_NRD_NRD_1	687	689	PF00675	0.430
CLV_NRD_NRD_1	798	800	PF00675	0.486
CLV_NRD_NRD_1	848	850	PF00675	0.609
CLV_NRD_NRD_1	856	858	PF00675	0.603
CLV_PCSK_FUR_1	795	799	PF00082	0.558
CLV_PCSK_FUR_1	846	850	PF00082	0.550
CLV_PCSK_KEX2_1	151	153	PF00082	0.587
CLV_PCSK_KEX2_1	395	397	PF00082	0.589
CLV_PCSK_KEX2_1	480	482	PF00082	0.403
CLV_PCSK_KEX2_1	498	500	PF00082	0.434
CLV_PCSK_KEX2_1	506	508	PF00082	0.478
CLV_PCSK_KEX2_1	527	529	PF00082	0.580
CLV_PCSK_KEX2_1	687	689	PF00082	0.430
CLV_PCSK_KEX2_1	797	799	PF00082	0.523
CLV_PCSK_KEX2_1	848	850	PF00082	0.614
CLV_PCSK_KEX2_1	855	857	PF00082	0.600
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.705
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.431
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.478
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.686
CLV_PCSK_SKI1_1	250	254	PF00082	0.608
CLV_PCSK_SKI1_1	330	334	PF00082	0.514
CLV_PCSK_SKI1_1	377	381	PF00082	0.545
CLV_PCSK_SKI1_1	409	413	PF00082	0.542
CLV_PCSK_SKI1_1	481	485	PF00082	0.301
CLV_PCSK_SKI1_1	610	614	PF00082	0.562
CLV_PCSK_SKI1_1	678	682	PF00082	0.504
CLV_PCSK_SKI1_1	724	728	PF00082	0.393
CLV_PCSK_SKI1_1	856	860	PF00082	0.667
CLV_PCSK_SKI1_1	96	100	PF00082	0.768
CLV_Separin_Metazoa	838	842	PF03568	0.448
DEG_APCC_DBOX_1	677	685	PF00400	0.579
DEG_APCC_DBOX_1	723	731	PF00400	0.409
DEG_SCF_FBW7_1	511	516	PF00400	0.297
DOC_CKS1_1	15	20	PF01111	0.496
DOC_CKS1_1	4	9	PF01111	0.521
DOC_CKS1_1	586	591	PF01111	0.463
DOC_CKS1_1	666	671	PF01111	0.432
DOC_CKS1_1	885	890	PF01111	0.647
DOC_CYCLIN_RxL_1	122	133	PF00134	0.612
DOC_CYCLIN_RxL_1	674	682	PF00134	0.503
DOC_CYCLIN_RxL_1	720	732	PF00134	0.479
DOC_MAPK_gen_1	220	227	PF00069	0.536
DOC_MAPK_gen_1	409	419	PF00069	0.423
DOC_MAPK_gen_1	480	488	PF00069	0.393
DOC_MAPK_gen_1	606	614	PF00069	0.596
DOC_MAPK_gen_1	797	806	PF00069	0.423
DOC_MAPK_MEF2A_6	412	421	PF00069	0.401
DOC_MAPK_MEF2A_6	480	488	PF00069	0.406
DOC_MAPK_RevD_3	513	528	PF00069	0.408
DOC_PP1_RVXF_1	249	256	PF00149	0.614
DOC_PP1_RVXF_1	722	729	PF00149	0.518
DOC_PP2B_LxvP_1	556	559	PF13499	0.503
DOC_PP2B_LxvP_1	701	704	PF13499	0.549
DOC_PP2B_LxvP_1	758	761	PF13499	0.394
DOC_PP4_FxxP_1	287	290	PF00568	0.480
DOC_PP4_FxxP_1	49	52	PF00568	0.720
DOC_PP4_FxxP_1	490	493	PF00568	0.410
