Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HI36_LEIBR

TriTrypDb:

LbrM.30.0930 , LBRM2903_300014900

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HI36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.397
CLV_NRD_NRD_1	171	173	PF00675	0.749
CLV_NRD_NRD_1	217	219	PF00675	0.475
CLV_PCSK_KEX2_1	12	14	PF00082	0.397
CLV_PCSK_KEX2_1	171	173	PF00082	0.596
CLV_PCSK_KEX2_1	217	219	PF00082	0.482
DEG_MDM2_SWIB_1	25	33	PF02201	0.213
DEG_Nend_UBRbox_3	1	3	PF02207	0.353
DOC_MAPK_gen_1	199	208	PF00069	0.568
DOC_PP1_RVXF_1	107	114	PF00149	0.466
DOC_PP2B_LxvP_1	206	209	PF13499	0.670
DOC_PP2B_LxvP_1	211	214	PF13499	0.678
DOC_PP4_FxxP_1	18	21	PF00568	0.213
DOC_USP7_MATH_1	107	111	PF00917	0.438
DOC_USP7_MATH_1	138	142	PF00917	0.447
DOC_USP7_MATH_1	177	181	PF00917	0.380
DOC_USP7_MATH_1	60	64	PF00917	0.627
DOC_WW_Pin1_4	151	156	PF00397	0.496
DOC_WW_Pin1_4	170	175	PF00397	0.581
LIG_14-3-3_CanoR_1	109	114	PF00244	0.459
LIG_14-3-3_CanoR_1	119	124	PF00244	0.344
LIG_14-3-3_CanoR_1	172	182	PF00244	0.384
LIG_14-3-3_CanoR_1	37	41	PF00244	0.591
LIG_14-3-3_CanoR_1	43	52	PF00244	0.299
LIG_14-3-3_CterR_2	217	222	PF00244	0.596
LIG_Actin_WH2_2	129	146	PF00022	0.505
LIG_BRCT_BRCA1_1	109	113	PF00533	0.399
LIG_Clathr_ClatBox_1	133	137	PF01394	0.467
LIG_FHA_1	106	112	PF00498	0.412
LIG_FHA_1	124	130	PF00498	0.389
LIG_FHA_1	151	157	PF00498	0.452
LIG_FHA_1	203	209	PF00498	0.565
LIG_FHA_1	45	51	PF00498	0.457
LIG_FHA_1	94	100	PF00498	0.417
LIG_IRF3_LxIS_1	155	161	PF10401	0.502
LIG_LIR_Gen_1	110	121	PF02991	0.466
LIG_LIR_Nem_3	110	116	PF02991	0.358
LIG_LIR_Nem_3	28	33	PF02991	0.595
LIG_PCNA_yPIPBox_3	80	92	PF02747	0.457
LIG_Pex14_2	25	29	PF04695	0.213
LIG_SH2_CRK	30	34	PF00017	0.422
LIG_SH2_NCK_1	57	61	PF00017	0.233
LIG_SH2_PTP2	86	89	PF00017	0.385
LIG_SH2_STAP1	34	38	PF00017	0.545
LIG_SH2_STAP1	57	61	PF00017	0.233
LIG_SH2_STAT5	86	89	PF00017	0.385
LIG_SH3_3	124	130	PF00018	0.439
LIG_SUMO_SIM_par_1	124	131	PF11976	0.479
LIG_SUMO_SIM_par_1	204	210	PF11976	0.595
LIG_WRC_WIRS_1	160	165	PF05994	0.345
MOD_CK1_1	145	151	PF00069	0.480
MOD_CK1_1	161	167	PF00069	0.334
MOD_CK1_1	170	176	PF00069	0.571
MOD_CK1_1	181	187	PF00069	0.432
MOD_CK1_1	48	54	PF00069	0.437
MOD_CK2_1	161	167	PF00069	0.535
MOD_GlcNHglycan	101	104	PF01048	0.627
MOD_GlcNHglycan	144	147	PF01048	0.662
MOD_GlcNHglycan	175	178	PF01048	0.694
MOD_GlcNHglycan	183	186	PF01048	0.400
MOD_GlcNHglycan	4	7	PF01048	0.718
MOD_GSK3_1	105	112	PF00069	0.373
MOD_GSK3_1	115	122	PF00069	0.356
MOD_GSK3_1	138	145	PF00069	0.433
MOD_GSK3_1	146	153	PF00069	0.459
MOD_GSK3_1	173	180	PF00069	0.509
MOD_GSK3_1	25	32	PF00069	0.434
MOD_GSK3_1	44	51	PF00069	0.433
MOD_NEK2_1	105	110	PF00069	0.371
MOD_NEK2_1	136	141	PF00069	0.472
MOD_NEK2_1	158	163	PF00069	0.401
MOD_NEK2_1	25	30	PF00069	0.351
MOD_NEK2_1	36	41	PF00069	0.586
MOD_NEK2_1	59	64	PF00069	0.597
MOD_NEK2_2	29	34	PF00069	0.424
MOD_PKA_2	36	42	PF00069	0.549
MOD_Plk_1	123	129	PF00069	0.451
MOD_Plk_4	138	144	PF00069	0.451
MOD_Plk_4	25	31	PF00069	0.401
MOD_Plk_4	45	51	PF00069	0.455
MOD_ProDKin_1	151	157	PF00069	0.496
MOD_ProDKin_1	170	176	PF00069	0.581
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.213
TRG_ENDOCYTIC_2	30	33	PF00928	0.421
TRG_ENDOCYTIC_2	86	89	PF00928	0.364
TRG_ER_diArg_1	11	13	PF00400	0.349
TRG_ER_diArg_1	216	218	PF00400	0.627
TRG_ER_diArg_1	40	43	PF00400	0.570
TRG_NES_CRM1_1	69	82	PF08389	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM14	Leptomonas seymouri	46%	100%
A0A1X0P359	Trypanosomatidae	34%	100%
A0A3S7X383	Leishmania donovani	79%	100%
A0A422P4T9	Trypanosoma rangeli	35%	100%
A4I5B2	Leishmania infantum	79%	100%
C9ZQP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B0K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q7M4	Leishmania major	79%	100%