Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI38_LEIBR

TriTrypDb:

LbrM.30.0950 , LBRM2903_300015100

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.407
CLV_C14_Caspase3-7	22	26	PF00656	0.516
CLV_C14_Caspase3-7	380	384	PF00656	0.506
CLV_C14_Caspase3-7	620	624	PF00656	0.615
CLV_C14_Caspase3-7	709	713	PF00656	0.634
CLV_NRD_NRD_1	107	109	PF00675	0.429
CLV_NRD_NRD_1	113	115	PF00675	0.467
CLV_NRD_NRD_1	117	119	PF00675	0.504
CLV_NRD_NRD_1	161	163	PF00675	0.483
CLV_NRD_NRD_1	180	182	PF00675	0.597
CLV_NRD_NRD_1	215	217	PF00675	0.490
CLV_NRD_NRD_1	232	234	PF00675	0.461
CLV_NRD_NRD_1	289	291	PF00675	0.537
CLV_NRD_NRD_1	455	457	PF00675	0.788
CLV_NRD_NRD_1	465	467	PF00675	0.604
CLV_NRD_NRD_1	656	658	PF00675	0.633
CLV_NRD_NRD_1	669	671	PF00675	0.671
CLV_NRD_NRD_1	681	683	PF00675	0.745
CLV_NRD_NRD_1	707	709	PF00675	0.624
CLV_PCSK_FUR_1	159	163	PF00082	0.419
CLV_PCSK_FUR_1	178	182	PF00082	0.497
CLV_PCSK_KEX2_1	107	109	PF00082	0.443
CLV_PCSK_KEX2_1	113	115	PF00082	0.452
CLV_PCSK_KEX2_1	117	119	PF00082	0.474
CLV_PCSK_KEX2_1	161	163	PF00082	0.487
CLV_PCSK_KEX2_1	180	182	PF00082	0.371
CLV_PCSK_KEX2_1	215	217	PF00082	0.490
CLV_PCSK_KEX2_1	231	233	PF00082	0.459
CLV_PCSK_KEX2_1	289	291	PF00082	0.590
CLV_PCSK_KEX2_1	455	457	PF00082	0.788
CLV_PCSK_KEX2_1	465	467	PF00082	0.604
CLV_PCSK_KEX2_1	656	658	PF00082	0.633
CLV_PCSK_KEX2_1	668	670	PF00082	0.673
CLV_PCSK_KEX2_1	681	683	PF00082	0.743
CLV_PCSK_KEX2_1	706	708	PF00082	0.689
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.390
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.459
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.689
CLV_PCSK_PC7_1	103	109	PF00082	0.399
CLV_PCSK_PC7_1	113	119	PF00082	0.401
CLV_PCSK_PC7_1	159	165	PF00082	0.530
CLV_PCSK_PC7_1	677	683	PF00082	0.565
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	180	184	PF00082	0.525
CLV_PCSK_SKI1_1	425	429	PF00082	0.429
CLV_PCSK_SKI1_1	47	51	PF00082	0.475
CLV_PCSK_SKI1_1	610	614	PF00082	0.541
CLV_Separin_Metazoa	175	179	PF03568	0.515
DEG_APCC_DBOX_1	102	110	PF00400	0.504
DEG_APCC_DBOX_1	179	187	PF00400	0.524
DEG_APCC_DBOX_1	424	432	PF00400	0.419
DEG_APCC_DBOX_1	491	499	PF00400	0.391
DEG_SCF_FBW7_1	691	698	PF00400	0.531
DEG_SPOP_SBC_1	39	43	PF00917	0.446
DEG_SPOP_SBC_1	645	649	PF00917	0.542
DOC_CKS1_1	683	688	PF01111	0.685
DOC_CYCLIN_RxL_1	144	152	PF00134	0.512
DOC_CYCLIN_RxL_1	392	403	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.545
DOC_MAPK_gen_1	113	123	PF00069	0.508
DOC_MAPK_gen_1	492	500	PF00069	0.466
DOC_PP1_RVXF_1	532	539	PF00149	0.429
DOC_PP4_FxxP_1	337	340	PF00568	0.480
DOC_USP7_MATH_1	472	476	PF00917	0.572
DOC_USP7_MATH_1	525	529	PF00917	0.458
DOC_USP7_MATH_1	643	647	PF00917	0.808
DOC_USP7_MATH_1	652	656	PF00917	0.649