DOC_PP4_FxxP_1	694	697	PF00568	0.523
DOC_PP4_FxxP_1	84	87	PF00568	0.630
DOC_USP7_MATH_1	107	111	PF00917	0.691
DOC_USP7_MATH_1	22	26	PF00917	0.699
DOC_USP7_MATH_1	80	84	PF00917	0.735
DOC_USP7_UBL2_3	170	174	PF12436	0.557
DOC_USP7_UBL2_3	247	251	PF12436	0.670
DOC_USP7_UBL2_3	606	610	PF12436	0.566
DOC_WW_Pin1_4	100	105	PF00397	0.717
DOC_WW_Pin1_4	11	16	PF00397	0.597
DOC_WW_Pin1_4	190	195	PF00397	0.647
DOC_WW_Pin1_4	203	208	PF00397	0.761
DOC_WW_Pin1_4	3	8	PF00397	0.625
DOC_WW_Pin1_4	509	514	PF00397	0.301
DOC_WW_Pin1_4	585	590	PF00397	0.465
DOC_WW_Pin1_4	665	670	PF00397	0.430
DOC_WW_Pin1_4	76	81	PF00397	0.646
DOC_WW_Pin1_4	884	889	PF00397	0.714
LIG_14-3-3_CanoR_1	111	118	PF00244	0.651
LIG_14-3-3_CanoR_1	23	27	PF00244	0.603
LIG_14-3-3_CanoR_1	396	402	PF00244	0.565
LIG_14-3-3_CanoR_1	456	461	PF00244	0.521
LIG_14-3-3_CanoR_1	644	652	PF00244	0.642
LIG_14-3-3_CanoR_1	678	684	PF00244	0.501
LIG_14-3-3_CanoR_1	687	691	PF00244	0.368
LIG_14-3-3_CanoR_1	825	830	PF00244	0.400
LIG_14-3-3_CanoR_1	856	863	PF00244	0.639
LIG_14-3-3_CanoR_1	880	885	PF00244	0.661
LIG_14-3-3_CanoR_1	912	921	PF00244	0.667
LIG_BIR_III_4	575	579	PF00653	0.637
LIG_BRCT_BRCA1_1	745	749	PF00533	0.407
LIG_BRCT_BRCA1_1	786	790	PF00533	0.437
LIG_BRCT_BRCA1_1	917	921	PF00533	0.625
LIG_Clathr_ClatBox_1	182	186	PF01394	0.621
LIG_Clathr_ClatBox_1	767	771	PF01394	0.623
LIG_deltaCOP1_diTrp_1	357	362	PF00928	0.533
LIG_eIF4E_1	433	439	PF01652	0.436
LIG_eIF4E_1	666	672	PF01652	0.556
LIG_FHA_1	118	124	PF00498	0.574
LIG_FHA_1	204	210	PF00498	0.497
LIG_FHA_1	403	409	PF00498	0.491
LIG_FHA_1	510	516	PF00498	0.496
LIG_FHA_1	533	539	PF00498	0.455
LIG_FHA_1	619	625	PF00498	0.596
LIG_FHA_1	666	672	PF00498	0.440
LIG_FHA_1	705	711	PF00498	0.400
LIG_FHA_2	362	368	PF00498	0.466
LIG_FHA_2	570	576	PF00498	0.583
LIG_FHA_2	767	773	PF00498	0.417
LIG_FXI_DFP_1	424	428	PF00024	0.401
LIG_LIR_Apic_2	285	290	PF02991	0.511
LIG_LIR_Apic_2	311	317	PF02991	0.344
LIG_LIR_Apic_2	430	436	PF02991	0.419
LIG_LIR_Apic_2	46	52	PF02991	0.501
LIG_LIR_Apic_2	663	669	PF02991	0.526
LIG_LIR_Apic_2	693	697	PF02991	0.334
LIG_LIR_Apic_2	83	87	PF02991	0.630
LIG_LIR_Gen_1	357	363	PF02991	0.519
LIG_LIR_Gen_1	366	376	PF02991	0.472
LIG_LIR_Gen_1	763	770	PF02991	0.631
LIG_LIR_Gen_1	918	928	PF02991	0.587
