Putative rac serine-threonine kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rac serine-threonine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HI35_LEIBR

TriTrypDb:

LbrM.30.0920 , LBRM2903_300014800

Length:

510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HI35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HI35

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	336	338	PF00675	0.266
CLV_NRD_NRD_1	345	347	PF00675	0.358
CLV_NRD_NRD_1	437	439	PF00675	0.603
CLV_NRD_NRD_1	495	497	PF00675	0.706
CLV_NRD_NRD_1	79	81	PF00675	0.573
CLV_PCSK_FUR_1	435	439	PF00082	0.610
CLV_PCSK_KEX2_1	336	338	PF00082	0.266
CLV_PCSK_KEX2_1	345	347	PF00082	0.358
CLV_PCSK_KEX2_1	437	439	PF00082	0.603
CLV_PCSK_KEX2_1	459	461	PF00082	0.617
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.617
CLV_PCSK_SKI1_1	109	113	PF00082	0.528
CLV_PCSK_SKI1_1	154	158	PF00082	0.319
CLV_PCSK_SKI1_1	227	231	PF00082	0.308
CLV_PCSK_SKI1_1	313	317	PF00082	0.401
CLV_PCSK_SKI1_1	336	340	PF00082	0.313
CLV_PCSK_SKI1_1	388	392	PF00082	0.558
CLV_PCSK_SKI1_1	48	52	PF00082	0.529
CLV_PCSK_SKI1_1	497	501	PF00082	0.634
DEG_APCC_DBOX_1	153	161	PF00400	0.345
DOC_CKS1_1	375	380	PF01111	0.537
DOC_CYCLIN_RxL_1	40	51	PF00134	0.528
DOC_CYCLIN_yClb1_LxF_4	297	303	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.484
DOC_MAPK_gen_1	227	236	PF00069	0.401
DOC_MAPK_gen_1	354	364	PF00069	0.497
DOC_PP1_RVXF_1	279	286	PF00149	0.308
DOC_PP2B_LxvP_1	372	375	PF13499	0.484
DOC_USP7_MATH_1	467	471	PF00917	0.615
DOC_USP7_UBL2_3	126	130	PF12436	0.341
DOC_WW_Pin1_4	374	379	PF00397	0.515
DOC_WW_Pin1_4	397	402	PF00397	0.640
DOC_WW_Pin1_4	420	425	PF00397	0.731
DOC_WW_Pin1_4	449	454	PF00397	0.721
LIG_14-3-3_CanoR_1	345	351	PF00244	0.401
LIG_14-3-3_CanoR_1	496	505	PF00244	0.712
LIG_14-3-3_CanoR_1	80	88	PF00244	0.562
LIG_Actin_WH2_2	38	55	PF00022	0.530
LIG_APCC_ABBAyCdc20_2	222	228	PF00400	0.401
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_EH1_1	178	186	PF00400	0.401
LIG_eIF4E_1	179	185	PF01652	0.401
LIG_eIF4E_1	268	274	PF01652	0.401
LIG_FHA_1	14	20	PF00498	0.441
LIG_FHA_1	314	320	PF00498	0.409
LIG_FHA_1	329	335	PF00498	0.438
LIG_FHA_1	389	395	PF00498	0.586
LIG_FHA_1	474	480	PF00498	0.658
LIG_FHA_1	58	64	PF00498	0.508
LIG_FHA_2	100	106	PF00498	0.479
LIG_FHA_2	190	196	PF00498	0.401
LIG_FHA_2	29	35	PF00498	0.481
LIG_FHA_2	347	353	PF00498	0.352
LIG_FHA_2	427	433	PF00498	0.655
LIG_FHA_2	49	55	PF00498	0.492
LIG_LIR_Apic_2	265	271	PF02991	0.308
LIG_LIR_Gen_1	15	26	PF02991	0.478
LIG_LIR_Gen_1	189	199	PF02991	0.437
LIG_LIR_Gen_1	2	8	PF02991	0.479
LIG_LIR_Gen_1	294	303	PF02991	0.364
LIG_LIR_Nem_3	116	120	PF02991	0.362
LIG_LIR_Nem_3	15	21	PF02991	0.455
