Prefoldin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin

Gene product:

prefoldin subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HI39_LEIBR

TriTrypDb:

LbrM.30.0960 , LBRM2903_300015200

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI39

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.374
CLV_NRD_NRD_1	51	53	PF00675	0.315
CLV_PCSK_KEX2_1	122	124	PF00082	0.376
CLV_PCSK_KEX2_1	47	49	PF00082	0.303
CLV_PCSK_KEX2_1	51	53	PF00082	0.311
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.299
CLV_PCSK_SKI1_1	129	133	PF00082	0.642
CLV_PCSK_SKI1_1	42	46	PF00082	0.387
DEG_APCC_DBOX_1	128	136	PF00400	0.644
DOC_CKS1_1	78	83	PF01111	0.446
DOC_MAPK_gen_1	47	57	PF00069	0.549
DOC_USP7_MATH_1	137	141	PF00917	0.726
DOC_USP7_MATH_1	98	102	PF00917	0.521
DOC_WW_Pin1_4	77	82	PF00397	0.460
LIG_14-3-3_CanoR_1	42	47	PF00244	0.509
LIG_14-3-3_CanoR_1	52	58	PF00244	0.482
LIG_14-3-3_CterR_2	141	146	PF00244	0.738
LIG_Actin_WH2_2	32	49	PF00022	0.586
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_FHA_1	108	114	PF00498	0.528
LIG_FHA_1	39	45	PF00498	0.544
LIG_FHA_2	113	119	PF00498	0.434
LIG_FHA_2	19	25	PF00498	0.683
LIG_FHA_2	54	60	PF00498	0.548
LIG_LIR_Nem_3	126	131	PF02991	0.476
LIG_SH2_CRK	70	74	PF00017	0.548
LIG_SUMO_SIM_par_1	84	92	PF11976	0.434
LIG_TRAF2_1	115	118	PF00917	0.564
LIG_TRAF2_1	124	127	PF00917	0.762
LIG_TYR_ITIM	68	73	PF00017	0.548
MOD_CDK_SPxxK_3	77	84	PF00069	0.434
MOD_CK1_1	101	107	PF00069	0.521
MOD_CK2_1	112	118	PF00069	0.502
MOD_CK2_1	18	24	PF00069	0.678
MOD_CK2_1	53	59	PF00069	0.492
MOD_GlcNHglycan	3	6	PF01048	0.571
MOD_GSK3_1	1	8	PF00069	0.737
MOD_GSK3_1	108	115	PF00069	0.515
MOD_GSK3_1	135	142	PF00069	0.488
MOD_GSK3_1	28	35	PF00069	0.586
MOD_GSK3_1	38	45	PF00069	0.554
MOD_LATS_1	105	111	PF00433	0.434
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	32	37	PF00069	0.505
MOD_PIKK_1	135	141	PF00454	0.614
MOD_PKA_2	101	107	PF00069	0.513
MOD_PKA_2	108	114	PF00069	0.518
MOD_PKA_2	32	38	PF00069	0.504
MOD_PKA_2	53	59	PF00069	0.462
MOD_Plk_1	18	24	PF00069	0.678
MOD_Plk_1	98	104	PF00069	0.521
MOD_Plk_2-3	87	93	PF00069	0.434
MOD_ProDKin_1	77	83	PF00069	0.460
MOD_SUMO_for_1	63	66	PF00179	0.502
TRG_ENDOCYTIC_2	70	73	PF00928	0.492
TRG_ER_diArg_1	121	123	PF00400	0.605
TRG_ER_diArg_1	51	54	PF00400	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDG9	Bodo saltans	45%	100%
A0A1X0P260	Trypanosomatidae	52%	100%
A0A3S7X344	Leishmania donovani	90%	100%
A0A422P4U7	Trypanosoma rangeli	50%	100%
A4I5B6	Leishmania infantum	90%	100%
C6K3X3	Leptomonas seymouri	87%	100%
C9ZQP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B0L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7M0	Leishmania major	90%	100%