LIG_LIR_Nem_3	254	258	PF02991	0.638
LIG_LIR_Nem_3	309	315	PF02991	0.455
LIG_LIR_Nem_3	357	362	PF02991	0.533
LIG_LIR_Nem_3	366	371	PF02991	0.451
LIG_LIR_Nem_3	535	540	PF02991	0.398
LIG_LIR_Nem_3	763	767	PF02991	0.610
LIG_LIR_Nem_3	787	793	PF02991	0.463
LIG_LIR_Nem_3	918	924	PF02991	0.604
LIG_MYND_1	669	673	PF01753	0.437
LIG_NRBOX	679	685	PF00104	0.496
LIG_PCNA_PIPBox_1	341	350	PF02747	0.486
LIG_PCNA_yPIPBox_3	494	507	PF02747	0.555
LIG_PCNA_yPIPBox_3	677	688	PF02747	0.465
LIG_PTB_Apo_2	454	461	PF02174	0.495
LIG_SH2_CRK	223	227	PF00017	0.523
LIG_SH2_CRK	433	437	PF00017	0.448
LIG_SH2_CRK	587	591	PF00017	0.466
LIG_SH2_CRK	666	670	PF00017	0.552
LIG_SH2_NCK_1	433	437	PF00017	0.448
LIG_SH2_NCK_1	587	591	PF00017	0.466
LIG_SH2_NCK_1	666	670	PF00017	0.552
LIG_SH2_PTP2	314	317	PF00017	0.587
LIG_SH2_STAP1	337	341	PF00017	0.453
LIG_SH2_STAP1	764	768	PF00017	0.620
LIG_SH2_STAT3	323	326	PF00017	0.571
LIG_SH2_STAT3	557	560	PF00017	0.635
LIG_SH2_STAT3	731	734	PF00017	0.411
LIG_SH2_STAT5	314	317	PF00017	0.440
LIG_SH2_STAT5	323	326	PF00017	0.451
LIG_SH2_STAT5	478	481	PF00017	0.427
LIG_SH2_STAT5	536	539	PF00017	0.397
LIG_SH2_STAT5	557	560	PF00017	0.525
LIG_SH2_STAT5	571	574	PF00017	0.458
LIG_SH2_STAT5	587	590	PF00017	0.463
LIG_SH2_STAT5	664	667	PF00017	0.478
LIG_SH2_STAT5	731	734	PF00017	0.395
LIG_SH2_STAT5	788	791	PF00017	0.436
LIG_SH2_STAT5	805	808	PF00017	0.382
LIG_SH3_3	12	18	PF00018	0.717
LIG_SH3_3	286	292	PF00018	0.589
LIG_SH3_3	526	532	PF00018	0.563
LIG_SH3_3	555	561	PF00018	0.504
LIG_SH3_3	716	722	PF00018	0.501
LIG_SH3_3	813	819	PF00018	0.459
LIG_SH3_3	833	839	PF00018	0.227
LIG_SH3_3	879	885	PF00018	0.720
LIG_SUMO_SIM_anti_2	679	685	PF11976	0.464
LIG_SUMO_SIM_par_1	417	423	PF11976	0.354
LIG_SUMO_SIM_par_1	765	772	PF11976	0.400
LIG_TRAF2_1	364	367	PF00917	0.477
LIG_TRFH_1	700	704	PF08558	0.401
LIG_WRC_WIRS_1	691	696	PF05994	0.332
LIG_WRC_WIRS_1	81	86	PF05994	0.637
MOD_CDK_SPK_2	203	208	PF00069	0.663
MOD_CK1_1	102	108	PF00069	0.743
MOD_CK1_1	14	20	PF00069	0.734
MOD_CK1_1	308	314	PF00069	0.359
MOD_CK1_1	62	68	PF00069	0.650
MOD_CK1_1	679	685	PF00069	0.446
MOD_CK1_1	874	880	PF00069	0.646
MOD_CK1_1	901	907	PF00069	0.733
MOD_CK1_1	915	921	PF00069	0.548
MOD_CK2_1	361	367	PF00069	0.478