LIG_LIR_Nem_3	189	194	PF02991	0.333
LIG_LIR_Nem_3	2	7	PF02991	0.427
LIG_LIR_Nem_3	284	288	PF02991	0.308
LIG_LIR_Nem_3	294	300	PF02991	0.308
LIG_LIR_Nem_3	363	367	PF02991	0.375
LIG_Pex14_1	14	18	PF04695	0.479
LIG_Pex14_2	106	110	PF04695	0.401
LIG_Pex14_2	386	390	PF04695	0.473
LIG_PTB_Apo_2	358	365	PF02174	0.442
LIG_SH2_CRK	117	121	PF00017	0.401
LIG_SH2_PTP2	18	21	PF00017	0.417
LIG_SH2_SRC	18	21	PF00017	0.428
LIG_SH2_SRC	218	221	PF00017	0.341
LIG_SH2_STAP1	208	212	PF00017	0.341
LIG_SH2_STAT3	170	173	PF00017	0.308
LIG_SH2_STAT3	193	196	PF00017	0.372
LIG_SH2_STAT5	18	21	PF00017	0.324
LIG_SH2_STAT5	193	196	PF00017	0.453
LIG_SH2_STAT5	218	221	PF00017	0.367
LIG_SH2_STAT5	262	265	PF00017	0.326
LIG_SH2_STAT5	268	271	PF00017	0.289
LIG_SH2_STAT5	27	30	PF00017	0.427
LIG_SH2_STAT5	4	7	PF00017	0.412
LIG_SH2_STAT5	411	414	PF00017	0.559
LIG_SH2_STAT5	72	75	PF00017	0.422
LIG_SH3_3	251	257	PF00018	0.372
LIG_SH3_3	316	322	PF00018	0.401
LIG_SH3_3	372	378	PF00018	0.458
LIG_SH3_3	448	454	PF00018	0.549
LIG_SH3_3	52	58	PF00018	0.566
LIG_TRAF2_1	171	174	PF00917	0.401
LIG_TRAF2_1	349	352	PF00917	0.321
LIG_TRAF2_1	418	421	PF00917	0.697
LIG_TYR_ITIM	224	229	PF00017	0.308
LIG_TYR_ITSM	14	21	PF00017	0.467
LIG_UBA3_1	334	341	PF00899	0.425
MOD_CK1_1	13	19	PF00069	0.401
MOD_CK1_1	320	326	PF00069	0.230
MOD_CK1_1	440	446	PF00069	0.704
MOD_CK1_1	462	468	PF00069	0.851
MOD_CK1_1	95	101	PF00069	0.592
MOD_CK2_1	101	107	PF00069	0.311
MOD_CK2_1	168	174	PF00069	0.379
MOD_CK2_1	189	195	PF00069	0.358
MOD_CK2_1	346	352	PF00069	0.352
MOD_CK2_1	415	421	PF00069	0.709
MOD_CK2_1	426	432	PF00069	0.560
MOD_CK2_1	443	449	PF00069	0.639
MOD_CK2_1	48	54	PF00069	0.497
MOD_Cter_Amidation	457	460	PF01082	0.560
MOD_Cter_Amidation	78	81	PF01082	0.353
MOD_GlcNHglycan	1	4	PF01048	0.432
MOD_GlcNHglycan	136	140	PF01048	0.351
MOD_GlcNHglycan	36	39	PF01048	0.505
MOD_GlcNHglycan	445	448	PF01048	0.602
MOD_GlcNHglycan	465	468	PF01048	0.611
MOD_GlcNHglycan	469	472	PF01048	0.612
MOD_GSK3_1	258	265	PF00069	0.325
MOD_GSK3_1	313	320	PF00069	0.247
MOD_GSK3_1	420	427	PF00069	0.730
MOD_GSK3_1	437	444	PF00069	0.537
MOD_GSK3_1	445	452	PF00069	0.725
MOD_GSK3_1	458	465	PF00069	0.823
MOD_GSK3_1	497	504	PF00069	0.783
MOD_GSK3_1	53	60	PF00069	0.624
MOD_GSK3_1	6	13	PF00069	0.345
MOD_GSK3_1	91	98	PF00069	0.623
MOD_N-GLC_1	397	402	PF02516	0.661
MOD_N-GLC_1	462	467	PF02516	0.848
MOD_N-GLC_1	501	506	PF02516	0.661
MOD_N-GLC_1	91	96	PF02516	0.567
MOD_NEK2_1	168	173	PF00069	0.319
MOD_NEK2_2	84	89	PF00069	0.489
MOD_PIKK_1	399	405	PF00454	0.691
MOD_PIKK_1	497	503	PF00454	0.498
MOD_PIKK_1	6	12	PF00454	0.326
MOD_PKA_1	125	131	PF00069	0.341
MOD_PKA_1	437	443	PF00069	0.676
MOD_PKA_1	459	465	PF00069	0.611