DOC_USP7_MATH_1	78	82	PF00917	0.541
DOC_USP7_MATH_2	78	84	PF00917	0.580
DOC_USP7_UBL2_3	530	534	PF12436	0.454
DOC_USP7_UBL2_3	702	706	PF12436	0.516
DOC_WW_Pin1_4	192	197	PF00397	0.534
DOC_WW_Pin1_4	298	303	PF00397	0.751
DOC_WW_Pin1_4	342	347	PF00397	0.470
DOC_WW_Pin1_4	400	405	PF00397	0.414
DOC_WW_Pin1_4	6	11	PF00397	0.640
DOC_WW_Pin1_4	646	651	PF00397	0.592
DOC_WW_Pin1_4	682	687	PF00397	0.678
DOC_WW_Pin1_4	691	696	PF00397	0.620
DOC_WW_Pin1_4	750	755	PF00397	0.625
DOC_WW_Pin1_4	84	89	PF00397	0.627
LIG_14-3-3_CanoR_1	139	143	PF00244	0.455
LIG_14-3-3_CanoR_1	289	293	PF00244	0.504
LIG_14-3-3_CanoR_1	377	386	PF00244	0.457
LIG_14-3-3_CanoR_1	387	393	PF00244	0.388
LIG_14-3-3_CanoR_1	482	490	PF00244	0.523
LIG_14-3-3_CanoR_1	513	523	PF00244	0.501
LIG_14-3-3_CanoR_1	610	615	PF00244	0.580
LIG_14-3-3_CanoR_1	656	661	PF00244	0.667
LIG_14-3-3_CanoR_1	669	678	PF00244	0.658
LIG_14-3-3_CanoR_1	681	686	PF00244	0.592
LIG_Actin_WH2_2	360	375	PF00022	0.422
LIG_Actin_WH2_2	92	109	PF00022	0.467
LIG_AP2alpha_2	552	554	PF02296	0.464
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	55	59	PF00533	0.474
LIG_BRCT_BRCA1_1	714	718	PF00533	0.531
LIG_BRCT_BRCA1_2	55	61	PF00533	0.428
LIG_CtBP_PxDLS_1	724	729	PF00389	0.518
LIG_deltaCOP1_diTrp_1	287	292	PF00928	0.502
LIG_FHA_1	171	177	PF00498	0.497
LIG_FHA_1	278	284	PF00498	0.675
LIG_FHA_1	392	398	PF00498	0.487
LIG_FHA_1	40	46	PF00498	0.548
LIG_FHA_1	457	463	PF00498	0.516
LIG_FHA_1	560	566	PF00498	0.515
LIG_FHA_1	631	637	PF00498	0.590
LIG_FHA_1	683	689	PF00498	0.663
LIG_FHA_1	692	698	PF00498	0.590
LIG_FHA_2	276	282	PF00498	0.627
LIG_FHA_2	343	349	PF00498	0.450
LIG_FHA_2	378	384	PF00498	0.500
LIG_FHA_2	421	427	PF00498	0.384
LIG_FHA_2	474	480	PF00498	0.611
LIG_FHA_2	55	61	PF00498	0.676
LIG_FHA_2	757	763	PF00498	0.497
LIG_LIR_Apic_2	358	363	PF02991	0.461
LIG_LIR_Gen_1	348	356	PF02991	0.400
LIG_LIR_Gen_1	391	400	PF02991	0.438
LIG_LIR_Gen_1	426	437	PF02991	0.447
LIG_LIR_Gen_1	552	561	PF02991	0.614
LIG_LIR_Gen_1	582	591	PF02991	0.509
LIG_LIR_Nem_3	263	268	PF02991	0.549
LIG_LIR_Nem_3	348	353	PF02991	0.410
LIG_LIR_Nem_3	391	396	PF02991	0.489
LIG_LIR_Nem_3	407	412	PF02991	0.391
LIG_LIR_Nem_3	426	432	PF02991	0.433
LIG_LIR_Nem_3	548	554	PF02991	0.495
LIG_LIR_Nem_3	582	588	PF02991	0.618
LIG_MYND_1	686	690	PF01753	0.676
LIG_Pex14_1	288	292	PF04695	0.504
LIG_Pex14_1	409	413	PF04695	0.521
LIG_Pex14_2	217	221	PF04695	0.452
LIG_Pex14_2	337	341	PF04695	0.531
LIG_SH2_NCK_1	429	433	PF00017	0.474
LIG_SH2_PTP2	585	588	PF00017	0.466
LIG_SH2_SRC	360	363	PF00017	0.472
LIG_SH2_STAP1	413	417	PF00017	0.502
LIG_SH2_STAT3	413	416	PF00017	0.402
LIG_SH2_STAT5	122	125	PF00017	0.535
LIG_SH2_STAT5	267	270	PF00017	0.567
LIG_SH2_STAT5	350	353	PF00017	0.455
LIG_SH2_STAT5	390	393	PF00017	0.438