MOD_CK2_1	513	519	PF00069	0.476
MOD_CK2_1	53	59	PF00069	0.773
MOD_CK2_1	571	577	PF00069	0.517
MOD_CK2_1	890	896	PF00069	0.739
MOD_Cter_Amidation	393	396	PF01082	0.568
MOD_GlcNHglycan	19	22	PF01048	0.713
MOD_GlcNHglycan	198	202	PF01048	0.607
MOD_GlcNHglycan	34	37	PF01048	0.714
MOD_GlcNHglycan	399	402	PF01048	0.557
MOD_GlcNHglycan	503	506	PF01048	0.399
MOD_GlcNHglycan	515	518	PF01048	0.386
MOD_GlcNHglycan	64	67	PF01048	0.699
MOD_GlcNHglycan	774	777	PF01048	0.626
MOD_GlcNHglycan	882	885	PF01048	0.722
MOD_GlcNHglycan	892	895	PF01048	0.755
MOD_GlcNHglycan	914	917	PF01048	0.675
MOD_GSK3_1	107	114	PF00069	0.673
MOD_GSK3_1	133	140	PF00069	0.597
MOD_GSK3_1	190	197	PF00069	0.667
MOD_GSK3_1	304	311	PF00069	0.357
MOD_GSK3_1	509	516	PF00069	0.504
MOD_GSK3_1	606	613	PF00069	0.563
MOD_GSK3_1	627	634	PF00069	0.666
MOD_GSK3_1	686	693	PF00069	0.427
MOD_GSK3_1	76	83	PF00069	0.599
MOD_GSK3_1	780	787	PF00069	0.460
MOD_GSK3_1	810	817	PF00069	0.495
MOD_GSK3_1	865	872	PF00069	0.681
MOD_GSK3_1	880	887	PF00069	0.526
MOD_GSK3_1	98	105	PF00069	0.751
MOD_LATS_1	604	610	PF00433	0.579
MOD_LATS_1	910	916	PF00433	0.777
MOD_N-GLC_1	2	7	PF02516	0.513
MOD_N-GLC_1	215	220	PF02516	0.671
MOD_N-GLC_1	305	310	PF02516	0.615
MOD_N-GLC_1	456	461	PF02516	0.498
MOD_N-GLC_1	68	73	PF02516	0.719
MOD_NEK2_1	612	617	PF00069	0.538
MOD_NEK2_1	658	663	PF00069	0.419
MOD_NEK2_1	686	691	PF00069	0.412
MOD_NEK2_1	729	734	PF00069	0.387
MOD_NEK2_1	74	79	PF00069	0.677
MOD_NEK2_1	782	787	PF00069	0.442
MOD_NEK2_1	809	814	PF00069	0.510
MOD_NEK2_2	704	709	PF00069	0.359
MOD_PIKK_1	361	367	PF00454	0.468
MOD_PIKK_1	658	664	PF00454	0.558
MOD_PIKK_1	730	736	PF00454	0.409
MOD_PK_1	465	471	PF00069	0.661
MOD_PKA_1	151	157	PF00069	0.701
MOD_PKA_1	606	612	PF00069	0.583
MOD_PKA_1	856	862	PF00069	0.637
MOD_PKA_2	107	113	PF00069	0.683
MOD_PKA_2	151	157	PF00069	0.573
MOD_PKA_2	188	194	PF00069	0.495
MOD_PKA_2	22	28	PF00069	0.695
MOD_PKA_2	627	633	PF00069	0.516
MOD_PKA_2	643	649	PF00069	0.592
MOD_PKA_2	686	692	PF00069	0.417
MOD_PKA_2	856	862	PF00069	0.637
MOD_PKB_1	375	383	PF00069	0.340
MOD_Plk_1	197	203	PF00069	0.664
MOD_Plk_1	308	314	PF00069	0.434
MOD_Plk_1	456	462	PF00069	0.498
MOD_Plk_1	465	471	PF00069	0.530
MOD_Plk_1	68	74	PF00069	0.706
MOD_Plk_1	898	904	PF00069	0.760