MOD_PKA_1	497	503	PF00069	0.640
MOD_PKA_2	414	420	PF00069	0.458
MOD_PKA_2	437	443	PF00069	0.634
MOD_PKA_2	459	465	PF00069	0.720
MOD_PKA_2	79	85	PF00069	0.500
MOD_PKB_1	435	443	PF00069	0.627
MOD_Plk_1	317	323	PF00069	0.381
MOD_Plk_1	501	507	PF00069	0.660
MOD_Plk_1	68	74	PF00069	0.479
MOD_Plk_1	91	97	PF00069	0.418
MOD_Plk_2-3	189	195	PF00069	0.355
MOD_Plk_2-3	99	105	PF00069	0.488
MOD_Plk_4	68	74	PF00069	0.477
MOD_ProDKin_1	374	380	PF00069	0.527
MOD_ProDKin_1	397	403	PF00069	0.646
MOD_ProDKin_1	420	426	PF00069	0.732
MOD_ProDKin_1	449	455	PF00069	0.721
MOD_SUMO_for_1	229	232	PF00179	0.308
MOD_SUMO_rev_2	104	111	PF00179	0.365
MOD_SUMO_rev_2	140	150	PF00179	0.401
MOD_SUMO_rev_2	329	334	PF00179	0.372
MOD_SUMO_rev_2	351	355	PF00179	0.230
MOD_SUMO_rev_2	44	50	PF00179	0.495
TRG_DiLeu_BaEn_1	330	335	PF01217	0.401
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.225
TRG_ENDOCYTIC_2	117	120	PF00928	0.401
TRG_ENDOCYTIC_2	179	182	PF00928	0.310
TRG_ENDOCYTIC_2	18	21	PF00928	0.332
TRG_ENDOCYTIC_2	226	229	PF00928	0.308
TRG_ENDOCYTIC_2	4	7	PF00928	0.418
TRG_ER_diArg_1	335	337	PF00400	0.268
TRG_ER_diArg_1	345	347	PF00400	0.367
TRG_ER_diArg_1	434	437	PF00400	0.743
TRG_NLS_Bipartite_1	480	500	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J7	Leptomonas seymouri	29%	100%
A0A0S4JER5	Bodo saltans	43%	100%
A0A0S4JI67	Bodo saltans	30%	100%
A0A1X0P3J5	Trypanosomatidae	41%	100%
A0A3Q8IC87	Leishmania donovani	28%	100%
A0A3Q8IIG1	Leishmania donovani	26%	100%
A0A3Q8INQ4	Leishmania donovani	36%	100%
A0A3Q8IRT6	Leishmania donovani	93%	100%
A0A3Q8IVR8	Leishmania donovani	24%	100%
A0A3S5H5U5	Leishmania donovani	29%	100%
A0A3S7WTN9	Leishmania donovani	31%	100%
A0A3S7WWE7	Leishmania donovani	25%	100%
A0A3S7X7Y2	Leishmania donovani	25%	100%
A0A3S7X9R4	Leishmania donovani	40%	100%
A0A3S7X9S2	Leishmania donovani	40%	100%
A0A422NZ62	Trypanosoma rangeli	36%	74%
A0A422P4V9	Trypanosoma rangeli	41%	100%
A4H4S9	Leishmania braziliensis	28%	100%
A4H8C4	Leishmania braziliensis	31%	100%
A4HAS1	Leishmania braziliensis	26%	100%
A4HBL4	Leishmania braziliensis	25%	100%
A4HCD7	Leishmania braziliensis	29%	100%
A4HCE6	Leishmania braziliensis	28%	100%
A4HED7	Leishmania braziliensis	37%	100%
A4HFF3	Leishmania braziliensis	27%	100%
A4HH03	Leishmania braziliensis	25%	100%
A4HHR5	Leishmania braziliensis	27%	99%
A4HHY4	Leishmania braziliensis	25%	100%
A4HN71	Leishmania braziliensis	40%	100%
A4HNT2	Leishmania braziliensis	23%	100%
A4HWP5	Leishmania infantum	31%	100%
A4HZA2	Leishmania infantum	25%	100%
A4HZV1	Leishmania infantum	28%	100%
A4I1T4	Leishmania infantum	36%	100%
A4I435	Leishmania infantum	26%	100%
A4I5B1	Leishmania infantum	93%	100%
A4I9Y5	Leishmania infantum	25%	100%