LIG_SH2_STAT5	585	588	PF00017	0.504
LIG_SH3_2	717	722	PF14604	0.525
LIG_SH3_3	193	199	PF00018	0.648
LIG_SH3_3	547	553	PF00018	0.569
LIG_SH3_3	683	689	PF00018	0.651
LIG_SH3_3	714	720	PF00018	0.551
LIG_SH3_3	83	89	PF00018	0.511
LIG_SH3_CIN85_PxpxPR_1	605	610	PF14604	0.518
LIG_TRAF2_1	471	474	PF00917	0.576
LIG_TRAF2_1	741	744	PF00917	0.516
LIG_TYR_ITIM	427	432	PF00017	0.388
LIG_TYR_ITIM	583	588	PF00017	0.625
LIG_WRC_WIRS_1	733	738	PF05994	0.516
MOD_CDK_SPK_2	646	651	PF00069	0.539
MOD_CK1_1	141	147	PF00069	0.503
MOD_CK1_1	573	579	PF00069	0.450
MOD_CK1_1	617	623	PF00069	0.650
MOD_CK1_1	641	647	PF00069	0.585
MOD_CK1_1	659	665	PF00069	0.585
MOD_CK1_1	673	679	PF00069	0.630
MOD_CK1_1	698	704	PF00069	0.681
MOD_CK1_1	750	756	PF00069	0.546
MOD_CK1_1	81	87	PF00069	0.566
MOD_CK2_1	21	27	PF00069	0.574
MOD_CK2_1	275	281	PF00069	0.628
MOD_CK2_1	306	312	PF00069	0.796
MOD_CK2_1	408	414	PF00069	0.514
MOD_CK2_1	420	426	PF00069	0.494
MOD_CK2_1	468	474	PF00069	0.662
MOD_CK2_1	54	60	PF00069	0.450
MOD_CK2_1	589	595	PF00069	0.443
MOD_CK2_1	738	744	PF00069	0.514
MOD_GlcNHglycan	1	4	PF01048	0.657
MOD_GlcNHglycan	237	240	PF01048	0.518
MOD_GlcNHglycan	357	360	PF01048	0.469
MOD_GlcNHglycan	42	45	PF01048	0.406
MOD_GlcNHglycan	470	473	PF01048	0.768
MOD_GlcNHglycan	619	622	PF01048	0.694
MOD_GlcNHglycan	640	643	PF01048	0.712
MOD_GlcNHglycan	658	661	PF01048	0.665
MOD_GlcNHglycan	709	712	PF01048	0.642
MOD_GlcNHglycan	714	717	PF01048	0.599
MOD_GlcNHglycan	74	77	PF01048	0.745
MOD_GlcNHglycan	79	83	PF01048	0.680
MOD_GSK3_1	141	148	PF00069	0.502
MOD_GSK3_1	275	282	PF00069	0.626
MOD_GSK3_1	311	318	PF00069	0.602
MOD_GSK3_1	324	331	PF00069	0.481
MOD_GSK3_1	373	380	PF00069	0.497
MOD_GSK3_1	400	407	PF00069	0.515
MOD_GSK3_1	468	475	PF00069	0.576
MOD_GSK3_1	50	57	PF00069	0.621
MOD_GSK3_1	509	516	PF00069	0.473
MOD_GSK3_1	572	579	PF00069	0.606
MOD_GSK3_1	610	617	PF00069	0.658
MOD_GSK3_1	641	648	PF00069	0.582
MOD_GSK3_1	652	659	PF00069	0.612
MOD_GSK3_1	668	675	PF00069	0.627
MOD_GSK3_1	691	698	PF00069	0.585
MOD_GSK3_1	723	730	PF00069	0.550
MOD_GSK3_1	732	739	PF00069	0.694
MOD_GSK3_1	78	85	PF00069	0.633
MOD_N-GLC_1	324	329	PF02516	0.502
MOD_N-GLC_1	53	58	PF02516	0.569
MOD_NEK2_1	279	284	PF00069	0.620
MOD_NEK2_1	311	316	PF00069	0.634
MOD_NEK2_1	328	333	PF00069	0.443
MOD_NEK2_1	37	42	PF00069	0.485
MOD_NEK2_1	372	377	PF00069	0.428
MOD_NEK2_1	399	404	PF00069	0.548
MOD_NEK2_1	420	425	PF00069	0.411
MOD_NEK2_1	437	442	PF00069	0.417
MOD_NEK2_1	581	586	PF00069	0.513
MOD_NEK2_1	589	594	PF00069	0.618
MOD_NEK2_1	614	619	PF00069	0.628
MOD_NEK2_1	697	702	PF00069	0.521
MOD_NEK2_1	727	732	PF00069	0.647
MOD_NEK2_1	736	741	PF00069	0.548
MOD_NEK2_2	388	393	PF00069	0.336
MOD_NEK2_2	525	530	PF00069	0.447
MOD_PIKK_1	170	176	PF00454	0.512
MOD_PIKK_1	306	312	PF00454	0.604