MOD_Plk_2-3	865	871	PF00069	0.728
MOD_Plk_4	158	164	PF00069	0.546
MOD_Plk_4	275	281	PF00069	0.595
MOD_Plk_4	427	433	PF00069	0.389
MOD_Plk_4	474	480	PF00069	0.500
MOD_Plk_4	532	538	PF00069	0.421
MOD_Plk_4	544	550	PF00069	0.397
MOD_Plk_4	660	666	PF00069	0.558
MOD_Plk_4	679	685	PF00069	0.289
MOD_Plk_4	69	75	PF00069	0.619
MOD_Plk_4	704	710	PF00069	0.371
MOD_Plk_4	874	880	PF00069	0.646
MOD_ProDKin_1	100	106	PF00069	0.721
MOD_ProDKin_1	11	17	PF00069	0.598
MOD_ProDKin_1	190	196	PF00069	0.651
MOD_ProDKin_1	203	209	PF00069	0.757
MOD_ProDKin_1	3	9	PF00069	0.627
MOD_ProDKin_1	509	515	PF00069	0.297
MOD_ProDKin_1	585	591	PF00069	0.469
MOD_ProDKin_1	665	671	PF00069	0.430
MOD_ProDKin_1	76	82	PF00069	0.646
MOD_ProDKin_1	884	890	PF00069	0.714
MOD_SUMO_for_1	638	641	PF00179	0.725
MOD_SUMO_rev_2	246	253	PF00179	0.600
MOD_SUMO_rev_2	268	278	PF00179	0.638
MOD_SUMO_rev_2	575	581	PF00179	0.380
MOD_SUMO_rev_2	599	609	PF00179	0.596
TRG_AP2beta_CARGO_1	366	375	PF09066	0.497
TRG_DiLeu_BaEn_3	357	363	PF01217	0.519
TRG_DiLeu_BaEn_4	180	186	PF01217	0.662
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.725
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.292
TRG_ENDOCYTIC_2	223	226	PF00928	0.527
TRG_ENDOCYTIC_2	764	767	PF00928	0.613
TRG_ENDOCYTIC_2	88	91	PF00928	0.492
TRG_ER_diArg_1	152	155	PF00400	0.600
TRG_ER_diArg_1	375	378	PF00400	0.391
TRG_ER_diArg_1	455	458	PF00400	0.458
TRG_ER_diArg_1	479	481	PF00400	0.402
TRG_ER_diArg_1	526	528	PF00400	0.571
TRG_ER_diArg_1	600	603	PF00400	0.680
TRG_ER_diArg_1	686	688	PF00400	0.440
TRG_ER_diArg_1	795	798	PF00400	0.532
TRG_ER_diArg_1	824	827	PF00400	0.395
TRG_ER_diArg_1	845	848	PF00400	0.562
TRG_ER_diArg_1	856	858	PF00400	0.620
TRG_NLS_MonoExtC_3	150	155	PF00514	0.692
TRG_NLS_MonoExtN_4	208	215	PF00514	0.552
TRG_NLS_MonoExtN_4	852	859	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAV8	Bodo saltans	56%	100%
A0A1X0P214	Trypanosomatidae	66%	96%
A0A3Q8IFP9	Leishmania donovani	89%	100%
A0A3R7N4Q1	Trypanosoma rangeli	66%	100%
A4I5B7	Leishmania infantum	89%	100%
C6K3X4	Leptomonas seymouri	73%	91%
C9ZQP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B0L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7L9	Leishmania major	88%	100%
V5BU91	Trypanosoma cruzi	64%	100%