A4IBT4	Leishmania infantum	40%	100%
A4IBT9	Leishmania infantum	40%	100%
A4ICR2	Leishmania infantum	24%	100%
C6K3W8	Leptomonas seymouri	73%	97%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZTP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AFM1	Leishmania major	40%	100%
E9AG71	Leishmania infantum	29%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
F1M7Y5	Rattus norvegicus	36%	86%
O97627	Didelphis virginiana	34%	74%
P05126	Bos taurus	34%	76%
P05772	Oryctolagus cuniculus	34%	76%
P18961	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	75%
P21146	Bos taurus	34%	74%
P23443	Homo sapiens	42%	97%
P25098	Homo sapiens	34%	74%
P26817	Rattus norvegicus	34%	74%
P28867	Mus musculus	33%	76%
P31748	AKT8 murine leukemia virus	36%	100%
P31750	Mus musculus	36%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	97%
P41743	Homo sapiens	36%	86%
P47196	Rattus norvegicus	36%	100%
P47197	Rattus norvegicus	35%	100%
P53894	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	67%
P54265	Mus musculus	30%	81%
P54644	Dictyostelium discoideum	37%	100%
P67998	Oryctolagus cuniculus	38%	97%
P67999	Rattus norvegicus	38%	97%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	90%
Q10364	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	79%
Q15349	Homo sapiens	26%	70%
Q15835	Homo sapiens	31%	91%
Q4Q0B0	Leishmania major	26%	100%
Q4Q204	Leishmania major	23%	100%
Q4Q7M5	Leishmania major	93%	100%
Q4Q7S2	Leishmania major	25%	100%
Q4Q7W2	Leishmania major	26%	100%
Q4Q9K2	Leishmania major	37%	100%
Q4QBR6	Leishmania major	30%	100%
Q4QCK0	Leishmania major	25%	100%
Q4QF23	Leishmania major	31%	100%
Q4QFK4	Leishmania major	24%	100%
Q4QIV8	Leishmania major	28%	100%
Q54IH8	Dictyostelium discoideum	29%	94%
Q54Y26	Dictyostelium discoideum	28%	96%
Q5AP53	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	70%
Q5R4K9	Pongo abelii	36%	86%
Q5R7A7	Pongo abelii	37%	100%
Q62074	Mus musculus	36%	86%
Q6BLJ9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	71%
Q6CFS5	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	87%
Q6IP76	Xenopus laevis	37%	100%
Q6PFQ0	Danio rerio	26%	69%
Q6TGC6	Pneumocystis carinii	30%	100%
Q6TJY3	Bos taurus	42%	97%
Q7TPS0	Mus musculus	26%	67%
Q7ZX15	Xenopus laevis	36%	100%
Q8BSK8	Mus musculus	42%	97%
Q8R4V0	Rattus norvegicus	38%	100%
Q8WP15	Sus scrofa	35%	92%
Q96BR1	Homo sapiens	37%	100%
Q98TY9	Xenopus laevis	34%	100%
Q99MK8	Mus musculus	34%	74%
Q9ERE3	Mus musculus	37%	100%
Q9GNR4	Leishmania major	40%	100%
Q9NY57	Homo sapiens	30%	100%
Q9UBS0	Homo sapiens	39%	100%
Q9UK32	Homo sapiens	26%	68%
Q9WUT3	Mus musculus	41%	70%
Q9Z1M4	Mus musculus	38%	100%
V5BCH2	Trypanosoma cruzi	34%	100%
V5DQT5	Trypanosoma cruzi	41%	100%