MOD_PIKK_1	362	368	PF00454	0.464
MOD_PIKK_1	404	410	PF00454	0.424
MOD_PIKK_1	481	487	PF00454	0.502
MOD_PIKK_1	614	620	PF00454	0.788
MOD_PIKK_1	739	745	PF00454	0.513
MOD_PIKK_1	94	100	PF00454	0.518
MOD_PK_1	14	20	PF00069	0.528
MOD_PK_1	224	230	PF00069	0.497
MOD_PKA_1	656	662	PF00069	0.670
MOD_PKA_1	668	674	PF00069	0.672
MOD_PKA_1	681	687	PF00069	0.661
MOD_PKA_1	706	712	PF00069	0.663
MOD_PKA_2	138	144	PF00069	0.507
MOD_PKA_2	288	294	PF00069	0.503
MOD_PKA_2	372	378	PF00069	0.497
MOD_PKA_2	481	487	PF00069	0.553
MOD_PKA_2	514	520	PF00069	0.437
MOD_PKA_2	630	636	PF00069	0.734
MOD_PKA_2	656	662	PF00069	0.670
MOD_PKA_2	668	674	PF00069	0.662
MOD_PKA_2	676	682	PF00069	0.494
MOD_PKA_2	706	712	PF00069	0.811
MOD_PKA_2	765	771	PF00069	0.610
MOD_PKB_1	668	676	PF00069	0.680
MOD_Plk_1	270	276	PF00069	0.545
MOD_Plk_1	311	317	PF00069	0.510
MOD_Plk_1	324	330	PF00069	0.396
MOD_Plk_1	473	479	PF00069	0.617
MOD_Plk_1	579	585	PF00069	0.513
MOD_Plk_2-3	21	27	PF00069	0.509
MOD_Plk_2-3	474	480	PF00069	0.611
MOD_Plk_2-3	559	565	PF00069	0.521
MOD_Plk_4	14	20	PF00069	0.608
MOD_Plk_4	224	230	PF00069	0.460
MOD_Plk_4	279	285	PF00069	0.543
MOD_Plk_4	324	330	PF00069	0.451
MOD_Plk_4	388	394	PF00069	0.357
MOD_Plk_4	581	587	PF00069	0.486
MOD_Plk_4	729	735	PF00069	0.516
MOD_Plk_4	756	762	PF00069	0.496
MOD_ProDKin_1	192	198	PF00069	0.539
MOD_ProDKin_1	298	304	PF00069	0.754
MOD_ProDKin_1	342	348	PF00069	0.459
MOD_ProDKin_1	400	406	PF00069	0.409
MOD_ProDKin_1	6	12	PF00069	0.639
MOD_ProDKin_1	646	652	PF00069	0.592
MOD_ProDKin_1	682	688	PF00069	0.677
MOD_ProDKin_1	691	697	PF00069	0.619
MOD_ProDKin_1	750	756	PF00069	0.622
MOD_ProDKin_1	84	90	PF00069	0.622
MOD_SUMO_for_1	284	287	PF00179	0.556
MOD_SUMO_for_1	486	489	PF00179	0.440
MOD_SUMO_rev_2	128	137	PF00179	0.369
TRG_DiLeu_BaEn_4	488	494	PF01217	0.363
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.465
TRG_ENDOCYTIC_2	350	353	PF00928	0.406
TRG_ENDOCYTIC_2	390	393	PF00928	0.402
TRG_ENDOCYTIC_2	429	432	PF00928	0.413
TRG_ENDOCYTIC_2	551	554	PF00928	0.482
TRG_ENDOCYTIC_2	585	588	PF00928	0.651
TRG_ER_diArg_1	106	108	PF00400	0.490
TRG_ER_diArg_1	116	118	PF00400	0.555
TRG_ER_diArg_1	159	162	PF00400	0.454
TRG_ER_diArg_1	177	180	PF00400	0.521
TRG_ER_diArg_1	215	217	PF00400	0.490
TRG_ER_diArg_1	232	234	PF00400	0.461
TRG_ER_diArg_1	288	290	PF00400	0.539
TRG_ER_diArg_1	667	670	PF00400	0.738
TRG_ER_diArg_1	681	683	PF00400	0.657
TRG_NES_CRM1_1	485	499	PF08389	0.504
TRG_NLS_Bipartite_1	215	235	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P210	Trypanosomatidae	30%	100%
A0A3Q8IBV7	Leishmania donovani	71%	100%
A4I5B5	Leishmania infantum	71%	100%
C6K3X2	Leptomonas seymouri	42%	97%
E9B0L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q7M1	Leishmania major	72%	99%