Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AdoMet dependent proline di-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI37_LEIBR

TriTrypDb:

LbrM.30.0940 , LBRM2903_300015000

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HI37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI37

PDB structure(s): 1xtp_A

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	13
GO:0006480	N-terminal protein amino acid methylation	5	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0008213	protein alkylation	5	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0031365	N-terminal protein amino acid modification	5	13
GO:0032259	methylation	2	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0008276	protein methyltransferase activity	3	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	130	132	PF00082	0.442
CLV_PCSK_KEX2_1	219	221	PF00082	0.306
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.442
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.306
CLV_PCSK_SKI1_1	103	107	PF00082	0.365
CLV_PCSK_SKI1_1	140	144	PF00082	0.403
CLV_PCSK_SKI1_1	182	186	PF00082	0.274
CLV_PCSK_SKI1_1	219	223	PF00082	0.293
CLV_PCSK_SKI1_1	228	232	PF00082	0.293
DEG_APCC_KENBOX_2	192	196	PF00400	0.293
DEG_SPOP_SBC_1	5	9	PF00917	0.574
DOC_CYCLIN_RxL_1	103	110	PF00134	0.340
DOC_CYCLIN_RxL_1	213	225	PF00134	0.388
DOC_CYCLIN_yClb5_NLxxxL_5	106	112	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.403
DOC_MAPK_gen_1	130	138	PF00069	0.442
DOC_SPAK_OSR1_1	201	205	PF12202	0.361
DOC_USP7_MATH_1	59	63	PF00917	0.306
DOC_WW_Pin1_4	182	187	PF00397	0.321
LIG_14-3-3_CanoR_1	220	229	PF00244	0.366
LIG_14-3-3_CanoR_1	25	31	PF00244	0.442
LIG_BRCT_BRCA1_1	78	82	PF00533	0.293
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.344
LIG_eIF4E_1	113	119	PF01652	0.340
LIG_FHA_1	113	119	PF00498	0.290
LIG_FHA_1	146	152	PF00498	0.302
LIG_FHA_1	153	159	PF00498	0.299
LIG_FHA_1	34	40	PF00498	0.538
LIG_FHA_2	167	173	PF00498	0.305
LIG_FHA_2	210	216	PF00498	0.293
LIG_FHA_2	231	237	PF00498	0.189
LIG_GBD_Chelix_1	104	112	PF00786	0.406
LIG_LIR_Apic_2	7	13	PF02991	0.384
LIG_LIR_Gen_1	153	161	PF02991	0.302
LIG_LIR_Gen_1	170	177	PF02991	0.292
LIG_LIR_Nem_3	153	159	PF02991	0.302
LIG_LIR_Nem_3	170	176	PF02991	0.292
LIG_LIR_Nem_3	215	221	PF02991	0.293
LIG_LIR_Nem_3	52	57	PF02991	0.416
LIG_Pex14_1	163	167	PF04695	0.293
LIG_Pex14_2	173	177	PF04695	0.388
LIG_Pex14_2	234	238	PF04695	0.388
LIG_REV1ctd_RIR_1	174	182	PF16727	0.356
LIG_REV1ctd_RIR_1	189	197	PF16727	0.200
LIG_SH2_CRK	10	14	PF00017	0.340
LIG_SH2_CRK	156	160	PF00017	0.285
LIG_SH2_CRK	218	222	PF00017	0.293
LIG_SH2_STAP1	156	160	PF00017	0.293
LIG_SH2_STAT3	248	251	PF00017	0.335
LIG_SH2_STAT5	167	170	PF00017	0.293
LIG_SH2_STAT5	189	192	PF00017	0.306
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.293
LIG_TRAF2_1	233	236	PF00917	0.403
LIG_TYR_ITIM	216	221	PF00017	0.420
MOD_CK1_1	145	151	PF00069	0.306
MOD_CK1_1	209	215	PF00069	0.293
MOD_CK1_1	8	14	PF00069	0.510
MOD_CK2_1	23	29	PF00069	0.444
MOD_CK2_1	230	236	PF00069	0.189
MOD_CK2_1	78	84	PF00069	0.305
MOD_GlcNHglycan	132	136	PF01048	0.362
MOD_GlcNHglycan	14	17	PF01048	0.426
MOD_GlcNHglycan	224	227	PF01048	0.422
MOD_GlcNHglycan	61	64	PF01048	0.293
MOD_GSK3_1	12	19	PF00069	0.443
MOD_GSK3_1	20	27	PF00069	0.445
MOD_GSK3_1	207	214	PF00069	0.293
MOD_GSK3_1	4	11	PF00069	0.572
MOD_GSK3_1	78	85	PF00069	0.387
MOD_N-GLC_1	194	199	PF02516	0.340
MOD_NEK2_1	222	227	PF00069	0.391
MOD_NEK2_1	82	87	PF00069	0.326
MOD_PKA_2	24	30	PF00069	0.461
MOD_Plk_1	206	212	PF00069	0.309
MOD_ProDKin_1	182	188	PF00069	0.321
MOD_SUMO_for_1	129	132	PF00179	0.306
MOD_SUMO_rev_2	69	79	PF00179	0.235
TRG_ENDOCYTIC_2	156	159	PF00928	0.285
TRG_ENDOCYTIC_2	189	192	PF00928	0.306
TRG_ENDOCYTIC_2	218	221	PF00928	0.293
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ3	Leptomonas seymouri	81%	100%
A0A0S4J7U1	Bodo saltans	61%	100%
A0A1X0P231	Trypanosomatidae	70%	99%
A0A3S7X350	Leishmania donovani	90%	100%
A0A422P4V7	Trypanosoma rangeli	70%	99%
A2XMJ1	Oryza sativa subsp. indica	43%	82%
A4I5B4	Leishmania infantum	90%	100%
A8WVR2	Caenorhabditis briggsae	38%	100%
B1H2P7	Xenopus tropicalis	37%	100%
B2RXM4	Mus musculus	34%	89%
B8JM82	Danio rerio	30%	90%
C9ZQP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZQQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
D2H163	Ailuropoda melanoleuca	36%	100%
D3ZVR1	Rattus norvegicus	34%	89%
E9B0L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O13748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P38340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q10CT5	Oryza sativa subsp. japonica	43%	82%
Q2T9N3	Bos taurus	36%	100%
Q4KL94	Xenopus laevis	38%	100%
Q4KLE6	Xenopus laevis	37%	100%
Q4Q7M2	Leishmania major	88%	100%
Q55DH6	Dictyostelium discoideum	39%	93%
Q5BJX0	Rattus norvegicus	35%	100%
Q5PP70	Arabidopsis thaliana	39%	91%
Q5VVY1	Homo sapiens	33%	89%
Q6NN40	Drosophila melanogaster	39%	91%
Q6NWX7	Danio rerio	35%	100%
Q8R2U4	Mus musculus	35%	100%
Q9BV86	Homo sapiens	36%	100%
Q9N4D9	Caenorhabditis elegans	37%	100%
V5B946	Trypanosoma cruzi	71%	99%